NO20043101L - Farmasoytiske blandinger av oralt aktive taxanderivater som har forsterket biotilgjenglighet - Google Patents
Farmasoytiske blandinger av oralt aktive taxanderivater som har forsterket biotilgjenglighetInfo
- Publication number
- NO20043101L NO20043101L NO20043101A NO20043101A NO20043101L NO 20043101 L NO20043101 L NO 20043101L NO 20043101 A NO20043101 A NO 20043101A NO 20043101 A NO20043101 A NO 20043101A NO 20043101 L NO20043101 L NO 20043101L
- Authority
- NO
- Norway
- Prior art keywords
- orally active
- enhanced bioavailability
- taxane derivatives
- pharmaceutical mixtures
- active taxane
- Prior art date
Links
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34288901P | 2001-12-20 | 2001-12-20 | |
| PCT/US2002/040127 WO2003053350A2 (en) | 2001-12-20 | 2002-12-12 | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20043101L true NO20043101L (no) | 2004-07-19 |
Family
ID=23343716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20043101A NO20043101L (no) | 2001-12-20 | 2004-07-19 | Farmasoytiske blandinger av oralt aktive taxanderivater som har forsterket biotilgjenglighet |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20030220391A1 (pl) |
| EP (1) | EP1465618A2 (pl) |
| JP (1) | JP2006501134A (pl) |
| KR (1) | KR20040066921A (pl) |
| CN (1) | CN1273130C (pl) |
| AR (1) | AR037951A1 (pl) |
| AU (1) | AU2002361701A1 (pl) |
| BR (1) | BR0215184A (pl) |
| CA (1) | CA2470826A1 (pl) |
| GE (1) | GEP20063806B (pl) |
| HR (1) | HRP20040545A2 (pl) |
| HU (1) | HUP0500843A2 (pl) |
| IL (1) | IL162118A0 (pl) |
| IS (1) | IS7306A (pl) |
| MX (1) | MXPA04005877A (pl) |
| NO (1) | NO20043101L (pl) |
| PE (1) | PE20030742A1 (pl) |
| PL (1) | PL374283A1 (pl) |
| RS (1) | RS52904A (pl) |
| RU (1) | RU2004119557A (pl) |
| TW (1) | TW200302086A (pl) |
| UY (1) | UY27598A1 (pl) |
| WO (1) | WO2003053350A2 (pl) |
| ZA (1) | ZA200404584B (pl) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050063940A1 (en) * | 2002-02-25 | 2005-03-24 | Sveinbjorn Gizurarson | Bioadhesive agent |
| US6855332B2 (en) * | 2002-07-03 | 2005-02-15 | Lyfjathroun Hf. | Absorption promoting agent |
| KR100533458B1 (ko) | 2002-07-20 | 2005-12-07 | 대화제약 주식회사 | 파클리탁셀의 가용화용 조성물 및 그의 제조 방법 |
| EP1498120A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid formulations for the oral administration of taxoids |
| EP1785416A3 (en) | 2003-09-25 | 2007-05-30 | Tapestry Pharmaceuticals, Inc. | 9, 10-alpha, alpha-OH-Taxane Analogs and methods for production thereof |
| US20060088591A1 (en) * | 2004-10-22 | 2006-04-27 | Jinghua Yuan | Tablets from a poorly compressible substance |
| US20060116420A1 (en) * | 2004-11-23 | 2006-06-01 | Ramakrishnan Chidambaram | Crystalline forms of 3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel |
| AU2012202903B2 (en) * | 2005-02-18 | 2014-12-11 | Abraxis Bioscience, Inc. | Drugs with improved hydrophobicity for incorporation in medical devices |
| US20090130163A1 (en) * | 2005-02-18 | 2009-05-21 | Abraxis Bio Scoence, Inc. | Drugs With Improved Hydrophobicity For Incorporation in Medical Devices |
| ES2744225T3 (es) | 2005-07-15 | 2020-02-24 | Angiochem Inc | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
| US20070015834A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing PEG/Poloxamer |
| LT3311805T (lt) | 2005-08-31 | 2020-04-27 | Abraxis Bioscience, Llc | Kompozicijos, apimančios silpnai vandenyje tirpius farmacinius agentus ir priešmikrobinius agentus |
| WO2007134354A1 (de) * | 2006-05-23 | 2007-11-29 | Ebewe Pharma Ges.M.B.H. Nfg. Kg | Pharmazeutische formulierung |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| EP1946747A1 (en) * | 2007-01-17 | 2008-07-23 | Sandoz AG | Pharmaceutical composition of improved stability containing taxane derivatives |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US9089544B2 (en) * | 2007-08-24 | 2015-07-28 | Slotervaart Participaties Bv | Composition |
| MX2010002179A (es) * | 2007-08-24 | 2010-04-27 | Stichting Het Nl Kanker I | Composicion para el tratamiento de enfermedades neoplasicas. |
| RU2488393C2 (ru) * | 2007-11-12 | 2013-07-27 | Новартис Аг | Жидкие композиции, включающие валсартан |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| ES2344674B1 (es) | 2008-08-07 | 2011-06-29 | Gp Pharm, S.A. | Composicion farmaceutica inyectable de taxanos. |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| EP2414560B1 (de) | 2009-03-31 | 2013-10-23 | Boehringer Ingelheim International GmbH | Verfahren zur beschichtung einer oberfläche eines bauteils |
| JP5763053B2 (ja) | 2009-05-18 | 2015-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アダプタ、吸入器具及びアトマイザ |
| CN102038635A (zh) | 2009-10-23 | 2011-05-04 | 天津天士力集团有限公司 | 一种含有pH值调节剂的紫杉烷类药物溶液及其制备方法 |
| BR112012012475B1 (pt) | 2009-11-25 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Nebulizador |
| WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2011160932A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| EP2777691A1 (en) * | 2013-03-14 | 2014-09-17 | Pharmachemie B.V. | Taxoid - Purification of Liquid Excipients |
| ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
| JP6643231B2 (ja) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| CN116036425A (zh) | 2014-05-07 | 2023-05-02 | 勃林格殷格翰国际有限公司 | 喷雾器、指示器装置及容器 |
| IL247927B (en) | 2014-05-07 | 2022-09-01 | Boehringer Ingelheim Int | Container, a device that turns a liquid into a fine spray and use |
| WO2015169430A1 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Nebulizer |
| CN103980232A (zh) * | 2014-06-05 | 2014-08-13 | 北京诺普德医药科技有限公司 | 10-乙酰基多西紫杉醇及其用途 |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| TWI838700B (zh) * | 2015-09-30 | 2024-04-11 | 香港商慧源香港創新有限公司 | 口服紫杉烷組合物及方法 |
| CN108066335B (zh) * | 2016-11-11 | 2020-02-21 | 北京康辰药业股份有限公司 | 一种含有紫杉醇或其类似物的药物组合物及其制备方法 |
| FR3113238B1 (fr) | 2020-08-05 | 2024-04-05 | Gattefosse Sas | Utilisation comme excipient, d’un melange de macrogolglyceride laurique et de polyethylene glycol |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5817321A (en) * | 1992-10-08 | 1998-10-06 | Supratek Pharma, Inc. | Biological agent compositions |
| AU5612694A (en) * | 1992-11-27 | 1994-06-22 | Napro Biotherapeutics, Inc. | Injectable composition |
| US6395770B1 (en) * | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
| CN1304058C (zh) * | 1996-03-12 | 2007-03-14 | Pg－Txl有限公司 | 水溶性紫杉醇产品 |
| US5756537A (en) * | 1996-11-08 | 1998-05-26 | Parkash S. Gill, M.D., Inc. | Regime for paclitaxel in Kaposi's sarcoma patients |
| US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| US5980936A (en) * | 1997-08-07 | 1999-11-09 | Alliance Pharmaceutical Corp. | Multiple emulsions comprising a hydrophobic continuous phase |
| HUP0101457A3 (en) * | 1997-12-31 | 2003-01-28 | Bristol Myers Squibb Co | Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them |
| IL131217A0 (en) * | 1998-03-10 | 2001-01-28 | Napro Biotherapeutics Inc | Novel methods and compositions for delivery of taxanes |
| US6979456B1 (en) * | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| HK1042302B (en) * | 1999-05-17 | 2004-10-08 | Bristol-Myers Squibb Company | Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol) and paclitaxel analogues |
