ECSP055659A - Derivados de cicloalquilamina antidepresiva de benzodioxanos fusionados con heterociclos - Google Patents
Derivados de cicloalquilamina antidepresiva de benzodioxanos fusionados con heterociclosInfo
- Publication number
- ECSP055659A ECSP055659A EC2005005659A ECSP055659A ECSP055659A EC SP055659 A ECSP055659 A EC SP055659A EC 2005005659 A EC2005005659 A EC 2005005659A EC SP055659 A ECSP055659 A EC SP055659A EC SP055659 A ECSP055659 A EC SP055659A
- Authority
- EC
- Ecuador
- Prior art keywords
- disorder
- cyclalkylamine
- heterocicles
- benzodioxanes
- antidepressive
- Prior art date
Links
- 230000001430 anti-depressive effect Effects 0.000 title 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 206010068631 Childhood depression Diseases 0.000 abstract 1
- 208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000027030 Premenstrual dysphoric disease Diseases 0.000 abstract 1
- 206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 206010041250 Social phobia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 229960003920 cocaine Drugs 0.000 abstract 1
- 201000006145 cocaine dependence Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 208000024732 dysthymic disease Diseases 0.000 abstract 1
- 238000011010 flushing procedure Methods 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 230000001457 vasomotor Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Los compuestos de la Fórmula I son eficaces en el tratamiento de depresión (incluyendo pero sin limitar depresión aguda, depresión en la niñez, y distimia), ansiedad, pánico, estrés post traumático, trastorno disfórico premenstrual (también conocido como síndrome premenstrual), trastorno de déficit de atención (con o sin hiperactividad), trastorno compulsivo obsesivo, trastorno de ansiedad social, trastorno de ansiedad generalizada, obesidad, trastornos alimenticios, adicción a la cocaína y al alcohol, disfunción sexual y enfermedades relacionadas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41007202P | 2002-09-12 | 2002-09-12 | |
| US10/659,174 US6911445B2 (en) | 2002-09-12 | 2003-09-10 | Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055659A true ECSP055659A (es) | 2005-07-06 |
Family
ID=31997897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005005659A ECSP055659A (es) | 2002-09-12 | 2005-03-10 | Derivados de cicloalquilamina antidepresiva de benzodioxanos fusionados con heterociclos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6911445B2 (es) |
| EP (1) | EP1546151B1 (es) |
| JP (1) | JP2006503040A (es) |
| KR (1) | KR20050042187A (es) |
| CN (1) | CN1309722C (es) |
| AT (1) | ATE323094T1 (es) |
| AU (1) | AU2003266029A1 (es) |
| BR (1) | BR0314430A (es) |
| CA (1) | CA2498131A1 (es) |
| DE (1) | DE60304590T2 (es) |
| DK (1) | DK1546151T3 (es) |
| EC (1) | ECSP055659A (es) |
| ES (1) | ES2259776T3 (es) |
| MX (1) | MXPA05002838A (es) |
| NO (1) | NO20051770L (es) |
| NZ (1) | NZ539253A (es) |
| PT (1) | PT1546151E (es) |
| RU (1) | RU2005107591A (es) |
| SI (1) | SI1546151T1 (es) |
| WO (1) | WO2004024732A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| TW200626142A (en) | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
| AU2006214233A1 (en) * | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| US20080139546A1 (en) * | 2006-09-29 | 2008-06-12 | Wyeth | Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| CL2008001563A1 (es) * | 2007-05-30 | 2008-10-10 | Wyeth6 3 | Compuestos derivados de benzodioxanos condensados con heterociclos; metodo de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como depresion, ansiedad, crisis de panico, entre otras. |
| JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ｉｋｋ２阻害剤としてのインドール誘導体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| US5468767A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives |
| AR004229A1 (es) | 1995-11-06 | 1998-11-04 | Wyeth Corp | Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos |
| GB9627005D0 (en) | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
| GB9704948D0 (en) * | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
| US6162803A (en) * | 1998-04-08 | 2000-12-19 | American Home Products Corp. | Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression |
| JP2002510682A (ja) * | 1998-04-08 | 2002-04-09 | アメリカン・ホーム・プロダクツ・コーポレイション | うつ病治療用のインドール−３−イル−シクロヘキシルアミン誘導体（５−ｈｔ１受容体拮抗薬） |
| PT1392697E (pt) | 2001-03-14 | 2005-01-31 | Wyeth Corp | Antidepressivos derivados aza-heterociclilmetilo de 2,3- di-hidro-1,4-dioxino[2,3-f]quinolina |
| JP2004532236A (ja) | 2001-04-26 | 2004-10-21 | ワイス | 抗うつ作用を持つ、オキサヘテロ環結合［１、４］−ベンゾジオキサンのアザヘテロシクリルメチル誘導体 |
-
2003
- 2003-09-10 US US10/659,174 patent/US6911445B2/en not_active Expired - Fee Related
- 2003-09-11 NZ NZ539253A patent/NZ539253A/en unknown
- 2003-09-11 RU RU2005107591/04A patent/RU2005107591A/ru not_active Application Discontinuation
