NO20030522L - 4-, 5-, 6- og 7-indolderivater, farmasoytiske sammensetninger inneholdende dem og deres anvendelse. - Google Patents

4-, 5-, 6- og 7-indolderivater, farmasoytiske sammensetninger inneholdende dem og deres anvendelse.

Info

Publication number
NO20030522L
NO20030522L NO20030522A NO20030522A NO20030522L NO 20030522 L NO20030522 L NO 20030522L NO 20030522 A NO20030522 A NO 20030522A NO 20030522 A NO20030522 A NO 20030522A NO 20030522 L NO20030522 L NO 20030522L
Authority
NO
Norway
Prior art keywords
pharmaceutical compositions
compositions containing
indole derivatives
indole
derivatives
Prior art date
Application number
NO20030522A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030522D0 (no
Inventor
Jan Kehler
Benny Bang-Andersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO20030522D0 publication Critical patent/NO20030522D0/no
Publication of NO20030522L publication Critical patent/NO20030522L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
NO20030522A 2000-08-18 2003-02-03 4-, 5-, 6- og 7-indolderivater, farmasoytiske sammensetninger inneholdende dem og deres anvendelse. NO20030522L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001229 2000-08-18
PCT/DK2001/000547 WO2002016349A1 (en) 2000-08-18 2001-08-17 4-, 5-, 6- and 7-indole derivatives useful for the treatment of cns disorders

Publications (2)

Publication Number Publication Date
NO20030522D0 NO20030522D0 (no) 2003-02-03
NO20030522L true NO20030522L (no) 2003-02-03

Family

ID=8159658

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030522A NO20030522L (no) 2000-08-18 2003-02-03 4-, 5-, 6- og 7-indolderivater, farmasoytiske sammensetninger inneholdende dem og deres anvendelse.

Country Status (29)

Country Link
US (2) US6958338B2 (de)
EP (1) EP1309586B1 (de)
JP (1) JP2004506731A (de)
KR (1) KR20030022363A (de)
CN (1) CN1243750C (de)
AR (1) AR030357A1 (de)
AT (1) ATE321040T1 (de)
AU (2) AU2001279611B2 (de)
BG (1) BG107611A (de)
BR (1) BR0113452A (de)
CA (1) CA2419266A1 (de)
CZ (1) CZ2003461A3 (de)
DE (1) DE60118205T2 (de)
DK (1) DK1309586T3 (de)
EA (1) EA006155B1 (de)
ES (1) ES2257424T3 (de)
HR (1) HRP20030052A2 (de)
HU (1) HUP0302777A2 (de)
IL (1) IL154051A0 (de)
IS (1) IS6694A (de)
MX (1) MXPA03000838A (de)
NO (1) NO20030522L (de)
NZ (1) NZ523786A (de)
PL (1) PL363309A1 (de)
PT (1) PT1309586E (de)
SK (1) SK3212003A3 (de)
UA (1) UA74837C2 (de)
WO (1) WO2002016349A1 (de)
ZA (1) ZA200300562B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2520567A3 (de) * 2006-02-23 2012-12-12 Shionogi & Co., Ltd. Mit cyclischen Gruppen substituierte, stickstoffhaltige heterocyclische Derivate
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
JP5420395B2 (ja) 2006-04-07 2014-02-19 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセット輸送体の調節剤
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
TWI404702B (zh) * 2007-08-31 2013-08-11 Lundbeck & Co As H 兒茶酚胺衍生物和其前藥
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2569678C2 (ru) 2010-04-22 2015-11-27 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
JO3425B1 (ar) 2013-07-15 2019-10-20 Novartis Ag مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b
PL3925607T5 (pl) 2014-04-15 2026-06-01 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421641A1 (de) * 1984-06-09 1985-12-12 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5576336A (en) * 1993-03-18 1996-11-19 Merck Sharp & Dohme Limited Indole derivatives as dopamine D4 antagonists
EP0757686A1 (de) * 1994-04-28 1997-02-12 MERCK SHARP & DOHME LTD. Benzofuranderivate als d4 rezeptor antagonisten
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
GB9520731D0 (en) * 1995-10-10 1995-12-13 Merck Sharp & Dohme Therapeutic agents
GB9604036D0 (en) * 1996-02-26 1996-04-24 Merck Sharp & Dohme Therapeutic agents
YU47600A (sh) * 1998-01-27 2002-09-19 Aventis Pharmaceuticals Products Inc. SUPSTITUISANI OKSOAZAHETEROCIKLIL INHIBITORI FAKTORA Xa
WO2001029025A2 (en) * 1999-10-19 2001-04-26 Merck & Co., Inc. Tyrosine kinase inhibitors
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists

Also Published As

Publication number Publication date
EP1309586B1 (de) 2006-03-22
AR030357A1 (es) 2003-08-20
DE60118205D1 (de) 2006-05-11
HUP0302777A2 (hu) 2003-12-29
EP1309586A1 (de) 2003-05-14
MXPA03000838A (es) 2003-06-06
NO20030522D0 (no) 2003-02-03
EA200300278A1 (ru) 2003-06-26
AU2001279611B2 (en) 2006-08-10
SK3212003A3 (en) 2003-07-01
KR20030022363A (ko) 2003-03-15
NZ523786A (en) 2005-07-29
EA006155B1 (ru) 2005-10-27
JP2004506731A (ja) 2004-03-04
HRP20030052A2 (en) 2005-02-28
US7105543B2 (en) 2006-09-12
PL363309A1 (en) 2004-11-15
CN1243750C (zh) 2006-03-01
AU7961101A (en) 2002-03-04
IL154051A0 (en) 2003-07-31
PT1309586E (pt) 2006-06-30
CZ2003461A3 (cs) 2003-05-14
US20030166665A1 (en) 2003-09-04
BG107611A (bg) 2003-12-31
IS6694A (is) 2003-01-20
ZA200300562B (en) 2004-08-23
WO2002016349A1 (en) 2002-02-28
BR0113452A (pt) 2003-07-15
HK1059438A1 (en) 2004-07-02
DE60118205T2 (de) 2006-11-02
CN1447806A (zh) 2003-10-08
ES2257424T3 (es) 2006-08-01
CA2419266A1 (en) 2002-02-28
ATE321040T1 (de) 2006-04-15
US6958338B2 (en) 2005-10-25
DK1309586T3 (da) 2006-07-10
UA74837C2 (en) 2006-02-15
US20060004022A1 (en) 2006-01-05

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application
FC2A Withdrawal, rejection or dismissal of laid open patent application