ATE321040T1 - 4-, 5-, 6- und 7-indolderivate die in der behandlung von störungen des cns benutzt werden können - Google Patents

4-, 5-, 6- und 7-indolderivate die in der behandlung von störungen des cns benutzt werden können

Info

Publication number
ATE321040T1
ATE321040T1 AT01957788T AT01957788T ATE321040T1 AT E321040 T1 ATE321040 T1 AT E321040T1 AT 01957788 T AT01957788 T AT 01957788T AT 01957788 T AT01957788 T AT 01957788T AT E321040 T1 ATE321040 T1 AT E321040T1
Authority
AT
Austria
Prior art keywords
treatment
cns disorders
indole derivatives
indole
derivatives
Prior art date
Application number
AT01957788T
Other languages
English (en)
Inventor
Benny Bang-Andersen
Jan Kehler
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE321040T1 publication Critical patent/ATE321040T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT01957788T 2000-08-18 2001-08-17 4-, 5-, 6- und 7-indolderivate die in der behandlung von störungen des cns benutzt werden können ATE321040T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001229 2000-08-18

Publications (1)

Publication Number Publication Date
ATE321040T1 true ATE321040T1 (de) 2006-04-15

Family

ID=8159658

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01957788T ATE321040T1 (de) 2000-08-18 2001-08-17 4-, 5-, 6- und 7-indolderivate die in der behandlung von störungen des cns benutzt werden können

Country Status (29)

Country Link
US (2) US6958338B2 (de)
EP (1) EP1309586B1 (de)
JP (1) JP2004506731A (de)
KR (1) KR20030022363A (de)
CN (1) CN1243750C (de)
AR (1) AR030357A1 (de)
AT (1) ATE321040T1 (de)
AU (2) AU7961101A (de)
BG (1) BG107611A (de)
BR (1) BR0113452A (de)
CA (1) CA2419266A1 (de)
CZ (1) CZ2003461A3 (de)
DE (1) DE60118205T2 (de)
DK (1) DK1309586T3 (de)
EA (1) EA006155B1 (de)
ES (1) ES2257424T3 (de)
HR (1) HRP20030052A2 (de)
HU (1) HUP0302777A2 (de)
IL (1) IL154051A0 (de)
IS (1) IS6694A (de)
MX (1) MXPA03000838A (de)
NO (1) NO20030522D0 (de)
NZ (1) NZ523786A (de)
PL (1) PL363309A1 (de)
PT (1) PT1309586E (de)
SK (1) SK3212003A3 (de)
UA (1) UA74837C2 (de)
WO (1) WO2002016349A1 (de)
ZA (1) ZA200300562B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2520567A3 (de) * 2006-02-23 2012-12-12 Shionogi & Co., Ltd. Mit cyclischen Gruppen substituierte, stickstoffhaltige heterocyclische Derivate
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
NZ596889A (en) 2006-04-07 2013-06-28 Vertex Pharma Use of amide indole derivatives as modulators of ATP-binding cassette transporters
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
TWI404702B (zh) * 2007-08-31 2013-08-11 Lundbeck & Co As H 兒茶酚胺衍生物和其前藥
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2745977C2 (ru) 2010-04-22 2021-04-05 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
JO3425B1 (ar) 2013-07-15 2019-10-20 Novartis Ag مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b
SG10201913575VA (en) 2014-04-15 2020-02-27 Vertex Pharma Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421641A1 (de) * 1984-06-09 1985-12-12 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
AU6215594A (en) * 1993-03-18 1994-10-11 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
JPH09512542A (ja) * 1994-04-28 1997-12-16 メルク シヤープ エンド ドーム リミテツド Ｄ▲下４▼リセプタ拮抗剤としてのベンゾフラン誘導体
DE19500689A1 (de) 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
GB9520731D0 (en) * 1995-10-10 1995-12-13 Merck Sharp & Dohme Therapeutic agents
GB9604036D0 (en) * 1996-02-26 1996-04-24 Merck Sharp & Dohme Therapeutic agents
WO1999037304A1 (en) * 1998-01-27 1999-07-29 Aventis Pharmaceuticals Products Inc. SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS
DZ3223A1 (fr) * 1999-10-19 2001-04-26 Merck & Co Inc Inhibiteurs de tyrosine kinases
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists

Also Published As

Publication number Publication date
EA200300278A1 (ru) 2003-06-26
HRP20030052A2 (en) 2005-02-28
DK1309586T3 (da) 2006-07-10
MXPA03000838A (es) 2003-06-06
BG107611A (bg) 2003-12-31
AU7961101A (en) 2002-03-04
PT1309586E (pt) 2006-06-30
NZ523786A (en) 2005-07-29
CN1243750C (zh) 2006-03-01
NO20030522L (no) 2003-02-03
DE60118205T2 (de) 2006-11-02
KR20030022363A (ko) 2003-03-15
PL363309A1 (en) 2004-11-15
UA74837C2 (en) 2006-02-15
HUP0302777A2 (hu) 2003-12-29
CN1447806A (zh) 2003-10-08
US6958338B2 (en) 2005-10-25
EA006155B1 (ru) 2005-10-27
NO20030522D0 (no) 2003-02-03
US20030166665A1 (en) 2003-09-04
US20060004022A1 (en) 2006-01-05
AU2001279611B2 (en) 2006-08-10
IS6694A (is) 2003-01-20
SK3212003A3 (en) 2003-07-01
AR030357A1 (es) 2003-08-20
US7105543B2 (en) 2006-09-12
JP2004506731A (ja) 2004-03-04
IL154051A0 (en) 2003-07-31
CA2419266A1 (en) 2002-02-28
ES2257424T3 (es) 2006-08-01
ZA200300562B (en) 2004-08-23
BR0113452A (pt) 2003-07-15
WO2002016349A1 (en) 2002-02-28
EP1309586B1 (de) 2006-03-22
DE60118205D1 (de) 2006-05-11
HK1059438A1 (en) 2004-07-02
CZ2003461A3 (cs) 2003-05-14
EP1309586A1 (de) 2003-05-14

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