| KR100634249B1 (ko) * | 1999-08-11 | 2006-10-17 | 브리스톨-마이어스스퀴브컴파니 | 파클리탁셀 ｃ-4 메틸 카르보네이트 동족체의 제조 방법 |
| US6136846A (en) * | 1999-10-25 | 2000-10-24 | Supergen, Inc. | Formulation for paclitaxel |
| US6916942B2 (en) * | 2000-02-03 | 2005-07-12 | Bristol-Myers Squibb Company | Process for the preparation of C-4 carbonate taxanes |
| US6750246B1 (en) * | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
| TWI310684B (en) * | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
| US6919370B2 (en) * | 2000-11-28 | 2005-07-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
| TWI297335B (en) * | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| WO2003045357A1 (en) * | 2001-11-27 | 2003-06-05 | Transform Pharmaceuticals, Inc. | Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof |
-
2002
- 2002-12-12 GE GE5614A patent/GEP20063806B/en unknown
- 2002-12-12 EP EP02797339A patent/EP1465618A2/en not_active Withdrawn
- 2002-12-12 HR HR20040545A patent/HRP20040545A2/xx not_active Application Discontinuation
- 2002-12-12 BR BRPI0215184-7A patent/BR0215184A/pt not_active IP Right Cessation
- 2002-12-12 CA CA002470826A patent/CA2470826A1/en not_active Abandoned
- 2002-12-12 JP JP2003554110A patent/JP2006501134A/ja not_active Withdrawn
- 2002-12-12 AU AU2002361701A patent/AU2002361701A1/en not_active Abandoned
- 2002-12-12 RU RU2004119557/15A patent/RU2004119557A/ru not_active Application Discontinuation
- 2002-12-12 CN CNB028254708A patent/CN1273130C/zh not_active Expired - Fee Related
- 2002-12-12 HU HU0500843A patent/HUP0500843A2/hu unknown
- 2002-12-12 KR KR10-2004-7009593A patent/KR20040066921A/ko not_active Withdrawn
- 2002-12-12 PL PL02374283A patent/PL374283A1/pl not_active Application Discontinuation
- 2002-12-12 IL IL16211802A patent/IL162118A0/xx unknown
- 2002-12-12 WO PCT/US2002/040127 patent/WO2003053350A2/en not_active Ceased
- 2002-12-12 RS YU52904A patent/RS52904A/sr unknown
- 2002-12-16 TW TW091136275A patent/TW200302086A/zh unknown
- 2002-12-19 AR ARP020105039A patent/AR037951A1/es unknown
- 2002-12-19 US US10/323,551 patent/US20030220391A1/en not_active Abandoned
- 2002-12-20 UY UY27598A patent/UY27598A1/es not_active Application Discontinuation
-
2003
- 2003-01-06 PE PE2003000013A patent/PE20030742A1/es not_active Application Discontinuation
-
2004
- 2004-06-09 ZA ZA200404584A patent/ZA200404584B/en unknown
- 2004-06-10 IS IS7306A patent/IS7306A/is unknown
- 2004-06-16 MX MXPA04005877A patent/MXPA04005877A/es unknown
- 2004-07-19 NO NO20043101A patent/NO20043101L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY27598A1 (es) | 2003-07-31 |
| BR0215184A (pt) | 2006-06-06 |
| IS7306A (is) | 2004-06-10 |
| AU2002361701A1 (en) | 2003-07-09 |
| CN1273130C (zh) | 2006-09-06 |
| WO2003053350A2 (en) | 2003-07-03 |
| TW200302086A (en) | 2003-08-01 |
| WO2003053350A3 (en) | 2004-01-15 |
| EP1465618A2 (en) | 2004-10-13 |
| PE20030742A1 (es) | 2003-09-02 |
| KR20040066921A (ko) | 2004-07-27 |
| RU2004119557A (ru) | 2005-04-20 |
| HRP20040545A2 (en) | 2005-08-31 |
| HUP0500843A2 (hu) | 2005-12-28 |
| AR037951A1 (es) | 2004-12-22 |
| MXPA04005877A (es) | 2004-09-13 |
| IL162118A0 (en) | 2005-11-20 |
| PL374283A1 (pl) | 2005-10-03 |
| CA2470826A1 (en) | 2003-07-03 |
| JP2006501134A (ja) | 2006-01-12 |
| CN1606437A (zh) | 2005-04-13 |
| RS52904A (sr) | 2006-12-15 |
| GEP20063806B (en) | 2006-04-25 |
| ZA200404584B (en) | 2005-09-13 |
| US20030220391A1 (en) | 2003-11-27 |
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