YU51202A - Postupak za dobijanje acetil-amidiniofenilalanil-cikloheksilglicil-piridinioalaninamida - Google Patents

Postupak za dobijanje acetil-amidiniofenilalanil-cikloheksilglicil-piridinioalaninamida

Info

Publication number
YU51202A
YU51202A YU51202A YUP51202A YU51202A YU 51202 A YU51202 A YU 51202A YU 51202 A YU51202 A YU 51202A YU P51202 A YUP51202 A YU P51202A YU 51202 A YU51202 A YU 51202A
Authority
YU
Yugoslavia
Prior art keywords
salt
amidiniophenylalanyl
cyclohexylglycyl
acetyl
preparation
Prior art date
Application number
YU51202A
Other languages
English (en)
Inventor
Gerhard Breipohl
Wolfgang Holla
Heiner Jendralla
Gerhard Beck
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of YU51202A publication Critical patent/YU51202A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Ovaj pronalazak se odnosi na postupak za dobijanje acetil-amidiniofenilalanilcikloheksilglicil-piridinioalanilamida formule (I), gde su anjoni X- fizioloski prihvatljivi anjoni, i njihovih analoga koji su efikasni inhibitori faktora Xa koagulacije krvi, i koji se mogu koristiti na primer, za prevenciju tromboze. Postupak u skladu sa ovim pronalaskom se sastoji od kuplovanja 2-[2-acetilamino-3-(4-amidinofenil)-propionilamino]-2-cikloheksilsircetne kiseline, koja se dobija iz 2-[2-acetilamino-3-(4-cijanofenil)-akriloilamino]-2-cikloheksilsircetne kiseline, asimetricnim hidrogenovanjem i konverzijom cijano grupe u amidin, ili njegovu so, sa 3-(2-amino-2-karbamoiletil)1-metilpiridinijum solju, ili njene soli. Ovaj pronalazak dalje daje polazne materijale i intermedijare za ovaj postupak, postupke za njihovo dobijanje i (S)-4-amidinofenilalanil-(S)-cikloheksilglicil-(S)-(1-metil-3-piridinio)alaninamid, kao ditozilatnu so.
YU51202A 2000-01-28 2001-01-18 Postupak za dobijanje acetil-amidiniofenilalanil-cikloheksilglicil-piridinioalaninamida YU51202A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10003586 2000-01-28

Publications (1)

Publication Number Publication Date
YU51202A true YU51202A (sh) 2005-11-28

Family

ID=7628946

Family Applications (1)

Application Number Title Priority Date Filing Date
YU51202A YU51202A (sh) 2000-01-28 2001-01-18 Postupak za dobijanje acetil-amidiniofenilalanil-cikloheksilglicil-piridinioalaninamida

Country Status (29)

Country Link
US (2) US20010031858A1 (sh)
EP (1) EP1254159B9 (sh)
JP (1) JP4778181B2 (sh)
KR (1) KR100758141B1 (sh)
CN (1) CN1176104C (sh)
AR (1) AR027246A1 (sh)
AT (1) ATE325810T1 (sh)
AU (1) AU779722B2 (sh)
BR (1) BR0107804A (sh)
CA (1) CA2398497C (sh)
CZ (1) CZ20022583A3 (sh)
DE (1) DE60119491T2 (sh)
DK (1) DK1254159T3 (sh)
EE (1) EE200200410A (sh)
ES (1) ES2262632T3 (sh)
HR (1) HRP20020631A2 (sh)
HU (1) HUP0301986A2 (sh)
IL (2) IL150897A0 (sh)
MX (1) MXPA02006762A (sh)
NO (1) NO20023577L (sh)
NZ (1) NZ520427A (sh)
PL (1) PL356801A1 (sh)
PT (1) PT1254159E (sh)
RU (1) RU2250212C2 (sh)
SK (1) SK10842002A3 (sh)
TW (1) TWI236481B (sh)
WO (1) WO2001055175A2 (sh)
YU (1) YU51202A (sh)
ZA (1) ZA200205990B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
CN101379077A (zh) * 2005-12-07 2009-03-04 夏洛特·豪泽 因子ⅷ和因子ⅷ-类似蛋白的小肽或者拟肽亲合性配体
CN101774942B (zh) * 2010-01-27 2012-08-22 宁波武盛化学有限公司 制备n-乙酰基-dl-环己基甘氨酸的方法
ES2686298T3 (es) * 2010-04-20 2018-10-17 Chiral Quest, Inc. Procedimiento enantioselectivo para alaninas beta sustituidas con cicloalquenilo
CN103249484B (zh) 2010-11-29 2015-09-30 高砂香料工业株式会社 不对称氢化催化剂和利用它制备光学活性的羰基化合物的方法
CN115068469B (zh) * 2022-07-08 2024-02-27 深圳市小分子新药创新中心有限公司 Tigit抑制剂及其应用
CN115612702A (zh) * 2022-10-09 2023-01-17 深圳市茵诺圣生物科技有限公司 L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4440679A (en) 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
CN1135717A (zh) * 1993-10-15 1996-11-13 罗纳-布朗克·罗莱尔药物有限公司 抗血栓形成的氮杂环烷基链烷酰肽和假肽
US5849510A (en) 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
AU707653B2 (en) * 1994-04-26 1999-07-15 Selectide Corporation Factor Xa inhibitors
PT868526E (pt) * 1995-12-20 2002-12-31 Aventis Pharma Inc Processo para a preparacao de n-acetil-(l)-4-cianofenilalanina ac-(l)-phe(4-cn)-oh e n-acetil-(l)-p-amidinofenilalanina-ciclo-hexilglicina-beta-(3-n-metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2
DE19856443A1 (de) 1998-12-08 2000-06-21 Centeon Pharma Gmbh Stabilisiertes Antithrombin III-Präparat

Also Published As

Publication number Publication date
BR0107804A (pt) 2002-10-22
NO20023577D0 (no) 2002-07-26
HRP20020631A2 (en) 2004-12-31
RU2250212C2 (ru) 2005-04-20
EP1254159A2 (en) 2002-11-06
JP4778181B2 (ja) 2011-09-21
WO2001055175A2 (en) 2001-08-02
EP1254159B9 (en) 2006-06-28
NZ520427A (en) 2004-02-27
DE60119491D1 (de) 2006-06-14
US7084250B2 (en) 2006-08-01
ZA200205990B (en) 2003-04-30
HK1051866A1 (en) 2003-08-22
JP2003523364A (ja) 2003-08-05
WO2001055175A3 (en) 2002-02-21
CN1176104C (zh) 2004-11-17
IL150897A0 (en) 2003-02-12
AU779722B2 (en) 2005-02-10
NO20023577L (no) 2002-08-28
IL150897A (en) 2008-08-07
AU4051601A (en) 2001-08-07
CZ20022583A3 (cs) 2002-10-16
EE200200410A (et) 2003-12-15
EP1254159B1 (en) 2006-05-10
US20010031858A1 (en) 2001-10-18
RU2002123046A (ru) 2004-01-10
AR027246A1 (es) 2003-03-19
CN1396928A (zh) 2003-02-12
HUP0301986A2 (hu) 2003-09-29
CA2398497C (en) 2011-04-26
SK10842002A3 (sk) 2003-04-01
MXPA02006762A (es) 2002-10-23
PT1254159E (pt) 2006-07-31
KR20030019306A (ko) 2003-03-06
PL356801A1 (en) 2004-07-12
TWI236481B (en) 2005-07-21
DE60119491T2 (de) 2006-11-16
DK1254159T3 (da) 2006-09-11
ES2262632T3 (es) 2006-12-01
KR100758141B1 (ko) 2007-09-13
CA2398497A1 (en) 2001-08-02
US20040225109A1 (en) 2004-11-11
ATE325810T1 (de) 2006-06-15

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