NO20050916L - Deteksjon av reseptoroligomerisering - Google Patents

Deteksjon av reseptoroligomerisering

Info

Publication number
NO20050916L
NO20050916L NO20050916A NO20050916A NO20050916L NO 20050916 L NO20050916 L NO 20050916L NO 20050916 A NO20050916 A NO 20050916A NO 20050916 A NO20050916 A NO 20050916A NO 20050916 L NO20050916 L NO 20050916L
Authority
NO
Norway
Prior art keywords
probes
binding
molecules
probe includes
cleaving
Prior art date
Application number
NO20050916A
Other languages
English (en)
Inventor
Sharat Singh
Yining Shi
Sailaja Pidaparthi
Rajiv Dua
Po-Ying Chan-Hui
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Publication of NO20050916L publication Critical patent/NO20050916L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

Det beskrives metoder for å detektere dannelsen av oligomere komplekser av molekyler på overflaten av cellemembraner. Disse metoder benytter par av taggede prober og spaltingsprober, hver av hvilke bindes spesifikt til et celleoverflatemolekyl. Den taggede probe inkluderer en molekylær tag som er bundet til en første bindingsforbindelse via en spaltbar binding, og den spaltbare probe inkluderer et andre bindingsmiddel og en spaltingsinduserende del som kan spalte bindingen når den befinner seg innenfor en definert nærhet dertil. Bindingen av de to prober til celleoverflatemolekyler som har dannet et oligomert kompleks resulterer i frigivningen av den molekylære tag fra bindingsforbindelsen og gir et middel for dannelse av komplekset.
NO20050916A 2002-07-25 2005-02-21 Deteksjon av reseptoroligomerisering NO20050916L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39872402P 2002-07-25 2002-07-25
PCT/US2003/022611 WO2004011900A2 (en) 2002-07-25 2003-07-17 Detecting receptor oligomerization

Publications (1)

Publication Number Publication Date
NO20050916L true NO20050916L (no) 2005-04-14

Family

ID=31188464

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050916A NO20050916L (no) 2002-07-25 2005-02-21 Deteksjon av reseptoroligomerisering

Country Status (13)

Country Link
US (2) US7105308B2 (no)
EP (1) EP1540347B1 (no)
JP (2) JP4443407B2 (no)
KR (1) KR20050025669A (no)
CN (1) CN1672054A (no)
AT (1) ATE442589T1 (no)
AU (1) AU2003259175B2 (no)
CA (1) CA2490654C (no)
DE (1) DE60329194D1 (no)
ES (1) ES2332310T3 (no)
NO (1) NO20050916L (no)
PL (1) PL374875A1 (no)
WO (1) WO2004011900A2 (no)

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Also Published As

Publication number Publication date
US7105308B2 (en) 2006-09-12
EP1540347A4 (en) 2006-09-20
ATE442589T1 (de) 2009-09-15
PL374875A1 (en) 2005-11-14
AU2003259175A1 (en) 2004-02-16
US20040126818A1 (en) 2004-07-01
AU2003259175B2 (en) 2010-08-12
WO2004011900A2 (en) 2004-02-05
CA2490654C (en) 2012-02-07
CA2490654A1 (en) 2004-02-05
JP2005534030A (ja) 2005-11-10
ES2332310T3 (es) 2010-02-02
CN1672054A (zh) 2005-09-21
EP1540347A2 (en) 2005-06-15
US20040197835A1 (en) 2004-10-07
US7135300B2 (en) 2006-11-14
JP2009271087A (ja) 2009-11-19
KR20050025669A (ko) 2005-03-14
EP1540347B1 (en) 2009-09-09
DE60329194D1 (de) 2009-10-22
JP4443407B2 (ja) 2010-03-31
WO2004011900A3 (en) 2004-06-10

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