NO20044764L - 1-(aminoalkyl)-3-sulfonylindol og -indazolderivater som 5-hydroksytryptamin-6 ligander - Google Patents
1-(aminoalkyl)-3-sulfonylindol og -indazolderivater som 5-hydroksytryptamin-6 liganderInfo
- Publication number
- NO20044764L NO20044764L NO20044764A NO20044764A NO20044764L NO 20044764 L NO20044764 L NO 20044764L NO 20044764 A NO20044764 A NO 20044764A NO 20044764 A NO20044764 A NO 20044764A NO 20044764 L NO20044764 L NO 20044764L
- Authority
- NO
- Norway
- Prior art keywords
- sulfonylindole
- hydroxytryptamine
- aminoalkyl
- ligands
- indazole derivatives
- Prior art date
Links
- 125000004103 aminoalkyl group Chemical group 0.000 title 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38569502P | 2002-06-04 | 2002-06-04 | |
| PCT/US2003/017472 WO2003101962A1 (en) | 2002-06-04 | 2003-06-03 | 1-(aminoalkyl)-3-sulfonylindole and -indazole derivatives as 5-hydroxytryptamine-6 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20044764L true NO20044764L (no) | 2005-01-03 |
Family
ID=29712202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20044764A NO20044764L (no) | 2002-06-04 | 2004-11-03 | 1-(aminoalkyl)-3-sulfonylindol og -indazolderivater som 5-hydroksytryptamin-6 ligander |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6727246B2 (es) |
| EP (1) | EP1509501B1 (es) |
| JP (1) | JP2005536473A (es) |
| CN (1) | CN1656069A (es) |
| AR (1) | AR040048A1 (es) |
| AT (1) | ATE348806T1 (es) |
| AU (1) | AU2003237355A1 (es) |
| BR (1) | BR0311436A (es) |
| CA (1) | CA2485871A1 (es) |
| CR (1) | CR7566A (es) |
| DE (1) | DE60310552T2 (es) |
| DK (1) | DK1509501T3 (es) |
| EC (1) | ECSP045473A (es) |
| ES (1) | ES2279125T3 (es) |
| MX (1) | MXPA04011315A (es) |
| NO (1) | NO20044764L (es) |
| NZ (1) | NZ536921A (es) |
| RU (1) | RU2004139099A (es) |
| TW (1) | TW200400177A (es) |
| WO (1) | WO2003101962A1 (es) |
| ZA (1) | ZA200500021B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRPK20040271B3 (en) * | 2001-09-27 | 2006-02-28 | F. Hoffmann - La Roche Ag | Indole derivatives as cox ii inhibitors |
| KR20040085179A (ko) * | 2002-02-13 | 2004-10-07 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 통합된 반도체 광학 디바이스, 이러한 디바이스를제조하는 방법 및 장치 |
| TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| EP1592683A2 (en) * | 2003-02-14 | 2005-11-09 | Wyeth | Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands |
| EP1647549A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
| AR054394A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de 2- (1h-indolilsulfanil)-aril amina |
| AU2006262016A1 (en) * | 2005-06-28 | 2007-01-04 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| WO2007002481A2 (en) * | 2005-06-28 | 2007-01-04 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| JP2008546839A (ja) * | 2005-06-28 | 2008-12-25 | メルク エンド カムパニー インコーポレーテッド | 非ヌクレオシド逆転写酵素阻害剤 |
| RU2008103700A (ru) * | 2005-08-15 | 2009-09-27 | Вайет (Us) | Производные азинил-3-сульфонилиндазола в качестве лиганд 5ов 5-гидрокситриптамина-6 |
| RU2429231C2 (ru) | 2005-08-15 | 2011-09-20 | Вайет | Производные замещенного-3-сульфонилиндазола в качестве лигандов 5-гидрокситриптамина-6 |
| WO2007053353A2 (en) * | 2005-10-28 | 2007-05-10 | Wyeth | Pyrrolo[2,3-f] and [3,2-f]isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands |
| JP2009532471A (ja) * | 2006-04-05 | 2009-09-10 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのスルホニル−３−ヘテロシクリルインダゾール誘導体 |
| WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
| MX2009012471A (es) * | 2007-05-24 | 2010-02-24 | Memory Pharm Corp | Compuestos 4´sustituidos que tienen afinidad al receptor 5-hidroxitriptamina 6. |
| US20090012308A1 (en) * | 2007-06-13 | 2009-01-08 | Wyeth | Process for the manufacture of benzylsulfonylarenes |
| US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
| US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
| US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
| ES2600318T3 (es) * | 2012-07-10 | 2017-02-08 | F. Hoffmann-La Roche Ag | Nuevos indazoles para el tratamiento y profilaxis de infección por virus sincitial respiratorio |
