NO20043841L - 1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for the preparation of drugs used in the treatment of immunological diseases - Google Patents

1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for the preparation of drugs used in the treatment of immunological diseases

Info

Publication number
NO20043841L
NO20043841L NO20043841A NO20043841A NO20043841L NO 20043841 L NO20043841 L NO 20043841L NO 20043841 A NO20043841 A NO 20043841A NO 20043841 A NO20043841 A NO 20043841A NO 20043841 L NO20043841 L NO 20043841L
Authority
NO
Norway
Prior art keywords
benzimidazole derivatives
preparation
treatment
heteroaryl
phenyl
Prior art date
Application number
NO20043841A
Other languages
Norwegian (no)
Other versions
NO329667B1 (en
Inventor
Herbert Schneider
Wolfgang Halfbrodt
Thorsten Blume
Joachim Kuhnke
Ursula Monning
Bernd Elger
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20043841L publication Critical patent/NO20043841L/en
Publication of NO329667B1 publication Critical patent/NO329667B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives nye benzimidazolderivater, deres fremstilling og deres anvendelse for fremstilling av legemidler for behandling og forebygging av sykdommer som er assosiert med en mikroglieaktivering, og av T-celle-formidlede immunologiske sykdommer, samt farmasøytiske preparater som inneholder de nye benzimidazolderivater.New benzimidazole derivatives are described, their preparation and their use in the manufacture of medicaments for the treatment and prevention of diseases associated with a microglial activation, and of T-cell mediated immunological diseases, as well as pharmaceutical preparations containing the new benzimidazole derivatives.

NO20043841A 2002-02-15 2004-09-14 1-Phenyl-2- (pyridyl or thienyl) -substituted benzimidazole derivatives, pharmaceutical compositions containing the compounds and their use in the manufacture of drugs used for the treatment of immunological diseases NO329667B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10207844A DE10207844A1 (en) 2002-02-15 2002-02-15 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the preparation of medicaments and pharmaceutical preparations containing these derivatives
PCT/EP2003/000462 WO2003068766A1 (en) 2002-02-15 2003-01-17 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for producing drugs used in the treatment of immunological diseases

Publications (2)

Publication Number Publication Date
NO20043841L true NO20043841L (en) 2004-11-12
NO329667B1 NO329667B1 (en) 2010-11-29

Family

ID=27674913

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20043841A NO329667B1 (en) 2002-02-15 2004-09-14 1-Phenyl-2- (pyridyl or thienyl) -substituted benzimidazole derivatives, pharmaceutical compositions containing the compounds and their use in the manufacture of drugs used for the treatment of immunological diseases

Country Status (30)

Country Link
EP (1) EP1474415B1 (en)
JP (1) JP4739675B2 (en)
KR (1) KR101027556B1 (en)
CN (1) CN1317274C (en)
AR (1) AR038492A1 (en)
AT (1) ATE517881T1 (en)
AU (1) AU2003205624B2 (en)
BR (1) BR0307723A (en)
CA (1) CA2475780C (en)
CR (1) CR7442A (en)
CY (1) CY1113230T1 (en)
DE (1) DE10207844A1 (en)
DK (1) DK1474415T3 (en)
EC (1) ECSP045296A (en)
ES (1) ES2369662T3 (en)
IL (1) IL163431A (en)
MX (1) MXPA04007949A (en)
NO (1) NO329667B1 (en)
NZ (1) NZ534660A (en)
PE (1) PE20030941A1 (en)
PL (1) PL216233B1 (en)
PT (1) PT1474415E (en)
RS (1) RS51831B (en)
RU (1) RU2325384C2 (en)
SI (1) SI1474415T1 (en)
TW (1) TWI328583B (en)
UA (1) UA81243C2 (en)
UY (1) UY27661A1 (en)
WO (1) WO2003068766A1 (en)
ZA (1) ZA200407381B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1497266T1 (en) 2002-03-27 2008-10-31 Glaxo Group Ltd Quinoline derivatives and their use as 5-ht6 ligands
CN1787817B (en) * 2003-05-19 2011-09-07 Irm责任有限公司 Immunosuppressant compounds and compositions
WO2014044611A1 (en) 2012-09-20 2014-03-27 Bayer Pharma Aktiengesellschaft 1-aryl-2-heteroaryl benzimidazoles for the induction of neuronal regeneration

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430502A (en) * 1982-08-13 1984-02-07 The Upjohn Company Pyridinyl substituted benzimidazoles and quinoxalines
EP0520200B1 (en) * 1991-06-24 1998-02-18 Neurosearch A/S Imidazole compounds, their preparation and use
DE4129603A1 (en) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K CONDENSED 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THESE COMPOUNDS
DE4330959A1 (en) * 1993-09-09 1995-03-16 Schering Ag New benzimidazole derivatives, processes for their preparation and their pharmaceutical use
IL132575A0 (en) * 1997-05-01 2001-03-19 Nissan Chemical Ind Ltd Benzimidazole derivative
WO2001021634A1 (en) * 1999-09-21 2001-03-29 Lion Bioscience Ag Benzimidazole derivatives and combinatorial libraries thereof
US7115645B2 (en) * 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
NZ519326A (en) * 2000-01-14 2005-02-25 Schering Ag 1,2-diarylbenzimidazoles for treating diseases that are associated with a microglia activation
DE10207843A1 (en) * 2002-02-15 2003-09-04 Schering Ag Microlia inhibitors for interruption of interleukin 12 and IFN-gamma mediated immune responses

Also Published As

Publication number Publication date
PL216233B1 (en) 2014-03-31
AU2003205624A1 (en) 2003-09-04
CA2475780A1 (en) 2003-08-21
TWI328583B (en) 2010-08-11
RU2004127678A (en) 2005-07-10
WO2003068766A1 (en) 2003-08-21
EP1474415A1 (en) 2004-11-10
CA2475780C (en) 2011-08-02
CY1113230T1 (en) 2016-04-13
UY27661A1 (en) 2003-09-30
DK1474415T3 (en) 2011-11-21
PL371269A1 (en) 2005-06-13
JP2005521686A (en) 2005-07-21
TW200303307A (en) 2003-09-01
SI1474415T1 (en) 2011-12-30
CN1317274C (en) 2007-05-23
ZA200407381B (en) 2005-11-30
MXPA04007949A (en) 2004-11-26
RU2325384C2 (en) 2008-05-27
RS51831B (en) 2012-02-29
RS71404A (en) 2006-10-27
BR0307723A (en) 2005-01-25
AR038492A1 (en) 2005-01-19
ATE517881T1 (en) 2011-08-15
EP1474415B1 (en) 2011-07-27
JP4739675B2 (en) 2011-08-03
PT1474415E (en) 2011-10-13
CR7442A (en) 2006-02-06
KR20040081795A (en) 2004-09-22
ECSP045296A (en) 2004-10-26
KR101027556B1 (en) 2011-04-06
UA81243C2 (en) 2007-12-25
NO329667B1 (en) 2010-11-29
CN1633429A (en) 2005-06-29
DE10207844A1 (en) 2003-09-04
AU2003205624B2 (en) 2009-08-27
ES2369662T3 (en) 2011-12-02
NZ534660A (en) 2006-02-24
IL163431A (en) 2010-11-30
PE20030941A1 (en) 2004-01-17

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

MM1K Lapsed by not paying the annual fees