ATE315566T1 - Heteroaryl derivate als bessere liganden des nociceptinrezeptors orl-1 - Google Patents

Heteroaryl derivate als bessere liganden des nociceptinrezeptors orl-1

Info

Publication number
ATE315566T1
ATE315566T1 AT02802860T AT02802860T ATE315566T1 AT E315566 T1 ATE315566 T1 AT E315566T1 AT 02802860 T AT02802860 T AT 02802860T AT 02802860 T AT02802860 T AT 02802860T AT E315566 T1 ATE315566 T1 AT E315566T1
Authority
AT
Austria
Prior art keywords
heteroaryl derivatives
nociceptin receptor
receptor orl
better ligands
ligands
Prior art date
Application number
AT02802860T
Other languages
English (en)
Inventor
Deen Tulshian
Ginny D Ho
Fay W Ng
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE315566T1 publication Critical patent/ATE315566T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
AT02802860T 2001-11-07 2002-11-06 Heteroaryl derivate als bessere liganden des nociceptinrezeptors orl-1 ATE315566T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33328401P 2001-11-07 2001-11-07

Publications (1)

Publication Number Publication Date
ATE315566T1 true ATE315566T1 (de) 2006-02-15

Family

ID=23302135

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02802860T ATE315566T1 (de) 2001-11-07 2002-11-06 Heteroaryl derivate als bessere liganden des nociceptinrezeptors orl-1

Country Status (26)

Country Link
US (1) US6727254B2 (de)
EP (1) EP1442036B1 (de)
JP (2) JP4246066B2 (de)
KR (1) KR100596261B1 (de)
CN (1) CN1252068C (de)
AR (1) AR037211A1 (de)
AT (1) ATE315566T1 (de)
BR (1) BR0213907A (de)
CA (1) CA2465871C (de)
CY (1) CY1105208T1 (de)
DE (1) DE60208724T2 (de)
DK (1) DK1442036T3 (de)
EC (1) ECSP045096A (de)
ES (1) ES2256590T3 (de)
HU (1) HUP0402329A2 (de)
IL (2) IL161120A0 (de)
MX (1) MXPA04004276A (de)
MY (1) MY126268A (de)
NO (1) NO329026B1 (de)
NZ (1) NZ532088A (de)
PE (1) PE20030719A1 (de)
PL (1) PL370269A1 (de)
RU (1) RU2327698C2 (de)
TW (1) TWI317360B (de)
WO (1) WO2003039469A2 (de)
ZA (1) ZA200403404B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US20040067950A1 (en) * 1998-07-27 2004-04-08 Schering-Plough Corporation High affinity ligands for nociceptin receptor ORL-1
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
EP1567497B1 (de) * 2002-12-06 2009-09-23 Purdue Research Foundation Pyridine zur behandlung von verletztemsäugetiernervengewebe
WO2005089761A1 (en) * 2004-03-17 2005-09-29 Pfizer Limited Combination for treating inflammatory diseases
WO2006031788A2 (en) * 2004-09-15 2006-03-23 Schering-Plough Ltd. Process for preparing substituted 8-azabicyclo[3.2.1] octan-3-ols
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
PE20071159A1 (es) * 2005-10-31 2007-11-30 Schering Corp Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
HRP20120841T4 (hr) * 2008-07-21 2015-07-03 Purdue Pharma L.P. Premošteni piperidinski spojevi substituiranog kinoksalin-tipa i njihova uporaba
GB201004311D0 (en) 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
GB201115853D0 (en) 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
US9724340B2 (en) * 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
AU2024364388A1 (en) * 2023-10-19 2026-03-19 Purdue Pharma L.P. Sunobinop for use in method of treating alcohol use disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
TW590268U (en) * 2000-08-08 2004-06-01 Wistron Corp Heat dissipating device

Also Published As

Publication number Publication date
ECSP045096A (es) 2004-06-28
TWI317360B (en) 2009-11-21
ES2256590T3 (es) 2006-07-16
KR20050043725A (ko) 2005-05-11
RU2327698C2 (ru) 2008-06-27
EP1442036A2 (de) 2004-08-04
WO2003039469A3 (en) 2003-10-16
RU2004117542A (ru) 2006-01-10
IL161120A (en) 2010-11-30
TW200301765A (en) 2003-07-16
DE60208724T2 (de) 2006-11-02
US6727254B2 (en) 2004-04-27
PL370269A1 (en) 2005-05-16
EP1442036B1 (de) 2006-01-11
ZA200403404B (en) 2005-08-15
CY1105208T1 (el) 2010-03-03
HK1063019A1 (en) 2004-12-10
KR100596261B1 (ko) 2006-06-30
MY126268A (en) 2006-09-29
WO2003039469A2 (en) 2003-05-15
MXPA04004276A (es) 2004-08-11
BR0213907A (pt) 2004-09-28
US20030119847A1 (en) 2003-06-26
JP2009035556A (ja) 2009-02-19
JP4246066B2 (ja) 2009-04-02
HUP0402329A2 (hu) 2005-02-28
CA2465871C (en) 2009-01-20
IL161120A0 (en) 2004-08-31
PE20030719A1 (es) 2003-08-28
CN1252068C (zh) 2006-04-19
DE60208724D1 (de) 2006-04-06
JP2005508367A (ja) 2005-03-31
NO329026B1 (no) 2010-08-02
AR037211A1 (es) 2004-10-27
CN1582288A (zh) 2005-02-16
NZ532088A (en) 2006-05-26
CA2465871A1 (en) 2003-05-15
NO20042294L (no) 2004-07-15
DK1442036T3 (da) 2006-05-15

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