NO20040500L - 1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister - Google Patents

1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister

Info

Publication number: NO20040500L
Authority: NO; Norway
Prior art keywords: receptor antagonists; gonadotropin; releasing hormone; trions; triazine
Prior art date: 2001-08-02

Application number

NO20040500A

Other languages

English (en)

Inventor

Chen Chen

Zhiqiang Guo

Fabio C Tucci

Dongpei Wu

Collin Regan

Original Assignee

Neurocrine Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-02

Filing date

2004-01-29

Publication date

2004-03-08

2004-01-29 Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc

2004-03-08 Publication of NO20040500L publication Critical patent/NO20040500L/no

Links

229940127445 Gonadotropin Releasing Hormone Receptor Antagonists Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
102000008238 LHRH Receptors Human genes 0.000 abstract 1
108010021290 LHRH Receptors Proteins 0.000 abstract 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
239000003163 gonadal steroid hormone Substances 0.000 abstract 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
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- A61P5/34—Gestagens
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C07D251/34—Cyanuric or isocyanuric esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Pregnancy & Childbirth (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO20040500A 2001-08-02 2004-01-29 1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister NO20040500L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31001801P	2001-08-02	2001-08-02
PCT/US2002/024451 WO2003011839A1 (en)	2001-08-02	2002-08-02	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists

Publications (1)

Publication Number	Publication Date
NO20040500L true NO20040500L (no)	2004-03-08

Family

ID=23200637

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20040500A NO20040500L (no)	2001-08-02	2004-01-29	1, 3, 5-triazin-2, 4, 6-trioner, fremstilling og anvendelse som gonadotropin-frigjorende hormon reseptor antagonister

Country Status (12)

Country	Link
US (2)	US6677340B2 (no)
EP (1)	EP1412338B1 (no)
JP (1)	JP4328617B2 (no)
KR (1)	KR20040030892A (no)
AT (1)	ATE316078T1 (no)
AU (1)	AU2002324586B2 (no)
CA (1)	CA2455833A1 (no)
DE (1)	DE60208803T2 (no)
ES (1)	ES2256522T3 (no)
MX (1)	MXPA04000984A (no)
NO (1)	NO20040500L (no)
WO (1)	WO2003011839A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002324586B2 (en) *	2001-08-02	2008-04-24	Neurocrine Biosciences, Inc.	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
US7015226B2 (en)	2003-07-07	2006-03-21	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
ATE428427T1 (de)	2003-07-07	2009-05-15	Neurocrine Biosciences Inc	Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
CN100424078C (zh)	2003-07-07	2008-10-08	纽罗克里生物科学有限公司	作为促性激素释放激素受体拮抗剂的嘧啶-2,4-二酮衍生物
DE102004033902A1 (de)	2004-07-14	2006-02-16	Zentaris Gmbh	Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
GB0622472D0 (en) *	2006-11-10	2006-12-20	Addex Pharmaceuticals Sa	Novel heterocyclic derivatives
PE20090044A1 (es)	2007-04-06	2009-01-23	Neurocrine Biosciences Inc	Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos
CL2008000986A1 (es)	2007-04-06	2008-10-17	Neurocrine Biosciences Inc	COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV
EP2095818A1 (en)	2008-02-29	2009-09-02	AEterna Zentaris GmbH	Use of LHRH antagonists at non-castrating doses
TW201130854A (en)	2009-12-22	2011-09-16	Bayer Schering Pharma Ag	Pyridinone derivatives and pharmaceutical compositions thereof
WO2012175514A1 (en)	2011-06-21	2012-12-27	Bayer Intellectual Property Gmbh	Pyridinone derivatives and pharmaceutical compositions thereof
MA52415A (fr)	2018-02-26	2021-01-06	AlzeCure Pharma AB	Dérivés de triazine pour le traitement de maladies associées à des neurotrophines
GB201810669D0 (en) *	2018-06-28	2018-08-15	Stiftelsen Alzecure	New compounds
GB201810668D0 (en)	2018-06-28	2018-08-15	Stiftelsen Alzecure	New compounds

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AU5844896A (en)	1995-06-01	1996-12-18	Takeda Chemical Industries Ltd.	Tricyclic diazepines useful as gnrh receptor antagonists
CZ146196A3 (en) *	1995-06-02	1997-05-14	American Cyanamid Co	1-(3-heterocyclylphenyl)-s-triazin-2,4,6-oxo or thiotriones and herbicidal agent based thereon
CA2229201A1 (en)	1995-10-19	1997-04-24	Satoshi Sasaki	Quinoline derivatives, their production and use
EP0862573A1 (en)	1995-10-19	1998-09-09	Takeda Chemical Industries, Ltd.	Thienopyridine derivatives as gonadotropin releasing hormone antagonists
CA2240115A1 (en)	1995-12-14	1997-06-19	Wallace T. Ashton	Antagonists of gonadotropin releasing hormone
US5780437A (en)	1995-12-14	1998-07-14	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
PL327146A1 (en)	1995-12-14	1998-11-23	Merck & Co Inc	Antagonists of the gonadotrophin liberating hormone
US5849764A (en)	1995-12-14	1998-12-15	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
CA2240048A1 (en)	1995-12-14	1997-06-19	Mark Goulet	Antagonists of gonadotropin releasing hormone
SK77498A3 (en)	1995-12-14	1999-01-11	Merck & Co Inc	Nonpeptide derivatives, pharmaceutical composition containing them and their use
WO1997044321A1 (en)	1996-05-20	1997-11-27	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
CA2254756A1 (en)	1996-05-20	1997-11-27	Mark Goulet	Antagonists of gonadotropin releasing hormone
CA2254974A1 (en)	1996-05-20	1997-11-27	Mark Goulet	Antagonists of gonadotropin releasing hormone
US6150352A (en) *	1996-05-20	2000-11-21	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
AU7806998A (en)	1997-06-05	1998-12-21	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
WO1998055470A1 (en)	1997-06-05	1998-12-10	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
AU729663B2 (en)	1997-06-05	2001-02-08	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
CA2292881A1 (en)	1997-06-05	1998-12-10	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US6313301B1 (en)	1997-08-13	2001-11-06	Takeda Chemical Industries, Ltd.	Thienopyridine derivatives, their intermediates and production thereof
US6194419B1 (en)	1997-12-26	2001-02-27	Takeda Chemical Industries, Ltd.	Nitrogen-containing heterocyclic compounds, their production and use
TWI225863B (en)	1999-03-24	2005-01-01	Takeda Chemical Industries Ltd	Thienopyrimidine compounds, their production and use
DE60022769T2 (de)	1999-10-15	2006-07-06	Neurocrine Biosciences, Inc., San Diego	Gonadotropin freisetzenden hormon rezeptor antagonisten und ihre verwandten verwendungen
AU2002324586B2 (en) *	2001-08-02	2008-04-24	Neurocrine Biosciences, Inc.	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists

2002
- 2002-08-01 AU AU2002324586A patent/AU2002324586B2/en not_active Expired - Fee Related
- 2002-08-02 EP EP02759239A patent/EP1412338B1/en not_active Expired - Lifetime
- 2002-08-02 ES ES02759239T patent/ES2256522T3/es not_active Expired - Lifetime
- 2002-08-02 DE DE60208803T patent/DE60208803T2/de not_active Expired - Lifetime
- 2002-08-02 CA CA002455833A patent/CA2455833A1/en not_active Abandoned
- 2002-08-02 US US10/211,955 patent/US6677340B2/en not_active Expired - Lifetime
- 2002-08-02 WO PCT/US2002/024451 patent/WO2003011839A1/en not_active Ceased
- 2002-08-02 JP JP2003517031A patent/JP4328617B2/ja not_active Expired - Fee Related
- 2002-08-02 KR KR10-2004-7001492A patent/KR20040030892A/ko not_active Withdrawn
- 2002-08-02 AT AT02759239T patent/ATE316078T1/de not_active IP Right Cessation
- 2002-08-02 MX MXPA04000984A patent/MXPA04000984A/es not_active Application Discontinuation
2003
- 2003-11-10 US US10/705,723 patent/US20040162290A1/en not_active Abandoned
2004
- 2004-01-29 NO NO20040500A patent/NO20040500L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20040162290A1 (en)	2004-08-19
ATE316078T1 (de)	2006-02-15
US6677340B2 (en)	2004-01-13
US20030130282A1 (en)	2003-07-10
ES2256522T3 (es)	2006-07-16
DE60208803T2 (de)	2006-08-31
KR20040030892A (ko)	2004-04-09
DE60208803D1 (de)	2006-04-06
AU2002324586B2 (en)	2008-04-24
EP1412338A1 (en)	2004-04-28
JP2005501055A (ja)	2005-01-13
WO2003011839A1 (en)	2003-02-13
EP1412338B1 (en)	2006-01-18
MXPA04000984A (es)	2005-02-17
CA2455833A1 (en)	2003-02-13
JP4328617B2 (ja)	2009-09-09

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