NO20051770L - Antidepressivt virkende cykloalkylaminderivater av heterocykle-kondenserte benzodioksaner - Google Patents

Antidepressivt virkende cykloalkylaminderivater av heterocykle-kondenserte benzodioksaner

Info

Publication number: NO20051770L
Authority: NO; Norway
Prior art keywords: disorder; benzodioxanes; depressant; heterocycle; condensed
Prior art date: 2002-09-12

Application number

NO20051770A

Other languages

English (en)

Norwegian (no)

Inventor

Gary Paul Stack

Deborah Ann Evrard

Uresh Shantilal Shah

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-12

Filing date

2005-04-11

Publication date

2005-06-07

2005-04-11 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-06-07 Publication of NO20051770L publication Critical patent/NO20051770L/no

Links

230000001430 anti-depressive effect Effects 0.000 title 1
239000000935 antidepressant agent Substances 0.000 title 1
BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical class C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 title 1
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
206010068631 Childhood depression Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
208000027030 Premenstrual dysphoric disease Diseases 0.000 abstract 1
206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
229960003920 cocaine Drugs 0.000 abstract 1
201000006145 cocaine dependence Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
208000024732 dysthymic disease Diseases 0.000 abstract 1
238000011010 flushing procedure Methods 0.000 abstract 1
208000029364 generalized anxiety disease Diseases 0.000 abstract 1
208000013403 hyperactivity Diseases 0.000 abstract 1
208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
208000024714 major depressive disease Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1
230000001457 vasomotor Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20051770A 2002-09-12 2005-04-11 Antidepressivt virkende cykloalkylaminderivater av heterocykle-kondenserte benzodioksaner NO20051770L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US41007202P	2002-09-12	2002-09-12
US10/659,174 US6911445B2 (en)	2002-09-12	2003-09-10	Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
PCT/US2003/028459 WO2004024732A1 (fr)	2002-09-12	2003-09-11	Derives cycloalkylamine antidepresseurs de benzodioxanes fusionnes au niveau des heterocycles

Publications (1)

Publication Number	Publication Date
NO20051770L true NO20051770L (no)	2005-06-07

Family

ID=31997897

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20051770A NO20051770L (no)	2002-09-12	2005-04-11	Antidepressivt virkende cykloalkylaminderivater av heterocykle-kondenserte benzodioksaner

Country Status (20)

Country	Link
US (1)	US6911445B2 (fr)
EP (1)	EP1546151B1 (fr)
JP (1)	JP2006503040A (fr)
KR (1)	KR20050042187A (fr)
CN (1)	CN1309722C (fr)
AT (1)	ATE323094T1 (fr)
AU (1)	AU2003266029A1 (fr)
BR (1)	BR0314430A (fr)
CA (1)	CA2498131A1 (fr)
DE (1)	DE60304590T2 (fr)
DK (1)	DK1546151T3 (fr)
EC (1)	ECSP055659A (fr)
ES (1)	ES2259776T3 (fr)
MX (1)	MXPA05002838A (fr)
NO (1)	NO20051770L (fr)
NZ (1)	NZ539253A (fr)
PT (1)	PT1546151E (fr)
RU (1)	RU2005107591A (fr)
SI (1)	SI1546151T1 (fr)
WO (1)	WO2004024732A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR050253A1 (es)	2004-06-24	2006-10-11	Smithkline Beecham Corp	Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
PE20060748A1 (es)	2004-09-21	2006-10-01	Smithkline Beecham Corp	Derivados de indolcarboxamida como inhibidores de quinasa ikk2
JP2008530229A (ja) *	2005-02-17	2008-08-07	ワイス	シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
US8063071B2 (en)	2007-10-31	2011-11-22	GlaxoSmithKline, LLC	Chemical compounds
US20080139546A1 (en) *	2006-09-29	2008-06-12	Wyeth	Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines
PE20081889A1 (es)	2007-03-23	2009-03-05	Smithkline Beecham Corp	Indol carboxamidas como inhibidores de ikk2
CL2008001563A1 (es) *	2007-05-30	2008-10-10	Wyeth6 3	Compuestos derivados de benzodioxanos condensados con heterociclos; metodo de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como depresion, ansiedad, crisis de panico, entre otras.
WO2010102968A1 (fr)	2009-03-10	2010-09-16	Glaxo Group Limited	Dérivés d'indole comme inhibiteurs de ikk2

