NO20051448L - Makrosykliske pyrimidiner, fremstilling derav og anvendelse av de samme som medikamenter - Google Patents

Makrosykliske pyrimidiner, fremstilling derav og anvendelse av de samme som medikamenter

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Publication number
NO20051448L
NO20051448L NO20051448A NO20051448A NO20051448L NO 20051448 L NO20051448 L NO 20051448L NO 20051448 A NO20051448 A NO 20051448A NO 20051448 A NO20051448 A NO 20051448A NO 20051448 L NO20051448 L NO 20051448L
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NO
Norway
Prior art keywords
aryl
heteroaryl
cycloalkyl
alkyl
alkenyl
Prior art date
Application number
NO20051448A
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English (en)
Other versions
NO20051448D0 (no
Inventor
Gerhard Siemeister
Martina Schafer
Ulrich Luecking
Hans Briem
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20051448L publication Critical patent/NO20051448L/no
Publication of NO20051448D0 publication Critical patent/NO20051448D0/no

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Cardiology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Oppfinnelsen vedrører makrosykliske pyrimidinderivater med generell formel (I), der R1 til R5, X, Y, A, B, m og n har betydningene som er gjengitt i beskrivelsen, som inhibitorer av den syklinavhengige kinasen. Oppfinnelsen vedrører også fremgangsmåter for fremstilling av nevnte derivater og anvendelsen av de samme som medikamenter til behandling av ulike sykdommer.
NO20051448A 2002-08-21 2005-03-18 Makrosykliske pyrimidiner, fremstilling derav og anvendelse av de samme som medikamenter NO20051448D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10239042A DE10239042A1 (de) 2002-08-21 2002-08-21 Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
PCT/EP2003/008664 WO2004026881A1 (de) 2002-08-21 2003-08-05 Makrozyklische pyrimidine, deren herstellung und verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
NO20051448L true NO20051448L (no) 2005-03-18
NO20051448D0 NO20051448D0 (no) 2005-03-18

Family

ID=31197382

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051448A NO20051448D0 (no) 2002-08-21 2005-03-18 Makrosykliske pyrimidiner, fremstilling derav og anvendelse av de samme som medikamenter

Country Status (24)

Country Link
US (1) US7312225B2 (no)
EP (1) EP1530574B1 (no)
JP (1) JP2006501271A (no)
KR (1) KR20050058360A (no)
CN (1) CN100357295C (no)
AT (1) ATE346073T1 (no)
AU (1) AU2003250212A1 (no)
BR (1) BR0312874A (no)
CA (1) CA2492319A1 (no)
DE (2) DE10239042A1 (no)
DK (1) DK1530574T3 (no)
EA (1) EA200500303A1 (no)
EC (1) ECSP055690A (no)
ES (1) ES2278222T3 (no)
HR (1) HRP20050240A2 (no)
IL (1) IL165913A0 (no)
IS (1) IS7762A (no)
MX (1) MXPA05001526A (no)
NO (1) NO20051448D0 (no)
PL (1) PL374686A1 (no)
PT (1) PT1530574E (no)
RS (1) RS20050162A (no)
WO (1) WO2004026881A1 (no)
ZA (1) ZA200502269B (no)

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