NO20051838L - Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor. - Google Patents

Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor.

Info

Publication number: NO20051838L
Authority: NO; Norway
Prior art keywords: growth factor; transforming growth; tgf; inhibitor; oxazole compounds
Prior art date: 2002-09-18

Application number

NO20051838A

Other languages

English (en)

Norwegian (no)

Inventor

Michael John Munchhof

Laura Cook Blomberg

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-18

Filing date

2005-04-15

Publication date

2005-04-15

2005-04-15 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2005-04-15 Publication of NO20051838L publication Critical patent/NO20051838L/no

Links

102000009618 Transforming Growth Factors Human genes 0.000 title abstract 4
108010009583 Transforming Growth Factors Proteins 0.000 title abstract 4
239000003112 inhibitor Substances 0.000 title abstract 2
150000002916 oxazoles Chemical class 0.000 title 1
150000003852 triazoles Chemical class 0.000 title 1
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003176 fibrotic effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1
150000003557 thiazoles Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO20051838A 2002-09-18 2005-04-15 Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor. NO20051838L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US41212002P	2002-09-18	2002-09-18
US47126503P	2003-05-16	2003-05-16
US48458103P	2003-07-02	2003-07-02
PCT/IB2003/003823 WO2004026863A1 (en)	2002-09-18	2003-09-08	Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors

Publications (1)

Publication Number	Publication Date
NO20051838L true NO20051838L (no)	2005-04-15

Family

ID=32034216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20051838A NO20051838L (no)	2002-09-18	2005-04-15	Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor.

Country Status (28)

Country	Link
US (1)	US7273936B2 (de)
EP (1)	EP1542994B1 (de)
JP (1)	JP4518956B2 (de)
KR (1)	KR20050057415A (de)
CN (1)	CN1681810A (de)
AP (1)	AP2005003261A0 (de)
AR (1)	AR041273A1 (de)
AT (1)	ATE430147T1 (de)
AU (1)	AU2003256003A1 (de)
BR (1)	BR0314383A (de)
CA (1)	CA2499429C (de)
CO (1)	CO5550473A2 (de)
CR (1)	CR7743A (de)
DE (1)	DE60327443D1 (de)
EA (1)	EA200500354A1 (de)
ES (1)	ES2323421T3 (de)
HR (1)	HRP20050250A2 (de)
IS (1)	IS7711A (de)
MA (1)	MA27443A1 (de)
MX (1)	MXPA05002332A (de)
NO (1)	NO20051838L (de)
OA (1)	OA12926A (de)
PA (1)	PA8582701A1 (de)
PE (1)	PE20040987A1 (de)
PL (1)	PL375975A1 (de)
TW (1)	TW200413362A (de)
UY (1)	UY27978A1 (de)
WO (1)	WO2004026863A1 (de)

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ES2401138T3 (es) *	2004-08-13	2013-04-17	Genentech, Inc.	Inhibidores basados en tiazol de enzimas que usan ATP
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TW200626138A (en)	2004-09-20	2006-08-01	Xenon Pharmaceuticals Inc	Heterocyclic derivatives and their use as therapeutic agents
BRPI0515482A (pt)	2004-09-20	2008-07-22	Xenon Pharmaceuticals Inc	derivados heterocìclicos e seus usos como agentes terapêuticos
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MX2007003327A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
AR051026A1 (es)	2004-09-20	2006-12-13	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CA2580855A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US8541457B2 (en)	2005-06-03	2013-09-24	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
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US8865732B2 (en)	2008-03-21	2014-10-21	Novartis Ag	Heterocyclic compounds and uses thereof
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US9242969B2 (en)	2013-03-14	2016-01-26	Novartis Ag	Biaryl amide compounds as kinase inhibitors
HUE050761T2 (hu)	2014-01-01	2021-01-28	Medivation Tech Llc	Vegyületek és alkalmazási eljárások
UY36294A (es)	2014-09-12	2016-04-29	Novartis Ag	Compuestos y composiciones como inhibidores de quinasa
CN105585565B (zh) *	2014-10-23	2019-10-01	中国医学科学院药物研究所	含2-苯胺基-4-噻唑基吡啶衍生物及其制法和药物组合物与用途
CN106243012A (zh) *	2016-08-02	2016-12-21	北方民族大学	新型吲哚类衍生物及其制备方法
WO2018051306A1 (en)	2016-09-19	2018-03-22	Novartis Ag	Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
KR20240032157A (ko)	2017-05-02	2024-03-08	노파르티스 아게	병용 요법
IL271149B2 (en) *	2017-06-14	2024-05-01	Trevena Inc	Compounds for modulating s1p1 activity and methods of using the same
MX2021013817A (es)	2019-05-13	2021-12-14	Novartis Ag	Nuevas formas cristalinas de n-(3-(2-(2-hidroxietoxi)-6-morfolinop iridin-4-il)-4-metilfenil)-2-(trifluorometil)isonicotinamida como inhibidores de raf para el tratamiento del cancer.
CN112694477B (zh) *	2019-10-22	2024-02-06	四川科伦博泰生物医药股份有限公司	吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途
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HRP20050252A2 (en)	2002-09-18	2005-10-31	Pfizer Products Inc.	Novel imidazole compounds as transforming growth factor (tfg) inhibitors
PL375979A1 (en)	2002-09-18	2005-12-12	Pfizer Products Inc.	Pyrazole derivatives as transforming growth factor (tgf) inhibitors
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2003
- 2003-09-08 WO PCT/IB2003/003823 patent/WO2004026863A1/en not_active Ceased
- 2003-09-08 EA EA200500354A patent/EA200500354A1/ru unknown
- 2003-09-08 AU AU2003256003A patent/AU2003256003A1/en not_active Abandoned
- 2003-09-08 DE DE60327443T patent/DE60327443D1/de not_active Expired - Lifetime
- 2003-09-08 AP AP2005003261A patent/AP2005003261A0/xx unknown
- 2003-09-08 CN CNA038222205A patent/CN1681810A/zh active Pending
- 2003-09-08 BR BR0314383-0A patent/BR0314383A/pt not_active IP Right Cessation
- 2003-09-08 EP EP03797426A patent/EP1542994B1/de not_active Expired - Lifetime
- 2003-09-08 JP JP2004568899A patent/JP4518956B2/ja not_active Expired - Fee Related
- 2003-09-08 MX MXPA05002332A patent/MXPA05002332A/es active IP Right Grant
- 2003-09-08 PL PL03375975A patent/PL375975A1/xx not_active Application Discontinuation
- 2003-09-08 CA CA2499429A patent/CA2499429C/en not_active Expired - Fee Related
- 2003-09-08 HR HR20050250A patent/HRP20050250A2/xx not_active Application Discontinuation
- 2003-09-08 OA OA1200500075A patent/OA12926A/en unknown
- 2003-09-08 ES ES03797426T patent/ES2323421T3/es not_active Expired - Lifetime
- 2003-09-08 AT AT03797426T patent/ATE430147T1/de not_active IP Right Cessation
- 2003-09-08 KR KR1020057004611A patent/KR20050057415A/ko not_active Ceased
- 2003-09-15 PA PA20038582701A patent/PA8582701A1/es unknown
- 2003-09-15 UY UY27978A patent/UY27978A1/es not_active Application Discontinuation
- 2003-09-15 PE PE2003000939A patent/PE20040987A1/es not_active Application Discontinuation
- 2003-09-16 AR ARP030103357A patent/AR041273A1/es unknown
- 2003-09-17 US US10/667,187 patent/US7273936B2/en not_active Expired - Fee Related
- 2003-09-17 TW TW092125637A patent/TW200413362A/zh unknown
2005
- 2005-02-24 IS IS7711A patent/IS7711A/is unknown
- 2005-03-15 CR CR7743A patent/CR7743A/es not_active Application Discontinuation
- 2005-03-16 CO CO05024531A patent/CO5550473A2/es not_active Application Discontinuation
- 2005-03-18 MA MA28157A patent/MA27443A1/fr unknown
- 2005-04-15 NO NO20051838A patent/NO20051838L/no unknown

Also Published As

Publication number	Publication date
CO5550473A2 (es)	2005-08-31
BR0314383A (pt)	2005-07-19
KR20050057415A (ko)	2005-06-16
CR7743A (es)	2005-06-15
EP1542994B1 (de)	2009-04-29
DE60327443D1 (de)	2009-06-10
WO2004026863A1 (en)	2004-04-01
UY27978A1 (es)	2004-04-30
PL375975A1 (en)	2005-12-12
CA2499429C (en)	2010-09-21
ES2323421T3 (es)	2009-07-15
EA200500354A1 (ru)	2005-10-27
CA2499429A1 (en)	2004-04-01
TW200413362A (en)	2004-08-01
OA12926A (en)	2006-10-13
WO2004026863A8 (en)	2005-04-21
MA27443A1 (fr)	2005-07-01
JP2006502235A (ja)	2006-01-19
AU2003256003A1 (en)	2004-04-08
CN1681810A (zh)	2005-10-12
HRP20050250A2 (en)	2005-10-31
AP2005003261A0 (en)	2005-03-31
MXPA05002332A (es)	2005-06-08
PE20040987A1 (es)	2004-12-27
EP1542994A1 (de)	2005-06-22
AR041273A1 (es)	2005-05-11
JP4518956B2 (ja)	2010-08-04
US20040110797A1 (en)	2004-06-10
IS7711A (is)	2005-02-24
PA8582701A1 (es)	2004-04-23
ATE430147T1 (de)	2009-05-15
US7273936B2 (en)	2007-09-25

Publication	Publication Date	Title
NO20051838L (no)	2005-04-15	Nye triazol- og oksazolforbindelser som transformerende vekstfaktor (TGF) inhibitor.
NO20050838L (no)	2005-05-18	Nye pyrazolforbindelser som transformerende vekstfaktor (TGF)-inhibitorer
NO20051010L (no)	2005-05-31	Triazolderivater som transformerende vekst faktor (TGF) inhibitorer
NO20051008L (no)	2005-06-07	Nye imidazolforbindelser som transformerende vekst faktor (TGF) inhibitorer
NO20051527D0 (no)	2005-03-22	3-(sulfonamidoetyl) -indol-derivater for anvendelse som glukocorticoid-mimetica ved behandling av inflammatoriske, allergiske og proliferative sykdommer.
NO20060415L (no)	2006-02-07	Piperidyl-Kinazolinderivater som Tyrosin-Kinase-Inhibitorer
NO20061743L (no)	2006-06-21	Kinazolinderivater
BRPI0407999A (pt)	2006-03-07	compostos heteroaromáticos fundidos como inibidores do fator de transformação do crescimento (tgf)
NO981628D0 (no)	1998-04-08	(Metylsulfonyl)fenyl-2-(5H)-furanoner som cox-2 inhibitorer
GB0112348D0 (en)	2001-07-11	Compounds
DE60034240D1 (de)	2007-05-16	Drogen zur behandlung maligner tumoren
CY1109422T1 (el)	2014-08-13	Παραγωγα φαιναιθανολαμινης για θεραπεια ασθενειων του αναπνευστικου
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