NO20042294L - Heteroarylderivater som overlegne ligander for nociceptinreseptor ORL-1 - Google Patents

Heteroarylderivater som overlegne ligander for nociceptinreseptor ORL-1

Info

Publication number
NO20042294L
NO20042294L NO20042294A NO20042294A NO20042294L NO 20042294 L NO20042294 L NO 20042294L NO 20042294 A NO20042294 A NO 20042294A NO 20042294 A NO20042294 A NO 20042294A NO 20042294 L NO20042294 L NO 20042294L
Authority
NO
Norway
Prior art keywords
heteroberl
derivatives
nociceptin receptor
receptor orl
ligands
Prior art date
Application number
NO20042294A
Other languages
English (en)
Other versions
NO329026B1 (no
Inventor
Deen Tulshian
Ginny D Ho
Fay W Ng
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20042294L publication Critical patent/NO20042294L/no
Publication of NO329026B1 publication Critical patent/NO329026B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
NO20042294A 2001-11-07 2004-06-04 Heteroarylderivater, farmasoytiske preparater som omfatter forbindelsene og eventuelt forbindelsene sammen med ett eller flere andre midler, samt anvendelse av forbindelsene eventuelt sammen med andre midler til fremstilling av preparater for behandling av hoste, smerte, angst, astma, depresjon eller alkoholmisbruk NO329026B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33328401P 2001-11-07 2001-11-07
PCT/US2002/035539 WO2003039469A2 (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1

Publications (2)

Publication Number Publication Date
NO20042294L true NO20042294L (no) 2004-07-15
NO329026B1 NO329026B1 (no) 2010-08-02

Family

ID=23302135

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042294A NO329026B1 (no) 2001-11-07 2004-06-04 Heteroarylderivater, farmasoytiske preparater som omfatter forbindelsene og eventuelt forbindelsene sammen med ett eller flere andre midler, samt anvendelse av forbindelsene eventuelt sammen med andre midler til fremstilling av preparater for behandling av hoste, smerte, angst, astma, depresjon eller alkoholmisbruk

Country Status (26)

Country Link
US (1) US6727254B2 (no)
EP (1) EP1442036B1 (no)
JP (2) JP4246066B2 (no)
KR (1) KR100596261B1 (no)
CN (1) CN1252068C (no)
AR (1) AR037211A1 (no)
AT (1) ATE315566T1 (no)
BR (1) BR0213907A (no)
CA (1) CA2465871C (no)
CY (1) CY1105208T1 (no)
DE (1) DE60208724T2 (no)
DK (1) DK1442036T3 (no)
EC (1) ECSP045096A (no)
ES (1) ES2256590T3 (no)
HU (1) HUP0402329A2 (no)
IL (2) IL161120A0 (no)
MX (1) MXPA04004276A (no)
MY (1) MY126268A (no)
NO (1) NO329026B1 (no)
NZ (1) NZ532088A (no)
PE (1) PE20030719A1 (no)
PL (1) PL370269A1 (no)
RU (1) RU2327698C2 (no)
TW (1) TWI317360B (no)
WO (1) WO2003039469A2 (no)
ZA (1) ZA200403404B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067950A1 (en) * 1998-07-27 2004-04-08 Schering-Plough Corporation High affinity ligands for nociceptin receptor ORL-1
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
CA2508165C (en) 2002-12-06 2014-05-06 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
WO2005089761A1 (en) * 2004-03-17 2005-09-29 Pfizer Limited Combination for treating inflammatory diseases
CN100577661C (zh) * 2004-09-15 2010-01-06 先灵-普劳有限公司 取代的8-氮杂双环[3.2.1]辛-3-醇的制备方法
DE102005016460A1 (de) 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
PE20071159A1 (es) * 2005-10-31 2007-11-30 Schering Corp Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
RS52590B2 (sr) * 2008-07-21 2018-05-31 Purdue Pharma Lp Jedinjenja tipa supstituisanog hinoksalina sa premošćenim piperidinom i njihova upotreba
GB201004311D0 (en) 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
GB201115853D0 (en) 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
US9724340B2 (en) * 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
IL326884A (en) * 2023-10-19 2026-04-01 Purdue Pharma Lp Sunobinop for use in method of treating alcohol use disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
TW590268U (en) * 2000-08-08 2004-06-01 Wistron Corp Heat dissipating device

Also Published As

Publication number Publication date
US20030119847A1 (en) 2003-06-26
WO2003039469A3 (en) 2003-10-16
IL161120A (en) 2010-11-30
ATE315566T1 (de) 2006-02-15
ECSP045096A (es) 2004-06-28
CN1582288A (zh) 2005-02-16
HUP0402329A2 (hu) 2005-02-28
ZA200403404B (en) 2005-08-15
ES2256590T3 (es) 2006-07-16
DE60208724T2 (de) 2006-11-02
AR037211A1 (es) 2004-10-27
CN1252068C (zh) 2006-04-19
DE60208724D1 (de) 2006-04-06
PE20030719A1 (es) 2003-08-28
BR0213907A (pt) 2004-09-28
KR20050043725A (ko) 2005-05-11
IL161120A0 (en) 2004-08-31
WO2003039469A2 (en) 2003-05-15
CY1105208T1 (el) 2010-03-03
PL370269A1 (en) 2005-05-16
KR100596261B1 (ko) 2006-06-30
JP4246066B2 (ja) 2009-04-02
NZ532088A (en) 2006-05-26
CA2465871C (en) 2009-01-20
EP1442036A2 (en) 2004-08-04
TW200301765A (en) 2003-07-16
MY126268A (en) 2006-09-29
EP1442036B1 (en) 2006-01-11
DK1442036T3 (da) 2006-05-15
RU2327698C2 (ru) 2008-06-27
CA2465871A1 (en) 2003-05-15
HK1063019A1 (en) 2004-12-10
JP2005508367A (ja) 2005-03-31
NO329026B1 (no) 2010-08-02
RU2004117542A (ru) 2006-01-10
TWI317360B (en) 2009-11-21
JP2009035556A (ja) 2009-02-19
MXPA04004276A (es) 2004-08-11
US6727254B2 (en) 2004-04-27

Similar Documents

Publication Publication Date Title
DK1173440T3 (da) Tetracycliske azepinoindolforbindelser som 5-HT receptorligander
DK1414440T3 (da) N-phenylpyrrolguanidinderivater som melanocortinreceptorligander
DK1560823T3 (da) 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander
DK1309559T3 (da) 4-phenyl-pyridinderivater som neurokinin-1-receptorantagonister
DK1381363T3 (da) Imidazo[1,2-a]pyridinderivater som mGluR5-antagonister
NO20015365D0 (no) Piperidinderivater som er anvendbare som CCR5-antagonister
DK1571145T3 (da) Substitueret piperidinforbindelser til anvendelse som H3 histaminreceptor-antagonister
NO20052739D0 (no) CCR5-antagonister som medikamenter
DK1501809T3 (da) Trizolderivater som tachykininreceptorantagonister
NO20041317L (no) Benzimidazolidinondenvater som muskarine midler
DK1562595T3 (da) Diarylethere som opioidreceptorantagonister
NO20015366D0 (no) Piperazinderivater som er anvendbare som CCR5-antagonister
DK1147112T3 (da) Diazabicykliske derivater som nicotiniske acetylcholinreceptorligander
NO20021450L (no) Cykliske aminforbindelser som CCR5-antagonister
NO20052797D0 (no) Fenyl eller heteroaryl aminoalkanderivater som IP-reseptorantagonister
DK1305319T3 (da) 4-phenyl-pyridinderivater som neurokinin-1-receptorantagonister
DK1442036T3 (da) Heteroarylderivater som fortræffelige ligander for nociceptinreceptor ORL-1
DK1360184T3 (da) Piperidinderivater som neurokinin-1-antagonister
DK1560828T3 (da) Imidazoquinolinderivater som adenosin-A3-receptorligander
NO20044373L (no) Azetidinderivater som CCR-3-reseptorantagonister
NO20043119L (no) Triazolokinolinderivater som kan anvendes som adenosinreseptorligander
DE60203820D1 (de) Pyridinderivate als nmda-rezeptorliganden
DK1347974T3 (da) Aminotriazolopyridinderivater som adenosinreceptorligander
ATE325092T1 (de) Azetidinyldiamine als nociceptin-rezeptor orl-1 liganden
SI1442036T1 (sl) Heteroarilni derivati kot superiorni ligandi za nociceptinski receptor ORL-1

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees