NO20032440L - Fremgangsmåte for fremstillingen av iopamidol og de nye intermediater deri - Google Patents

Fremgangsmåte for fremstillingen av iopamidol og de nye intermediater deri

Info

Publication number: NO20032440L
Authority: NO; Norway
Prior art keywords: iopamidol; preparation; novel intermediates; intermediates; novel
Prior art date: 2000-12-01

Application number

NO20032440A

Other languages

English (en)

Other versions

NO328627B1 (no

NO20032440D0 (no

Inventor

Pier Lucio Anelli

Marino Brocchetta

Giovanna Lux

Enrico Cappelletti

Original Assignee

Bracco Imaging Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-01

Filing date

2003-05-28

Publication date

2003-05-28

2003-05-28 Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa

2003-05-28 Publication of NO20032440L publication Critical patent/NO20032440L/no

2003-05-28 Publication of NO20032440D0 publication Critical patent/NO20032440D0/no

2010-04-12 Publication of NO328627B1 publication Critical patent/NO328627B1/no

Links

239000000543 intermediate Substances 0.000 title 1
XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title 1
229960004647 iopamidol Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20032440A 2000-12-01 2003-05-28 Fremgangsmate for fremstillingen av iopamidol og de nye intermediater deri NO328627B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI002601A IT1319671B1 (it)	2000-12-01	2000-12-01	Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
PCT/EP2001/013939 WO2002044132A1 (en)	2000-12-01	2001-11-29	A process for the preparation of iopamidol and the new intermediates therein

Publications (3)

Publication Number	Publication Date
NO20032440L true NO20032440L (no)	2003-05-28
NO20032440D0 NO20032440D0 (no)	2003-05-28
NO328627B1 NO328627B1 (no)	2010-04-12

Family

ID=11446159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20032440A NO328627B1 (no)	2000-12-01	2003-05-28	Fremgangsmate for fremstillingen av iopamidol og de nye intermediater deri

Country Status (22)

Country	Link
US (2)	US7034183B2 (no)
EP (2)	EP1353899B1 (no)
JP (1)	JP4263910B2 (no)
KR (1)	KR100855765B1 (no)
CN (1)	CN100345821C (no)
AU (1)	AU2002217068B8 (no)
BG (1)	BG66276B1 (no)
BR (1)	BRPI0115785B8 (no)
CA (1)	CA2430339C (no)
CZ (1)	CZ304015B6 (no)
EA (1)	EA005922B1 (no)
HU (1)	HU230702B1 (no)
IL (2)	IL156188A0 (no)
IT (1)	IT1319671B1 (no)
MX (1)	MXPA03004774A (no)
NO (1)	NO328627B1 (no)
NZ (1)	NZ526188A (no)
PL (1)	PL204819B1 (no)
SK (1)	SK287570B6 (no)
UA (1)	UA75956C2 (no)
WO (1)	WO2002044132A1 (no)
ZA (1)	ZA200304199B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE034436T2 (en)	2008-11-18	2018-02-28	Bracco Imaging Spa	A method for producing iodinated contrast media
EP2230227A1 (en) *	2009-03-20	2010-09-22	Bracco Imaging S.p.A	Process for the preparation of triiodinated carboxylic aromatic derivatives
US20110021833A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US20110021822A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
PT105770B (pt) *	2011-06-24	2013-07-08	Hovione Farmaciencia S A	Novo intermediário e seu uso na preparação de agente de contrate triiodado
CN103382160B (zh) *	2012-05-02	2017-10-27	上海海神化学生物科技有限公司	碘帕醇的合成及其合成中间体的制备
CN105705483B (zh)	2013-11-05	2018-09-04	伯拉考成像股份公司	碘帕醇的制备方法
CN104098484A (zh) *	2014-07-21	2014-10-15	杭州杜易科技有限公司	一种碘帕醇的制备方法
CN106366015B (zh) *	2015-07-22	2019-01-25	正大天晴药业集团股份有限公司	一种碘普罗胺的制备方法及其中间体
CN106366016B (zh) *	2015-07-22	2019-03-05	连云港润众制药有限公司	一种碘普罗胺的制备方法及其中间体
CN110023279B (zh) *	2016-12-05	2022-03-11	伯拉考成像股份公司	放射照相剂中间体的机械化学合成
GB202009917D0 (en) *	2020-06-29	2020-08-12	Ge Healthcare As	Process for the preparation of iopamidol
KR102764630B1 (ko) *	2021-04-08	2025-02-11	한양대학교 에리카산학협력단	이오파미돌의 제조방법
CN115010617B (zh) *	2022-07-11	2024-06-11	安徽普利药业有限公司	一种碘帕醇的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (no) *	1974-12-13	1978-12-29	Savac Ag
CH616403A5 (en) *	1975-10-29	1980-03-31	Bracco Ind Chimica Spa	Process for the preparation of 2,4,6-triodoisophthalamides which are readily soluble in water.
CH627653A5 (en) *	1977-03-28	1982-01-29	Bracco Ind Chimica Spa	Non-ionic X-ray contrast media and process for the preparation of their radiopaque components
IT1193211B (it) *	1979-08-09	1988-06-15	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) *	1979-08-09	1989-05-17	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
US4396598A (en) *	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
US5278311A (en)	1992-06-05	1994-01-11	E. R. Squibb & Sons, Inc.	Nonionic radiographic contrast agents
IL110391A (en)	1993-07-30	1998-12-06	Zambon Spa	Process for the crystallization of iopamidol
US5811581A (en)	1994-08-04	1998-09-22	Dibra S.P.A.	Process for the purification of opacifying contrast agents
IT1282653B1 (it)	1996-02-20	1998-03-31	Bracco Spa	Dispositivo e metodo per la rigenerazione di letti misti di resine a scambio ionico
US6803485B2 (en) *	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol

2000
- 2000-12-01 IT IT2000MI002601A patent/IT1319671B1/it active
2001
- 2001-11-29 SK SK656-2003A patent/SK287570B6/sk not_active IP Right Cessation
- 2001-11-29 BR BRPI0115785A patent/BRPI0115785B8/pt not_active IP Right Cessation
- 2001-11-29 EP EP01998532.4A patent/EP1353899B1/en not_active Expired - Lifetime
- 2001-11-29 JP JP2002546502A patent/JP4263910B2/ja not_active Expired - Lifetime
- 2001-11-29 HU HU0302758A patent/HU230702B1/hu unknown
- 2001-11-29 AU AU2002217068A patent/AU2002217068B8/en not_active Expired
- 2001-11-29 UA UA2003054617A patent/UA75956C2/uk unknown
- 2001-11-29 US US10/433,389 patent/US7034183B2/en not_active Expired - Lifetime
- 2001-11-29 CA CA2430339A patent/CA2430339C/en not_active Expired - Lifetime
- 2001-11-29 PL PL363799A patent/PL204819B1/pl unknown
- 2001-11-29 IL IL15618801A patent/IL156188A0/xx unknown
- 2001-11-29 NZ NZ526188A patent/NZ526188A/en not_active IP Right Cessation
- 2001-11-29 CN CNB01819785XA patent/CN100345821C/zh not_active Expired - Lifetime
- 2001-11-29 EP EP15179960.8A patent/EP2975021B1/en not_active Expired - Lifetime
- 2001-11-29 EA EA200300513A patent/EA005922B1/ru not_active IP Right Cessation
- 2001-11-29 MX MXPA03004774A patent/MXPA03004774A/es active IP Right Grant
- 2001-11-29 WO PCT/EP2001/013939 patent/WO2002044132A1/en not_active Ceased
- 2001-11-29 CZ CZ20031506A patent/CZ304015B6/cs not_active IP Right Cessation
- 2001-11-29 KR KR1020037007134A patent/KR100855765B1/ko not_active Expired - Lifetime
2003
- 2003-05-19 BG BG107824A patent/BG66276B1/bg unknown
- 2003-05-28 NO NO20032440A patent/NO328627B1/no not_active IP Right Cessation
- 2003-05-29 IL IL156188A patent/IL156188A/en active IP Right Grant
- 2003-05-29 ZA ZA200304199A patent/ZA200304199B/en unknown
2005
- 2005-12-21 US US11/316,559 patent/US7368101B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IT1319671B1 (it)	2003-10-23
IL156188A0 (en)	2003-12-23
CA2430339C (en)	2011-01-25
EP2975021B1 (en)	2017-07-26
BR0115785A (pt)	2003-10-21
EP1353899B1 (en)	2016-01-20
CA2430339A1 (en)	2002-06-06
WO2002044132A1 (en)	2002-06-06
EP1353899A1 (en)	2003-10-22
HUP0302758A2 (hu)	2003-12-29
EP2975021A1 (en)	2016-01-20
HU230702B1 (hu)	2017-10-30
AU1706802A (en)	2002-06-11
MXPA03004774A (es)	2004-03-26
IL156188A (en)	2008-12-29
BG66276B1 (bg)	2012-12-28
EA200300513A1 (ru)	2003-12-25
UA75956C2 (en)	2006-06-15
BRPI0115785B8 (pt)	2021-05-25
CZ20031506A3 (cs)	2003-08-13
KR20030077546A (ko)	2003-10-01
JP2004514705A (ja)	2004-05-20
BR0115785B1 (pt)	2014-11-04
CN100345821C (zh)	2007-10-31
HUP0302758A3 (en)	2005-04-28
US7034183B2 (en)	2006-04-25
CN1478068A (zh)	2004-02-25
US20040082812A1 (en)	2004-04-29
PL204819B1 (pl)	2010-02-26
US20060106253A1 (en)	2006-05-18
SK287570B6 (sk)	2011-03-04
AU2002217068B2 (en)	2006-11-02
AU2002217068B8 (en)	2007-02-01
CZ304015B6 (cs)	2013-08-21
SK6562003A3 (en)	2003-10-07
PL363799A1 (en)	2004-11-29
NO328627B1 (no)	2010-04-12
ITMI20002601A1 (it)	2002-06-01
NO20032440D0 (no)	2003-05-28
NZ526188A (en)	2004-11-26
EA005922B1 (ru)	2005-08-25
ZA200304199B (en)	2004-06-24
KR100855765B1 (ko)	2008-09-01
US7368101B2 (en)	2008-05-06
JP4263910B2 (ja)	2009-05-13
BG107824A (bg)	2004-02-27

Legal Events

Date	Code	Title	Description
2021-12-13	MK1K	Patent expired

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