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9318431D0 (en) *	1993-09-06	1993-10-20	Boots Co Plc	Therapeutic agents
US5468767A (en) *	1994-01-06	1995-11-21	Bristol-Myers Squibb Company	Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
AR004229A1 (es)	1995-11-06	1998-11-04	Wyeth Corp	Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
GB9627005D0 (en)	1996-12-27	1997-02-12	Knoll Ag	Therapeutic agents
GB9704948D0 (en) *	1997-03-11	1997-04-30	Knoll Ag	Therapeutic agents
US6162803A (en) *	1998-04-08	2000-12-19	American Home Products Corp.	Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression
JP2002510682A (ja) *	1998-04-08	2002-04-09	アメリカン・ホーム・プロダクツ・コーポレイション	うつ病治療用のインドール−３−イル−シクロヘキシルアミン誘導体（５−ｈｔ１受容体拮抗薬）
SI1392697T1 (en)	2001-03-14	2005-02-28	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino 2,3-f)quinoline
ES2229138T3 (es)	2001-04-26	2005-04-16	Wyeth	Derivados antidepresivos azaheterociclilmetilicos de (1,4)- benzodiaxanos condensados con oxaheterociclos.

2003
- 2003-09-10 US US10/659,174 patent/US6911445B2/en not_active Expired - Fee Related
- 2003-09-11 EP EP03795686A patent/EP1546151B1/fr not_active Expired - Lifetime
- 2003-09-11 CA CA002498131A patent/CA2498131A1/fr not_active Abandoned
- 2003-09-11 KR KR1020057004091A patent/KR20050042187A/ko not_active Withdrawn
- 2003-09-11 PT PT03795686T patent/PT1546151E/pt unknown
- 2003-09-11 MX MXPA05002838A patent/MXPA05002838A/es active IP Right Grant
- 2003-09-11 NZ NZ539253A patent/NZ539253A/en unknown
- 2003-09-11 JP JP2004536479A patent/JP2006503040A/ja active Pending
- 2003-09-11 WO PCT/US2003/028459 patent/WO2004024732A1/fr not_active Ceased
- 2003-09-11 DK DK03795686T patent/DK1546151T3/da active
- 2003-09-11 ES ES03795686T patent/ES2259776T3/es not_active Expired - Lifetime
- 2003-09-11 AU AU2003266029A patent/AU2003266029A1/en not_active Abandoned
- 2003-09-11 SI SI200330260T patent/SI1546151T1/sl unknown
- 2003-09-11 DE DE60304590T patent/DE60304590T2/de not_active Expired - Fee Related
- 2003-09-11 RU RU2005107591/04A patent/RU2005107591A/ru not_active Application Discontinuation
- 2003-09-11 AT AT03795686T patent/ATE323094T1/de not_active IP Right Cessation
- 2003-09-11 BR BR0314430-5A patent/BR0314430A/pt not_active IP Right Cessation
- 2003-09-11 CN CNB038214695A patent/CN1309722C/zh not_active Expired - Fee Related
2005
- 2005-03-10 EC EC2005005659A patent/ECSP055659A/es unknown
- 2005-04-11 NO NO20051770A patent/NO20051770L/no unknown

