NO20041379L - Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater - Google Patents
Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivaterInfo
- Publication number
- NO20041379L NO20041379L NO20041379A NO20041379A NO20041379L NO 20041379 L NO20041379 L NO 20041379L NO 20041379 A NO20041379 A NO 20041379A NO 20041379 A NO20041379 A NO 20041379A NO 20041379 L NO20041379 L NO 20041379L
- Authority
- NO
- Norway
- Prior art keywords
- acid derivatives
- hydroxybutyric acid
- substituted
- preparation
- enzymatic processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40243602P | 2002-08-09 | 2002-08-09 | |
| US10/639,159 US7125693B2 (en) | 2002-08-09 | 2003-08-11 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| PCT/US2003/025263 WO2004015132A2 (en) | 2002-08-09 | 2003-08-11 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20041379L true NO20041379L (no) | 2004-06-01 |
Family
ID=31715856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20041379A NO20041379L (no) | 2002-08-09 | 2004-04-02 | Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7125693B2 (de) |
| EP (1) | EP1537222B1 (de) |
| JP (2) | JP4578240B2 (de) |
| AT (1) | ATE501264T1 (de) |
| AU (1) | AU2003258187A1 (de) |
| BR (1) | BR0305767A (de) |
| CA (1) | CA2493941A1 (de) |
| DE (1) | DE60336324D1 (de) |
| MX (1) | MXPA05001537A (de) |
| NO (1) | NO20041379L (de) |
| WO (1) | WO2004015132A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60336324D1 (de) | 2002-08-09 | 2011-04-21 | Codexis Inc | Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate |
| CA2533838A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| CA2535147A1 (en) * | 2003-08-11 | 2005-05-19 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
| WO2005017141A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved halohydrin dehalogenases and related polynucleotides |
| KR20060071397A (ko) * | 2003-08-11 | 2006-06-26 | 코덱시스, 인코포레이티드 | 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법 |
| US7541171B2 (en) | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| JP2008537477A (ja) * | 2005-02-23 | 2008-09-18 | コデクシス, インコーポレイテッド | 改良されたハロヒドリンデハロゲナーゼおよび関連のポリヌクレオチド |
| ITMI20051971A1 (it) * | 2005-10-18 | 2007-04-19 | Dipharma Spa | Procedimento per la preparazione di - modafinil |
| JP5551448B2 (ja) | 2007-03-16 | 2014-07-16 | ジェノマティカ・インコーポレイテッド | 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法 |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| AU2009291825B2 (en) | 2008-09-10 | 2016-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| EP2379713A4 (de) * | 2008-12-18 | 2013-07-10 | Codexis Inc | Rekombinante halohydrin-dehalogenase-polypeptide |
| ES2625623T3 (es) | 2009-06-04 | 2017-07-20 | Genomatica, Inc. | Procedimiento de separación de componentes de un caldo de fermentación |
| EP4056706A1 (de) | 2009-06-04 | 2022-09-14 | Genomatica, Inc. | Mikroorganismen zur herstellung von 1,4-butandiol und entsprechende verfahren |
| SG177331A1 (en) | 2009-06-22 | 2012-02-28 | Codexis Inc | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| CN105441374A (zh) * | 2009-10-13 | 2016-03-30 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
| US8530210B2 (en) | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| US9080192B2 (en) | 2010-02-10 | 2015-07-14 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| EP2590991B1 (de) | 2010-06-30 | 2016-01-20 | Codexis, Inc. | Sehr stabile kohlenstoffhaltige und für kohlenstofffangsysteme nützliche beta-klasse-anhydrasen |
| CN102168117B (zh) * | 2011-01-12 | 2014-05-07 | 江苏阿尔法药业有限公司 | 一种制备(r)-4-氰基-3-羟基丁酸乙酯的方法 |
| JP5705580B2 (ja) | 2011-02-21 | 2015-04-22 | 公益財団法人微生物化学研究会 | チオアミド化合物、チオアミド化合物の製造方法、[(4r,6r)−6−アミノエチル−1,3−ジオキサン−4−イル]アセテート誘導体の製造方法、及びアトルバスタチンの製造方法 |
| CN102676597A (zh) * | 2011-03-16 | 2012-09-19 | 苏州国镝医药科技有限公司 | 生物酶手性合成立普妥中间体ats-5 |
| US11932845B2 (en) | 2012-06-04 | 2024-03-19 | Genomatica, Inc. | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds |
| CN103695486A (zh) * | 2014-01-03 | 2014-04-02 | 黄冈华阳药业有限公司 | 一种(3r,5r)-6-氰基-3,5-二羟基己酸叔丁酯的生物制备方法 |
| CN105368886A (zh) * | 2015-12-11 | 2016-03-02 | 江苏万年长药业有限公司 | 一种树脂固定卤醇脱卤酶催化合成(r)-4-氰基-3-羟基丁酸乙酯的工艺 |
| CN109439700A (zh) * | 2018-11-09 | 2019-03-08 | 浙江宏元药业股份有限公司 | 一种脱卤酶高效催化合成他汀类药物中间体的方法 |
| CN111876448A (zh) * | 2020-08-03 | 2020-11-03 | 连云港宏业化工有限公司 | 4-氰基-3-羟基丁酸乙酯合成方法 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3019450A1 (de) | 1980-05-21 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus |
| IE56322B1 (en) * | 1982-12-06 | 1991-06-19 | Sigma Tau Ind Farmaceuti | Process for preparing l-carnitine and chemical intermediates employed therein |
| US4542098A (en) | 1983-05-06 | 1985-09-17 | Institut Francais Du Petrole | Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine |
| US4710468A (en) * | 1983-10-24 | 1987-12-01 | Sigma-Tau Industrie Pharmaceutiche Riunite S.P.A. | Process for preparing L-carnitine and chemical intermediates employed therein |
| US4877733A (en) | 1986-05-02 | 1989-10-31 | Toyo Jozo Kabushiki Kaisha | Glucose dehydrogenase and its production |
| US5250415A (en) | 1987-04-08 | 1993-10-05 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Process for the preparation of glucose dehydrogenase from Bacillus megaterium |
| DE3711881A1 (de) | 1987-04-08 | 1988-10-27 | Merck Patent Gmbh | Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium |
| JPH0286779A (ja) | 1988-09-22 | 1990-03-27 | Amano Pharmaceut Co Ltd | 改良型組換えdna、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法 |
| JP2742281B2 (ja) | 1988-12-29 | 1998-04-22 | 旭化成工業株式会社 | グルコース―6―リン酸デヒドロゲナーゼ遺伝子 |
| JP2840722B2 (ja) * | 1989-07-20 | 1998-12-24 | 日東化学工業株式会社 | 4‐ハロ‐3‐ヒドロキシブチロニトリルの製造法 |
| US5210031A (en) | 1989-07-20 | 1993-05-11 | Nitto Chemical Industry Co., Ltd. | Process for the production of R(-)-4-halo-3-hydroxybutyronitrile |
| JP2850515B2 (ja) | 1990-09-25 | 1999-01-27 | 東洋紡績株式会社 | グルコースデヒドロゲナーゼおよびその製造法 |
| US5244796A (en) | 1990-10-12 | 1993-09-14 | Syracuse University | Cloned leuconostoc mesenteroides glucose-6-phosphate dehydrogenase genes and method of making glucose-6-phospate dehydrogenase |
| US5155251A (en) * | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| US5385833A (en) | 1992-02-26 | 1995-01-31 | The Scripps Research Institute | Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase |
| JP3672307B2 (ja) | 1992-03-13 | 2005-07-20 | フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 新規ケトエステル‐還元酵素,その製造方法及びこれを酵素酸化還元反応に使用する方法 |
| US5413921A (en) | 1992-05-28 | 1995-05-09 | Ajinomoto Co., Ltd. | Method of the production of (s)-gamma-halogenated-γ-hydroxybutyric acid esters |
| JP3171931B2 (ja) * | 1992-06-02 | 2001-06-04 | 高砂香料工業株式会社 | (R)−(−)−4−シアノ−3−ヒドロキシ酪酸t−ブチルエステル及びその製造方法 |
| JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性4−ハロ−3−ヒドロキシ酪酸エステルの製造方法 |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| GB9512837D0 (en) | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
| US5891685A (en) | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
| US5908953A (en) | 1996-12-18 | 1999-06-01 | Mitsubishi Chemical Corporation | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester |
| ES2235246T3 (es) | 1997-02-07 | 2005-07-01 | Kaneka Corporation | Una reductasa novedosa de carbonilo, gen que codifica la misma y metodo de utilizacion. |
| US6531308B2 (en) | 1997-11-04 | 2003-03-11 | Eli Lilly And Company | Ketoreductase gene and protein from yeast |
| JPH11171850A (ja) * | 1997-12-12 | 1999-06-29 | Kanegafuchi Chem Ind Co Ltd | 酪酸エステル誘導体の製造方法 |
| IL135562A (en) | 1997-12-19 | 2005-08-31 | Warner Lambert Exp Ltd | Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis |
| JPH11187869A (ja) | 1997-12-25 | 1999-07-13 | Daicel Chem Ind Ltd | 新規な4−ハロアセト酢酸エステル還元酵素、該酵素の製造方法、及び該酵素を利用したアルコールの製造方法 |
| JP4012299B2 (ja) | 1998-02-25 | 2007-11-21 | ダイセル化学工業株式会社 | ハロゲン置換を含む光学活性アルコールの製造方法 |
| ES2207202T3 (es) | 1998-04-30 | 2004-05-16 | Kaneka Corporation | Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico. |
| CN1162422C (zh) | 1998-08-05 | 2004-08-18 | 钟渊化学工业株式会社 | 制备光学活性的2-[6-(羟甲基)-1,3-二噁烷-4-基]乙酸衍生物的方法 |
| JP2000236883A (ja) | 1998-12-21 | 2000-09-05 | Daicel Chem Ind Ltd | 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするdnaおよびこれを利用したアルコールの製造方法 |
| KR100313668B1 (ko) * | 1999-02-03 | 2001-11-26 | 박영구 | (r)-4-시아노-3-히드록시부티르산 에스테르의 제조방법 |
| JP2003504070A (ja) | 1999-07-09 | 2003-02-04 | フォルシュングスツェントルム ユーリッヒ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ケトカルボン酸及びそのエステルの還元のための方法 |
| ES2240205T3 (es) | 1999-12-03 | 2005-10-16 | Kaneka Corporation | Nueva reductasa de carbonilo, su gen y su procedimiento de utilizacion. |
| EP1158054A1 (de) * | 2000-05-25 | 2001-11-28 | Rijksuniversiteit te Groningen | Enzymatische Umwandlung von Epoxiden |
| JP2001335554A (ja) * | 2000-05-30 | 2001-12-04 | Mitsubishi Chemicals Corp | (r)−4−シアノ−3−ヒドロキシ酪酸低級アルキルエステルの製造方法 |
| DE60105734T2 (de) * | 2000-10-31 | 2006-02-16 | Sumitomo Chemical Co. Ltd. | Verfahren zur Herstellung von 4-Cyano-4-Oxobuttersäureester und 4-Cyano-3-Hydroxybuttersäureester |
| JP2002201169A (ja) * | 2000-10-31 | 2002-07-16 | Sumitomo Chem Co Ltd | 4−シアノ−3−オキソブタン酸エステルの製造法 |
| JP4603171B2 (ja) * | 2001-01-22 | 2010-12-22 | ダイセル化学工業株式会社 | (s)−4−ハロ−3−ヒドロキシ酪酸エステルの製造に有用な酵素をコードする遺伝子、その取得方法、およびこれを利用した光学活性アルコールの製造方法 |
| JP4493333B2 (ja) | 2001-07-02 | 2010-06-30 | 株式会社カネカ | 酵素改変方法および酸化還元酵素変異体 |
| DE60336324D1 (de) | 2002-08-09 | 2011-04-21 | Codexis Inc | Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate |
| WO2005017141A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved halohydrin dehalogenases and related polynucleotides |
| CA2533838A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| KR20060071397A (ko) | 2003-08-11 | 2006-06-26 | 코덱시스, 인코포레이티드 | 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법 |
| US7541171B2 (en) | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| CA2535147A1 (en) | 2003-08-11 | 2005-05-19 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
-
2003
- 2003-08-11 DE DE60336324T patent/DE60336324D1/de not_active Expired - Lifetime
- 2003-08-11 AU AU2003258187A patent/AU2003258187A1/en not_active Abandoned
- 2003-08-11 MX MXPA05001537A patent/MXPA05001537A/es unknown
- 2003-08-11 BR BR0305767-4A patent/BR0305767A/pt not_active IP Right Cessation
- 2003-08-11 EP EP03785237A patent/EP1537222B1/de not_active Expired - Lifetime
- 2003-08-11 WO PCT/US2003/025263 patent/WO2004015132A2/en not_active Ceased
- 2003-08-11 AT AT03785237T patent/ATE501264T1/de not_active IP Right Cessation
- 2003-08-11 JP JP2004528083A patent/JP4578240B2/ja not_active Expired - Lifetime
- 2003-08-11 US US10/639,159 patent/US7125693B2/en not_active Expired - Lifetime
- 2003-08-11 CA CA002493941A patent/CA2493941A1/en not_active Abandoned
-
2004
- 2004-04-02 NO NO20041379A patent/NO20041379L/no not_active Application Discontinuation
-
2010
- 2010-05-19 JP JP2010115827A patent/JP2010172348A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP4578240B2 (ja) | 2010-11-10 |
| MXPA05001537A (es) | 2005-11-17 |
| AU2003258187A8 (en) | 2004-02-25 |
| US20040137585A1 (en) | 2004-07-15 |
| DE60336324D1 (de) | 2011-04-21 |
| JP2005535330A (ja) | 2005-11-24 |
| US7125693B2 (en) | 2006-10-24 |
| WO2004015132A3 (en) | 2005-04-14 |
| EP1537222A4 (de) | 2008-10-01 |
| BR0305767A (pt) | 2005-05-24 |
| WO2004015132A2 (en) | 2004-02-19 |
| HK1074059A1 (en) | 2005-10-28 |
| JP2010172348A (ja) | 2010-08-12 |
| ATE501264T1 (de) | 2011-03-15 |
| EP1537222A2 (de) | 2005-06-08 |
| CA2493941A1 (en) | 2004-02-19 |
| EP1537222B1 (de) | 2011-03-09 |
| AU2003258187A1 (en) | 2004-02-25 |
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