BRPI0406893A - Derivados de acilaminotiazol, a respectiva preparação e a respectiva utilização como inibidores da produção do peptìdeo betaamilóide - Google Patents
Derivados de acilaminotiazol, a respectiva preparação e a respectiva utilização como inibidores da produção do peptìdeo betaamilóideInfo
- Publication number
- BRPI0406893A BRPI0406893A BR0406893-9A BRPI0406893A BRPI0406893A BR PI0406893 A BRPI0406893 A BR PI0406893A BR PI0406893 A BRPI0406893 A BR PI0406893A BR PI0406893 A BRPI0406893 A BR PI0406893A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- preparation
- peptide production
- betaamyloid
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"DERIVADOS DE ACILAMINOTIAZOL, A RESPECTIVA PREPARAçãO E A RESPECTIVA UTILIZAçãO COMO INIBIDORES DA PRODUçãO DO PEPTìDEO BETAAMILóIDE". A presente invenção refere-se a um composto correspondente à fórmula geral (1). Esses compostos são úteis tanto como inibidores da produção do peptídeo <225>amilóide (<225>-A4) por inibição da gama protease.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0300703A FR2850380B1 (fr) | 2003-01-23 | 2003-01-23 | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
| PCT/FR2004/000140 WO2004067520A1 (fr) | 2003-01-23 | 2004-01-22 | Derives d'acylaminothiazole, leur preparation et leur utilisation en tant qu’inhibiteurs de la production du peptide beta-amyloide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0406893A true BRPI0406893A (pt) | 2006-01-03 |
Family
ID=32669150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0406893-9A BRPI0406893A (pt) | 2003-01-23 | 2004-01-22 | Derivados de acilaminotiazol, a respectiva preparação e a respectiva utilização como inibidores da produção do peptìdeo betaamilóide |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7563903B2 (pt) |
| EP (1) | EP1590337B1 (pt) |
| JP (1) | JP2006515888A (pt) |
| KR (1) | KR101059669B1 (pt) |
| CN (1) | CN100532370C (pt) |
| AR (1) | AR042745A1 (pt) |
| AT (1) | ATE404545T1 (pt) |
| AU (1) | AU2004207658B2 (pt) |
| BR (1) | BRPI0406893A (pt) |
| CA (1) | CA2511610A1 (pt) |
| DE (1) | DE602004015726D1 (pt) |
| FR (1) | FR2850380B1 (pt) |
| HR (1) | HRP20050637A2 (pt) |
| IL (1) | IL169428A (pt) |
| MA (1) | MA27610A1 (pt) |
| ME (1) | MEP16708A (pt) |
| MX (1) | MXPA05007847A (pt) |
| NO (1) | NO330415B1 (pt) |
| NZ (1) | NZ541147A (pt) |
| PL (1) | PL377999A1 (pt) |
| RS (1) | RS51168B (pt) |
| RU (1) | RU2360907C2 (pt) |
| TW (1) | TWI320710B (pt) |
| WO (1) | WO2004067520A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004258841B8 (en) * | 2003-06-05 | 2010-01-07 | Elan Pharmaceuticals, Inc. | Acylated amino acid amidyl pyrazoles and related compounds |
| AU2007207743B2 (en) * | 2006-01-18 | 2010-07-08 | Amgen Inc. | Thiazole compounds as protein kinase B (PKB) inhibitors |
| US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
| US7919504B2 (en) * | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
| WO2009108760A2 (en) | 2008-02-26 | 2009-09-03 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
| EP2371421A1 (en) * | 2010-03-04 | 2011-10-05 | Université de Lille 2 Droit et Santé | Ligands of insulin degrading enzyme and their uses |
| EP2508511A1 (en) * | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| CN103145692B (zh) * | 2013-03-12 | 2014-07-16 | 盐城工学院 | 一种4,5-二氢-6H-环戊烷并[b]噻吩-6-酮的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9401034D0 (en) * | 1994-01-20 | 1994-03-16 | British Bio Technology | Metalloproteinase inhibitors |
| ID22499A (id) * | 1996-11-22 | 1999-10-21 | Elan Pharmaceuticals Inc Cs | Amida-amida asam n-(aril/heteroaril/alkilasetil) amino, komposisi farmasi yang terdiri dari amida asam amino tersebut, dan metode untuk menghambat pelepasan b-amiloid peptida dan/atau pembuatannya dengan menggunakan senyawa-senyawa tersebut |
| ZA9711537B (en) * | 1996-12-23 | 1998-06-25 | Athena Neurosciences Inc Eli L | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ß-amyloid peptide release and/or its synthesis by use of such compounds. |
| AU768751B2 (en) * | 1998-06-18 | 2004-01-08 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| WO2000024392A1 (en) * | 1998-10-26 | 2000-05-04 | Sumitomo Pharmaceuticals Company, Limited | β-AMYLOID FORMATION INHIBITORS |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
-
2003
- 2003-01-23 FR FR0300703A patent/FR2850380B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 JP JP2006502115A patent/JP2006515888A/ja not_active Ceased
- 2004-01-22 HR HR20050637A patent/HRP20050637A2/hr not_active Application Discontinuation
- 2004-01-22 NZ NZ541147A patent/NZ541147A/en not_active IP Right Cessation
- 2004-01-22 KR KR1020057013441A patent/KR101059669B1/ko not_active Expired - Fee Related
- 2004-01-22 CA CA002511610A patent/CA2511610A1/en not_active Abandoned
- 2004-01-22 PL PL377999A patent/PL377999A1/pl not_active Application Discontinuation
- 2004-01-22 AT AT04704255T patent/ATE404545T1/de not_active IP Right Cessation
- 2004-01-22 ME MEP-167/08A patent/MEP16708A/xx unknown
- 2004-01-22 CN CNB2004800027812A patent/CN100532370C/zh not_active Expired - Fee Related
- 2004-01-22 AU AU2004207658A patent/AU2004207658B2/en not_active Ceased
- 2004-01-22 EP EP04704255A patent/EP1590337B1/fr not_active Expired - Lifetime
- 2004-01-22 RS YUP-2005/0563A patent/RS51168B/sr unknown
- 2004-01-22 RU RU2005126608/04A patent/RU2360907C2/ru not_active IP Right Cessation
- 2004-01-22 BR BR0406893-9A patent/BRPI0406893A/pt not_active IP Right Cessation
- 2004-01-22 DE DE602004015726T patent/DE602004015726D1/de not_active Expired - Lifetime
- 2004-01-22 AR ARP040100169A patent/AR042745A1/es unknown
- 2004-01-22 WO PCT/FR2004/000140 patent/WO2004067520A1/fr not_active Ceased
- 2004-01-22 MX MXPA05007847A patent/MXPA05007847A/es active IP Right Grant
- 2004-01-27 TW TW093101748A patent/TWI320710B/zh not_active IP Right Cessation
-
2005
- 2005-06-27 IL IL169428A patent/IL169428A/en not_active IP Right Cessation
- 2005-07-12 MA MA28385A patent/MA27610A1/fr unknown
- 2005-07-21 US US11/186,507 patent/US7563903B2/en not_active Expired - Fee Related
- 2005-07-22 NO NO20053588A patent/NO330415B1/no not_active IP Right Cessation
-
2009
- 2009-06-22 US US12/488,658 patent/US7879889B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES. |
|
| B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2257 DE 08/04/2014 POR TER SIDO INDEVIDA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |