NO20053470L - Triazolopyridaziner som proteinkinase-inhibitorer - Google Patents

Triazolopyridaziner som proteinkinase-inhibitorer

Info

Publication number
NO20053470L
NO20053470L NO20053470A NO20053470A NO20053470L NO 20053470 L NO20053470 L NO 20053470L NO 20053470 A NO20053470 A NO 20053470A NO 20053470 A NO20053470 A NO 20053470A NO 20053470 L NO20053470 L NO 20053470L
Authority
NO
Norway
Prior art keywords
protein kinase
triazolopyridazines
kinase inhibitors
compounds
pharmaceutically acceptable
Prior art date
Application number
NO20053470A
Other languages
English (en)
Inventor
Jeremy Green
Jr Ronald Grey
Albert C Pierce
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20053470L publication Critical patent/NO20053470L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings

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Abstract

Foreliggende oppfinnelse tilveiebringer en forbindelse med formel (I): eller et farmasøytisk akseptabelt salt derav. Disse forbindelser er inhibitorer av proteinkinaser, spesielt er de inhibitorer av PIM-1-, CDK-2-, GSK-3- og SRC-proteinkinaser fra pattedyr. Oppfinnelsen tilveiebringer også farmasøytisk akseptable sammensetninger omfattende forbindelsene ifølge oppfinnelsen og metoder for å utnytte forbindelsene og sammensetningene i behandlingen av forskjellige proteinkinase-medierte forstyrrelser.
NO20053470A 2002-12-18 2005-07-15 Triazolopyridaziner som proteinkinase-inhibitorer NO20053470L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43512402P 2002-12-18 2002-12-18
PCT/US2003/039990 WO2004058769A2 (en) 2002-12-18 2003-12-17 Triazolopyridazines as protein kinases inhibitors

Publications (1)

Publication Number Publication Date
NO20053470L true NO20053470L (no) 2005-09-02

Family

ID=32682164

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053470A NO20053470L (no) 2002-12-18 2005-07-15 Triazolopyridaziner som proteinkinase-inhibitorer

Country Status (14)

Country Link
US (1) US7268136B2 (no)
EP (1) EP1575959B1 (no)
JP (1) JP4817661B2 (no)
KR (1) KR101075812B1 (no)
CN (1) CN100567296C (no)
AT (1) ATE473980T1 (no)
AU (1) AU2003297161B8 (no)
CA (1) CA2510534C (no)
DE (1) DE60333387D1 (no)
MX (1) MXPA05006478A (no)
NO (1) NO20053470L (no)
NZ (1) NZ541151A (no)
RU (1) RU2005122484A (no)
WO (1) WO2004058769A2 (no)

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EP1575959B1 (en) 2010-07-14
CA2510534A1 (en) 2004-07-15
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DE60333387D1 (de) 2010-08-26
MXPA05006478A (es) 2005-09-08
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RU2005122484A (ru) 2006-01-20
WO2004058769A3 (en) 2004-09-30
CN1742012A (zh) 2006-03-01
KR20050084428A (ko) 2005-08-26
ATE473980T1 (de) 2010-07-15
NZ541151A (en) 2008-09-26
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EP1575959A2 (en) 2005-09-21
US20040192696A1 (en) 2004-09-30
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