ATE455862T1 - Verbesserter rezeptornachweis - Google Patents
Verbesserter rezeptornachweisInfo
- Publication number
- ATE455862T1 ATE455862T1 AT03756374T AT03756374T ATE455862T1 AT E455862 T1 ATE455862 T1 AT E455862T1 AT 03756374 T AT03756374 T AT 03756374T AT 03756374 T AT03756374 T AT 03756374T AT E455862 T1 ATE455862 T1 AT E455862T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme
- fragment
- binding
- galactosidase
- conjugated
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 102000005936 beta-Galactosidase Human genes 0.000 abstract 2
- 108010005774 beta-Galactosidase Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 102000006240 membrane receptors Human genes 0.000 abstract 2
- 108020004084 membrane receptors Proteins 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000001952 enzyme assay Methods 0.000 abstract 1
- 238000003174 enzyme fragment complementation Methods 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000007306 turnover Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Prostheses (AREA)
- Glass Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Paints Or Removers (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38406002P | 2002-05-29 | 2002-05-29 | |
| PCT/US2003/017428 WO2003102154A2 (en) | 2002-05-29 | 2003-05-29 | Improved receptor detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455862T1 true ATE455862T1 (de) | 2010-02-15 |
Family
ID=29711971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03756374T ATE455862T1 (de) | 2002-05-29 | 2003-05-29 | Verbesserter rezeptornachweis |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040018562A1 (de) |
| EP (1) | EP1507869B1 (de) |
| JP (1) | JP2005527239A (de) |
| AT (1) | ATE455862T1 (de) |
| AU (1) | AU2003243375A1 (de) |
| CA (1) | CA2487513A1 (de) |
| DE (1) | DE60331059D1 (de) |
| WO (1) | WO2003102154A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
| US20040229380A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
| US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| JP2006503582A (ja) * | 2002-10-21 | 2006-02-02 | ディスカヴァーエックス インコーポレイテッド | Ｉｐ３タンパク質結合測定法 |
| US7402399B2 (en) * | 2003-10-14 | 2008-07-22 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
| CA2544688A1 (en) * | 2003-11-06 | 2005-05-26 | Discoverx Corporation | Cellular membrane protein assay |
| US7608415B2 (en) * | 2004-06-30 | 2009-10-27 | Discoverx Corporation | Analysis of intracellular modifications |
| EP1945782A4 (de) * | 2005-10-24 | 2009-03-25 | Discoverx Inc | Nachweis eines intrazellulären enzymkomplexes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708929A (en) * | 1984-10-29 | 1987-11-24 | Microgenics Corporation | Methods for protein binding enzyme complementation assays |
| US5223393A (en) * | 1990-06-12 | 1993-06-29 | Microgenics Corporation | Detection of analytes having binding sites for at least two binding moieties |
| US5976857A (en) * | 1996-01-26 | 1999-11-02 | Boehringer Mannheim Corporation | Cross-linked polypeptide fragments of β-galactosidase |
| EP1392870B1 (de) * | 2001-05-09 | 2008-02-27 | Discoverx, Inc. | Screening auf enzyminhibitoren |
| US7135325B2 (en) * | 2002-05-02 | 2006-11-14 | Discoverx, Inc. | Short enzyme donor fragment |
-
2003
- 2003-05-29 DE DE60331059T patent/DE60331059D1/de not_active Expired - Fee Related
- 2003-05-29 AU AU2003243375A patent/AU2003243375A1/en not_active Abandoned
- 2003-05-29 CA CA002487513A patent/CA2487513A1/en not_active Abandoned
- 2003-05-29 JP JP2004510396A patent/JP2005527239A/ja active Pending
- 2003-05-29 WO PCT/US2003/017428 patent/WO2003102154A2/en not_active Ceased
- 2003-05-29 AT AT03756374T patent/ATE455862T1/de not_active IP Right Cessation
- 2003-05-29 US US10/448,609 patent/US20040018562A1/en not_active Abandoned
- 2003-05-29 EP EP03756374A patent/EP1507869B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003243375A1 (en) | 2003-12-19 |
| WO2003102154A3 (en) | 2004-05-06 |
| JP2005527239A (ja) | 2005-09-15 |
| AU2003243375A8 (en) | 2003-12-19 |
| US20040018562A1 (en) | 2004-01-29 |
| WO2003102154A2 (en) | 2003-12-11 |
| EP1507869A2 (de) | 2005-02-23 |
| CA2487513A1 (en) | 2003-12-11 |
| EP1507869B1 (de) | 2010-01-20 |
| EP1507869A4 (de) | 2006-10-25 |
| DE60331059D1 (de) | 2010-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |