NO20051242L - Blandinger for inhibering av protein kinase C alfa for behandling av Diabetes mellitus og kardiovaskulaere sykdommer - Google Patents

Blandinger for inhibering av protein kinase C alfa for behandling av Diabetes mellitus og kardiovaskulaere sykdommer

Info

Publication number
NO20051242L
NO20051242L NO20051242A NO20051242A NO20051242L NO 20051242 L NO20051242 L NO 20051242L NO 20051242 A NO20051242 A NO 20051242A NO 20051242 A NO20051242 A NO 20051242A NO 20051242 L NO20051242 L NO 20051242L
Authority
NO
Norway
Prior art keywords
treatment
protein kinase
diabetes mellitus
activity
cardiovascular diseases
Prior art date
Application number
NO20051242A
Other languages
English (en)
Inventor
Jan Menne
Hermann Haller
Original Assignee
Phenos Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenos Gmbh filed Critical Phenos Gmbh
Publication of NO20051242L publication Critical patent/NO20051242L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Anvendelsen av midler som hemmer ekspresjonen og/eller aktiviteten av proteinkinase C-alfa (PKC-a), spesielt ved behandling av pasienter med diabetes og komplikasjoner, så som diabetisk nefropati, retinopati eller neuropati, beskrives.
NO20051242A 2002-09-24 2005-03-10 Blandinger for inhibering av protein kinase C alfa for behandling av Diabetes mellitus og kardiovaskulaere sykdommer NO20051242L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10244453A DE10244453A1 (de) 2002-09-24 2002-09-24 Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten
PCT/DE2003/003165 WO2004028516A2 (de) 2002-09-24 2003-09-23 Zusammensetzungen zur hemmung der proteinkinase c alpha zur behandlung von diabetes mellitus und kardiovaskulärer erkrankungen

Publications (1)

Publication Number Publication Date
NO20051242L true NO20051242L (no) 2005-06-01

Family

ID=31969524

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051242A NO20051242L (no) 2002-09-24 2005-03-10 Blandinger for inhibering av protein kinase C alfa for behandling av Diabetes mellitus og kardiovaskulaere sykdommer

Country Status (19)

Country Link
US (2) US20050250719A1 (no)
EP (2) EP2338498A1 (no)
JP (1) JP2006503841A (no)
KR (1) KR20050059180A (no)
CN (1) CN1684694A (no)
AT (1) ATE475422T1 (no)
AU (1) AU2003280288B2 (no)
CA (1) CA2499818A1 (no)
DE (3) DE10244453A1 (no)
DK (1) DK1545560T3 (no)
EA (1) EA007926B1 (no)
ES (1) ES2356286T3 (no)
IS (1) IS7777A (no)
MX (1) MXPA05002930A (no)
NO (1) NO20051242L (no)
NZ (1) NZ538857A (no)
PL (1) PL374829A1 (no)
UA (1) UA88257C2 (no)
WO (1) WO2004028516A2 (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031714A1 (it) 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
US20050066381A1 (en) * 2003-09-19 2005-03-24 Children's Hospital Medical Center Regulation of cardiac contractility and heart failure propensity
WO2005038013A1 (en) * 2003-10-07 2005-04-28 Isis Pharmaceuticals, Inc. Artisense oligonucleotides optimized for kidney targeting
US9144594B2 (en) * 2005-11-08 2015-09-29 University Of Miami Cathepsin L mediated diseases and associated methods and products
JP2009518439A (ja) * 2005-12-09 2009-05-07 メタプロテオミクス，エルエルシー ホップ及びアカシア産物によるプロテインキナーゼ調節
US20080181877A1 (en) * 2006-03-22 2008-07-31 Leangene Ab, C/O Cit Ekonomiservice Ab Method For Monitoring the Effect of Compounds on Foxc2 Expression
US10369222B2 (en) 2012-01-18 2019-08-06 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters for the treatment of stroke
US9974764B2 (en) 2007-01-31 2018-05-22 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters in the treatment of neoplasms
US11564901B2 (en) 2007-01-31 2023-01-31 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters
US9533938B2 (en) 2007-01-31 2017-01-03 Biosuccess Biotech Co., Ltd. Compositions and methods of use of phorbol esters for the treatment of stroke
EP2170053A4 (en) 2007-01-31 2010-06-23 Biosuccess Biotech Company Compositions and methods of use of phorbol esters
US11696908B2 (en) 2007-01-31 2023-07-11 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters
US9636317B2 (en) 2007-01-31 2017-05-02 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters
EP1982722A1 (en) * 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
EP2637672B1 (en) 2010-11-12 2018-08-22 Gentium S.r.l. Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd).
NZ727304A (en) * 2012-01-18 2018-08-31 Biosuccess Biotech Co Ltd Compositions and methods of use of phorbol esters for the treatment of stroke
US10099996B2 (en) 2012-01-18 2018-10-16 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbol esters in the treatment of neoplasms
US9550722B2 (en) 2012-01-18 2017-01-24 Biosuccess Biotech Co. Ltd. Compositions and methods of use of phorbal esters for the treatment of stroke
US20150079111A1 (en) * 2012-06-05 2015-03-19 Jonas Axelsson Mechanism, diagnostic, and treatments for complications of renal failure
ES2660969T5 (es) 2012-06-22 2021-09-03 Gentium S R L Método basado en euglobulina para determinar la actividad biológica de defibrotida
TWI630909B (zh) * 2013-01-18 2018-08-01 華鴻新藥股份有限公司 用於中風治療之巴豆酯組成物及使用方法
TWI687217B (zh) * 2014-01-10 2020-03-11 華鴻新藥股份有限公司 用於中風治療之巴豆酯組成物及使用方法
EP3501531A1 (en) * 2014-01-29 2019-06-26 Université de Strasbourg New target for diabetes treatment and prevention
RU2738833C9 (ru) * 2014-04-14 2022-02-28 Арвинас, Оперэйшнз, Инк. Имидные модуляторы протеолиза и способы их применения
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
EP3313993A4 (en) 2015-06-29 2019-06-19 Regents of the University of Minnesota ANTI-APOBEC3 ANTIBODIES AND METHOD OF PREPARATION AND USE
EP3421485A1 (en) 2017-06-30 2019-01-02 Université de Strasbourg Peptides for treatment and prevention of hyperglycaemia
US20190100929A1 (en) * 2017-09-29 2019-04-04 Safeworks, Llc Hoist system with direct current power supply
RU2765117C2 (ru) * 2019-09-24 2022-01-25 Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" Применение натриевой соли диэтилового эфира 4-оксо-1,4-дигидропиразоло[5,1-с]-1,2,4-триазин-3,8-дикарбоновой кислоты, моногидрата в качестве средства лечения и профилактики поздних осложнений сахарного диабета
WO2022092884A1 (ko) * 2020-10-29 2022-05-05 가톨릭관동대학교산학협력단 13-ｏ-아세틸포볼을 포함하는 골질환 및 혈관석회화증 예방 또는 치료용 약학적 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3914764A1 (de) * 1989-05-05 1990-11-08 Goedecke Ag Maleinimid-derivate und deren verwendung als arzneimittel
DE3924538A1 (de) * 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazol und dessen verwendung
JPH06501695A (ja) * 1990-10-01 1994-02-24 ブリガム・アンド・ウイメンズ・ホスピタル 主要血管事象を抑制するためのベータ−カロテン及びビタミンｅ療法
AU637014B2 (en) * 1990-11-02 1993-05-13 Sphinx Pharmaceuticals Corporation Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase c
AU1783092A (en) * 1991-04-08 1992-11-02 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The Inhibitors of protein kinase c function
CA2179650C (en) 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors
US5481003A (en) 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
SI0776895T1 (en) * 1995-11-20 1999-04-30 Eli Lilly And Company Protein kinase C inhibitor
EA001450B1 (ru) * 1996-05-01 2001-04-23 Эли Лилли Энд Компани Галогензамещенные ингибиторы протеинкиназы с
US6063814A (en) * 1997-04-14 2000-05-16 Chang; Richard L. Phorbol esters as anti-neoplastic and white blood cell elevating agents
DE19740384A1 (de) * 1997-09-08 1999-03-11 Max Delbrueck Centrum Antisense Oligodesoxynukleotide (ODN) gegen Proteinkinase C (PKC)-Isoformen, ihre Verwendung und pharmazeutische Zubereitungen dieser ODN
US20050066381A1 (en) * 2003-09-19 2005-03-24 Children's Hospital Medical Center Regulation of cardiac contractility and heart failure propensity

Also Published As

Publication number Publication date
IS7777A (is) 2005-03-30
EA007926B1 (ru) 2007-02-27
WO2004028516A2 (de) 2004-04-08
AU2003280288B2 (en) 2008-08-28
US20050250719A1 (en) 2005-11-10
CA2499818A1 (en) 2004-04-08
CN1684694A (zh) 2005-10-19
DE10244453A1 (de) 2004-04-01
NZ538857A (en) 2010-10-29
ATE475422T1 (de) 2010-08-15
DK1545560T3 (da) 2010-11-22
MXPA05002930A (es) 2005-09-30
AU2003280288A1 (en) 2004-04-19
WO2004028516A3 (de) 2004-11-11
EP1545560A2 (de) 2005-06-29
EP1545560B1 (de) 2010-07-28
ES2356286T3 (es) 2011-04-06
JP2006503841A (ja) 2006-02-02
UA88257C2 (ru) 2009-10-12
PL374829A1 (en) 2005-10-31
DE10393825D2 (de) 2005-08-11
US20090191194A1 (en) 2009-07-30
EA200500529A1 (ru) 2005-08-25
KR20050059180A (ko) 2005-06-17
DE50312935D1 (de) 2010-09-09
EP2338498A1 (de) 2011-06-29

Similar Documents

Publication Publication Date Title
NO20051242L (no) Blandinger for inhibering av protein kinase C alfa for behandling av Diabetes mellitus og kardiovaskulaere sykdommer
DE602004011985D1 (de) Modulatoren des peroxisomproliferatoraktivierten rezeptors
MXPA04004548A (es) Acidos heteroarilalalcanoicos substituidos y su uso como inhibidores de aldosa reductasa.
BR0210167A (pt) Composto, composição farmacêutica, métodos para modular um receptor ativado com proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição e para abaixar a glicose no sangue, e, uso de um composto
NO20062292L (no) Fremgangsmate for behandling av transplantasjonsavstoting
DE60023518D1 (de) Verwendung von ace inhibitoren zur prophylaxe von kongestivem herzversagen
BR0009563A (pt) Inibidores de ap2 de bifenilas contendo heterocìclico e método
EA200501058A1 (ru) Фармацевтическая комбинация из телмисартана и аторвастатина для профилактики или терапевтического лечения сердечно-сосудистых, сердечно-легочных, легочных или почечных заболеваний
NO20051965D0 (no) Nye piperidinderivater for anvendelse ved behandling av kemokinmedierte sykdomstilstander.
NO20015394L (no) Karboksylsyrederivater som hemmer bindingen av integriner til deres reseptorer
NO20034986D0 (no) Furan og tiofenderivater som aktiverer human peroksisom proliferator aktiverte reseptorer
NO20060864L (no) Farmasoytisk sammensetning omfattende en kombinasjon av metformin og et statin
PE20040291A1 (es) COMBINACION QUE COMPRENDE UN INHIBIDOR DE HMG-CoA-REDUCTASA Y UN POTENCIADOR DE LA SECRECION DE INSULINA Y/O UN SENSIBILIZANTE DE INSULINA
WO2004024093A3 (en) Device and method for treating restenosis
NO20083068L (no) Optisk aktive karbamater, fremgangsmate for deres fremstilling og anvendelse derav som farmasoytiske mellomprodukter
ATE401877T1 (de) Verwendung von methylenamid-derivaten bei kardiovaskulären erkrankungen
PL376213A1 (en) Pharmaceutical combination for the prophylaxis or treatment of cardiovascular, cardiopulmonary, pulmonary or renal diseases
AU2003212769A1 (en) Piperidine derivatives useful as modulators of chemokine receptor activity
ES2156574A1 (es) Nuevos derivados de tiazonlindiona como agentes antidiabeticos
NO20012831L (no) Diazepinoindoler for behandling av kronisk obstruktiv lungesykdom
NO20043286L (no) Piperidinderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel
SE0201939D0 (sv) New combination
IL175997A0 (en) Selective peroxisome proliferator activated receptor modulators
UA83265C2 (ru) Селективные модуляторы рецепторов, которые активируются пролифераторами пероксисом
TH64458A (th) ตัวยับยั้ง Rho-Kinase

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application