ATE477504T1 - Auf nmr basiertes verfahren zum erkennen von liganden, wobei ligand oder ziel hyperpolarisiert sind und das nmr-spektrum mit einem referenzspektrum des liganden oder ziels verglichen wird - Google Patents

Auf nmr basiertes verfahren zum erkennen von liganden, wobei ligand oder ziel hyperpolarisiert sind und das nmr-spektrum mit einem referenzspektrum des liganden oder ziels verglichen wird

Info

Publication number
ATE477504T1
ATE477504T1 AT03812390T AT03812390T ATE477504T1 AT E477504 T1 ATE477504 T1 AT E477504T1 AT 03812390 T AT03812390 T AT 03812390T AT 03812390 T AT03812390 T AT 03812390T AT E477504 T1 ATE477504 T1 AT E477504T1
Authority
AT
Austria
Prior art keywords
ligand
target
nmr
spectrum
hyperpolarized
Prior art date
Application number
AT03812390T
Other languages
English (en)
Inventor
Jan-Henrik Ardenkjaer-Larsen
Herbert Baumann
Graham John Cotton
Klaes Golman
Mark Howard
Mathilde H Lerche
Rolf Servin
Mikkel Thaning
Jan Wolber
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Application granted granted Critical
Publication of ATE477504T1 publication Critical patent/ATE477504T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Semiconductor Lasers (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Analysis (AREA)
AT03812390T 2002-11-29 2003-11-27 Auf nmr basiertes verfahren zum erkennen von liganden, wobei ligand oder ziel hyperpolarisiert sind und das nmr-spektrum mit einem referenzspektrum des liganden oder ziels verglichen wird ATE477504T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20025738A NO20025738D0 (no) 2002-11-29 2002-11-29 Metode
PCT/NO2003/000396 WO2004051300A1 (en) 2002-11-29 2003-11-27 Nmr-based methods for detecting ligands, where the ligand or target are hyperpolarised and the nmr-spectrum is compared with a reference spectrum of the ligand or target

Publications (1)

Publication Number Publication Date
ATE477504T1 true ATE477504T1 (de) 2010-08-15

Family

ID=19914233

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03812390T ATE477504T1 (de) 2002-11-29 2003-11-27 Auf nmr basiertes verfahren zum erkennen von liganden, wobei ligand oder ziel hyperpolarisiert sind und das nmr-spektrum mit einem referenzspektrum des liganden oder ziels verglichen wird

Country Status (9)

Country Link
US (1) US7557573B2 (de)
EP (1) EP1579232B1 (de)
JP (1) JP2006508359A (de)
AT (1) ATE477504T1 (de)
AU (1) AU2003302527A1 (de)
DE (1) DE60333791D1 (de)
ES (1) ES2348608T3 (de)
NO (1) NO20025738D0 (de)
WO (1) WO2004051300A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
EP1954321B1 (de) 2005-12-01 2011-11-23 Ge Healthcare As Verfahren zur dynamischen kernpolarisation (dnp) unter verwendung eines tritylrests und eines paramagnetischen metallions
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
US7847547B2 (en) * 2008-01-30 2010-12-07 Wisconsin Alumni Research Foundation Method and system for determining compound concentrations in a mixture using regression of NMR intensity peak values
JP5258107B2 (ja) * 2009-04-17 2013-08-07 独立行政法人国立環境研究所 磁気共鳴装置
SG178927A1 (en) * 2009-08-31 2012-04-27 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US20130149250A1 (en) * 2011-06-23 2013-06-13 The Regents Of The University Of California Hyperpolarized agents for mri characterization of redox systems in vivo
WO2018152434A1 (en) * 2017-02-17 2018-08-23 The Regents Of The University Of California Systems and methods for making assignments in isotope-labelled proteins using nuclear magnetic resonance data
EP4130727A1 (de) * 2021-08-03 2023-02-08 ETH Zurich Analyse der ligand-target-interaktion durch erweiterte nmr-spektroskopie mit fotochemisch induzierter kernpolarisation (photo-cidnp)
US20230072083A1 (en) * 2021-08-20 2023-03-09 The Texas A&M University System System and method for screening of protein-ligand interactions using para-hydrogen polarization and nmr
WO2025074311A1 (en) * 2023-10-04 2025-04-10 Nvision Imaging Technologies Gmbh Systems and methods for use of hyperpolarized materials

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010004528A1 (en) * 1995-11-14 2001-06-21 Stephen W. Fesik Use of 13c nuclear magnetic resonance to detect binding to target molecules
US5698401A (en) 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
AU711092B2 (en) * 1995-11-14 1999-10-07 Abbvie Inc. Use of nuclear magnetic resonance to design ligands to target biomolecules
RU2186405C2 (ru) * 1996-03-29 2002-07-27 Лоренс Беркли Нэшнл Лэборэтори Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов
US6043024A (en) * 1997-04-18 2000-03-28 Abbott Laboratories Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB9828853D0 (en) * 1998-12-30 1999-02-17 Nycomed Amersham Plc Nmr spectroscopy method
WO2000040988A1 (en) * 1998-12-30 2000-07-13 Nycomed Amersham Plc Nmr spectroscopic in vitro assay using hyperpolarization
EA003094B1 (ru) * 1999-02-26 2002-12-26 Тойо Суйсан Кайся, Лтд. Лекарственное средство, содержащее производное сульфопиранозилацилглицерина
WO2001023889A1 (en) * 1999-09-29 2001-04-05 Smithkline Beecham Corporation Method of using one-dimensional and multi-dimensional nuclear magnetic resonance to identify compounds that interact with target biomolecules
GB9925677D0 (en) * 1999-10-29 1999-12-29 Pharmacia & Upjohn Spa Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules
GB0003865D0 (en) * 2000-02-21 2000-04-05 Univ Leeds Method of screening compounds for biological activity
GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
US6652833B2 (en) * 2000-07-13 2003-11-25 The Regents Of The University Of California Functionalized active-nucleus complex sensor
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US20020119496A1 (en) * 2000-10-20 2002-08-29 Johan Weigelt Nuclear magnetic resonance screening method
SE0003811D0 (sv) 2000-10-20 2000-10-20 Pharmacia Ab Screening methods
DE10160177A1 (de) 2001-12-07 2003-06-26 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden die an ein drug target binden mittels 1H,1H-Kernresonanzspektroskopie
US20050287527A1 (en) 2002-01-11 2005-12-29 National Research Council Of Canada Quantitative ranking of transient ligand binding to target biomolecules
DE10221158A1 (de) 2002-05-13 2004-02-19 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden, die an ein drug target binden, mittels heteronuklearer Kernresonanzspektroskopie
GB0308586D0 (en) * 2003-04-14 2003-05-21 Amersham Health R & D Ab Method and arrangements in NMR spectroscopy
US7196119B2 (en) * 2003-10-21 2007-03-27 The Regents Of The University Of California Development of new selective estrogen receptor modulators

Also Published As

Publication number Publication date
DE60333791D1 (de) 2010-09-23
US7557573B2 (en) 2009-07-07
AU2003302527A1 (en) 2004-06-23
US20060171891A1 (en) 2006-08-03
JP2006508359A (ja) 2006-03-09
EP1579232B1 (de) 2010-08-11
WO2004051300A1 (en) 2004-06-17
NO20025738D0 (no) 2002-11-29
EP1579232A1 (de) 2005-09-28
ES2348608T3 (es) 2010-12-09

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