- 2003-09-11 EP EP03795686A patent/EP1546151B1/en not_active Expired - Lifetime
- 2003-09-11 BR BR0314430-5A patent/BR0314430A/pt not_active IP Right Cessation
- 2003-09-11 PT PT03795686T patent/PT1546151E/pt unknown
- 2003-09-11 JP JP2004536479A patent/JP2006503040A/ja active Pending
- 2003-09-11 DK DK03795686T patent/DK1546151T3/da active
- 2003-09-11 AU AU2003266029A patent/AU2003266029A1/en not_active Abandoned
- 2003-09-11 MX MXPA05002838A patent/MXPA05002838A/es active IP Right Grant
- 2003-09-11 ES ES03795686T patent/ES2259776T3/es not_active Expired - Lifetime
- 2003-09-11 KR KR1020057004091A patent/KR20050042187A/ko not_active Withdrawn
- 2003-09-11 SI SI200330260T patent/SI1546151T1/sl unknown
- 2003-09-11 WO PCT/US2003/028459 patent/WO2004024732A1/en not_active Ceased
- 2003-09-11 AT AT03795686T patent/ATE323094T1/de not_active IP Right Cessation
- 2003-09-11 CA CA002498131A patent/CA2498131A1/en not_active Abandoned
- 2003-09-11 CN CNB038214695A patent/CN1309722C/zh not_active Expired - Fee Related
- 2003-09-11 DE DE60304590T patent/DE60304590T2/de not_active Expired - Fee Related
-
2005
- 2005-03-10 EC EC2005005659A patent/ECSP055659A/es unknown
- 2005-04-11 NO NO20051770A patent/NO20051770L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60304590D1 (de) | 2006-05-24 |
| US6911445B2 (en) | 2005-06-28 |
| WO2004024732A1 (en) | 2004-03-25 |
| US20040171667A1 (en) | 2004-09-02 |
| CA2498131A1 (en) | 2004-03-25 |
| CN1681821A (zh) | 2005-10-12 |
| AU2003266029A1 (en) | 2004-04-30 |
| MXPA05002838A (es) | 2005-08-16 |
| DE60304590T2 (de) | 2007-05-10 |
| KR20050042187A (ko) | 2005-05-04 |
| PT1546151E (pt) | 2006-07-31 |
| ES2259776T3 (es) | 2006-10-16 |
| BR0314430A (pt) | 2005-09-27 |
| RU2005107591A (ru) | 2006-01-20 |
| SI1546151T1 (sl) | 2006-08-31 |
| ATE323094T1 (de) | 2006-04-15 |
| EP1546151B1 (en) | 2006-04-12 |
| NZ539253A (en) | 2006-09-29 |
| DK1546151T3 (da) | 2006-07-31 |
| HK1073849A1 (en) | 2005-10-21 |
| NO20051770L (no) | 2005-06-07 |
| CN1309722C (zh) | 2007-04-11 |
| JP2006503040A (ja) | 2006-01-26 |
| EP1546151A1 (en) | 2005-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0314429A (pt) | Derivados de aza-heterociclil-metil antidepressivo e benzodioxanos fundidos por heterociclo | |
| TW200505942A (en) | Antibody molecules having specificity for human IL-1β | |
| TW200728466A (en) | Antibody molecules having specificity for human IL-6 | |
| BR0314277A (pt) | Composto; método de tratamento de um indivìduo acometido por uma condição de depressão, ansiedade, distúrbios do pânico, de tensão pós-traumática, disfórico pré-menstrual, de deficiência da atenção, obsessivos-compulsivos e alimentares, obesidade, rubor vasomotor, dependência de álcool e cocaìna e disfunção sexual; composição farmacêutica e uso do mesmo | |
| ATE490253T1 (de) | Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen | |
| DE60201829D1 (de) | Azaheterocyclylmethyl derivative des 2,3-dihydro-1,4-dioxino(2,3-f)quinolins als antidepressiva | |
| ECSP055659A (es) | Derivados de cicloalquilamina antidepresiva de benzodioxanos fusionados con heterociclos | |
| DE60315843D1 (de) | Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen | |
| AR035083A1 (es) | Derivados azaheterociclilmetilicos de 7,8-dihidro-6h-5-oxa-1-aza-fenantreno, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de un medicamento antidepresivo e intermediarios | |
| EA200801109A1 (ru) | Состав для литья и способ его получения | |
| BRPI0607224A2 (pt) | processo para preparação de ciclohexanona e ciclohexanol | |
| WO2002088136A3 (en) | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene | |
| BR0209343A (pt) | Antidepressivos de azaheterociclilmetila derivados de [1,4]-benzodioxanos oxaheterociclo-fundidos; métodos de tratamento usando tais compostos; processo para prepará-los | |
| BR0314431A (pt) | Derivados de piperidina antidepressiva dos benzodioxanos fundidos por heterocilo | |
| CY1110087T1 (el) | Μεθοδοι παρασκευης ενωσεων που περιεχουν πυρραζολιο | |
| CY1107139T1 (el) | Μεθοδος παρασκευης πυρρολιδινοξιμων | |
| PA8659601A1 (es) | Procedimiento para la preparacion de alcoholes aminoetoxibencilicos | |
| EA200801239A1 (ru) | Новые способы получения пиперазинильных и диазепанильных производных бензамина | |
| BR0314280A (pt) | Composto; método de tratamento de um indivìduo acometido por uma condição de depressão, ansiedade, distúrbios do pânico, de tensão pós-traumática, disfórico pré-menstrual, de deficiência da atenção, obsessivos-compulsivos e alimentares, obesidade, rubor vasomotor, dependência de álcool e cocaìna e disfunção sexual; composição farmacêutica e uso do mesmo | |
| CR7726A (es) | Antidepresivos derivados de indoalquilo de benzodioxan metilaminas de heterociclo fusionado | |
| ATE417055T1 (de) | Steroid modifizierte solatriosen | |
| EA200701031A1 (ru) | Молекулы, способствующие гематопоэзу | |
| SE0400759D0 (sv) | Novel amination process |