NO20030876L - Fremgangsmåte for racemisering av 1-benzyl-4-(4-fluorfenyl)-3- hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese avparoxetin - Google Patents

Fremgangsmåte for racemisering av 1-benzyl-4-(4-fluorfenyl)-3- hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese avparoxetin

Info

Publication number
NO20030876L
NO20030876L NO20030876A NO20030876A NO20030876L NO 20030876 L NO20030876 L NO 20030876L NO 20030876 A NO20030876 A NO 20030876A NO 20030876 A NO20030876 A NO 20030876A NO 20030876 L NO20030876 L NO 20030876L
Authority
NO
Norway
Prior art keywords
tetrahydropyridine
paroxetine
racemization
fluorophenyl
hydroxymethyl
Prior art date
Application number
NO20030876A
Other languages
English (en)
Other versions
NO324944B1 (no
NO20030876D0 (no
Inventor
Jayne Froggett
Dean Riley
Andrew Turner
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO20030876D0 publication Critical patent/NO20030876D0/no
Publication of NO20030876L publication Critical patent/NO20030876L/no
Publication of NO324944B1 publication Critical patent/NO324944B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20030876A 2000-08-30 2003-02-25 Fremgangsmate for racemisering av 1-benzyl-4-(4-fluorfenyl)-3-hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese av paroxetin samt slike mellomprodukter NO324944B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0021147.4A GB0021147D0 (en) 2000-08-30 2000-08-30 Chemical process
PCT/EP2001/009998 WO2002018338A1 (en) 2000-08-30 2001-08-30 Process for the racemisation of 1-benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-1,2,3,6-tetrahydropyridine to be used as intermediate in the synthesis of paroxetine

Publications (3)

Publication Number Publication Date
NO20030876D0 NO20030876D0 (no) 2003-02-25
NO20030876L true NO20030876L (no) 2003-02-25
NO324944B1 NO324944B1 (no) 2008-01-07

Family

ID=9898420

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030876A NO324944B1 (no) 2000-08-30 2003-02-25 Fremgangsmate for racemisering av 1-benzyl-4-(4-fluorfenyl)-3-hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese av paroxetin samt slike mellomprodukter

Country Status (16)

Country Link
US (1) US6949650B2 (no)
EP (1) EP1315701B1 (no)
JP (1) JP2004518620A (no)
AT (1) ATE421953T1 (no)
AU (1) AU2002213865A1 (no)
CA (1) CA2420579C (no)
CZ (1) CZ2003503A3 (no)
DE (1) DE60137577D1 (no)
ES (1) ES2320631T3 (no)
GB (1) GB0021147D0 (no)
HR (1) HRP20030227A2 (no)
HU (1) HUP0302910A3 (no)
IL (2) IL154302A0 (no)
NO (1) NO324944B1 (no)
SK (1) SK2342003A3 (no)
WO (1) WO2002018338A1 (no)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2748140A (en) * 1954-10-07 1956-05-29 Rohm & Haas 3-hydroxymethyl-4-phenyltetrahydro-pyridines and their esters
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
BR9608471A (pt) * 1995-05-17 1998-12-29 Novo Nordisk As Processo para a preparação de um composto
GB9526645D0 (en) * 1995-12-28 1996-02-28 Chiroscience Ltd Stereoselective synthesis
HU221921B1 (hu) 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
GB9710004D0 (en) 1997-05-17 1997-07-09 Knoll Ag Chemical process
DE19900576A1 (de) * 1999-01-09 2000-07-13 Merck Patent Gmbh Benzolderivate

Also Published As

Publication number Publication date
GB0021147D0 (en) 2000-10-11
NO324944B1 (no) 2008-01-07
ES2320631T3 (es) 2009-05-27
IL154302A (en) 2008-11-03
US20040014786A1 (en) 2004-01-22
EP1315701B1 (en) 2009-01-28
HRP20030227A2 (en) 2005-02-28
ATE421953T1 (de) 2009-02-15
SK2342003A3 (en) 2003-09-11
CA2420579C (en) 2009-11-03
IL154302A0 (en) 2003-09-17
NO20030876D0 (no) 2003-02-25
CZ2003503A3 (cs) 2003-08-13
EP1315701A1 (en) 2003-06-04
HUP0302910A3 (en) 2008-02-28
WO2002018338A1 (en) 2002-03-07
HUP0302910A2 (hu) 2004-01-28
US6949650B2 (en) 2005-09-27
JP2004518620A (ja) 2004-06-24
AU2002213865A1 (en) 2002-03-13
CA2420579A1 (en) 2002-03-07
DE60137577D1 (de) 2009-03-19

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