NO20041054L - Krystaller som inneholder et eplesyresalt av N-[2-(dietylamino)etyl]-5-[(5-fluor- 2-okso-3H-indol-3-yliden)metyl]-2,4-dimetyl-1H-pyrrol-3-karboksamid, fremgangsmater for fremstilling av disse og preparater derav - Google Patents

Krystaller som inneholder et eplesyresalt av N-[2-(dietylamino)etyl]-5-[(5-fluor- 2-okso-3H-indol-3-yliden)metyl]-2,4-dimetyl-1H-pyrrol-3-karboksamid, fremgangsmater for fremstilling av disse og preparater derav

Info

Publication number: NO20041054L
Authority: NO; Norway
Prior art keywords: ylidene; indol; carboxamide; diethylamino; pyrrole
Prior art date: 2001-08-15

Application number

NO20041054A

Other languages

English (en)

Other versions

NO326508B1 (no

Inventor

Thomas J Fleck

Michael Hawley

Stephen P Prescott

Mark T Maloney

Original Assignee

Pharmacia & Upjohn Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-15

Filing date

2004-03-12

Publication date

2004-03-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23211067&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20041054(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-03-12 Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc

2004-03-12 Publication of NO20041054L publication Critical patent/NO20041054L/no

2008-12-15 Publication of NO326508B1 publication Critical patent/NO326508B1/no

Links

238000002360 preparation method Methods 0.000 title 2
WINHZLLDWRZWRT-UHFFFAOYSA-N N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(C=C2C3=CC(F)=CC=C3NC2=O)=C1C WINHZLLDWRZWRT-UHFFFAOYSA-N 0.000 title 1
239000013078 crystal Substances 0.000 title 1
150000004701 malic acid derivatives Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Oncology (AREA)
Obesity (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)

NO20041054A 2001-08-15 2004-03-12 Krystaller som inneholder et eplesyresalt av N-[2-(dietylamino)etyl]-5-[(5-fluor- 2-okso-3H-indol-3-yliden)metyl]-2,4-dimetyl-1H-pyrrol-3-karboksamid, fremgangsmater for fremstilling av disse og preparater derav NO326508B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31235301P	2001-08-15	2001-08-15
PCT/US2002/025649 WO2003016305A1 (en)	2001-08-15	2002-08-13	Crystals including a malic acid salt of n-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3h-indole-3-ylidene) methyl]-2, 4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof

Publications (2)

Publication Number	Publication Date
NO20041054L true NO20041054L (no)	2004-03-12
NO326508B1 NO326508B1 (no)	2008-12-15

Family

ID=23211067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20041054A NO326508B1 (no)	2001-08-15	2004-03-12	Krystaller som inneholder et eplesyresalt av N-[2-(dietylamino)etyl]-5-[(5-fluor- 2-okso-3H-indol-3-yliden)metyl]-2,4-dimetyl-1H-pyrrol-3-karboksamid, fremgangsmater for fremstilling av disse og preparater derav

Country Status (42)

Country	Link
US (2)	US20030069298A1 (no)
EP (3)	EP2332934B1 (no)
JP (1)	JP4159988B2 (no)
KR (1)	KR100639281B1 (no)
CN (2)	CN100364991C (no)
AP (1)	AP1660A (no)
AR (1)	AR036261A1 (no)
AU (1)	AU2002324684B2 (no)
BG (1)	BG108553A (no)
BR (1)	BR0211612A (no)
CA (1)	CA2455050C (no)
CO (1)	CO5550431A2 (no)
CU (1)	CU23713B7 (no)
CY (1)	CY1121552T1 (no)
CZ (1)	CZ2004196A3 (no)
DK (2)	DK3168218T3 (no)
EA (1)	EA006445B9 (no)
EC (1)	ECSP044975A (no)
ES (3)	ES2705063T3 (no)
GE (1)	GEP20063777B (no)
HR (1)	HRP20040112B1 (no)
HU (1)	HU229206B1 (no)
IL (1)	IL160097A0 (no)
IS (1)	IS7147A (no)
MA (1)	MA27058A1 (no)
ME (1)	ME00414B (no)
MX (1)	MXPA04001452A (no)
MY (1)	MY139383A (no)
NO (1)	NO326508B1 (no)
NZ (1)	NZ531232A (no)
OA (1)	OA12650A (no)
PL (1)	PL216524B1 (no)
PT (2)	PT3168218T (no)
RS (1)	RS53251B (no)
SI (2)	SI3168218T1 (no)
SK (1)	SK902004A3 (no)
TN (1)	TNSN04028A1 (no)
TR (1)	TR201900509T4 (no)
TW (1)	TWI269796B (no)
UA (1)	UA76483C2 (no)
WO (1)	WO2003016305A1 (no)
ZA (1)	ZA200400706B (no)

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WO2009156837A2 (en)	2008-06-26	2009-12-30	Medichem, S.A.	Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt

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Publication number	Publication date
HK1066542A1 (en)	2005-03-24
OA12650A (en)	2006-06-19
HRP20040112A2 (en)	2004-06-30
IL160097A0 (en)	2004-06-20
EP1419151A1 (en)	2004-05-19
TWI269796B (en)	2007-01-01
ECSP044975A (es)	2004-03-23
BG108553A (bg)	2005-04-30
US20030069298A1 (en)	2003-04-10
MY139383A (en)	2009-09-30
SI1419151T1 (sl)	2014-04-30
EA006445B9 (ru)	2017-02-28
EP2332934B1 (en)	2017-03-01
AP1660A (en)	2006-09-09
HRP20040112B1 (en)	2012-03-31
EP3168218A1 (en)	2017-05-17
PL216524B1 (pl)	2014-04-30
RS53251B (sr)	2014-08-29
JP4159988B2 (ja)	2008-10-01
CU20040029A7 (es)	2008-03-14
PT3168218T (pt)	2019-01-11
HK1088008A1 (zh)	2006-10-27
JP2005503386A (ja)	2005-02-03
CN100364991C (zh)	2008-01-30
HU229206B1 (en)	2013-09-30
MXPA04001452A (es)	2004-05-20
WO2003016305A1 (en)	2003-02-27
GEP20063777B (en)	2006-03-27
IS7147A (is)	2004-02-10
TR201900509T4 (tr)	2019-02-21
EA006445B1 (ru)	2005-12-29
CN1789264A (zh)	2006-06-21
ES2705063T3 (es)	2019-03-21
SK902004A3 (sk)	2005-03-04
EA200400183A1 (ru)	2004-08-26
PL368317A1 (en)	2005-03-21
CA2455050C (en)	2007-02-20
CN1543462A (zh)	2004-11-03
CN100439360C (zh)	2008-12-03
US7435832B2 (en)	2008-10-14
NZ531232A (en)	2004-11-26
CZ2004196A3 (cs)	2005-01-12
ES2623094T3 (es)	2017-07-10
EP3168218B1 (en)	2018-11-14
TNSN04028A1 (fr)	2006-06-01
KR100639281B1 (ko)	2006-10-31
AP2004002976A0 (en)	2004-03-31
HUP0700036A2 (en)	2008-10-28
EP1419151B1 (en)	2014-02-26
KR20040030074A (ko)	2004-04-08
PT1419151E (pt)	2014-03-27
ES2453164T3 (es)	2014-04-04
NO326508B1 (no)	2008-12-15
CY1121552T1 (el)	2020-05-29
MA27058A1 (fr)	2004-12-20
CA2455050A1 (en)	2003-02-27
EP2332934A1 (en)	2011-06-15
SI3168218T1 (sl)	2019-05-31
ME00414B (me)	2011-10-10
ZA200400706B (en)	2005-05-25
DK1419151T3 (da)	2014-03-31
AR036261A1 (es)	2004-08-25
UA76483C2 (en)	2006-08-15
CU23713B7 (es)	2011-10-05
RS10304A (sr)	2007-02-05
CO5550431A2 (es)	2005-08-31
US20070191458A1 (en)	2007-08-16
DK3168218T3 (en)	2019-01-14
AU2002324684B2 (en)	2006-10-05
BR0211612A (pt)	2004-08-24

Legal Events

Date	Code	Title	Description
2022-09-12	MK1K	Patent expired

Publication	Publication Date	Title
NO20041054L (no)	2004-03-12	Krystaller som inneholder et eplesyresalt av N-[2-(dietylamino)etyl]-5-[(5-fluor- 2-okso-3H-indol-3-yliden)metyl]-2,4-dimetyl-1H-pyrrol-3-karboksamid, fremgangsmater for fremstilling av disse og preparater derav
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