NO20053588L - Acylaminotiazol-derivater, fremstilling og anvendelse derav som beta-amyloidpeptid-produksjonsinhibitorer. - Google Patents

Acylaminotiazol-derivater, fremstilling og anvendelse derav som beta-amyloidpeptid-produksjonsinhibitorer.

Info

Publication number: NO20053588L
Authority: NO; Norway
Prior art keywords: beta; preparation; amyloid peptide; peptide production; production inhibitors
Prior art date: 2003-01-23

Application number

NO20053588A

Other languages

English (en)

Other versions

NO330415B1 (no

NO20053588D0 (no

Inventor

Viviane Van Dorsselaer

Pierre Despeyroux

Daniel Frehel

Bruno Schoentjes

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-23

Filing date

2005-07-22

Publication date

2005-09-22

2005-07-22 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2005-07-22 Publication of NO20053588D0 publication Critical patent/NO20053588D0/no

2005-09-22 Publication of NO20053588L publication Critical patent/NO20053588L/no

2011-04-11 Publication of NO330415B1 publication Critical patent/NO330415B1/no

Links

DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20053588A 2003-01-23 2005-07-22 Acylaminotiazol-derivater, fremgangsmate for fremstilling derav, anvendelse derav som beta-amyloidpeptid-produksjonsinhibitorer og farmasoytisk sammemsetning inneholdende de samme NO330415B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0300703A FR2850380B1 (fr)	2003-01-23	2003-01-23	Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
PCT/FR2004/000140 WO2004067520A1 (fr)	2003-01-23	2004-01-22	Derives d'acylaminothiazole, leur preparation et leur utilisation en tant qu’inhibiteurs de la production du peptide beta-amyloide

Publications (3)

Publication Number	Publication Date
NO20053588D0 NO20053588D0 (no)	2005-07-22
NO20053588L true NO20053588L (no)	2005-09-22
NO330415B1 NO330415B1 (no)	2011-04-11

Family

ID=32669150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20053588A NO330415B1 (no)	2003-01-23	2005-07-22	Acylaminotiazol-derivater, fremgangsmate for fremstilling derav, anvendelse derav som beta-amyloidpeptid-produksjonsinhibitorer og farmasoytisk sammemsetning inneholdende de samme

Country Status (24)

Country	Link
US (2)	US7563903B2 (no)
EP (1)	EP1590337B1 (no)
JP (1)	JP2006515888A (no)
KR (1)	KR101059669B1 (no)
CN (1)	CN100532370C (no)
AR (1)	AR042745A1 (no)
AT (1)	ATE404545T1 (no)
AU (1)	AU2004207658B2 (no)
BR (1)	BRPI0406893A (no)
CA (1)	CA2511610A1 (no)
DE (1)	DE602004015726D1 (no)
FR (1)	FR2850380B1 (no)
HR (1)	HRP20050637A2 (no)
IL (1)	IL169428A (no)
MA (1)	MA27610A1 (no)
ME (1)	MEP16708A (no)
MX (1)	MXPA05007847A (no)
NO (1)	NO330415B1 (no)
NZ (1)	NZ541147A (no)
PL (1)	PL377999A1 (no)
RS (1)	RS51168B (no)
RU (1)	RU2360907C2 (no)
TW (1)	TWI320710B (no)
WO (1)	WO2004067520A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004258841B8 (en) *	2003-06-05	2010-01-07	Elan Pharmaceuticals, Inc.	Acylated amino acid amidyl pyrazoles and related compounds
AU2007207743B2 (en) *	2006-01-18	2010-07-08	Amgen Inc.	Thiazole compounds as protein kinase B (PKB) inhibitors
US7897619B2 (en)	2007-07-17	2011-03-01	Amgen Inc.	Heterocyclic modulators of PKB
US7919504B2 (en) *	2007-07-17	2011-04-05	Amgen Inc.	Thiadiazole modulators of PKB
WO2009108760A2 (en)	2008-02-26	2009-09-03	Board Of Regents, The University Of Texas System	Dendritic macroporous hydrogels prepared by crystal templating
EP2371421A1 (en) *	2010-03-04	2011-10-05	Université de Lille 2 Droit et Santé	Ligands of insulin degrading enzyme and their uses
EP2508511A1 (en) *	2011-04-07	2012-10-10	Laboratoire Biodim	Inhibitors of viral replication, their process of preparation and their therapeutical uses
CN103145692B (zh) *	2013-03-12	2014-07-16	盐城工学院	一种4,5-二氢-6H-环戊烷并[b]噻吩-6-酮的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9401034D0 (en) *	1994-01-20	1994-03-16	British Bio Technology	Metalloproteinase inhibitors
ID22499A (id) *	1996-11-22	1999-10-21	Elan Pharmaceuticals Inc Cs	Amida-amida asam n-(aril/heteroaril/alkilasetil) amino, komposisi farmasi yang terdiri dari amida asam amino tersebut, dan metode untuk menghambat pelepasan b-amiloid peptida dan/atau pembuatannya dengan menggunakan senyawa-senyawa tersebut
ZA9711537B (en) *	1996-12-23	1998-06-25	Athena Neurosciences Inc Eli L	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ß-amyloid peptide release and/or its synthesis by use of such compounds.
AU768751B2 (en) *	1998-06-18	2004-01-08	Bristol-Myers Squibb Company	Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
WO2000024392A1 (en) *	1998-10-26	2000-05-04	Sumitomo Pharmaceuticals Company, Limited	β-AMYLOID FORMATION INHIBITORS
GB9823871D0 (en) *	1998-10-30	1998-12-23	Pharmacia & Upjohn Spa	2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
US6114365A (en) *	1999-08-12	2000-09-05	Pharmacia & Upjohn S.P.A.	Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
AR039059A1 (es) *	2001-08-06	2005-02-09	Sanofi Aventis	Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios

2003
- 2003-01-23 FR FR0300703A patent/FR2850380B1/fr not_active Expired - Fee Related
2004
- 2004-01-22 JP JP2006502115A patent/JP2006515888A/ja not_active Ceased
- 2004-01-22 HR HR20050637A patent/HRP20050637A2/hr not_active Application Discontinuation
- 2004-01-22 NZ NZ541147A patent/NZ541147A/en not_active IP Right Cessation
- 2004-01-22 KR KR1020057013441A patent/KR101059669B1/ko not_active Expired - Fee Related
- 2004-01-22 CA CA002511610A patent/CA2511610A1/en not_active Abandoned
- 2004-01-22 PL PL377999A patent/PL377999A1/pl not_active Application Discontinuation
- 2004-01-22 AT AT04704255T patent/ATE404545T1/de not_active IP Right Cessation
- 2004-01-22 ME MEP-167/08A patent/MEP16708A/xx unknown
- 2004-01-22 CN CNB2004800027812A patent/CN100532370C/zh not_active Expired - Fee Related
- 2004-01-22 AU AU2004207658A patent/AU2004207658B2/en not_active Ceased
- 2004-01-22 EP EP04704255A patent/EP1590337B1/fr not_active Expired - Lifetime
- 2004-01-22 RS YUP-2005/0563A patent/RS51168B/sr unknown
- 2004-01-22 RU RU2005126608/04A patent/RU2360907C2/ru not_active IP Right Cessation
- 2004-01-22 BR BR0406893-9A patent/BRPI0406893A/pt not_active IP Right Cessation
- 2004-01-22 DE DE602004015726T patent/DE602004015726D1/de not_active Expired - Lifetime
- 2004-01-22 AR ARP040100169A patent/AR042745A1/es unknown
- 2004-01-22 WO PCT/FR2004/000140 patent/WO2004067520A1/fr not_active Ceased
- 2004-01-22 MX MXPA05007847A patent/MXPA05007847A/es active IP Right Grant
- 2004-01-27 TW TW093101748A patent/TWI320710B/zh not_active IP Right Cessation
2005
- 2005-06-27 IL IL169428A patent/IL169428A/en not_active IP Right Cessation
- 2005-07-12 MA MA28385A patent/MA27610A1/fr unknown
- 2005-07-21 US US11/186,507 patent/US7563903B2/en not_active Expired - Fee Related
- 2005-07-22 NO NO20053588A patent/NO330415B1/no not_active IP Right Cessation
2009
- 2009-06-22 US US12/488,658 patent/US7879889B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2006515888A (ja)	2006-06-08
US20090253753A1 (en)	2009-10-08
KR101059669B1 (ko)	2011-08-25
AU2004207658A1 (en)	2004-08-12
CN1777593A (zh)	2006-05-24
MEP16708A (en)	2010-06-10
HRP20050637A2 (en)	2005-10-31
AU2004207658B2 (en)	2009-10-29
IL169428A (en)	2010-12-30
US7879889B2 (en)	2011-02-01
TWI320710B (en)	2010-02-21
RU2360907C2 (ru)	2009-07-10
EP1590337B1 (fr)	2008-08-13
NZ541147A (en)	2008-06-30
RS51168B (sr)	2010-10-31
PL377999A1 (pl)	2006-02-20
MXPA05007847A (es)	2006-05-17
ATE404545T1 (de)	2008-08-15
KR20050094039A (ko)	2005-09-26
TW200503699A (en)	2005-02-01
RU2005126608A (ru)	2006-04-27
NO330415B1 (no)	2011-04-11
BRPI0406893A (pt)	2006-01-03
MA27610A1 (fr)	2005-11-01
NO20053588D0 (no)	2005-07-22
EP1590337A1 (fr)	2005-11-02
CN100532370C (zh)	2009-08-26
FR2850380A1 (fr)	2004-07-30
WO2004067520A1 (fr)	2004-08-12
AR042745A1 (es)	2005-06-29
FR2850380B1 (fr)	2006-07-07
CA2511610A1 (en)	2004-08-12
US20060052426A1 (en)	2006-03-09
DE602004015726D1 (de)	2008-09-25
US7563903B2 (en)	2009-07-21
RS20050563A (sr)	2007-06-04

Legal Events

Date	Code	Title	Description
2012-08-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20053356D0 (no)	2005-07-11	Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
NO20035298D0 (no)	2003-11-28	CDK-inhiberende pyrimider, deres fremstilling og deres anvendelse som legemidler
NO20052855D0 (no)	2005-06-13	Fosfonoksykinazolinderivater og farmasoytisk anvendelse derav.
DK1425014T3 (da)	2007-04-10	Diarylcycloalkylderivater, fremgangsmåde til deres fremstilling og deres anvendelse som PPAR-aktivatorer
DK1532149T3 (da)	2010-05-10	8-[3-amino-piperiden-1-yl]-xanthiner, fremstilling deraf og anvendelse deraf som lægemiddel
DK1500654T3 (da)	2006-06-06	Benzoxazinonderivater, fremstilling deraf og anvendelse deraf som lægemidler
DK1670458T3 (da)	2007-04-23	1-Amino-2-oxy-substituerede tetrahydronaphthalenderivater, fremgangsmåder til fremstilling deraf og deres anvendelse som antiphlogistika
DK1368349T3 (da)	2007-05-21	Xanthinderivater, deres fremstilling og deres anvendelse som lægemidler
NO20054905D0 (no)	2005-10-24	2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
NO20032830L (no)	2003-08-04	Tetrahydropyridinderivater, fremstilling derav og anvendelse som celleproliferasjonsinhibitorer
DK1511734T3 (da)	2010-08-02	Forbindelser, præparater og fremgangsmåder
IS2733B (is)	2011-04-15	Afleiður af díoxan-2-alkýlkarbamötum, framleiðsluaðferð þeirra, milliefni notuð við framleiðsluna, og notkun þeirra í meðferð.
DK1513835T3 (da)	2006-12-27	Piperazinylacylpiperidinderivater, fremstilling og terapeutisk anvendelse heraf
IS8422A (is)	2006-04-21	Bensímídasólafleiður, efnablöndur sem innihalda þær, framleiðsla þeirra og notkun þeirra
DK1590321T3 (da)	2010-08-09	Arylalkylcarbamat-derivater, fremstilling og terapeutisk anvendelse deraf
NO20043349L (no)	2004-10-05	Kumarinderivater, fremgangsmate for deres framstilling og anvendelse derav
IS8219A (is)	2006-01-04	Bensímídasólafleiður, efnablöndur sem innihalda þær, framleiðsla þeirra og notkun
DK1387838T3 (da)	2006-08-14	Cyanoanthranylamid-derivater og deres anvendelse som lægemidler
IS7829A (is)	2005-04-28	Nýjar 1,4-díazabísýklóalkan-afleiður, framleiðslaþeirra og notkun
NO20051983D0 (no)	2005-04-22	3-fenyl-substituert pyridoindolon, fremstilling derav og terapeutisk anvendelse derav.
IS7798A (is)	2005-04-11	Efnasambönd, lyfjablöndur og aðferðir
NO20053809D0 (no)	2005-08-12	Diarylmetylindenpiperidinderivater,fremgangsmate for fremstilling derav, og anvendelse derav
DK1709018T3 (da)	2011-11-14	Acylaminothiazolderivater og anvendelse deraf som beta-amyloid-hæmmere
DK1753725T3 (da)	2013-05-27	Tetra-hydro-iso-quinolinsulfonamidderivater, fremstilling og terapeutisk anvendelse heraf.
NO20053588D0 (no)	2005-07-22	Acylaminotiazol-derivater, fremstilling og anvendelse derav som beta-amyloidpeptid-produksjonsinhibitorer.