NO20051617L - Piperidinderivater av heterocyklusfusjonerte benzodioksaner med antidepressiv aktivitet - Google Patents

Piperidinderivater av heterocyklusfusjonerte benzodioksaner med antidepressiv aktivitet

Info

Publication number
NO20051617L
NO20051617L NO20051617A NO20051617A NO20051617L NO 20051617 L NO20051617 L NO 20051617L NO 20051617 A NO20051617 A NO 20051617A NO 20051617 A NO20051617 A NO 20051617A NO 20051617 L NO20051617 L NO 20051617L
Authority
NO
Norway
Prior art keywords
disorder
depression
benzodioxanes
heterocycle
fused
Prior art date
Application number
NO20051617A
Other languages
English (en)
Other versions
NO20051617D0 (no
Inventor
Gary Paul Stack
Magda Asselin
Deborah Ann Evrard
Michael Byron Webb
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20051617D0 publication Critical patent/NO20051617D0/no
Publication of NO20051617L publication Critical patent/NO20051617L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Forbindelser av formel (I) er nyttige for behandling av depresjon (irmbefattende, men ikke begrenset til, alvorhg depresjonshdelse, bamedepresjon og dystymi), angst, panikklidelse, postttaumatisk stresslidelse, premenstruell dysforisk tilstand (også kjent som premenstruell syndrom), oppmerksomhetssviktiidelse (med eller uten hyper- aktivitet), obsessiv kompulsiv lidelse, sosial angstiidelse, generalisert angstiidelse, overvekt, spiseforstyrrelser så som anoreksia nervose og bulimia nervosa, vasomotorisk "flushing", kokain- og alkoholavhengig, seksuell dysfimksjon og beslektede sykdommer.
NO20051617A 2002-09-12 2005-03-31 Piperidinderivater av heterocyklusfusjonerte benzodioksaner med antidepressiv aktivitet NO20051617L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41003302P 2002-09-12 2002-09-12
US10/659,160 US6939877B2 (en) 2002-09-12 2003-09-10 Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
PCT/US2003/028523 WO2004024733A1 (en) 2002-09-12 2003-09-11 Antidepressant piperidine derivatives of heterocycle-fused benzodioxans

Publications (2)

Publication Number Publication Date
NO20051617D0 NO20051617D0 (no) 2005-03-31
NO20051617L true NO20051617L (no) 2005-03-31

Family

ID=31994047

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051617A NO20051617L (no) 2002-09-12 2005-03-31 Piperidinderivater av heterocyklusfusjonerte benzodioksaner med antidepressiv aktivitet

Country Status (13)

Country Link
US (3) US6939877B2 (no)
EP (1) EP1537120A1 (no)
JP (1) JP2006510594A (no)
KR (1) KR20050042192A (no)
CN (2) CN100351256C (no)
AU (1) AU2003270559A1 (no)
BR (1) BR0314431A (no)
EC (1) ECSP055657A (no)
MX (1) MXPA05002830A (no)
NO (1) NO20051617L (no)
RU (1) RU2005107588A (no)
WO (1) WO2004024733A1 (no)
ZA (1) ZA200502042B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
JP2008530229A (ja) * 2005-02-17 2008-08-07 ワイス シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
AR060493A1 (es) * 2006-04-18 2008-06-18 Wyeth Corp Derivados de benzodioxano y benzodioxolano. procesos de obtencion.
US8101628B2 (en) * 2006-12-21 2012-01-24 Eli Lilly And Company Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer
US20090042874A1 (en) * 2007-05-30 2009-02-12 Wyeth Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans
US8399432B2 (en) * 2009-10-27 2013-03-19 Lipogen Ltd. Compositions and methods of treatment for alleviating premenstrual syndrome symptoms
WO2012114347A1 (en) * 2011-02-21 2012-08-30 Avra Laboratories Pvt. Ltd. Synthesis of chiral substituted benzenes and related aromatic compounds containing 1,2 diols protected as diacetal groups

Family Cites Families (24)

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US2266677A (en) * 1941-12-16 Garden implement
US1706658A (en) * 1927-04-15 1929-03-26 Winthrop S Davis Hoe
US3293674A (en) * 1965-04-02 1966-12-27 Sapia James Combination sickle and weed pulling tool
GB1354554A (en) 1970-08-31 1974-06-05 Robins Co Inc A H 2-substituted benzimidazoles
PH23995A (en) 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
AU639536B2 (en) 1990-03-15 1993-07-29 Pharmacia & Upjohn Company Therapeutically useful heterocyclic indole compounds
JPH06502854A (ja) * 1990-11-24 1994-03-31 ビーチャム・グループ・パブリック・リミテッド・カンパニー 老年痴呆、過食症、片頭痛または食欲不振の治療用のパロキセチンの使用
NZ254113A (en) 1992-07-13 1995-08-28 Janssen Pharmaceutica Nv Fused piperidine derivatives and medicaments
US5276042A (en) * 1993-04-16 1994-01-04 Crenshaw Roger T Treatment of premature ejaculation
GB9318431D0 (en) 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
GB9402029D0 (en) * 1994-02-03 1994-03-30 Smithkline Beecham Plc Novel formulation
US5756532A (en) * 1995-11-06 1998-05-26 American Home Products Corporation Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
DE19602355A1 (de) * 1996-01-24 1997-07-31 Hoechst Ag Mehrfach fucosylierte Dicarbonsäuren mit antiadhäsiven Eigenschaften
US5869490A (en) * 1996-10-15 1999-02-09 American Home Products Corporation Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
JP2001502327A (ja) 1996-10-15 2001-02-20 アメリカン・ホーム・プロダクツ・コーポレイション ２，３，８，９―テトラヒドロ―７Ｈ―１，４―ジオキシノ［２，３―ｅ］インドール―８―オンのアザヘテロサイクリルメチル誘導体
GB9627005D0 (en) * 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9704948D0 (en) * 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
TWI242011B (en) * 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US6720003B2 (en) * 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
US6458802B1 (en) * 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6593350B2 (en) * 2001-04-26 2003-07-15 Wyeth Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans

Also Published As

Publication number Publication date
KR20050042192A (ko) 2005-05-04
US7479500B2 (en) 2009-01-20
CN101230066A (zh) 2008-07-30
BR0314431A (pt) 2005-09-27
US20090042895A1 (en) 2009-02-12
JP2006510594A (ja) 2006-03-30
ECSP055657A (es) 2005-07-06
AU2003270559A1 (en) 2004-04-30
CN1681820A (zh) 2005-10-12
US20050228009A1 (en) 2005-10-13
MXPA05002830A (es) 2005-08-16
EP1537120A1 (en) 2005-06-08
WO2004024733A1 (en) 2004-03-25
US6939877B2 (en) 2005-09-06
US20040147523A1 (en) 2004-07-29
RU2005107588A (ru) 2006-01-20
CN100351256C (zh) 2007-11-28
NO20051617D0 (no) 2005-03-31
ZA200502042B (en) 2006-08-30

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