Also Published As

Publication number	Publication date
CA2498131A1 (fr)	2004-03-25
CN1309722C (zh)	2007-04-11
DK1546151T3 (da)	2006-07-31
DE60304590T2 (de)	2007-05-10
AU2003266029A1 (en)	2004-04-30
EP1546151A1 (fr)	2005-06-29
EP1546151B1 (fr)	2006-04-12
PT1546151E (pt)	2006-07-31
US6911445B2 (en)	2005-06-28
SI1546151T1 (sl)	2006-08-31
WO2004024732A1 (fr)	2004-03-25
US20040171667A1 (en)	2004-09-02
RU2005107591A (ru)	2006-01-20
JP2006503040A (ja)	2006-01-26
ES2259776T3 (es)	2006-10-16
HK1073849A1 (en)	2005-10-21
NZ539253A (en)	2006-09-29
ECSP055659A (es)	2005-07-06
CN1681821A (zh)	2005-10-12
MXPA05002838A (es)	2005-08-16
BR0314430A (pt)	2005-09-27
ATE323094T1 (de)	2006-04-15
DE60304590D1 (de)	2006-05-24
KR20050042187A (ko)	2005-05-04

Publication	Publication Date	Title
BR0314429A (pt)	2005-08-23	Derivados de aza-heterociclil-metil antidepressivo e benzodioxanos fundidos por heterociclo
BR0314277A (pt)	2005-07-26	Composto; método de tratamento de um indivìduo acometido por uma condição de depressão, ansiedade, distúrbios do pânico, de tensão pós-traumática, disfórico pré-menstrual, de deficiência da atenção, obsessivos-compulsivos e alimentares, obesidade, rubor vasomotor, dependência de álcool e cocaìna e disfunção sexual; composição farmacêutica e uso do mesmo
TW200505942A (en)	2005-02-16	Antibody molecules having specificity for human IL-1β
ATE281459T1 (de)	2004-11-15	Azaheterocyclylmethyl derivative des 2,3-dihydro- 1,4-dioxino(2,3-f)quinolins als antidepressiva
MY147217A (en)	2012-11-14	Antibody molecules having specificity for human il-06
DE502004011239D1 (de)	2010-07-15	Verfahren zur dehydratisierung substituierter 4-dimethylamino-2-aryl-butan-2-ol-verbindungen und verfahren zur herstellung substituierter dimethyl-(3-katalyse
NO20051770L (no)	2005-06-07	Antidepressivt virkende cykloalkylaminderivater av heterocykle-kondenserte benzodioksaner
DE60315843D1 (de)	2007-10-04	Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen
SI1626720T1 (sl)	2008-12-31	Derivati 4-(2-fenilsulfanil-fenil)-piperidina kotzaviralci ponovnega vnosa serotonina
WO2002088136A3 (fr)	2003-03-20	Derives azaheterocyclylmethyliques de 1,4,5-trioxa-phenanthrene antidepresseurs
BR0209343A (pt)	2004-06-15	Antidepressivos de azaheterociclilmetila derivados de [1,4]-benzodioxanos oxaheterociclo-fundidos; métodos de tratamento usando tais compostos; processo para prepará-los
BRPI0607224A2 (pt)	2009-08-25	processo para preparação de ciclohexanona e ciclohexanol
BR0314431A (pt)	2005-09-27	Derivados de piperidina antidepressiva dos benzodioxanos fundidos por heterocilo
BR0209342A (pt)	2004-06-15	Antidepressivos de azaheterociclilmetila derivados de 2,3 dihidro-1,4-dioxino[2,3-f]quinoxalina; método de tratamento usando tais compostos; processo para prepará-los
ATE446299T1 (de)	2009-11-15	Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
DE50310200D1 (de)	2008-09-04	Verfahren zur herstellung von aminoalkoxybenzylaminen und aminoalkoxybenzonitrilen als zwischenprodukte
BRPI0909824A2 (pt)	2019-03-06	2-aminoquinolinas
BR0314280A (pt)	2005-07-26	Composto; método de tratamento de um indivìduo acometido por uma condição de depressão, ansiedade, distúrbios do pânico, de tensão pós-traumática, disfórico pré-menstrual, de deficiência da atenção, obsessivos-compulsivos e alimentares, obesidade, rubor vasomotor, dependência de álcool e cocaìna e disfunção sexual; composição farmacêutica e uso do mesmo
DK1725526T3 (da)	2008-03-03	Fremgangsmåde til fremstilling af pyrrolidinoximer
ATE417055T1 (de)	2008-12-15	Steroid modifizierte solatriosen