NO20035721L - 1,2,4-trioksolan-antimalariamidler - Google Patents
1,2,4-trioksolan-antimalariamidlerInfo
- Publication number
- NO20035721L NO20035721L NO20035721A NO20035721A NO20035721L NO 20035721 L NO20035721 L NO 20035721L NO 20035721 A NO20035721 A NO 20035721A NO 20035721 A NO20035721 A NO 20035721A NO 20035721 L NO20035721 L NO 20035721L
- Authority
- NO
- Norway
- Prior art keywords
- trioxolane
- group
- trioxolanes
- spirocyclohexyl
- antimalarials
- Prior art date
Links
- 239000003430 antimalarial agent Substances 0.000 title 1
- 229940033495 antimalarials Drugs 0.000 title 1
- 201000004792 malaria Diseases 0.000 abstract 2
- MAAKQSASDHJHIR-UHFFFAOYSA-N trioxolane Chemical group C1COOO1 MAAKQSASDHJHIR-UHFFFAOYSA-N 0.000 abstract 2
- RZYIPLSVRHWROD-UHFFFAOYSA-N 1,2,4-trioxolane Chemical class C1OCOO1 RZYIPLSVRHWROD-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical class C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 201000004409 schistosomiasis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/02—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dental Preparations (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/886,666 US6486199B1 (en) | 2001-06-21 | 2001-06-21 | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| PCT/US2002/019767 WO2003000676A1 (fr) | 2001-06-21 | 2002-06-21 | Antipaludiques a base de 1,2,4-trioxolane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20035721D0 NO20035721D0 (no) | 2003-12-19 |
| NO20035721L true NO20035721L (no) | 2004-02-23 |
Family
ID=25389491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20035721A NO20035721L (no) | 2001-06-21 | 2003-12-19 | 1,2,4-trioksolan-antimalariamidler |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6486199B1 (fr) |
| EP (1) | EP1414813B1 (fr) |
| JP (1) | JP4303585B2 (fr) |
| KR (1) | KR100759144B1 (fr) |
| CN (1) | CN1545508B (fr) |
| AT (1) | ATE339411T1 (fr) |
| AU (1) | AU2002327183B2 (fr) |
| BR (1) | BRPI0210549B8 (fr) |
| CA (1) | CA2451006C (fr) |
| CY (1) | CY1106214T1 (fr) |
| DE (1) | DE60214733T8 (fr) |
| DK (1) | DK1414813T3 (fr) |
| ES (1) | ES2271323T3 (fr) |
| HU (1) | HUP0400246A3 (fr) |
| IL (1) | IL159474A0 (fr) |
| MX (1) | MXPA03011915A (fr) |
| NO (1) | NO20035721L (fr) |
| PL (1) | PL226418B1 (fr) |
| PT (1) | PT1414813E (fr) |
| RU (1) | RU2271357C2 (fr) |
| SI (1) | SI1414813T1 (fr) |
| UA (1) | UA78709C2 (fr) |
| WO (1) | WO2003000676A1 (fr) |
| YU (1) | YU100703A (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048850B2 (en) * | 2002-06-06 | 2011-11-01 | University Of Washington | Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use |
| US7371778B2 (en) * | 2002-06-21 | 2008-05-13 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US20080125441A1 (en) * | 2002-06-21 | 2008-05-29 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US6906205B2 (en) * | 2002-06-21 | 2005-06-14 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US6825230B2 (en) * | 2002-06-21 | 2004-11-30 | Medicines For Malaria Venture Mmv | Spiro and dispiro 1,2,4-trixolane antimalarials |
| FR2862304A1 (fr) * | 2003-11-14 | 2005-05-20 | Centre Nat Rech Scient | Molecules duales racemiques ou achirales contenant un derive peroxydique, leur synthese et leurs applications therapeutiques |
| WO2006010362A1 (fr) * | 2004-07-23 | 2006-02-02 | Justus-Liebig-Universität Giessen | Derives d'aminoadamantane, leurs procedes de production et leur utilisation |
| US20060040761A1 (en) * | 2004-08-23 | 2006-02-23 | Sam-Kyu Shin | Scale mark mat for putting practice |
| US8067620B2 (en) * | 2005-05-04 | 2011-11-29 | Medicines For Malaria Venture Mmv | Dispiro 1,2,4-trioxolane antimalarials |
| WO2006123314A2 (fr) * | 2005-05-18 | 2006-11-23 | Ranbaxy Laboratories Limited | Formes dosifiees stables de substances antipaludiques de spiro 1,2,4-trioxolane et de dispiro 1,2,4-trioxolane |
| WO2007036947A1 (fr) * | 2005-09-30 | 2007-04-05 | Ipca Laboratories Limited | Composition anti-paludéenne à libération retardée |
| CN101282956B (zh) | 2005-10-04 | 2013-03-20 | 防卫研究与发展组织总干事 | 从白锥花中分离的抗疟化合物 |
| US20070231300A1 (en) * | 2006-03-28 | 2007-10-04 | Washington, University Of | Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents |
| WO2007115821A2 (fr) | 2006-04-11 | 2007-10-18 | Novartis Ag | Composés organiques |
| CN101472582A (zh) * | 2006-05-17 | 2009-07-01 | 兰贝克赛实验室有限公司 | 联用合成青蒿素衍生物和双喹啉衍生物的抗疟疗法 |
| DK2029569T3 (da) * | 2006-05-24 | 2013-02-11 | Ranbaxy Lab Ltd | Fremgangsmåde til fremstillingen af dispiro-1,2,4-trioxolan-antimalariamidler (oz277 salte) |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| GB0619333D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Liverpool | Dispiro tetraoxane compounds |
| US7692030B2 (en) | 2006-10-13 | 2010-04-06 | University Of Washington | Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| WO2010001824A1 (fr) | 2008-07-01 | 2010-01-07 | 国立大学法人 岡山大学 | Nouvel agent antischistosomique |
| WO2010011684A2 (fr) | 2008-07-21 | 2010-01-28 | The Regents Of The University Of California | Promédicament et compositions fluorogéniques et leurs procédés d’utilisation |
| AP2014007413A0 (en) | 2011-07-14 | 2014-02-28 | Ranbaxy Lab Ltd | Stable dosage forms of arterolane and piperaquine |
| US10287312B2 (en) * | 2014-02-14 | 2019-05-14 | The Regents Of The University Of California | Cyclic peroxides as prodrugs for selective delivery of agents |
| WO2016102672A2 (fr) * | 2014-12-23 | 2016-06-30 | Bergenbio As | Composés pharmaceutiquement actifs |
| RU2601315C1 (ru) * | 2015-06-10 | 2016-11-10 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения пентаоксаспироалканов |
| WO2019005977A1 (fr) * | 2017-06-27 | 2019-01-03 | The Regents Of The University Of California | Agents trioxolane |
| CN108424371B (zh) * | 2018-01-19 | 2021-07-16 | 北京理工大学 | 2-(4-氨基环己基)-乙酸乙酯的制备方法 |
| US20210386814A1 (en) * | 2020-05-20 | 2021-12-16 | Amanuel Tesfazion | Methods and compound for the treatment of malaria |
| US20240101584A1 (en) * | 2021-02-01 | 2024-03-28 | Westlake University | Targeted delivery of 1,2,4,5 tetraoxane compounds and their uses |
| CN117085004A (zh) * | 2023-09-27 | 2023-11-21 | 赣南师范大学 | 一种2,6-二苯亚甲基环己酮类似物在制备抗血吸虫药物中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3621062A (en) | 1966-10-25 | 1971-11-16 | Sterling Drug Inc | 2-(8-cyclohexyloctanoyl or 7-cyclohexylheptanoyl)-1-naphthol |
| US3673222A (en) | 1969-11-26 | 1972-06-27 | Sydney Archer | 2-(8-cyclohexyloctyl or 7-cyclohexylheptyl)-1,4-naphthoquinone and process for preparation and use thereof |
| US3682991A (en) | 1970-10-19 | 1972-08-08 | Sterling Drug Inc | 3,3,5-trimethylcyclohexyl-alkyl-carboxylic acids |
| SU1421743A1 (ru) * | 1987-02-18 | 1988-09-07 | Физико-химический институт им.А.В.Богатского | Способ получени 11-нитро-12- @ (2-метокси)-этокси @ -бензо-9-краун-3 |
| US4916204A (en) | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
| US4816478A (en) | 1987-08-24 | 1989-03-28 | Thornfeldt Carl R | Treatment of acquired immunodeficiency syndrome |
| US5053342A (en) | 1987-12-24 | 1991-10-01 | Litmus Concepts, Inc. | Fecal occult blood test reagents |
| US5559145A (en) | 1988-06-01 | 1996-09-24 | Oxaco S.A. | 1,2,4-trioxane derivatives |
| US5270344A (en) | 1988-06-24 | 1993-12-14 | Stephen Herman | Method of treating a systemic disorder using trioxolane and diperoxide compounds |
| JP2867529B2 (ja) | 1990-01-22 | 1999-03-08 | 三菱電機株式会社 | 投写型表示装置 |
| US5216175A (en) | 1990-03-23 | 1993-06-01 | Sri International | Antimalarial analogs of artemisinin |
| US5219880A (en) | 1991-03-29 | 1993-06-15 | Dermatologic Research Corporation | Treatment of viral tumors and hemorrhoids with artemisinin and derivatives |
| DE4125201C1 (fr) * | 1991-07-30 | 1992-10-01 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
| US5510356A (en) | 1991-10-03 | 1996-04-23 | University Of Nebraska Board Of Regents | Bisquinolines and processes for their production and use to treat malaria |
| US5171676A (en) | 1991-10-31 | 1992-12-15 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of introducing hydroxyl groups into artemisinin and its derivatives |
| US5430148A (en) | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| ATE152630T1 (de) | 1992-07-28 | 1997-05-15 | Procter & Gamble | Pharmazeutische zusammensetzung zur topischen anwendung die ein vernetztes kationisches polymer und einen alkoxylierte äther enthält |
| US5721209A (en) | 1995-02-03 | 1998-02-24 | The Regents Of The University Of California | Iron chelator and inhibitor of iron-mediated oxidant injury |
| US5780675A (en) | 1995-04-28 | 1998-07-14 | The University Of New Mexico | Deoxygossylic compounds |
| US5578637A (en) | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
| US5672624A (en) | 1995-11-22 | 1997-09-30 | The Johns Hopkins University | Endoperoxides useful as antiparasitic agents |
| US5817692A (en) | 1995-11-22 | 1998-10-06 | The Johns Hopkins University | Endoperoxides useful as antiparasitic agents |
| US5932591A (en) | 1996-12-02 | 1999-08-03 | Johns Hopkins University | C3 substituted trioxanes useful as antiparasitic drugs |
-
2001
- 2001-06-21 US US09/886,666 patent/US6486199B1/en not_active Expired - Lifetime
-
2002
- 2002-06-21 WO PCT/US2002/019767 patent/WO2003000676A1/fr not_active Ceased
- 2002-06-21 BR BR0210549-7 patent/BRPI0210549B8/pt not_active IP Right Cessation
- 2002-06-21 YU YU100703A patent/YU100703A/sh unknown
- 2002-06-21 DK DK02763208T patent/DK1414813T3/da active
- 2002-06-21 UA UA2004010426A patent/UA78709C2/uk unknown
- 2002-06-21 ES ES02763208T patent/ES2271323T3/es not_active Expired - Lifetime
- 2002-06-21 SI SI200230411T patent/SI1414813T1/sl unknown
- 2002-06-21 AU AU2002327183A patent/AU2002327183B2/en not_active Expired
- 2002-06-21 PT PT02763208T patent/PT1414813E/pt unknown
