NO20030604L - Anvendelse av perfluoralkylholdige metallkomplekser som kontrastmiddel vedMR-avbildning for å påvise plakk, tumorer og nekroser - Google Patents

Anvendelse av perfluoralkylholdige metallkomplekser som kontrastmiddel vedMR-avbildning for å påvise plakk, tumorer og nekroser

Info

Publication number
NO20030604L
NO20030604L NO20030604A NO20030604A NO20030604L NO 20030604 L NO20030604 L NO 20030604L NO 20030604 A NO20030604 A NO 20030604A NO 20030604 A NO20030604 A NO 20030604A NO 20030604 L NO20030604 L NO 20030604L
Authority
NO
Norway
Prior art keywords
perfluoroalkyl
necrosis
tumors
imaging
contrast agent
Prior art date
Application number
NO20030604A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030604D0 (no
Inventor
Johannes Platzek
Peter Mareski
Ulrich Niedballa
Bernd Raduechel
Hanns-Joachim Weinmann
Bernd Misselwitz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040380A external-priority patent/DE10040380B4/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20030604D0 publication Critical patent/NO20030604D0/no
Publication of NO20030604L publication Critical patent/NO20030604L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO20030604A 2000-08-11 2003-02-07 Anvendelse av perfluoralkylholdige metallkomplekser som kontrastmiddel vedMR-avbildning for å påvise plakk, tumorer og nekroser NO20030604L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10040380A DE10040380B4 (de) 2000-08-11 2000-08-11 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
PCT/EP2001/008498 WO2002013874A2 (fr) 2000-08-11 2001-07-23 Utilisation de complexes metalliques contenant du perfluoroalkyle, en tant qu'agents de contraste dans le cadre de l'imagerie rm servant a representer des plaques, tumeurs et necroses

Publications (2)

Publication Number Publication Date
NO20030604D0 NO20030604D0 (no) 2003-02-07
NO20030604L true NO20030604L (no) 2003-04-11

Family

ID=7652860

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030604A NO20030604L (no) 2000-08-11 2003-02-07 Anvendelse av perfluoralkylholdige metallkomplekser som kontrastmiddel vedMR-avbildning for å påvise plakk, tumorer og nekroser

Country Status (26)

Country Link
EP (1) EP1307236A2 (fr)
JP (1) JP2004506025A (fr)
KR (1) KR20030022387A (fr)
CN (1) CN1469757A (fr)
AR (1) AR034139A1 (fr)
AU (2) AU2001277549B2 (fr)
BG (1) BG107542A (fr)
BR (1) BR0113188A (fr)
CA (1) CA2419223A1 (fr)
CZ (1) CZ2003392A3 (fr)
DE (1) DE10066210B4 (fr)
EE (1) EE200300061A (fr)
HR (1) HRP20030173A2 (fr)
HU (1) HUP0300736A3 (fr)
IL (1) IL154385A0 (fr)
MX (1) MXPA03001287A (fr)
NO (1) NO20030604L (fr)
NZ (1) NZ523932A (fr)
PL (1) PL365596A1 (fr)
RU (1) RU2290206C2 (fr)
SK (1) SK1572003A3 (fr)
TW (1) TWI296931B (fr)
UA (1) UA82642C2 (fr)
WO (1) WO2002013874A2 (fr)
YU (1) YU10603A (fr)
ZA (1) ZA200301949B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) * 2006-09-19 2011-02-15 Fujifilm Corporation Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en) * 2014-03-26 2018-05-22 Chevron U.S.A. Inc. Multicarboxylate compositions and method of making the same
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
JP7037069B2 (ja) * 2016-09-14 2022-03-16 ダイキン工業株式会社 分枝含フッ素化合物
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009856A1 (fr) * 1993-10-01 1995-04-13 The Regents Of The University Of California Metalloporphyrines de bore et leurs utilisations therapeutiques
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
JPH10112939A (ja) * 1996-10-07 1998-04-28 Nec Corp 電源切替回路
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

