NO20025738D0 - Metode - Google Patents

Metode

Info

Publication number
NO20025738D0
NO20025738D0 NO20025738A NO20025738A NO20025738D0 NO 20025738 D0 NO20025738 D0 NO 20025738D0 NO 20025738 A NO20025738 A NO 20025738A NO 20025738 A NO20025738 A NO 20025738A NO 20025738 D0 NO20025738 D0 NO 20025738D0
Authority
NO
Norway
Prior art keywords
nmr
hyperpolarised
ligands
targets
relates
Prior art date
Application number
NO20025738A
Other languages
English (en)
Norwegian (no)
Inventor
Mathilde H Lerche
Jan Henrik Ardenkjaer-Larsen
Rolf Servin
Mikkel Thanning
Jan Wolber
Klaes Golman
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health As filed Critical Amersham Health As
Priority to NO20025738A priority Critical patent/NO20025738D0/no
Publication of NO20025738D0 publication Critical patent/NO20025738D0/no
Priority to ES03812390T priority patent/ES2348608T3/es
Priority to PCT/NO2003/000396 priority patent/WO2004051300A1/fr
Priority to AT03812390T priority patent/ATE477504T1/de
Priority to AU2003302527A priority patent/AU2003302527A1/en
Priority to JP2004556995A priority patent/JP2006508359A/ja
Priority to DE60333791T priority patent/DE60333791D1/de
Priority to EP03812390A priority patent/EP1579232B1/fr
Priority to US10/537,235 priority patent/US7557573B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Semiconductor Lasers (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Analysis (AREA)
NO20025738A 2002-11-29 2002-11-29 Metode NO20025738D0 (no)

Priority Applications (9)

Application Number Priority Date Filing Date Title
NO20025738A NO20025738D0 (no) 2002-11-29 2002-11-29 Metode
ES03812390T ES2348608T3 (es) 2002-11-29 2003-11-27 Procedimientos basados en rmn para detectar ligandos, en los que el ligando o diana estan hiperpolarizados y el espectro de rmn de compara con un espectro de referencia de ligando o diana.
PCT/NO2003/000396 WO2004051300A1 (fr) 2002-11-29 2003-11-27 Procédés basés sur la rmn pour détecter des ligands, selon lesquels le ligand ou la cible sont hyperpolarisés et le spectre rmn est comparé à un spectre de référence du ligand ou de la cible
AT03812390T ATE477504T1 (de) 2002-11-29 2003-11-27 Auf nmr basiertes verfahren zum erkennen von liganden, wobei ligand oder ziel hyperpolarisiert sind und das nmr-spektrum mit einem referenzspektrum des liganden oder ziels verglichen wird
AU2003302527A AU2003302527A1 (en) 2002-11-29 2003-11-27 Nmr-based methods for detecting ligands, where the ligand or target are hyperpolarised and the nmr-spectrum is compared with a reference spectrum of the ligand or target
JP2004556995A JP2006508359A (ja) 2002-11-29 2003-11-27 リガンド又は標的を過分極させて核磁気共鳴スペクトルをリガンド又は標的の参照スペクトルと比較するリガンドの核磁気共鳴検出法
DE60333791T DE60333791D1 (de) 2002-11-29 2003-11-27 Auf nmr basiertes verfahren zum erkennen von liganden, wobei ligand oder ziel hyperpolarisiert sind und das nmr-spektrum mit einem referenzspektrum des liganden oder ziels verglichen wird
EP03812390A EP1579232B1 (fr) 2002-11-29 2003-11-27 Procedes bases sur la rmn pour detecter des ligands, selon lesquels le ligand ou la cible sont hyperpolaris et le spectre rmn est compare a un spectre de reference du ligand ou de la cible
US10/537,235 US7557573B2 (en) 2002-11-29 2003-11-27 NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO20025738A NO20025738D0 (no) 2002-11-29 2002-11-29 Metode

Publications (1)

Publication Number Publication Date
NO20025738D0 true NO20025738D0 (no) 2002-11-29

Family

ID=19914233

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025738A NO20025738D0 (no) 2002-11-29 2002-11-29 Metode

Country Status (9)

Country Link
US (1) US7557573B2 (fr)
EP (1) EP1579232B1 (fr)
JP (1) JP2006508359A (fr)
AT (1) ATE477504T1 (fr)
AU (1) AU2003302527A1 (fr)
DE (1) DE60333791D1 (fr)
ES (1) ES2348608T3 (fr)
NO (1) NO20025738D0 (fr)
WO (1) WO2004051300A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
EP1954321B1 (fr) 2005-12-01 2011-11-23 Ge Healthcare As Procede de polarisation nucleaire dynamique (dnp) utilisant un radical trityle et un ion metallique paramagnetique
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
US7847547B2 (en) * 2008-01-30 2010-12-07 Wisconsin Alumni Research Foundation Method and system for determining compound concentrations in a mixture using regression of NMR intensity peak values
JP5258107B2 (ja) * 2009-04-17 2013-08-07 独立行政法人国立環境研究所 磁気共鳴装置
SG178927A1 (en) * 2009-08-31 2012-04-27 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US20130149250A1 (en) * 2011-06-23 2013-06-13 The Regents Of The University Of California Hyperpolarized agents for mri characterization of redox systems in vivo
WO2018152434A1 (fr) * 2017-02-17 2018-08-23 The Regents Of The University Of California Systèmes et procédés pour effectuer des affectations dans des protéines marquées par isotope au moyen de données de résonance magnétique nucléaire
EP4130727A1 (fr) * 2021-08-03 2023-02-08 ETH Zurich Analyse d'interaction ligand-cible par spectroscopie rmn améliorée par polarisation nucléaire dynamique induite photochimiquement (photo-cidnp)
US20230072083A1 (en) * 2021-08-20 2023-03-09 The Texas A&M University System System and method for screening of protein-ligand interactions using para-hydrogen polarization and nmr
WO2025074311A1 (fr) * 2023-10-04 2025-04-10 Nvision Imaging Technologies Gmbh Systèmes et procédés d'utilisation de matériaux hyperpolarisés

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004528A1 (en) * 1995-11-14 2001-06-21 Stephen W. Fesik Use of 13c nuclear magnetic resonance to detect binding to target molecules
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
AU711092B2 (en) * 1995-11-14 1999-10-07 Abbvie Inc. Use of nuclear magnetic resonance to design ligands to target biomolecules
RU2186405C2 (ru) * 1996-03-29 2002-07-27 Лоренс Беркли Нэшнл Лэборэтори Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов
US6043024A (en) * 1997-04-18 2000-03-28 Abbott Laboratories Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB9828853D0 (en) * 1998-12-30 1999-02-17 Nycomed Amersham Plc Nmr spectroscopy method
WO2000040988A1 (fr) * 1998-12-30 2000-07-13 Nycomed Amersham Plc Essai in vitro recourant a la spectroscopie rmn utilisant l'hyperpolarisation
EA003094B1 (ru) * 1999-02-26 2002-12-26 Тойо Суйсан Кайся, Лтд. Лекарственное средство, содержащее производное сульфопиранозилацилглицерина
WO2001023889A1 (fr) * 1999-09-29 2001-04-05 Smithkline Beecham Corporation Procede relatif a l'utilisation de la resonance magnetique nucleaire (rmn) uni- et pluridimensionnelle pour identifier les composes ayant une interaction avec des biomolecules cibles
GB9925677D0 (en) * 1999-10-29 1999-12-29 Pharmacia & Upjohn Spa Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules
GB0003865D0 (en) * 2000-02-21 2000-04-05 Univ Leeds Method of screening compounds for biological activity
GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
US6652833B2 (en) * 2000-07-13 2003-11-25 The Regents Of The University Of California Functionalized active-nucleus complex sensor
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US20020119496A1 (en) * 2000-10-20 2002-08-29 Johan Weigelt Nuclear magnetic resonance screening method
SE0003811D0 (sv) 2000-10-20 2000-10-20 Pharmacia Ab Screening methods
DE10160177A1 (de) 2001-12-07 2003-06-26 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden die an ein drug target binden mittels 1H,1H-Kernresonanzspektroskopie
US20050287527A1 (en) 2002-01-11 2005-12-29 National Research Council Of Canada Quantitative ranking of transient ligand binding to target biomolecules
DE10221158A1 (de) 2002-05-13 2004-02-19 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden, die an ein drug target binden, mittels heteronuklearer Kernresonanzspektroskopie
GB0308586D0 (en) * 2003-04-14 2003-05-21 Amersham Health R & D Ab Method and arrangements in NMR spectroscopy
US7196119B2 (en) * 2003-10-21 2007-03-27 The Regents Of The University Of California Development of new selective estrogen receptor modulators

Also Published As

Publication number Publication date
DE60333791D1 (de) 2010-09-23
US7557573B2 (en) 2009-07-07
AU2003302527A1 (en) 2004-06-23
US20060171891A1 (en) 2006-08-03
ATE477504T1 (de) 2010-08-15
JP2006508359A (ja) 2006-03-09
EP1579232B1 (fr) 2010-08-11
WO2004051300A1 (fr) 2004-06-17
EP1579232A1 (fr) 2005-09-28
ES2348608T3 (es) 2010-12-09

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