NO20052373L - Nye substituert benzo[e][1,4]oksazino[3,2-g]isoindolforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem - Google Patents

Nye substituert benzo[e][1,4]oksazino[3,2-g]isoindolforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Info

Publication number
NO20052373L
NO20052373L NO20052373A NO20052373A NO20052373L NO 20052373 L NO20052373 L NO 20052373L NO 20052373 A NO20052373 A NO 20052373A NO 20052373 A NO20052373 A NO 20052373A NO 20052373 L NO20052373 L NO 20052373L
Authority
NO
Norway
Prior art keywords
branched
linear
group
preparation
aryl
Prior art date
Application number
NO20052373A
Other languages
English (en)
Inventor
Alain Pierre
Pierre Renard
John Hickman
Laurence Kraus-Berthier
Gerard Coudert
Daniel-Henri Caignard
Frank Lepifre
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20052373L publication Critical patent/NO20052373L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Indole Compounds (AREA)

Abstract

Oppfinnelsen vedrører forbindelser med formel (I): hvori: * W1 representerer, med karbonatomene til hvilke den er bundet, en fenylgruppe eller en pyridylgruppe, * Z representerer en gruppe valgt fra hydrogen, halogen, og gruppene lineær eller forgrenet (C1-C6)alkyl, aryl, aryl-(Cl-C6)alkyl hvor alkylenheten kan være lineær eller forgrenet, aryloksy, aryl-(Cl-C6)alkoksy hvor alkoksyenheten kan være lineær eller forgrenet, hydroksy og lineær eller forgrenet (Cl-C6)alkoksy, * R1 er som definert i beskrivelsen, * R2 representerer et hydrogenatom eller en gruppe med formel -CH2CH2O-R8, * R3 og R4 representerer hver et hydrogenatom, en lineær eller forgrenet (Cl-C6)alkylgruppe, en arylgruppe eller en aryl-(Cl-C6)alkylgruppe hvor alkylenheten kan være lineær eller forgrenet, * n representerer et heltall på fra 1 til og med 6. Oppfinnelsen er nyttig for fremstilling av medikamenter.
NO20052373A 2002-10-18 2005-05-13 Nye substituert benzo[e][1,4]oksazino[3,2-g]isoindolforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem NO20052373L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0212964A FR2845994B1 (fr) 2002-10-18 2002-10-18 Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2003/003068 WO2004037830A1 (fr) 2002-10-18 2003-10-17 Derives de benzo (e) (1,4) oxazino & (3,2-g) isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
NO20052373L true NO20052373L (no) 2005-05-13

Family

ID=32050501

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052373A NO20052373L (no) 2002-10-18 2005-05-13 Nye substituert benzo[e][1,4]oksazino[3,2-g]isoindolforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Country Status (26)

Country Link
US (1) US7312213B2 (no)
EP (1) EP1556387B1 (no)
JP (1) JP2006506375A (no)
KR (1) KR100699661B1 (no)
CN (1) CN100338071C (no)
AR (1) AR041653A1 (no)
AT (1) ATE358677T1 (no)
AU (1) AU2003301531A1 (no)
BR (1) BR0314877A (no)
CA (1) CA2502484A1 (no)
DE (1) DE60313012T2 (no)
DK (1) DK1556387T3 (no)
EA (1) EA009697B1 (no)
ES (1) ES2285259T3 (no)
FR (1) FR2845994B1 (no)
GE (1) GEP20074180B (no)
MA (1) MA27339A1 (no)
MX (1) MXPA05003693A (no)
NO (1) NO20052373L (no)
NZ (1) NZ539194A (no)
PL (1) PL375957A1 (no)
PT (1) PT1556387E (no)
SI (1) SI1556387T1 (no)
UA (1) UA79163C2 (no)
WO (1) WO2004037830A1 (no)
ZA (1) ZA200502831B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2906249B1 (fr) * 2006-09-26 2008-12-19 Servier Lab Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process
DK0556310T3 (da) * 1990-11-06 1995-08-21 Pfizer Quinazolinderivater til forhøjelse af antitumoraktivitet
PT2177517E (pt) * 1996-07-24 2011-11-10 Celgene Corp 2-(2,6-dioxopiperidin-3-il)-ftalimida amino-substituída para redução dos níveis de tnf-alfa
FR2755691B1 (fr) * 1996-11-08 1998-12-04 Adir Nouveaux derives 7,12-dioxa-benzo[a]anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2757855B1 (fr) * 1996-12-30 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
US7312213B2 (en) 2007-12-25
ES2285259T3 (es) 2007-11-16
AU2003301531A1 (en) 2004-05-13
DE60313012D1 (de) 2007-05-16
NZ539194A (en) 2007-05-31
ZA200502831B (en) 2006-07-26
HK1084112A1 (en) 2006-07-21
SI1556387T1 (sl) 2007-08-31
US20060003997A1 (en) 2006-01-05
CA2502484A1 (fr) 2004-05-06
DE60313012T2 (de) 2007-12-27
MA27339A1 (fr) 2005-05-02
FR2845994A1 (fr) 2004-04-23
DK1556387T3 (da) 2007-08-06
BR0314877A (pt) 2005-08-02
AR041653A1 (es) 2005-05-26
KR20050059272A (ko) 2005-06-17
CN100338071C (zh) 2007-09-19
WO2004037830A1 (fr) 2004-05-06
UA79163C2 (en) 2007-05-25
EP1556387B1 (fr) 2007-04-04
ATE358677T1 (de) 2007-04-15
JP2006506375A (ja) 2006-02-23
EA200500654A1 (ru) 2005-10-27
KR100699661B1 (ko) 2007-03-23
CN1705669A (zh) 2005-12-07
PT1556387E (pt) 2007-06-26
PL375957A1 (en) 2005-12-12
FR2845994B1 (fr) 2006-05-19
EP1556387A1 (fr) 2005-07-27
EA009697B1 (ru) 2008-02-28
MXPA05003693A (es) 2005-06-17
GEP20074180B (en) 2007-08-10

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