NO20051838L - Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor. - Google Patents

Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor.

Info

Publication number: NO20051838L
Authority: NO; Norway
Prior art keywords: growth factor; transforming growth; tgf; inhibitor; oxazole compounds
Prior art date: 2002-09-18

Application number

NO20051838A

Other languages

English (en)

Norwegian (no)

Inventor

Michael John Munchhof

Laura Cook Blomberg

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-18

Filing date

2005-04-15

Publication date

2005-04-15

2005-04-15 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2005-04-15 Publication of NO20051838L publication Critical patent/NO20051838L/no

Links

102000009618 Transforming Growth Factors Human genes 0.000 title abstract 4
108010009583 Transforming Growth Factors Proteins 0.000 title abstract 4
239000003112 inhibitor Substances 0.000 title abstract 2
150000002916 oxazoles Chemical class 0.000 title 1
150000003852 triazoles Chemical class 0.000 title 1
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003176 fibrotic effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1
150000003557 thiazoles Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20051838A 2002-09-18 2005-04-15 Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor. NO20051838L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US41212002P	2002-09-18	2002-09-18
US47126503P	2003-05-16	2003-05-16
US48458103P	2003-07-02	2003-07-02
PCT/IB2003/003823 WO2004026863A1 (en)	2002-09-18	2003-09-08	Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors

Publications (1)

Publication Number	Publication Date
NO20051838L true NO20051838L (no)	2005-04-15

Family

ID=32034216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20051838A NO20051838L (no)	2002-09-18	2005-04-15	Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor.

Country Status (28)

Country	Link
US (1)	US7273936B2 (de)
EP (1)	EP1542994B1 (de)
JP (1)	JP4518956B2 (de)
KR (1)	KR20050057415A (de)
CN (1)	CN1681810A (de)
AP (1)	AP2005003261A0 (de)
AR (1)	AR041273A1 (de)
AT (1)	ATE430147T1 (de)
AU (1)	AU2003256003A1 (de)
BR (1)	BR0314383A (de)
CA (1)	CA2499429C (de)
CO (1)	CO5550473A2 (de)
CR (1)	CR7743A (de)
DE (1)	DE60327443D1 (de)
EA (1)	EA200500354A1 (de)
ES (1)	ES2323421T3 (de)
HR (1)	HRP20050250A2 (de)
IS (1)	IS7711A (de)
MA (1)	MA27443A1 (de)
MX (1)	MXPA05002332A (de)
NO (1)	NO20051838L (de)
OA (1)	OA12926A (de)
PA (1)	PA8582701A1 (de)
PE (1)	PE20040987A1 (de)
PL (1)	PL375975A1 (de)
TW (1)	TW200413362A (de)
UY (1)	UY27978A1 (de)
WO (1)	WO2004026863A1 (de)

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PA8595001A1 (es)	2003-03-04	2004-09-28	Pfizer Prod Inc	Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
GB0313914D0 (en) *	2003-06-16	2003-07-23	Smithkline Beecham Corp	Compounds
BRPI0515012A (pt) *	2004-08-13	2008-07-01	Genentech Inc	substáncia quìmica, composição e formulação farmacêutica, método de tratamento, método de inibição de pelo menos uma enzima que utiliza atp e uso
US20070275968A1 (en) *	2004-09-07	2007-11-29	Hitoshi Kurata	Substituted Biphenyl Derivative
EP2289510A1 (de)	2004-09-20	2011-03-02	Xenon Pharmaceuticals Inc.	Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten
US7767677B2 (en)	2004-09-20	2010-08-03	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP1799667B1 (de)	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe
EP2316458A1 (de)	2004-09-20	2011-05-04	Xenon Pharmaceuticals Inc.	Pyridazin-Derivate zur Verhinderung menschlicher Stearoyl-coa-desaturas
EP1804799B1 (de)	2004-09-20	2013-08-21	Xenon Pharmaceuticals Inc.	Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
US7951805B2 (en)	2004-09-20	2011-05-31	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
CA2580856A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2029138A1 (de)	2005-06-03	2009-03-04	Xenon Pharmaceuticals Inc.	Aminothiazolderivate als humane stearoyl-coa desaturasehemmer
CN101330914A (zh) *	2005-12-16	2008-12-24	爱尔康公司	使用alk5调节剂控制眼内压
EP2154965A4 (de) *	2007-05-29	2011-08-17	Glaxosmithkline Llc	Naphthyridinderivate als p13-kinasehemmer
US8268874B2 (en)	2008-03-03	2012-09-18	University Of Notre Dame Du Lac	Anti-cancer compounds, synthesis thereof, and methods of using same
US8865732B2 (en)	2008-03-21	2014-10-21	Novartis Ag	Heterocyclic compounds and uses thereof
AU2012203026B2 (en) *	2008-03-21	2014-06-12	Novartis Ag	Novel heterocyclic compounds and uses thereof
EP2300466B1 (de)	2008-06-20	2014-08-06	Bristol-Myers Squibb Company	Imidazopyridin- und imidazopyrazinverbindungen als kinasehemmer
US9242969B2 (en)	2013-03-14	2016-01-26	Novartis Ag	Biaryl amide compounds as kinase inhibitors
PL3089971T3 (pl)	2014-01-01	2021-01-25	Medivation Technologies Llc	Związki i sposoby ich zastosowania
UY36294A (es)	2014-09-12	2016-04-29	Novartis Ag	Compuestos y composiciones como inhibidores de quinasa
CN105585565B (zh) *	2014-10-23	2019-10-01	中国医学科学院药物研究所	含2-苯胺基-4-噻唑基吡啶衍生物及其制法和药物组合物与用途
CN106243012A (zh) *	2016-08-02	2016-12-21	北方民族大学	新型吲哚类衍生物及其制备方法
CN109715163B (zh)	2016-09-19	2022-11-22	诺华股份有限公司	包含raf抑制剂和erk抑制剂的治疗组合
WO2018203219A1 (en)	2017-05-02	2018-11-08	Novartis Ag	Combination therapy
CN110831593A (zh) *	2017-06-14	2020-02-21	特维娜有限公司	用于调节s1p1活性的化合物及其使用方法
EP4563150A3 (de)	2019-05-13	2025-07-23	Novartis AG	Neue kristalline formen von n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonikotinamid als raf-hemmer zur behandlung von krebs
CN112694477B (zh) *	2019-10-22	2024-02-06	四川科伦博泰生物医药股份有限公司	吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途
MX2022005766A (es)	2019-11-19	2022-08-08	Trevena Inc	Compuestos y métodos para la preparación de compuestos moduladores de esfingosina 1-fosfato tipo 1 (s1p1).
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AR039241A1 (es)	2002-04-04	2005-02-16	Biogen Inc	Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
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CN1681805A (zh)	2002-09-18	2005-10-12	辉瑞产品公司	作为转化生长因子(tgf)抑制剂的新的咪唑类化合物
JP2006502236A (ja)	2002-09-18	2006-01-19	ファイザー・プロダクツ・インク	形質転換成長因子（ｔｇｆ）阻害剤としてのトリアゾール誘導体
KR20050057441A (ko)	2002-09-18	2005-06-16	화이자 프로덕츠 인코포레이티드	전환 성장 인자 억제제로서의 신규한 아이소티아졸 및아이속사졸 화합물