Also Published As

Publication number Publication date
JP2004506025A (ja) 2004-02-26
IL154385A0 (en) 2003-09-17
RU2290206C2 (ru) 2006-12-27
HUP0300736A3 (en) 2010-01-28
WO2002013874A8 (fr) 2002-06-13
AU7754901A (en) 2002-02-25
EE200300061A (et) 2004-12-15
MXPA03001287A (es) 2003-10-06
NO20030604D0 (no) 2003-02-07
SK1572003A3 (en) 2003-10-07
AR034139A1 (es) 2004-02-04
NZ523932A (en) 2007-07-27
KR20030022387A (ko) 2003-03-15
HRP20030173A2 (en) 2005-04-30
DE10066210B4 (de) 2008-02-28
CN1469757A (zh) 2004-01-21
BR0113188A (pt) 2003-06-24
PL365596A1 (en) 2005-01-10
WO2002013874A2 (fr) 2002-02-21
BG107542A (bg) 2003-09-30
EP1307236A2 (fr) 2003-05-07
HUP0300736A2 (hu) 2003-09-29
TWI296931B (en) 2008-05-21
CZ2003392A3 (cs) 2003-09-17
CA2419223A1 (fr) 2003-02-11
YU10603A (sh) 2006-05-25
ZA200301949B (en) 2004-12-14
UA82642C2 (uk) 2008-05-12
AU2001277549B2 (en) 2007-02-08

Similar Documents

Publication Publication Date Title
NO20030604L (no) Anvendelse av perfluoralkylholdige metallkomplekser som kontrastmiddel vedMR-avbildning for å påvise plakk, tumorer og nekroser
AU2002339865A8 (en) Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors
EP1578996A4 (fr) Compositions et methodes pour diagnostiquer et traiter des tumeurs
IS7079A (is) Fenýlsúlfónýl-1,3-díhýdró-2H-indól-2-ón afleiður,framleiðsla þeirra og notkun í meðferðarskyni
WO2006066104A3 (fr) Derives de stilbene et leur utilisation pour la liaison et l'imagerie de plaques amyloides
PL369655A1 (en) Novel-beta-phenyl-alpha-oxysubstituted propionic derivatives, process for its preparation and their use in the preparation of pharmaceutically important compounds
WO2007002109A3 (fr) Chelateurs multicoordinants derives de pyrone destines a l'imagerie medicale et a la chelation
AU9086801A (en) Detection of microsatellite instability and its use in diagnosis of tumors
AU2001277549A1 (en) Use of metal complexes containing perfluoroalkyl as contrast agents in mr-imaging for the representation of plaques, tumours and necroses
AU2002328323A1 (en) 2- 4-(naphtalin-2-yl)-thiazol-2-ylaminocarbonyl benzoic acid and 2- 4-(naphtalin-2-yl)-pyrimidin-2-ylaminocarbonyl benzoic acid and additional compounds serving as telomerase inhibitors for use in tumor therapy
ITMI20011708A0 (it) Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
IL158254A0 (en) Indolinones, substituted in position 6, and their use as kinase inhibitors
AU2001225150A1 (en) Paramagnetic dota derivatives, pharmaceutical agents containing the same, methods for the production thereof and their use for the mr imaging of necrosis and infarction
YU57803A (sh) Upotreba inhibitora il-18 za lečenje i/ili prevenciju srčanih oboljenja
JP2003503705A5 (fr)
EE200300060A (et) Polaarsete rühmadega perfluoroalküülrühma sisaldavad kompleksid, nende valmistamismeetod ja kasutamine
DK1519756T3 (da) Anvendelse af perfluoralkylholdige metalkomplekser som kontrastmiddel i MR-imaging til visning af intravasale tromber
AU2002307100A1 (en) Use of tumor necrosis factor inhibitors to treat cardiovascular disease
EP1613585A4 (fr) Compositions et methodes utilisees dans le traitement de la neoplasie et du cancer, basees sur des inhibiteurs de l'isoprenylcysteine methyltransferase
IL152388A0 (en) Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione
DK1292290T3 (da) Kombineret terapi mod tumorer omfattende substitueret acryloyl distamycinderivater og topoisomerase I og II inhibitorer
WO2008063749A3 (fr) 2-nitroimidazoles faiblement basiques pour la détection non invasive d'une hypoxie tissulaire
CA2410160A1 (fr) Polytherapie anticancereuse a base de derives de distamycine a substitution acryloyle et d'agents alkylants
HUP0100318A3 (en) Salicyli denaminoalcohol derivatives, their chiral copper complexes, their preparations and use of the latter
HUP0301334A3 (en) Combined compositions against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolited

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application