ATE304016T1 - Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h- 6,9-dioxa-1,3-diazacyclopenta (a) naphthalin - Google Patents

Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h- 6,9-dioxa-1,3-diazacyclopenta (a) naphthalin

Info

Publication number: ATE304016T1
Authority: AT; Austria
Prior art keywords: sssri; diazacyclopenta; naphthaline; dioxa; antidepressant
Prior art date: 2001-04-26

Application number

AT02728968T

Other languages

English (en)

Inventor

Gary Paul Stack

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-26

Filing date

2002-04-23

Publication date

2005-09-15

2002-04-23 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE304016T1 publication Critical patent/ATE304016T1/de

Links

QWLONAKTOUSDIR-UHFFFAOYSA-N 7,8-dihydro-3h-[1,4]dioxino[2,3-e]benzimidazole Chemical class O1CCOC2=C1C=CC1=C2NC=N1 QWLONAKTOUSDIR-UHFFFAOYSA-N 0.000 title 1
230000001430 anti-depressive effect Effects 0.000 title 1
239000000935 antidepressant agent Substances 0.000 title 1
229940005513 antidepressants Drugs 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
206010013654 Drug abuse Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
206010033664 Panic attack Diseases 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
206010001584 alcohol abuse Diseases 0.000 abstract 1
208000025746 alcohol use disease Diseases 0.000 abstract 1
201000001272 cocaine abuse Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
208000029364 generalized anxiety disease Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT02728968T 2001-04-26 2002-04-23 Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h- 6,9-dioxa-1,3-diazacyclopenta (a) naphthalin ATE304016T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28657901P	2001-04-26	2001-04-26
PCT/US2002/012993 WO2002088131A1 (en)	2001-04-26	2002-04-23	Antidepressant (sssri) azaheterocyclymethyl derivatives of 7,8-dihydro-3h-t,9-dioxa-1,3-diazacyclopenta[a]naphthalene

Publications (1)

Publication Number	Publication Date
ATE304016T1 true ATE304016T1 (de)	2005-09-15

Family

ID=23099245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02728968T ATE304016T1 (de)	2001-04-26	2002-04-23	Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h- 6,9-dioxa-1,3-diazacyclopenta (a) naphthalin

Country Status (12)

Country	Link
US (1)	US6573283B2 (de)
EP (1)	EP1401839B9 (de)
JP (1)	JP2004527561A (de)
CN (1)	CN1267434C (de)
AT (1)	ATE304016T1 (de)
BR (1)	BR0209408A (de)
CA (1)	CA2445552A1 (de)
DE (1)	DE60206048T2 (de)
DK (1)	DK1401839T5 (de)
ES (1)	ES2247327T3 (de)
MX (1)	MXPA03009828A (de)
WO (1)	WO2002088131A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6927226B2 (en) *	2001-04-26	2005-08-09	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
ES2364340T3 (es)	2004-03-30	2011-08-31	Vertex Pharmaceuticals Incorporated	Azaindoles útiles como inhibidores de jak y otras proteína quinasas.
WO2008079346A1 (en)	2006-12-21	2008-07-03	Vertex Pharmaceuticals Incorporated	5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
GEP20207129B (en)	2009-06-17	2020-07-10	Vertex Pharma	Inhibitors of influenza viruses replication
RU2013132681A (ru)	2010-12-16	2015-01-27	Вертекс Фармасьютикалз Инкорпорейтед	Ингибиторы репликации вирусов гриппа
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
PT3068776T (pt)	2013-11-13	2019-08-26	Vertex Pharma	Inibidores da replicação de vírus da gripe
HUE038820T2 (hu)	2013-11-13	2018-11-28	Vertex Pharma	Eljárás influenzavírusok replikációjának inhibitorai elõállítására
WO2016183120A1 (en)	2015-05-13	2016-11-17	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
EP3294717B1 (de)	2015-05-13	2020-07-29	Vertex Pharmaceuticals Inc.	Verfahren zur herstellung von inhibitoren der influenzavirenreplikation
AU2022234737A1 (en) *	2021-03-08	2023-09-07	Research Triangle Institute	Small molecule antagonists for the relaxin-3/rxfp3 system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU639536B2 (en)	1990-03-15	1993-07-29	Pharmacia & Upjohn Company	Therapeutically useful heterocyclic indole compounds
DE4135474A1 (de)	1991-10-28	1993-04-29	Bayer Ag	2-aminomethyl-chromane
DE4140540A1 (de)	1991-12-09	1993-06-17	Bayer Ag	Neue azaheterocyclylmethyl-chromane
US5741789A (en)	1995-01-17	1998-04-21	Eli Lilly And Company	Compounds having effects on serotonin-related systems
US5756532A (en) *	1995-11-06	1998-05-26	American Home Products Corporation	Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
GB9526495D0 (en)	1995-12-23	1996-02-28	Knoll Ag	Therapeutic agents
US5869490A (en)	1996-10-15	1999-02-09	American Home Products Corporation	Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
JP2001502327A (ja)	1996-10-15	2001-02-20	アメリカン・ホーム・プロダクツ・コーポレイション	２，３，８，９―テトラヒドロ―７Ｈ―１，４―ジオキシノ［２，３―ｅ］インドール―８―オンのアザヘテロサイクリルメチル誘導体
GB9627005D0 (en) *	1996-12-27	1997-02-12	Knoll Ag	Therapeutic agents
GB9704948D0 (en)	1997-03-11	1997-04-30	Knoll Ag	Therapeutic agents
US6458802B1 (en) *	2001-03-14	2002-10-01	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline

2002
- 2002-04-23 MX MXPA03009828A patent/MXPA03009828A/es active IP Right Grant
- 2002-04-23 US US10/128,762 patent/US6573283B2/en not_active Expired - Fee Related
- 2002-04-23 AT AT02728968T patent/ATE304016T1/de not_active IP Right Cessation
- 2002-04-23 WO PCT/US2002/012993 patent/WO2002088131A1/en not_active Ceased
- 2002-04-23 CN CNB028088174A patent/CN1267434C/zh not_active Expired - Fee Related
- 2002-04-23 CA CA002445552A patent/CA2445552A1/en not_active Abandoned
- 2002-04-23 DK DK02728968T patent/DK1401839T5/da active
- 2002-04-23 ES ES02728968T patent/ES2247327T3/es not_active Expired - Lifetime
- 2002-04-23 DE DE60206048T patent/DE60206048T2/de not_active Expired - Fee Related
- 2002-04-23 BR BR0209408-8A patent/BR0209408A/pt not_active IP Right Cessation
- 2002-04-23 EP EP02728968A patent/EP1401839B9/de not_active Expired - Lifetime
- 2002-04-23 JP JP2002585430A patent/JP2004527561A/ja active Pending

Also Published As

Publication number	Publication date
ES2247327T3 (es)	2006-03-01
EP1401839B9 (de)	2005-11-30
JP2004527561A (ja)	2004-09-09
CA2445552A1 (en)	2002-11-07
DK1401839T5 (da)	2006-03-13
US20020183351A1 (en)	2002-12-05
EP1401839A1 (de)	2004-03-31
CN1535274A (zh)	2004-10-06
DE60206048T2 (de)	2006-07-13
CN1267434C (zh)	2006-08-02
WO2002088131A1 (en)	2002-11-07
DE60206048D1 (de)	2005-10-13
US6573283B2 (en)	2003-06-03
EP1401839B1 (de)	2005-09-07
BR0209408A (pt)	2004-07-06
DK1401839T3 (da)	2005-10-24
MXPA03009828A (es)	2005-03-07

Legal Events

Date

Code

Title

Description

2006-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1401839

Country of ref document: EP

2007-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
WO2002085896A8 (en)	2002-11-28	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
BR0209580A (pt)	2004-06-22	Derivados de ciclohexan-1, 4 diamina substituìdos
BR122012023120B8 (pt)	2022-01-18	Composto inibidor da recaptação de serotonina
DE60221098D1 (de)	2007-08-23	Kondensierte heterocyclische derivate
ATE279415T1 (de)	2004-10-15	Antidepressiv wirksame azaheterocyclymethyl- derivative von oxaheterocycyl-anellierten (1,4)- benzodioxanen
GEP20094640B (en)	2009-03-10	Aryl-and heteroaryl-substituted tetrahydro isoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
DE60206048D1 (de)	2005-10-13	Antidepressive (sssri) azaheterocyclylmethylderivate von 7,8-dihydro-3h-6,9-dioxa-1,3-diazacyclopenta [a] naphthalin
ATE277934T1 (de)	2004-10-15	Antidepressive azaheterocyclylmethylderivate von 7,8-dihydro-1,6,9-trioxa-3- azacyclopenta(a)naphthalin
DE60213576D1 (de)	2006-09-14	ANTIDEPRESSIVE AZAHETEROCYCLYLMETHYL-DERIVATE VON 2,3-DIHYDRO-1,4-DIOXINOi2,3-föCHINOXALIN
EA200200137A1 (ru)	2002-06-27	Лечение невротических нарушений
NO20055208L (no)	2005-11-04	4-(2-fenylsulfanyl-fenyl)-piperidinderivater som serotonin-reopptaksinhibitorer
DE60335404D1 (de)	2011-01-27	Verwendung von 4-aminochinolin-verbindungen zur behandlung entzündlicher erkrankungen des auges
ATE279418T1 (de)	2004-10-15	Antidepressive indoltetrahydropyridin-derivate von 2,3-dihydro-7h(1,4)dioxino(2,3-e)indol
NO20035673D0 (no)	2003-12-18	Nye heteroarylderivater, deres fremstilling og anvendelse
BRPI0408320A (pt)	2006-03-07	composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
NO20052308D0 (no)	2005-05-11	Nye benzoksazociner og deres terapeutiske anvendelse.
CA2451229A1 (en)	2003-01-09	Indole derivatives