NO20043841L - 1-fenyl-2-heteroaryl-substituerte benzimidazolderivater, anvendelsen derav for fremstilling av legemidler benyttet i behandlingen av immunologiske sykdommer - Google Patents

1-fenyl-2-heteroaryl-substituerte benzimidazolderivater, anvendelsen derav for fremstilling av legemidler benyttet i behandlingen av immunologiske sykdommer

Info

Publication number
NO20043841L
NO20043841L NO20043841A NO20043841A NO20043841L NO 20043841 L NO20043841 L NO 20043841L NO 20043841 A NO20043841 A NO 20043841A NO 20043841 A NO20043841 A NO 20043841A NO 20043841 L NO20043841 L NO 20043841L
Authority
NO
Norway
Prior art keywords
benzimidazole derivatives
preparation
treatment
heteroaryl
phenyl
Prior art date
Application number
NO20043841A
Other languages
English (en)
Other versions
NO329667B1 (no
Inventor
Herbert Schneider
Wolfgang Halfbrodt
Thorsten Blume
Joachim Kuhnke
Ursula Monning
Bernd Elger
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20043841L publication Critical patent/NO20043841L/no
Publication of NO329667B1 publication Critical patent/NO329667B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives nye benzimidazolderivater, deres fremstilling og deres anvendelse for fremstilling av legemidler for behandling og forebygging av sykdommer som er assosiert med en mikroglieaktivering, og av T-celle-formidlede immunologiske sykdommer, samt farmasøytiske preparater som inneholder de nye benzimidazolderivater.
NO20043841A 2002-02-15 2004-09-14 1-fenyl-2-(pyridyl eller tienyl)-substituerte benzimidazolderivater, farmasoytiske preparater som inneholder forbindelsene og anvendelse av disse for fremstilling av legemidler benyttet for behandling av immunologiske sykdommer NO329667B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10207844A DE10207844A1 (de) 2002-02-15 2002-02-15 1-Phenyl-2-heteroaryl-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
PCT/EP2003/000462 WO2003068766A1 (de) 2002-02-15 2003-01-17 1-phenyl-2-heteroaryl-substituierte benzimidazolderivate, deren verwendung zur herstellung von arzneimitteln zur behandlung von immunologischen erkrankungen

Publications (2)

Publication Number Publication Date
NO20043841L true NO20043841L (no) 2004-11-12
NO329667B1 NO329667B1 (no) 2010-11-29

Family

ID=27674913

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20043841A NO329667B1 (no) 2002-02-15 2004-09-14 1-fenyl-2-(pyridyl eller tienyl)-substituerte benzimidazolderivater, farmasoytiske preparater som inneholder forbindelsene og anvendelse av disse for fremstilling av legemidler benyttet for behandling av immunologiske sykdommer

Country Status (30)

Country Link
EP (1) EP1474415B1 (no)
JP (1) JP4739675B2 (no)
KR (1) KR101027556B1 (no)
CN (1) CN1317274C (no)
AR (1) AR038492A1 (no)
AT (1) ATE517881T1 (no)
AU (1) AU2003205624B2 (no)
BR (1) BR0307723A (no)
CA (1) CA2475780C (no)
CR (1) CR7442A (no)
CY (1) CY1113230T1 (no)
DE (1) DE10207844A1 (no)
DK (1) DK1474415T3 (no)
EC (1) ECSP045296A (no)
ES (1) ES2369662T3 (no)
IL (1) IL163431A (no)
MX (1) MXPA04007949A (no)
NO (1) NO329667B1 (no)
NZ (1) NZ534660A (no)
PE (1) PE20030941A1 (no)
PL (1) PL216233B1 (no)
PT (1) PT1474415E (no)
RS (1) RS51831B (no)
RU (1) RU2325384C2 (no)
SI (1) SI1474415T1 (no)
TW (1) TWI328583B (no)
UA (1) UA81243C2 (no)
UY (1) UY27661A1 (no)
WO (1) WO2003068766A1 (no)
ZA (1) ZA200407381B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039127A1 (es) 2002-03-27 2005-02-09 Glaxo Group Ltd Compuesto de quinolina, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso del mismo para la fabricacion de un medicamento
AU2004240649A1 (en) * 2003-05-19 2004-12-02 Irm, Llc Immunosuppressant compounds and compositions
WO2014044611A1 (en) 2012-09-20 2014-03-27 Bayer Pharma Aktiengesellschaft 1-aryl-2-heteroaryl benzimidazoles for the induction of neuronal regeneration

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430502A (en) * 1982-08-13 1984-02-07 The Upjohn Company Pyridinyl substituted benzimidazoles and quinoxalines
DK0520200T3 (da) * 1991-06-24 1998-09-23 Neurosearch As Imadazol-forbindelser, deres fremstilling og anvendelse
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4330959A1 (de) * 1993-09-09 1995-03-16 Schering Ag Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
NZ337749A (en) * 1997-05-01 2000-09-29 Nissan Chemical Ind Ltd Benzimidazole derivative and their use in allergy-related disease
EP1214330A1 (en) * 1999-09-21 2002-06-19 LION Bioscience AG Benzimidazole derivatives and combinatorial libraries thereof
IL150150A0 (en) 2000-01-14 2002-12-01 Schering Ag 1,2-diaryl benzimidazoles for treating illnesses associated with a microglia activation
US7115645B2 (en) * 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
DE10207843A1 (de) * 2002-02-15 2003-09-04 Schering Ag Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen

Also Published As

Publication number Publication date
EP1474415B1 (de) 2011-07-27
AU2003205624A1 (en) 2003-09-04
CN1317274C (zh) 2007-05-23
WO2003068766A1 (de) 2003-08-21
EP1474415A1 (de) 2004-11-10
RS71404A (sr) 2006-10-27
RS51831B (sr) 2012-02-29
ZA200407381B (en) 2005-11-30
CR7442A (es) 2006-02-06
CA2475780C (en) 2011-08-02
ATE517881T1 (de) 2011-08-15
JP4739675B2 (ja) 2011-08-03
KR20040081795A (ko) 2004-09-22
DK1474415T3 (da) 2011-11-21
MXPA04007949A (es) 2004-11-26
KR101027556B1 (ko) 2011-04-06
RU2325384C2 (ru) 2008-05-27
PT1474415E (pt) 2011-10-13
AU2003205624B2 (en) 2009-08-27
CA2475780A1 (en) 2003-08-21
ES2369662T3 (es) 2011-12-02
AR038492A1 (es) 2005-01-19
CY1113230T1 (el) 2016-04-13
IL163431A (en) 2010-11-30
NZ534660A (en) 2006-02-24
BR0307723A (pt) 2005-01-25
DE10207844A1 (de) 2003-09-04
TW200303307A (en) 2003-09-01
CN1633429A (zh) 2005-06-29
ECSP045296A (es) 2004-10-26
NO329667B1 (no) 2010-11-29
TWI328583B (en) 2010-08-11
PL216233B1 (pl) 2014-03-31
UY27661A1 (es) 2003-09-30
JP2005521686A (ja) 2005-07-21
PL371269A1 (en) 2005-06-13
UA81243C2 (en) 2007-12-25
RU2004127678A (ru) 2005-07-10
PE20030941A1 (es) 2004-01-17
SI1474415T1 (sl) 2011-12-30

Similar Documents

Publication Publication Date Title
DE602004017194D1 (de) Pyridylpyrrol-derivate als wirksame kinase-hemmer
DK1636236T3 (da) Pyrazolo-quinazolin-derivater, en fremgangsmåde til fremstilling deraf, og deres anvendelse som kinase-inhibitorer
NO20093060L (no) Spirosykliske sykloheksanderivater
AR033423A1 (es) Sales farmaceuticas constituidas de una sustancia activa farmaceutica y al menos un edulcorante, medicamentos que contienen estas sales y uso de estas sales para la preparacion de medicamentos
NO20065878L (no) Terapeutiske forbindelser
CO5011096A1 (es) Medicamentos que contienen antagonistas del receptor 5-ht3 para el tratamiento de la ibs
WO2004000209A3 (en) Administration of therapeutic viruses
BRPI0311701B8 (pt) formulação farmacêutica de dosagem multiparticulada revestida com liberação controlada de lamotrigina
UY27455A1 (es) Derivados n-(1,4,5,6-tetrahidro-ciclopentapirazol -3-il)- sustituidos. su obtención y uso como fármacos.
EP1391200A4 (en) DRUG
AR034213A1 (es) Composiciones de medicamentos sobre la base de agentes anticolinergicos e inhibidores de pde-iv
DK1546127T3 (da) Nye pyrimidinamidderivater og anvendelse deraf
NO20065904L (no) Terapeutiske forbindelser
CY1106430T1 (el) Φαρμακα για εισπνοη που πepιλαμβανουν βηταμιμητικα και αντιχολινepγικο
DE602004014163D1 (de) Pyrimidylpyrrolderivate, die als kinaseinhibitoren wirken
SE0101932D0 (sv) Pharmaceutical combinations
AU2003293593A8 (en) Pharmaceutical preparations, use of said preparations and method for increasing the bioavailability of medicaments for peroral administration
BR0107628A (pt) l,2-diarilbenzimidazóis para tratamento de doenças que estão associadas a uma ativação microglial
YU84503A (sh) Upotreba azitromicina za pripremanje leka za lečenje neinfektivnih inflamatornih oboljenja
CY1109001T1 (el) Οι καππα-οπιοιδεις αγωνιστες στη θεραπεια των παθησεων της κυστης
BRPI0517792A (pt) macrolonas - quinolonas amino-substituìdas
BRPI0508485A (pt) compostos de pentafluorsulfanila, sua fabricação e uso como agentes farmacêuticos
NO323466B1 (no) Nye kinolinyl-piperidin-4-yliden-metyl-benzamidderivater, fremgangsmate til fremstilling derav, anvendelse derav i medikamenter til behandling av smerte, samt farmasoytisk sammensetning som innbefatter slike derivater
DK0479093T3 (da) Oligosaccharidderivater og deres anvendelse som lægemidler
NO20031410L (no) Anvendelse av distamycinderivater for fremstilling av medikamenter

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

MM1K Lapsed by not paying the annual fees