- 2002-06-21 CA CA2451006A patent/CA2451006C/fr not_active Expired - Lifetime
- 2002-06-21 IL IL15947402A patent/IL159474A0/xx active IP Right Grant
- 2002-06-21 PL PL367158A patent/PL226418B1/pl unknown
- 2002-06-21 RU RU2004101409/04A patent/RU2271357C2/ru active
- 2002-06-21 JP JP2003507080A patent/JP4303585B2/ja not_active Expired - Fee Related
- 2002-06-21 AT AT02763208T patent/ATE339411T1/de not_active IP Right Cessation
- 2002-06-21 KR KR1020037016719A patent/KR100759144B1/ko not_active Expired - Lifetime
- 2002-06-21 MX MXPA03011915A patent/MXPA03011915A/es active IP Right Grant
- 2002-06-21 CN CN028164539A patent/CN1545508B/zh not_active Expired - Lifetime
- 2002-06-21 EP EP02763208A patent/EP1414813B1/fr not_active Expired - Lifetime
- 2002-06-21 DE DE60214733T patent/DE60214733T8/de active Active
- 2002-06-21 HU HU0400246A patent/HUP0400246A3/hu unknown
-
2003
- 2003-12-19 NO NO20035721A patent/NO20035721L/no not_active Application Discontinuation
-
2006
- 2006-10-23 CY CY20061101517T patent/CY1106214T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20035721L (no) | 1,2,4-trioksolan-antimalariamidler | |
| CY1117133T1 (el) | Ανθελονοσιακα δισπειρο-1,2,4-τριοξολανιων | |
| DK0507861T3 (fr) | ||
| NO20052760D0 (no) | Fremgangsmate for behandling av kreft og beslektede fremgangsmater. | |
| LU91928I2 (fr) | Ipilimumab et ses dérivés pharmaceutiquement acceptables (YERVOY®) | |
| DK1441737T3 (da) | Staurosporin-derivater som inhibitorer af FLT3-receptor-tyrosinkinase-aktivitet | |
| WO2002009713A3 (fr) | Inhibiteurs selectifs de pde 2 comme medicaments ameliorant la perception | |
| ATE349209T1 (de) | Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren | |
| AU2001228759A1 (en) | Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols | |
| NO20043016L (no) | 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav | |
| NO20024197L (no) | Fremgangsmåte ved fremstilling av 5-cyano-1-(4-fluorfenyl)- 1,3-dihydroisobenzofuraner | |
| AU2002218337A1 (en) | Method for inducing cognition enhancement by use of trimethyl-bicyclo(2.2.1)heptane derivatives | |
| NO20033318D0 (no) | 2H-1-benzopyranderivater, fremgangsmåte ved fremstilling samt farmasöytiskesammensetninger derav | |
| WO2002076396A3 (fr) | Composes utiles en tant qu'inhibiteurs de kinase pour le traitement de maladies hyperproliferatives | |
| MXPA04000272A (es) | Derivados de 4-aminociclohexanol sustituidos. | |
| WO2004108687A3 (fr) | Derives heteroaryles contenant de l'azote | |
| MY127328A (en) | 5-amino-1-pentene-3-ol substituted derivatives | |
| DE60001581D1 (de) | Ethylthiophen-thioharnstoff-derivate und ihre verwendung | |
| NO20032297D0 (no) | Fremgangsmåte for fremstilling av distamycinderivater | |
| NO20041542L (no) | Fremgangsmate ved fremstilling av 14 beta-hydroksy-baccatin III-1,14-karbonat | |
| NO20041537L (no) | Fremgangsmate ved fremstilling av 14beta-hydroksy-baccatin III-1, 14-karbonat | |
| SE0200205D0 (sv) | Method | |
| DE60203740D1 (de) | Luminacine analoge und deren verwendung | |
| ITMI20022738A1 (it) | Derivati ftalazinici inibitori della fosfodiesterasi 4. | |
| ITMI20011529A0 (it) | Processo per la preparazione di derivati tetraidroisobenzofuranici, loro intermedi ed uso |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |