NO20051908L - Kjemiske forbindelser - Google Patents

Kjemiske forbindelser

Info

Publication number
NO20051908L
NO20051908L NO20051908A NO20051908A NO20051908L NO 20051908 L NO20051908 L NO 20051908L NO 20051908 A NO20051908 A NO 20051908A NO 20051908 A NO20051908 A NO 20051908A NO 20051908 L NO20051908 L NO 20051908L
Authority
NO
Norway
Prior art keywords
alkyl
heteroaryl
aryl
carbocyclyl
heterocyclyl
Prior art date
Application number
NO20051908A
Other languages
English (en)
Inventor
Elisa Henderson
Richard Kelsey
Lara Wilson
Phil Chambers
Malcolm Carter
Debra Taylor
Stan Tyms
Original Assignee
Arrow Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0221923.6A external-priority patent/GB0221923D0/en
Priority claimed from GB0302078A external-priority patent/GB0302078D0/en
Application filed by Arrow Therapeutics Ltd filed Critical Arrow Therapeutics Ltd
Publication of NO20051908L publication Critical patent/NO20051908L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Benzodiazepinderivat med formel (I), og farmasøytisk akseptable salter derav, er funnet å være aktive mot RSV hvori: - R1 representerer C1-6 alkyl, aryl eller heteroaryl; - R2 representerer hydrogen eller C1-6 alkyl; - hver R3 er det samme eller forskjellige og representerer halogen, hydroksy, Cl-6 alkyl, Cl-6 alkoksy, Cl-6 alkyltio, Cl-6 haloalkyl, Cl-6 haloalkoksy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, -CO2R', -CONR'R'', -NH-CO-R', -S(O)R', -S(O)2R', -NH-S(O)2R', -S(O)NR'R" eller -S(O)2NR'R'', hvori hver R' og R'' er det samme eller forskjellige og representerer hydrogen eller C1-6 alkyl; - n er fra 0 til 3; - R4 representerer hydrogen eller Cl-6 alkyl; - R5 representerer Cl-6 alkyl, aryl, heteroaryl, karbocyklyl, heterocyklyl, aryl-(C1-6 alkyl)-, heteroaryl(C1-6 alkyl) -, karbocyklyl- (C1-6 alkyl) -, heterocyklyl- (C1-6 alkyl)-, aryl-C(O)-C(O)-, heteroaryl-C(O)-C(O)-, karbocyklyl-C(O)-C(O)-, heterocyklyl-C(O)-C(O)- eller -XR6; - X representerer -CO-, -S(O)- eller -S(0)2; og - R6 representerer Cl-6 alkyl, hydroksy, Cl-6 alkoksy, Cl-6 alkyltio, aryl, heteroaryl, karbocyklyl, heterocyklyl, aryl- (C1-6 alkyl) -, heteroaryl- (C1-6 alkyl) -, karbocyklyl- (C1-6 alkyl) -, heterocyklyl- (C1-6 alkyl) -, aryl- (C1-6 hydroksyalkyl) -, heteroaryl- (C1-6 hydroksyalkyl)-, karbocyklyl-(C1-6 hydroksyalkyl)-, heterocyklyl-(C1-6 hydroksyalkyl) -, aryl- (C1-6 alkyl)-O-, heteroaryl- (C1-6 alkyl)-O-, karbocyklyl-(C1-6 alkyl)-O-, heterocyklyl-(C1-6 alkyl)-O- eller -NR'R'' hvori hver R' og R'' er det samme eller forskjellige og representerer hydrogen, Cl-6 alkyl, karbocyklyl, heterocyklyl, aryl, heteroaryl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, karbocyklyl- (C1-6 alkyl)-, eller heterocyklyl- (C1-6 alkyl)-.
NO20051908A 2002-09-20 2005-04-19 Kjemiske forbindelser NO20051908L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0221923.6A GB0221923D0 (en) 2002-09-20 2002-09-20 Chemical compounds
GB0302078A GB0302078D0 (en) 2003-01-29 2003-01-29 Chemical compounds
PCT/GB2003/004050 WO2004026843A1 (en) 2002-09-20 2003-09-22 Benzodiazepine derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
NO20051908L true NO20051908L (no) 2005-04-19

Family

ID=32031886

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20051908A NO20051908L (no) 2002-09-20 2005-04-19 Kjemiske forbindelser
NO20140629A NO20140629L (no) 2002-09-20 2014-05-19 Kjemiske forbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20140629A NO20140629L (no) 2002-09-20 2014-05-19 Kjemiske forbindelser

Country Status (16)

Country Link
US (2) US7582624B2 (no)
EP (1) EP1539716A1 (no)
JP (2) JP4719466B2 (no)
KR (1) KR101125899B1 (no)
AU (1) AU2003267587B2 (no)
BR (1) BR0314595A (no)
CA (1) CA2499322C (no)
EA (1) EA012387B1 (no)
IL (1) IL167332A (no)
IS (1) IS7735A (no)
MX (1) MXPA05002871A (no)
NO (2) NO20051908L (no)
NZ (2) NZ570344A (no)
PL (1) PL375860A1 (no)
WO (1) WO2004026843A1 (no)
ZA (1) ZA200502001B (no)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406280D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Chemical compounds
WO2005090319A1 (en) * 2004-03-19 2005-09-29 Arrow Therapeutics Limited Process for preparing benzodiazepines
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
EP1807111A4 (en) * 2004-10-08 2009-05-27 Abbott Biotech Ltd SYNCYTIAL RESPIRATORY VIRUS INFECTION (RSV)
AU2005336627A1 (en) * 2005-09-19 2007-03-29 Arrow Therapeutics Limited Benzodiazepine derivatives for treating hepatitis C infection
PL2029556T3 (pl) * 2006-05-23 2011-04-29 Novartis Ag Sole i ich modyfikacje postaci krystalicznej
MX2009005368A (es) * 2006-11-21 2009-06-05 Novartis Ag Formulacion parenteral estable que contiene un inhibidor de rsv de una estructura de benzodiazepina.
US20100278835A1 (en) 2009-03-10 2010-11-04 Astrazeneca Uk Limited Novel compounds 660
TWI530489B (zh) 2011-03-22 2016-04-21 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯二氮呯酮化合物
HK1211589A1 (zh) 2012-08-23 2016-05-27 Alios Biopharma, Inc. 用於治疗副粘病毒病毒性感染的化合物
EP2897947B1 (en) 2012-09-21 2016-10-26 Bristol-Myers Squibb Company Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds
TWI614238B (zh) 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
JP2015533811A (ja) 2012-09-21 2015-11-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｎ−置換ビス（フルオロアルキル）１，４−ベンゾジアゼピノン化合物
CN104822677A (zh) 2012-09-21 2015-08-05 百时美施贵宝公司 氟烷基-1,4-苯并二氮杂*酮化合物
WO2014047369A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Substituted 1,5-benzodiazepinone compounds
US9273075B2 (en) 2012-09-21 2016-03-01 Bristol-Myers Squibb Company Prodrugs of 1,4-benzodiazepinone compounds
US9249157B2 (en) 2012-09-21 2016-02-02 Bristol-Myers Squibb Company Tricyclic heterocycle compounds
CN104854094A (zh) 2012-09-21 2015-08-19 百时美施贵宝公司 氟烷基二苯并二氮杂*酮化合物
WO2014047397A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds as notch|inhibitors
US9492469B2 (en) 2013-04-04 2016-11-15 Bristol-Myers Squibb Company Combination therapy for the treatment of proliferative diseases
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
GB201506448D0 (en) * 2015-04-16 2015-06-03 Univ Durham An antimicrobial compound
AU2016297024B2 (en) 2015-07-22 2021-03-04 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
EP3402799B1 (en) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
WO2017189663A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
WO2017189652A1 (en) 2016-04-26 2017-11-02 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as fxr agonists and methods of use thereof
US10080742B2 (en) 2016-04-26 2018-09-25 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as FXR agonists and methods of use thereof
GB201613942D0 (en) 2016-08-15 2016-09-28 Univ Of Durham The An antimicrobial compound
US10597391B2 (en) 2016-10-26 2020-03-24 Enanta Pharmaceuticals, Inc. Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof
WO2018129287A1 (en) * 2017-01-06 2018-07-12 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as rsv inhibitors
AU2018221820B2 (en) 2017-02-16 2023-11-02 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
WO2018226801A1 (en) * 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as rsv inhibitors
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
WO2019006291A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
WO2019067864A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV
WO2019094920A1 (en) * 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as rsv inhibitors
MX394621B (es) 2017-11-13 2025-03-24 Enanta Pharm Inc Procesos para la resolucion de los derivados de la benzodiazepina-2-ona y de la benzoazepin-2-ona
US10975094B2 (en) 2018-04-11 2021-04-13 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
JP7558189B2 (ja) 2019-03-18 2024-09-30 エナンタ ファーマシューティカルズ インコーポレイテッド Ｒｓｖ阻害剤としてのベンゾジアゼピン誘導体
US11179400B2 (en) 2019-04-09 2021-11-23 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
GB201911944D0 (en) 2019-08-20 2019-10-02 Reviral Ltd Pharmaceutical compounds
CA3153297A1 (en) 2019-10-04 2021-04-08 Adam SZYMANIAK Antiviral heterocyclic compounds
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
GB201915273D0 (en) * 2019-10-22 2019-12-04 Reviral Ltd Pharmaceutical compounds
GB201915932D0 (en) 2019-11-01 2019-12-18 Reviral Ltd Pharmaceutical compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
GB202010408D0 (en) 2020-07-07 2020-08-19 Reviral Ltd Pharmaceutical compounds
GB202010409D0 (en) * 2020-07-07 2020-08-19 Reviral Ltd Pharmaceutical compounds
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
GB202102602D0 (en) 2021-02-24 2021-04-07 Reviral Ltd Pharmaceutical compounds
WO2022182861A1 (en) 2021-02-26 2022-09-01 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
AR129003A1 (es) 2022-04-07 2024-07-03 Enanta Pharm Inc Compuestos heterocíclicos antivirales
WO2023211997A1 (en) 2022-04-27 2023-11-02 Enanta Pharmaceuticals, Inc. Antiviral compounds
WO2024252355A1 (en) 2023-06-08 2024-12-12 Pfizer Inc. Pediatric dosing regimens comprising a fusion inhibitor for the treatment of rsv
WO2025120500A1 (en) 2023-12-06 2025-06-12 Pfizer Inc. Benzodiazepine compounds as n-protein inhibitors
WO2025153942A1 (en) 2024-01-16 2025-07-24 Pfizer Inc. Benzodiazepine pyrazolo carboxamides as n-protein inhibitors

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE656606A (no) * 1963-12-03
US4820834A (en) 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
FR2641280B1 (fr) 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
CA2026856A1 (en) 1989-10-05 1991-04-06 Mark G. Bock 3-substituted-1,4-benzodiazepines useful as oxytocin
IL96613A0 (en) 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
EP0475231A1 (en) 1990-09-10 1992-03-18 F. Hoffmann-La Roche Ag Benzodiazepines
EP0491218A1 (en) * 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinones
US5220017A (en) 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
US5218115A (en) 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5220018A (en) * 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
EP0523845A3 (en) 1991-06-14 1993-11-18 Merck & Co Inc New benzodiazepine analogs
US5593988A (en) * 1991-10-11 1997-01-14 Yoshitomi Pharmaceutical Industries, Ltd. Therapeutic agent for osteoporosis and diazepine compound
US5428031A (en) 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5550124A (en) 1991-12-10 1996-08-27 University Of Southern California Use of peripheral-type benzodiazpine sites for treatment of CNS trauma or disease
GB9203790D0 (en) 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
US5426185A (en) 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
FR2716195B1 (fr) 1994-02-14 1996-06-21 Sanofi Sa Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
AU3591697A (en) 1996-07-02 1998-01-21 Merck & Co., Inc. Method for the treatment of preterm labor
KR100212435B1 (ko) 1996-09-04 1999-08-02 이서봉 1,4-벤조디아제핀-2,5-디온 유도체 및 약학적으로 허용되는 그의 염
WO1998018473A1 (en) 1996-10-31 1998-05-07 Merck & Co., Inc. Benzodiazepine hydrazide derivatives as inhibitors of hiv integrase
US6100254A (en) 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
WO2000012547A2 (en) * 1998-09-01 2000-03-09 Innogenetics N.V. Benzodiazepines and benzothiazepines derivatives and hbsag peptides binding to annexins, their compositions and use
FR2785803B1 (fr) 1998-11-17 2005-03-25 Sanofi Sa Utilisation d'une substance se liant au recepteur peripherique des benzodiazepines dans le traitement des stress cutanes
IL146222A0 (en) 1999-04-30 2002-07-25 Univ Michigan Therapeutic applications of pro-apoptotic benzodiazepines
CA2376781A1 (en) 1999-06-28 2001-01-04 Janssen Pharmaceutica N.V. Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors
US6436971B2 (en) * 2000-02-09 2002-08-20 Smithkline Beecham Corporation Use of PDE 4-specific inhibitors to reduce the severity of a bacterial infection after a respiratory viral infection
AU2001253090A1 (en) 2000-04-03 2001-10-15 Bristol-Myers Squibb Pharma Company Cyclic lactams as inhibitors of abeta protein production
GB0012671D0 (en) 2000-05-24 2000-07-19 Merck Sharp & Dohme Therapeutic agents
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
CN1179752C (zh) 2000-08-16 2004-12-15 中国医学科学院药物研究所 含咪唑丙酰胺基的苯并二氮杂�类化合物以及制法和用途
AU2002219846A1 (en) 2000-11-16 2002-05-27 Smith Kline Beecham Corporation Novel use
SE0104250D0 (sv) * 2001-12-14 2001-12-14 Astrazeneca Ab Heterocyclic compounds

Also Published As

Publication number Publication date
AU2003267587B2 (en) 2010-05-20
US7582624B2 (en) 2009-09-01
CA2499322C (en) 2012-04-24
PL375860A1 (en) 2005-12-12
MXPA05002871A (es) 2005-10-05
EA200500511A1 (ru) 2006-02-24
ZA200502001B (en) 2006-05-31
EA012387B1 (ru) 2009-10-30
NZ538870A (en) 2007-04-27
US20060040923A1 (en) 2006-02-23
JP5298103B2 (ja) 2013-09-25
IS7735A (is) 2005-03-10
US20100015063A1 (en) 2010-01-21
US8119630B2 (en) 2012-02-21
KR101125899B1 (ko) 2012-04-12
WO2004026843A1 (en) 2004-04-01
JP2006503054A (ja) 2006-01-26
IL167332A (en) 2013-10-31
CA2499322A1 (en) 2004-04-01
KR20050051664A (ko) 2005-06-01
AU2003267587A1 (en) 2004-04-08
NZ570344A (en) 2010-04-30
JP2011088907A (ja) 2011-05-06
EP1539716A1 (en) 2005-06-15
NO20140629L (no) 2005-04-19
JP4719466B2 (ja) 2011-07-06
BR0314595A (pt) 2005-08-09

Similar Documents

Publication Publication Date Title
NO20051908L (no) Kjemiske forbindelser
NO20073465L (no) Benzotiazol-derivater
AU715049B2 (en) N-substituted piperazine nonoates
ES2977656T3 (es) Inhibidores de KDM1A para el tratamiento de enfermedades
CY1120169T1 (el) Παραγωγο αμιδιου και φαρμακο
NO20055421L (no) Kinolinderivater som fosfodiestrase-inhibitorer
JO2371B1 (en) 4-phenyl-pyridine derivatives
NO20062726L (no) Nye pyridazin-3(2H)-on derivater
CA2379560A1 (en) Purine derivatives inhibitors of tyrosine protein kinase syk
NO20021328L (no) Pyrazolopyrimidier som terapeutiske midler
CY1117015T1 (el) 2,4-δι(φαινυλαμινο)-πυριμιδινες χρησιμες στην αντιμετωπιση νεοπλασματικων νοσων, φλεγμονωδων διαταραχων και διαταραχων του ανοσοποιητικου συστηματος
NO20055562L (no) Substituerte indolin- og indolderivater
NO20063748L (no) Kinolinderivater og anvendelse derav som mykobakterielle inhibitorer
MXPA05007671A (es) Derivados de triazina como absorbedores de uv.
EP1442016A4 (en) 1H-INDOLDERIVATE AS HIGH-DETECTIVE CYCLOOXYGENASE-2 INHIBITORS
NO20063468L (no) Triazolforbindelser og deres anvendelse som metabotrofe glutamatreseptorantagonister
BRPI0508968A (pt) benzodiazepinas para tratamento ou prevenção de infecção pelo rsv
NO20035524D0 (no) 4'-substituerte nukleosider
NO20064599L (no) Substituerte morfolin- og tiomorfolinderivater
NO20054848L (no) Substituerte p-diaminobenzenderivater
CA2401812A1 (en) Use of pdgf receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
NO20081861L (no) Benzodiazepinderivater for behandling av hepatitt C-infeksjon
MY140235A (en) New benzimidazole derivatives
ATE316962T1 (de) Pyrimidin-derivate als selective inhibitoren von cox-2
MXPA05009282A (es) Derivados de anilina sustituidos.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application