NO20024111D0 - Fremgangsmåte samt intermediater ved fremstilling av substituerte asparaginsyreacetater - Google Patents
Fremgangsmåte samt intermediater ved fremstilling av substituerte asparaginsyreacetaterInfo
- Publication number
- NO20024111D0 NO20024111D0 NO20024111A NO20024111A NO20024111D0 NO 20024111 D0 NO20024111 D0 NO 20024111D0 NO 20024111 A NO20024111 A NO 20024111A NO 20024111 A NO20024111 A NO 20024111A NO 20024111 D0 NO20024111 D0 NO 20024111D0
- Authority
- NO
- Norway
- Prior art keywords
- sup
- sub
- intermediates
- preparation
- well
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- SBAWUJIHCMNFHY-DKWTVANSSA-N acetic acid;(2s)-2-aminobutanedioic acid Chemical class CC(O)=O.OC(=O)[C@@H](N)CC(O)=O SBAWUJIHCMNFHY-DKWTVANSSA-N 0.000 title 1
- 229940123169 Caspase inhibitor Drugs 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19932900P | 2000-04-24 | 2000-04-24 | |
| PCT/US2001/012769 WO2001081330A2 (en) | 2000-04-24 | 2001-04-19 | Process and intermediates for making substituted aspartic acid acetals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20024111L NO20024111L (no) | 2002-08-28 |
| NO20024111D0 true NO20024111D0 (no) | 2002-08-28 |
Family
ID=22737094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20024111A NO20024111D0 (no) | 2000-04-24 | 2002-08-28 | Fremgangsmåte samt intermediater ved fremstilling av substituerte asparaginsyreacetater |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7109357B2 (de) |
| EP (1) | EP1278737B1 (de) |
| AT (1) | ATE472539T1 (de) |
| AU (2) | AU5369201A (de) |
| BG (1) | BG107028A (de) |
| CA (1) | CA2402128A1 (de) |
| CZ (1) | CZ20023506A3 (de) |
| DE (1) | DE60142470D1 (de) |
| ES (1) | ES2347133T3 (de) |
| IL (1) | IL152393A (de) |
| NO (1) | NO20024111D0 (de) |
| RU (1) | RU2002135317A (de) |
| SK (1) | SK15592002A3 (de) |
| WO (1) | WO2001081330A2 (de) |
| ZA (1) | ZA200206658B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7053056B2 (en) | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| WO2004081184A2 (en) | 2003-03-07 | 2004-09-23 | Seminis Vegetable Seeds, Inc. | Markerless transformation |
| AU2003902704A0 (en) * | 2003-05-29 | 2003-06-19 | Crc For Waste Management And Pollution Control Limited Of Unsw | Process for producing a nanoscale zero-valent metal |
| US7652153B2 (en) | 2004-02-27 | 2010-01-26 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| EP2399916B1 (de) * | 2004-03-12 | 2014-12-10 | Vertex Pharmaceuticals Incorporated | Verfahren und Zwischenprodukte zur Herstellung von Asparaginacetal-Caspase-Inhibitoren |
| AU2012201242B2 (en) * | 2004-03-12 | 2014-06-12 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
| WO2005115362A1 (en) * | 2004-05-15 | 2005-12-08 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
| CN101268084A (zh) * | 2005-07-28 | 2008-09-17 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物 |
| DE602007012269D1 (de) | 2006-08-31 | 2011-03-10 | Monsanto Technology Llc | Verfahren zur herstellung transgener pflanzen |
| CN101534824A (zh) * | 2006-11-17 | 2009-09-16 | 艾博特公司 | 作为化学活素受体拮抗剂的氨基吡咯烷 |