| WO2018064094A1 (en) * | 2016-09-28 | 2018-04-05 | Bristol-Myers Squibb Company | Enantioselective synthesis of pyrroloindole compounds |
| EP3519816A4 (en) | 2016-09-29 | 2020-05-06 | The Regents of the University of California | CONNECTIONS FOR INCREASING NEURONAL PLASTICITY |
| WO2018165501A1 (en) * | 2017-03-10 | 2018-09-13 | Lycera Corporation | INDOLINYL SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATMENT OF DISEASE |
| CN111269165A (zh) * | 2018-12-05 | 2020-06-12 | 中国科学院大连化学物理研究所 | 一种3-芳基磺酰基吲哚衍生物的合成方法 |
| KR102946120B1 (ko) | 2019-02-27 | 2026-03-30 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클 |
| IL313455A (en) | 2021-12-15 | 2024-08-01 | Delix Therapeutics Inc | Phenoxy and benzyloxy modified psychroplastogens and their uses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654360A (en) | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
| FR2642755B1 (es) | 1989-02-07 | 1993-11-05 | Sanofi | |
| US5132319A (en) | 1991-03-28 | 1992-07-21 | Merck Frosst Canada, Inc. | 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis |
| US6100291A (en) * | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| PL198983B1 (pl) | 1998-04-28 | 2008-08-29 | Elbion Ag | Nowe hydroksyindole, ich zastosowanie jako inhibitorów fosfodiesterazy 4 oraz sposoby ich wytwarzania |
| GB9819032D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds IV |
| GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| CA2407677A1 (en) | 2000-04-28 | 2002-10-28 | Baxter Healthcare Sa | 2-acyl indol derivatives and their use as anti-tumour agents |
| BR0210929A (pt) * | 2001-06-07 | 2004-06-08 | Hoffmann La Roche | Derivados de indol com afinidade para o receptor 5-ht6 |
-
2003
- 2003-05-19 TW TW092113450A patent/TW200400177A/zh unknown
- 2003-05-23 AR ARP030101812A patent/AR040048A1/es unknown
- 2003-06-03 BR BR0311436-8A patent/BR0311436A/pt not_active IP Right Cessation
- 2003-06-03 WO PCT/US2003/017472 patent/WO2003101962A1/en not_active Ceased
- 2003-06-03 NZ NZ536921A patent/NZ536921A/en unknown
- 2003-06-03 AT AT03736818T patent/ATE348806T1/de not_active IP Right Cessation
- 2003-06-03 US US10/453,009 patent/US6727246B2/en not_active Expired - Fee Related
- 2003-06-03 EP EP03736818A patent/EP1509501B1/en not_active Expired - Lifetime
- 2003-06-03 DE DE60310552T patent/DE60310552T2/de not_active Expired - Lifetime
- 2003-06-03 AU AU2003237355A patent/AU2003237355A1/en not_active Withdrawn
- 2003-06-03 CA CA002485871A patent/CA2485871A1/en not_active Withdrawn
- 2003-06-03 MX MXPA04011315A patent/MXPA04011315A/es active IP Right Grant
- 2003-06-03 DK DK03736818T patent/DK1509501T3/da active
- 2003-06-03 CN CNA038124998A patent/CN1656069A/zh active Pending
- 2003-06-03 JP JP2004509655A patent/JP2005536473A/ja active Pending
- 2003-06-03 ES ES03736818T patent/ES2279125T3/es not_active Expired - Lifetime
- 2003-06-03 RU RU2004139099/04A patent/RU2004139099A/ru not_active Application Discontinuation
-
2004
- 2004-11-03 NO NO20044764A patent/NO20044764L/no not_active Application Discontinuation
- 2004-11-04 CR CR7566A patent/CR7566A/es unknown
- 2004-12-02 EC EC2004005473A patent/ECSP045473A/es unknown
-
2005
- 2005-01-03 ZA ZA200500021A patent/ZA200500021B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003101962A1 (en) | 2003-12-11 |
| BR0311436A (pt) | 2005-03-22 |
| ECSP045473A (es) | 2005-01-28 |
| JP2005536473A (ja) | 2005-12-02 |
| EP1509501B1 (en) | 2006-12-20 |
| ZA200500021B (en) | 2006-06-28 |
| EP1509501A1 (en) | 2005-03-02 |
| CR7566A (es) | 2005-01-05 |
| AR040048A1 (es) | 2005-03-09 |
| NZ536921A (en) | 2006-06-30 |
| US6727246B2 (en) | 2004-04-27 |
| US20030232828A1 (en) | 2003-12-18 |
| CA2485871A1 (en) | 2003-12-11 |
| CN1656069A (zh) | 2005-08-17 |
| DK1509501T3 (da) | 2007-03-12 |
| ES2279125T3 (es) | 2007-08-16 |
| ATE348806T1 (de) | 2007-01-15 |
| DE60310552T2 (de) | 2007-09-27 |
| AU2003237355A1 (en) | 2003-12-19 |
| RU2004139099A (ru) | 2005-06-10 |
| MXPA04011315A (es) | 2005-02-14 |
| DE60310552D1 (de) | 2007-02-01 |
| TW200400177A (en) | 2004-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |