NO20034863L - Deutererte 3-piperidinopropiofenon så vel som legemidler som inneholder disse forbindelser - Google Patents

Deutererte 3-piperidinopropiofenon så vel som legemidler som inneholder disse forbindelser

Info

Publication number
NO20034863L
NO20034863L NO20034863A NO20034863A NO20034863L NO 20034863 L NO20034863 L NO 20034863L NO 20034863 A NO20034863 A NO 20034863A NO 20034863 A NO20034863 A NO 20034863A NO 20034863 L NO20034863 L NO 20034863L
Authority
NO
Norway
Prior art keywords
deuterated
well
piperidinopropiophenone
compounds
piperidinopropiophenones
Prior art date
Application number
NO20034863A
Other languages
English (en)
Norwegian (no)
Other versions
NO20034863D0 (no
Inventor
Rudolf-Giesbert Alken
Thomas Stabingis
Original Assignee
Turicum Drug Dev Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Turicum Drug Dev Ag filed Critical Turicum Drug Dev Ag
Publication of NO20034863D0 publication Critical patent/NO20034863D0/no
Publication of NO20034863L publication Critical patent/NO20034863L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20034863A 2001-05-02 2003-10-31 Deutererte 3-piperidinopropiofenon så vel som legemidler som inneholder disse forbindelser NO20034863L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10123129A DE10123129A1 (de) 2001-05-02 2001-05-02 Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel
PCT/DE2002/001607 WO2002088100A2 (de) 2001-05-02 2002-04-29 Deuterierte 3-piperidinopropiophenone sowie diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
NO20034863D0 NO20034863D0 (no) 2003-10-31
NO20034863L true NO20034863L (no) 2003-12-30

Family

ID=7684543

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034863A NO20034863L (no) 2001-05-02 2003-10-31 Deutererte 3-piperidinopropiofenon så vel som legemidler som inneholder disse forbindelser

Country Status (22)

Country Link
US (1) US7307091B2 (cs)
EP (1) EP1383752B1 (cs)
JP (1) JP4373097B2 (cs)
KR (1) KR100894846B1 (cs)
CN (2) CN1293064C (cs)
AT (1) ATE298324T1 (cs)
AU (1) AU2002257562B2 (cs)
CA (1) CA2446890C (cs)
CZ (1) CZ20033060A3 (cs)
DE (2) DE10123129A1 (cs)
DK (1) DK1383752T3 (cs)
ES (1) ES2244768T3 (cs)
HU (1) HUP0400077A2 (cs)
IL (1) IL158668A0 (cs)
IS (1) IS7006A (cs)
NO (1) NO20034863L (cs)
NZ (1) NZ529586A (cs)
PL (1) PL363313A1 (cs)
PT (1) PT1383752E (cs)
RU (1) RU2296755C2 (cs)
SI (1) SI1383752T1 (cs)
WO (1) WO2002088100A2 (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10261807A1 (de) 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
HUP0300929A3 (en) * 2003-04-09 2005-06-28 Richter Gedeon Vegyeszet Analgetic and/or muscle relaxant pharmaceutical composition
DE102005014080B4 (de) * 2005-03-21 2007-11-22 Birds Pharma Gmbh Berolina Innovative Research & Development Services Additionssalze des Tolperison, Verfahren zu deren Herstellung, Verwendung derselben und diese enthaltende Arzneimittel
MX2008000901A (es) * 2005-07-26 2008-03-26 Nycomed Gmbh Inhibidores de bomba de protones isotopicamente sustituidos.
US7601737B2 (en) * 2005-07-26 2009-10-13 Nycomed Gmbh Isotopically substituted proton pump inhibitors
AU2006274037B2 (en) * 2005-07-26 2012-04-26 Takeda Gmbh Isotopically substituted pantoprazole
EP1934201A1 (en) * 2005-10-06 2008-06-25 Auspex Pharmaceuticals Inc. Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties
WO2007136790A2 (en) 2006-05-18 2007-11-29 Mannkind Corporation Intracellular kinase inhibitors
EP2049117A4 (en) * 2006-08-08 2010-08-25 Auspex Pharmaceuticals Inc PREPARATION AND USE OF SUBSTITUTED CHINAZOLIN COMPOUNDS WITH ALPHA-ADRENERGER BLOKING EFFECT
JP2013536825A (ja) * 2010-09-03 2013-09-26 イバックス・インターナショナル・ゲーエムベーハー ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体
KR102373288B1 (ko) 2013-12-03 2022-03-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
WO2017105881A1 (en) * 2015-12-15 2017-06-22 NeuForm Pharmaceuticals, Inc. Deuterated compounds for treating pain
DK3407889T3 (da) 2016-03-25 2021-08-09 Intra Cellular Therapies Inc Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet
EP3525763B1 (en) 2016-10-12 2025-03-05 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
CN106588817A (zh) * 2016-12-13 2017-04-26 湖南亚大制药有限公司 一种盐酸乙哌立松的合成方法
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
BR112021003655A2 (pt) 2018-08-31 2021-05-18 Intra-Cellular Therapies, Inc. métodos novos
WO2021007245A1 (en) 2019-07-07 2021-01-14 Intra-Cellular Therapies, Inc. Novel methods
CN110845443B (zh) * 2019-12-11 2023-09-05 嘉实（湖南）医药科技有限公司 一种制备高纯度盐酸托哌酮的方法
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
CN117003605B (zh) * 2023-08-07 2024-06-11 宁波萃英化学技术有限公司 一种氘代萘基蒽类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995047A (en) * 1973-12-14 1976-11-30 Eisai Co., Ltd. Propiophenone derivatives in the treatment of pathological muscular conditions
JPS5527914B2 (cs) * 1973-12-14 1980-07-24
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
HU33131A (cs) * 1984-01-26 1984-10-29

Also Published As

Publication number Publication date
NO20034863D0 (no) 2003-10-31
CN1527823A (zh) 2004-09-08
CA2446890C (en) 2010-02-23
PT1383752E (pt) 2005-11-30
WO2002088100A2 (de) 2002-11-07
IL158668A0 (en) 2004-05-12
DE50203456D1 (de) 2005-07-28
KR100894846B1 (ko) 2009-04-24
US20040186136A1 (en) 2004-09-23
SI1383752T1 (sl) 2005-12-31
CA2446890A1 (en) 2002-11-07
JP4373097B2 (ja) 2009-11-25
EP1383752A2 (de) 2004-01-28
IS7006A (is) 2003-10-30
ES2244768T3 (es) 2005-12-16
AU2002257562B2 (en) 2007-01-11
RU2003133924A (ru) 2005-05-10
CZ20033060A3 (cs) 2004-09-15
CN101002770A (zh) 2007-07-25
DK1383752T3 (da) 2005-10-17
PL363313A1 (en) 2004-11-15
ATE298324T1 (de) 2005-07-15
EP1383752B1 (de) 2005-06-22
DE10123129A1 (de) 2002-11-14
HUP0400077A2 (hu) 2004-04-28
NZ529586A (en) 2005-07-29
KR20040015240A (ko) 2004-02-18
WO2002088100A3 (de) 2003-05-30
JP2004527558A (ja) 2004-09-09
US7307091B2 (en) 2007-12-11
CN1293064C (zh) 2007-01-03
RU2296755C2 (ru) 2007-04-10

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