| WO2010062846A1 (en) * | 2008-11-26 | 2010-06-03 | Hammond Gerald B | Synthesis of stable organogold compounds and methods of use thereof |
| IL287136B2 (en) | 2016-02-05 | 2023-09-01 | Denali Therapeutics Inc | Receptor inhibitors - interacting with protein kinase 1 |
| JP7208137B2 (ja) | 2016-12-09 | 2023-01-18 | デナリ セラピューティクス インコーポレイテッド | 化合物、組成物および方法 |
| PT3558335T (pt) | 2016-12-23 | 2023-07-20 | Casp Aid Inc | Inibição da caspase-1 e sua utilização na prevenção e tratamento de doenças neurológicas |
| TW202334164A (zh) | 2022-01-12 | 2023-09-01 | 美商戴納立製藥公司 | （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2510560A1 (fr) * | 1981-07-29 | 1983-02-04 | Synthelabo | Procede de preparation d'amino-4 butyramide |
| DD279672A1 (de) * | 1989-01-31 | 1990-06-13 | Akad Wissenschaften Ddr | Verfahren zur herstellung von neuen 5-azido-4-halogen-2(5h)-furanonen |
| DD279673A1 (de) * | 1989-01-31 | 1990-06-13 | Akad Wissenschaften Ddr | Verfahren zur herstellung von neuen 4,5-diazido-2(5h)-furanonen |
| FR2766188B1 (fr) * | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
-
2001
- 2001-04-19 EP EP01927217A patent/EP1278737B1/de not_active Expired - Lifetime
- 2001-04-19 AU AU5369201A patent/AU5369201A/xx active Pending
- 2001-04-19 SK SK1559-2002A patent/SK15592002A3/sk unknown
- 2001-04-19 ES ES01927217T patent/ES2347133T3/es not_active Expired - Lifetime
- 2001-04-19 CZ CZ20023506A patent/CZ20023506A3/cs unknown
- 2001-04-19 IL IL152393A patent/IL152393A/en active IP Right Grant
- 2001-04-19 DE DE60142470T patent/DE60142470D1/de not_active Expired - Lifetime
- 2001-04-19 RU RU2002135317/04A patent/RU2002135317A/ru not_active Application Discontinuation
- 2001-04-19 WO PCT/US2001/012769 patent/WO2001081330A2/en not_active Ceased
- 2001-04-19 AU AU2001253692A patent/AU2001253692B2/en not_active Ceased
- 2001-04-19 CA CA002402128A patent/CA2402128A1/en not_active Abandoned
- 2001-04-19 AT AT01927217T patent/ATE472539T1/de not_active IP Right Cessation
-
2002
- 2002-08-20 ZA ZA200206658A patent/ZA200206658B/en unknown
- 2002-08-22 BG BG107028A patent/BG107028A/bg unknown
- 2002-08-28 US US10/229,981 patent/US7109357B2/en not_active Expired - Lifetime
- 2002-08-28 NO NO20024111A patent/NO20024111D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002135317A (ru) | 2004-04-10 |
| US20030119899A1 (en) | 2003-06-26 |
| NO20024111L (no) | 2002-08-28 |
| US7109357B2 (en) | 2006-09-19 |
| CA2402128A1 (en) | 2001-11-01 |
| IL152393A (en) | 2008-03-20 |
| AU5369201A (en) | 2001-11-07 |
| ES2347133T3 (es) | 2010-10-26 |
| DE60142470D1 (de) | 2010-08-12 |
| HK1053307A1 (en) | 2003-10-17 |
| ZA200206658B (en) | 2004-04-28 |
| EP1278737A2 (de) | 2003-01-29 |
| EP1278737B1 (de) | 2010-06-30 |
| WO2001081330A2 (en) | 2001-11-01 |
| WO2001081330A3 (en) | 2002-03-07 |
| SK15592002A3 (sk) | 2003-04-01 |
| BG107028A (bg) | 2003-06-30 |
| AU2001253692B2 (en) | 2006-11-02 |
| ATE472539T1 (de) | 2010-07-15 |
| IL152393A0 (en) | 2003-05-29 |
| CZ20023506A3 (cs) | 2003-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Reestablishment of rights (par. 72 patents act) | ||
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |