NO20031939L - Acyl- og sulfonylderivater av 6,9-disubstituerte 2-(trans-1,4-diaminocykloheksyl)-puriner og deres anvendelse som antiproliferative midler - Google Patents

Acyl- og sulfonylderivater av 6,9-disubstituerte 2-(trans-1,4-diaminocykloheksyl)-puriner og deres anvendelse som antiproliferative midler

Info

Publication number: NO20031939L
Authority: NO; Norway
Prior art keywords: diaminocyclohexyl; purines; disubstituted; acyl; trans
Prior art date: 2000-10-31

Application number

NO20031939A

Other languages

English (en)

Norwegian (no)

Other versions

NO20031939D0 (no

Inventor

David Roger Borcherding

Jennifer Ann Dumont

Norton P Peet

Paul S Wright

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-31

Filing date

2003-04-29

Publication date

2003-06-19

2001-07-13 Priority claimed from GBGB0117075.2A external-priority patent/GB0117075D0/en

2003-04-29 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2003-04-29 Publication of NO20031939D0 publication Critical patent/NO20031939D0/no

2003-06-19 Publication of NO20031939L publication Critical patent/NO20031939L/no

Links

125000002252 acyl group Chemical group 0.000 title abstract 2
230000001028 anti-proliverative effect Effects 0.000 title abstract 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 title abstract 2
150000003212 purines Chemical class 0.000 title 1
230000006907 apoptotic process Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20031939A 2000-10-31 2003-04-29 Acyl- og sulfonylderivater av 6,9-disubstituerte 2-(trans-1,4-diaminocykloheksyl)-puriner og deres anvendelse som antiproliferative midler NO20031939L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24456700P	2000-10-31	2000-10-31
GBGB0117075.2A GB0117075D0 (en)	2000-10-31	2001-07-13	Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
PCT/US2001/044835 WO2002042303A2 (en)	2000-10-31	2001-10-31	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

Publications (2)

Publication Number	Publication Date
NO20031939D0 NO20031939D0 (no)	2003-04-29
NO20031939L true NO20031939L (no)	2003-06-19

Family

ID=26246308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031939A NO20031939L (no)	2000-10-31	2003-04-29	Acyl- og sulfonylderivater av 6,9-disubstituerte 2-(trans-1,4-diaminocykloheksyl)-puriner og deres anvendelse som antiproliferative midler

Country Status (14)

Country	Link
EP (1)	EP1377579B1 (da)
JP (1)	JP4348081B2 (da)
AT (1)	ATE426603T1 (da)
AU (2)	AU2002239388B2 (da)
BR (1)	BR0115080A (da)
CA (1)	CA2427338C (da)
DE (1)	DE60138140D1 (da)
DK (1)	DK1377579T3 (da)
ES (1)	ES2324763T3 (da)
IL (1)	IL155590A0 (da)
MX (1)	MXPA03003774A (da)
NO (1)	NO20031939L (da)
NZ (1)	NZ525264A (da)
WO (1)	WO2002042303A2 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7563810B2 (en) *	2002-11-06	2009-07-21	Celgene Corporation	Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
FR2851248B1 (fr) *	2003-02-18	2005-04-08	Aventis Pharma Sa	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
CA2525207A1 (en) *	2003-06-12	2004-12-23	Novo Nordisk A/S	Substituted piperidine carbamates for use as inhibitors of hormone sensitive lipase
US8389533B2 (en) *	2008-04-07	2013-03-05	Amgen Inc.	Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
WO2011090738A2 (en)	2009-12-29	2011-07-28	Dana-Farber Cancer Institute, Inc.	Type ii raf kinase inhibitors
US9382239B2 (en)	2011-11-17	2016-07-05	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-Jun-N-terminal kinase (JNK)
EP3057956B1 (en)	2013-10-18	2021-05-05	Dana-Farber Cancer Institute, Inc.	Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
JP6854762B2 (ja)	2014-12-23	2021-04-07	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
USRE50776E1 (en)	2015-03-27	2026-02-03	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
AU2016319125B2 (en)	2015-09-09	2021-04-08	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
EP3810132A4 (en)	2018-06-25	2022-06-22	Dana-Farber Cancer Institute, Inc.	TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
US11066404B2 (en)	2018-10-11	2021-07-20	Incyte Corporation	Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US11384083B2 (en)	2019-02-15	2022-07-12	Incyte Corporation	Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
TW202100520A (zh)	2019-03-05	2021-01-01	美商英塞特公司	作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
WO2020205560A1 (en)	2019-03-29	2020-10-08	Incyte Corporation	Sulfonylamide compounds as cdk2 inhibitors
WO2020223469A1 (en)	2019-05-01	2020-11-05	Incyte Corporation	N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
US11447494B2 (en)	2019-05-01	2022-09-20	Incyte Corporation	Tricyclic amine compounds as CDK2 inhibitors
CA3150681A1 (en)	2019-08-14	2021-02-18	Incyte Corporation	Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
US11851426B2 (en) *	2019-10-11	2023-12-26	Incyte Corporation	Bicyclic amines as CDK2 inhibitors
US11981671B2 (en)	2021-06-21	2024-05-14	Incyte Corporation	Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en)	2021-12-10	2024-05-07	Incyte Corporation	Bicyclic amines as CDK2 inhibitors
US20240247001A1 (en)	2022-12-16	2024-07-25	Astrazeneca Ab	2,6,9-trisubstituted purines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR200002482T2 (tr) *	1998-02-26	2002-10-21	Aventis Pharmaceuticals Inc.	6,9-Diikameli 2-(Trans-(4-Aminosiklohekzil) Amino)Pürinler
US6479487B1 (en) *	1998-02-26	2002-11-12	Aventis Pharmaceuticals Inc.	6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
FR2793794B1 (fr) *	1999-05-21	2001-07-27	Hoechst Marion Roussel Inc	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
ATE327242T1 (de) *	1999-12-17	2006-06-15	Ariad Pharma Inc	Neue purine
IL150594A0 (en) *	2000-01-07	2003-02-12	Ustav Ex Botan Adademie Ved Ce	Purine derivatives, process for their preparation and use

2001
- 2001-10-31 DK DK01987144T patent/DK1377579T3/da active
- 2001-10-31 IL IL15559001A patent/IL155590A0/xx unknown
- 2001-10-31 BR BR0115080-4A patent/BR0115080A/pt not_active Application Discontinuation
- 2001-10-31 JP JP2002544437A patent/JP4348081B2/ja not_active Expired - Lifetime
- 2001-10-31 AT AT01987144T patent/ATE426603T1/de active
- 2001-10-31 EP EP01987144A patent/EP1377579B1/en not_active Expired - Lifetime
- 2001-10-31 NZ NZ525264A patent/NZ525264A/en not_active IP Right Cessation
- 2001-10-31 AU AU2002239388A patent/AU2002239388B2/en not_active Expired
- 2001-10-31 DE DE60138140T patent/DE60138140D1/de not_active Expired - Lifetime
- 2001-10-31 MX MXPA03003774A patent/MXPA03003774A/es active IP Right Grant
- 2001-10-31 WO PCT/US2001/044835 patent/WO2002042303A2/en not_active Ceased
- 2001-10-31 AU AU3938802A patent/AU3938802A/xx active Pending
- 2001-10-31 CA CA002427338A patent/CA2427338C/en not_active Expired - Lifetime
- 2001-10-31 ES ES01987144T patent/ES2324763T3/es not_active Expired - Lifetime
2003
- 2003-04-29 NO NO20031939A patent/NO20031939L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1377579A2 (en)	2004-01-07
NO20031939D0 (no)	2003-04-29
DK1377579T3 (da)	2009-08-31
MXPA03003774A (es)	2003-07-28
NZ525264A (en)	2005-12-23
JP2004517075A (ja)	2004-06-10
WO2002042303A2 (en)	2002-05-30
ES2324763T3 (es)	2009-08-14
EP1377579B1 (en)	2009-03-25
WO2002042303A3 (en)	2003-10-30
DE60138140D1 (de)	2009-05-07
IL155590A0 (en)	2003-11-23
CA2427338C (en)	2008-06-10
JP4348081B2 (ja)	2009-10-21
CA2427338A1 (en)	2002-05-30
AU2002239388B2 (en)	2006-05-25
BR0115080A (pt)	2003-09-23
ATE426603T1 (de)	2009-04-15
AU3938802A (en)	2002-06-03

Legal Events

Date	Code	Title	Description
2010-09-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20031939L (no)	2003-06-19	Acyl- og sulfonylderivater av 6,9-disubstituerte 2-(trans-1,4-diaminocykloheksyl)-puriner og deres anvendelse som antiproliferative midler
NO331175B1 (no)	2011-10-24	Kinazolin-derivater som angiogenese-inhibitorer og mellomprodukter derav.
DK1254899T3 (da)	2005-09-05	Piperazinderivater og deres anvendelse som anti-inflammatoriske midler
IT1309590B1 (it)	2002-01-24	Derivati di 1-alcossi-polialchil-piperidine e loro impiego comeregolatori della polimerizzazione.
ITRM20010356A0 (it)	2001-06-21	"5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
NO20005265D0 (no)	2000-10-19	Substituerte benzamider, deres fremstilling og anvendelse som inhibitorer av cystin-proteaser
MA25836A1 (fr)	2003-07-01	Derives de pyridine avec une activite inhibitrice de ikb-kinase (ikk-b)
DK1204649T3 (da)	2007-12-03	Arylmethylcarbonylaminothiazolderivater og deres anvendelse som antitumormidler
DK0797439T3 (da)	2003-08-25	Anvendelse af pramipexol som et neurobeskyttende middel
DK1097173T3 (da)	2008-09-01	Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
NO20030374D0 (no)	2003-01-24	Syklopentanoindoler, preparater som inneholder slike forbindelser og behandlingsfremgangsmåter
NO20023613D0 (no)	2002-07-30	Nikotinamid benzokondenserte heterocyclyl derivater nyttige som selektive inhibitorer av PDE4 isozymer
ATE332903T1 (de)	2006-08-15	Kondensierte pyridoindolderivate
NO20025150L (no)	2002-12-16	2-acylindolderivater og deres anvendelse som antitumormidler
DK0625987T3 (da)	1999-01-11	Aminoacetylmercaptoacetylamid-derivater, der kan anvendes som inhibitorer af enkephalinase og ACE
DK1073416T3 (da)	2009-03-09	Anvendelse af NO som anti-inflammatorisk middel
NO20034434D0 (no)	2003-10-03	Indolinoner substituert i 6-stilling og deres anvendelse som kinase-inhibitorer
AR020563A1 (es)	2002-05-15	Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
NO20043173L (no)	2004-07-26	Benzotiazol- og benzoksazol-4,7-dionderivater og deres anvendelse som CDC25-fosfataseinhibitorer
BR0308170A (pt)	2005-01-04	Composição para limpeza lìquida aquosa, método para limpeza de um substrato, e, uso de um polioxometalato
NO20030998L (no)	2003-03-04	Arylpiperazinderivater og deres anvendelse som psykotropiske midler
IT1289154B1 (it)	1998-09-29	Derivati di isoflavone loro preparazione e loro impiego terapeutico
NO20003199D0 (no)	2000-06-20	Benzo(C)kinolizinderivater og deres anvendelse som 5- <alfa>reduktaseinhibitorer
ATE246690T1 (de)	2003-08-15	Thiazolopyrimidine verwendbar als tnf-alpha inhibitoren