NO20053431L - Ny krystallinsk modifikasjon av 2-(3,5-bis-trifluormetyl-fenyl)-N-(6-(1,1-diokso-1gamma6-tiomorfolin-4-yl)-4(4-fluor-2-metyl-fenyl)-pyridin-3-yl)-N-metyl-isobutyramid. - Google Patents
Ny krystallinsk modifikasjon av 2-(3,5-bis-trifluormetyl-fenyl)-N-(6-(1,1-diokso-1gamma6-tiomorfolin-4-yl)-4(4-fluor-2-metyl-fenyl)-pyridin-3-yl)-N-metyl-isobutyramid.Info
- Publication number
- NO20053431L NO20053431L NO20053431A NO20053431A NO20053431L NO 20053431 L NO20053431 L NO 20053431L NO 20053431 A NO20053431 A NO 20053431A NO 20053431 A NO20053431 A NO 20053431A NO 20053431 L NO20053431 L NO 20053431L
- Authority
- NO
- Norway
- Prior art keywords
- phenyl
- methyl
- dioxo
- pyridin
- trifluoromethyl
- Prior art date
Links
- -1 3,5-bis-trifluoromethyl-phenyl Chemical group 0.000 title abstract 4
- 230000004048 modification Effects 0.000 title abstract 2
- 238000012986 modification Methods 0.000 title abstract 2
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P7/10—Antioedematous agents; Diuretics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03002134 | 2003-01-31 | ||
| PCT/EP2004/000547 WO2004067007A1 (en) | 2003-01-31 | 2004-01-23 | NEW CRYSTALLINE MODIFICATION OF 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)-4(4-FLUORO-2-METHYL-PHENYL)-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20053431D0 NO20053431D0 (no) | 2005-07-14 |
| NO20053431L true NO20053431L (no) | 2005-10-05 |
Family
ID=32798734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20053431A NO20053431L (no) | 2003-01-31 | 2005-07-14 | Ny krystallinsk modifikasjon av 2-(3,5-bis-trifluormetyl-fenyl)-N-(6-(1,1-diokso-1gamma6-tiomorfolin-4-yl)-4(4-fluor-2-metyl-fenyl)-pyridin-3-yl)-N-metyl-isobutyramid. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7160881B2 (de) |
| EP (1) | EP1592428B1 (de) |
| JP (1) | JP5026702B2 (de) |
| KR (1) | KR100700421B1 (de) |
| CN (1) | CN100562320C (de) |
| AR (1) | AR042980A1 (de) |
| AT (1) | ATE366576T1 (de) |
| AU (1) | AU2004208483B8 (de) |
| BR (1) | BRPI0406702A (de) |
| CA (1) | CA2514037C (de) |
| CL (1) | CL2004000150A1 (de) |
| CO (1) | CO5580750A2 (de) |
| DE (1) | DE602004007486T2 (de) |
| ES (1) | ES2290666T3 (de) |
| GT (1) | GT200400009A (de) |
| HR (1) | HRP20050664A2 (de) |
| IL (1) | IL169600A (de) |
| MX (1) | MXPA05008171A (de) |
| MY (1) | MY135785A (de) |
| NO (1) | NO20053431L (de) |
| NZ (1) | NZ541243A (de) |
| PA (1) | PA8594601A1 (de) |
| PE (1) | PE20040944A1 (de) |
| PL (1) | PL378404A1 (de) |
| RU (1) | RU2330022C2 (de) |
| TW (1) | TWI293294B (de) |
| WO (1) | WO2004067007A1 (de) |
| ZA (1) | ZA200505567B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1776342B1 (de) | 2004-07-06 | 2011-03-02 | F. Hoffmann-La Roche AG | Herstellungsverfahren für carboxamid-pyridin-derivate als zwischenprodukte bei der synthese von nk-1-rezeptor-antagonisten |
| CN101128189A (zh) | 2005-02-25 | 2008-02-20 | 弗·哈夫曼-拉罗切有限公司 | 药物物质分散性改善的片剂 |
| JP2013503134A (ja) * | 2009-08-27 | 2013-01-31 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 無水形態のピリジン誘導体 |
| CN103755592A (zh) * | 2013-12-30 | 2014-04-30 | 镇江圣安医药有限公司 | (2z)-氰基-3-羟基-n-[4-(三氟甲基)苯基]-2-丁烯酰胺的衍生物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2024507C1 (ru) * | 1991-11-18 | 1994-12-15 | Евгений Яковлевич Левитин | 5-хлор-2-пиридиламид-4-нитро-n-(карбоксиметил)антраниловой кислоты, проявляющий противовоспалительную активность |
| IL111960A (en) * | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| DE69428913T2 (de) * | 1993-12-29 | 2002-05-29 | Merck Sharp & Dohme Ltd., Hoddesdon | Substituierte morpholinderivate und ihre verwendung als arzneimittel |
| TW385308B (en) * | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
| US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| DE60045564D1 (de) | 1999-02-24 | 2011-03-03 | Hoffmann La Roche | 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten |
| MXPA03009720A (es) * | 2001-04-23 | 2004-01-29 | Hoffmann La Roche | USO DE ANTAGONISTAS DEL RECEPTOR DE NK-1 PARA TRATAMIENTO O PREVENCIoN DE HIPERPLASIA PROSTATICA BENIGNA. |
| US6849624B2 (en) * | 2001-07-31 | 2005-02-01 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted amides |
-
2004
- 2004-01-23 CN CN200480003306.7A patent/CN100562320C/zh not_active Expired - Fee Related
- 2004-01-23 KR KR1020057014025A patent/KR100700421B1/ko not_active Expired - Fee Related
- 2004-01-23 AU AU2004208483A patent/AU2004208483B8/en not_active Ceased
- 2004-01-23 NZ NZ541243A patent/NZ541243A/en unknown
- 2004-01-23 PL PL378404A patent/PL378404A1/pl unknown
- 2004-01-23 EP EP04704575A patent/EP1592428B1/de not_active Expired - Lifetime
- 2004-01-23 BR BR0406702-9A patent/BRPI0406702A/pt not_active Application Discontinuation
- 2004-01-23 RU RU2005127216/04A patent/RU2330022C2/ru not_active IP Right Cessation
- 2004-01-23 HR HR20050664A patent/HRP20050664A2/xx not_active Application Discontinuation
- 2004-01-23 MX MXPA05008171A patent/MXPA05008171A/es active IP Right Grant
- 2004-01-23 DE DE602004007486T patent/DE602004007486T2/de not_active Expired - Lifetime
- 2004-01-23 ES ES04704575T patent/ES2290666T3/es not_active Expired - Lifetime
- 2004-01-23 AT AT04704575T patent/ATE366576T1/de active
- 2004-01-23 CA CA2514037A patent/CA2514037C/en not_active Expired - Fee Related
- 2004-01-23 JP JP2005518353A patent/JP5026702B2/ja not_active Expired - Fee Related
- 2004-01-23 WO PCT/EP2004/000547 patent/WO2004067007A1/en not_active Ceased
- 2004-01-27 TW TW093101746A patent/TWI293294B/zh active
- 2004-01-27 US US10/766,122 patent/US7160881B2/en not_active Expired - Fee Related
- 2004-01-28 PE PE2004000110A patent/PE20040944A1/es not_active Application Discontinuation
- 2004-01-28 PA PA20048594601A patent/PA8594601A1/es unknown
- 2004-01-29 GT GT200400009A patent/GT200400009A/es unknown
- 2004-01-30 CL CL200400150A patent/CL2004000150A1/es unknown
- 2004-01-30 AR ARP040100284A patent/AR042980A1/es unknown
- 2004-01-30 MY MYPI20040288A patent/MY135785A/en unknown
-
2005
- 2005-07-07 IL IL169600A patent/IL169600A/en unknown
- 2005-07-11 ZA ZA200505567A patent/ZA200505567B/en unknown
- 2005-07-14 NO NO20053431A patent/NO20053431L/no not_active Application Discontinuation
- 2005-07-18 CO CO05070753A patent/CO5580750A2/es not_active Application Discontinuation
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| FC2A | Withdrawal, rejection or dismissal of laid open patent application |