2003
- 2003-09-08 MX MXPA05002332A patent/MXPA05002332A/es active IP Right Grant
- 2003-09-08 PL PL03375975A patent/PL375975A1/xx not_active Application Discontinuation
- 2003-09-08 EA EA200500354A patent/EA200500354A1/ru unknown
- 2003-09-08 AP AP2005003261A patent/AP2005003261A0/xx unknown
- 2003-09-08 ES ES03797426T patent/ES2323421T3/es not_active Expired - Lifetime
- 2003-09-08 CA CA2499429A patent/CA2499429C/en not_active Expired - Fee Related
- 2003-09-08 AT AT03797426T patent/ATE430147T1/de not_active IP Right Cessation
- 2003-09-08 JP JP2004568899A patent/JP4518956B2/ja not_active Expired - Fee Related
- 2003-09-08 EP EP03797426A patent/EP1542994B1/de not_active Expired - Lifetime
- 2003-09-08 AU AU2003256003A patent/AU2003256003A1/en not_active Abandoned
- 2003-09-08 OA OA1200500075A patent/OA12926A/en unknown
- 2003-09-08 WO PCT/IB2003/003823 patent/WO2004026863A1/en not_active Ceased
- 2003-09-08 CN CNA038222205A patent/CN1681810A/zh active Pending
- 2003-09-08 HR HR20050250A patent/HRP20050250A2/xx not_active Application Discontinuation
- 2003-09-08 DE DE60327443T patent/DE60327443D1/de not_active Expired - Lifetime
- 2003-09-08 KR KR1020057004611A patent/KR20050057415A/ko not_active Ceased
- 2003-09-08 BR BR0314383-0A patent/BR0314383A/pt not_active IP Right Cessation
- 2003-09-15 PE PE2003000939A patent/PE20040987A1/es not_active Application Discontinuation
- 2003-09-15 PA PA20038582701A patent/PA8582701A1/es unknown
- 2003-09-15 UY UY27978A patent/UY27978A1/es not_active Application Discontinuation
- 2003-09-16 AR ARP030103357A patent/AR041273A1/es unknown
- 2003-09-17 TW TW092125637A patent/TW200413362A/zh unknown
- 2003-09-17 US US10/667,187 patent/US7273936B2/en not_active Expired - Fee Related
2005
- 2005-02-24 IS IS7711A patent/IS7711A/is unknown
- 2005-03-15 CR CR7743A patent/CR7743A/es not_active Application Discontinuation
- 2005-03-16 CO CO05024531A patent/CO5550473A2/es not_active Application Discontinuation
- 2005-03-18 MA MA28157A patent/MA27443A1/fr unknown
- 2005-04-15 NO NO20051838A patent/NO20051838L/no unknown

Also Published As

Publication number	Publication date
MA27443A1 (fr)	2005-07-01
CR7743A (es)	2005-06-15
CO5550473A2 (es)	2005-08-31
ATE430147T1 (de)	2009-05-15
JP2006502235A (ja)	2006-01-19
JP4518956B2 (ja)	2010-08-04
HRP20050250A2 (en)	2005-10-31
AU2003256003A1 (en)	2004-04-08
KR20050057415A (ko)	2005-06-16
WO2004026863A8 (en)	2005-04-21
US7273936B2 (en)	2007-09-25
IS7711A (is)	2005-02-24
DE60327443D1 (de)	2009-06-10
US20040110797A1 (en)	2004-06-10
EP1542994A1 (de)	2005-06-22
CA2499429A1 (en)	2004-04-01
ES2323421T3 (es)	2009-07-15
WO2004026863A1 (en)	2004-04-01
BR0314383A (pt)	2005-07-19
AP2005003261A0 (en)	2005-03-31
PA8582701A1 (es)	2004-04-23
CA2499429C (en)	2010-09-21
EP1542994B1 (de)	2009-04-29
CN1681810A (zh)	2005-10-12
MXPA05002332A (es)	2005-06-08
UY27978A1 (es)	2004-04-30
AR041273A1 (es)	2005-05-11
OA12926A (en)	2006-10-13
TW200413362A (en)	2004-08-01
PL375975A1 (en)	2005-12-12
EA200500354A1 (ru)	2005-10-27
PE20040987A1 (es)	2004-12-27

Publication	Publication Date	Title
NO20050838L (no)	2005-05-18	Nye pyrazolforbindelser som transformerende vekstfaktor (TGF)-inhibitorer
NO20051010L (no)	2005-05-31	Triazolderivater som transformerende vekst faktor (TGF) inhibitorer
NO20051008L (no)	2005-06-07	Nye imidazolforbindelser som transformerende vekst faktor (TGF) inhibitorer
WO2004026863A8 (en)	2005-04-21	Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors
NO20051527D0 (no)	2005-03-22	3-(sulfonamidoetyl) -indol-derivater for anvendelse som glukocorticoid-mimetica ved behandling av inflammatoriske, allergiske og proliferative sykdommer.
TW200504069A (en)	2005-02-01	Novel fused heteroaromatic compounds as transforming growth factor (TGF) inhibitors
NO20060415L (no)	2006-02-07	Piperidyl-Kinazolinderivater som Tyrosin-Kinase-Inhibitorer
NO20061743L (no)	2006-06-21	Kinazolinderivater
EA200500286A1 (ru)	2005-08-25	Новые изотиазольные и изоксазольные соединения в качестве ингибиторов трансформирующего фактора роста (тфр)
SE0103836D0 (sv)	2001-11-16	Novel compounds
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