NO20053748L - Pyrrolopyridazinderivater. - Google Patents

Pyrrolopyridazinderivater.

Info

Publication number
NO20053748L
NO20053748L NO20053748A NO20053748A NO20053748L NO 20053748 L NO20053748 L NO 20053748L NO 20053748 A NO20053748 A NO 20053748A NO 20053748 A NO20053748 A NO 20053748A NO 20053748 L NO20053748 L NO 20053748L
Authority
NO
Norway
Prior art keywords
pyrrolopyridazine derivatives
pyrrolopyridazine
derivatives
pde
tnf
Prior art date
Application number
NO20053748A
Other languages
English (en)
Other versions
NO20053748D0 (no
Inventor
Kazuhiko Ohne
Yuki Sawada
Tsuyoshi Mizutani
Kenichiro Imamura
Yoshito Abe
Makoto Inoue
Kozo Sawada
Mitsuaki Okumura
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003900189A external-priority patent/AU2003900189A0/en
Priority claimed from AU2003903628A external-priority patent/AU2003903628A0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NO20053748D0 publication Critical patent/NO20053748D0/no
Publication of NO20053748L publication Critical patent/NO20053748L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Oppfinnelsen vedrører forbindelser med formel (I) eller deres salter, der R1, R2, R3 og R4 er som definert i beskrivelsen, deres anvendelse som legemiddel, fremgangsmåten for deres fremstilling og anvendelsen for behandling av PDE-IV eller TNF-oc medierte sykdommer.
NO20053748A 2003-01-09 2005-08-04 Pyrrolopyridazinderivater. NO20053748L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2003900189A AU2003900189A0 (en) 2003-01-09 2003-01-09 Heterocyclic derivatives
AU2003903628A AU2003903628A0 (en) 2003-07-14 2003-07-14 Pyrrolopyridazine derivatives
PCT/JP2003/017091 WO2004063197A1 (en) 2003-01-09 2003-12-26 Pyrrolopyridazine derivatives

Publications (2)

Publication Number Publication Date
NO20053748D0 NO20053748D0 (no) 2005-08-04
NO20053748L true NO20053748L (no) 2005-10-07

Family

ID=32714072

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053748A NO20053748L (no) 2003-01-09 2005-08-04 Pyrrolopyridazinderivater.

Country Status (21)

Country Link
US (2) US7153854B2 (no)
EP (1) EP1581535B3 (no)
JP (1) JP4671104B2 (no)
KR (1) KR101026819B1 (no)
AR (1) AR042833A1 (no)
AT (1) ATE376549T1 (no)
BR (1) BR0317358A (no)
CA (1) CA2513081C (no)
CY (1) CY1107084T1 (no)
DE (1) DE60317102T3 (no)
DK (1) DK1581535T5 (no)
ES (1) ES2291729T7 (no)
IL (1) IL169500A0 (no)
MX (1) MXPA05007462A (no)
NO (1) NO20053748L (no)
NZ (1) NZ541232A (no)
PL (1) PL378245A1 (no)
PT (1) PT1581535E (no)
RU (1) RU2328499C2 (no)
TW (1) TWI332004B (no)
WO (1) WO2004063197A1 (no)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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PL378245A1 (pl) 2003-01-09 2006-03-20 Astellas Pharma Inc. Pochodne pirolopirydazyny
US7030112B2 (en) * 2003-03-25 2006-04-18 Bristol-Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
WO2006004191A1 (en) * 2004-07-05 2006-01-12 Astellas Pharma Inc. Pyrrolopyridazine derivatives which inhibit pde iv and tnf alfa
ATE415400T1 (de) * 2004-07-05 2008-12-15 Astellas Pharma Inc Pyrazolopyridinderivate
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
BRPI0718266A2 (pt) 2006-10-30 2014-01-07 Novartis Ag Compostos heterocíclicos como agentes anti-inflamatórios.
JP2009114123A (ja) * 2007-11-06 2009-05-28 Astellas Pharma Inc ２−アシル−１−アミノピロール化合物の新規製造法
CN103351390A (zh) * 2007-11-21 2013-10-16 解码遗传Ehf公司 用于治疗肺部和心血管病症的联芳基pde4 抑制剂
JP5584138B2 (ja) 2008-01-11 2014-09-03 ノバルティス アーゲー キナーゼ阻害剤としてのピリミジン類
WO2009154230A1 (ja) * 2008-06-17 2009-12-23 持田製薬株式会社 非アルコール性脂肪肝炎の予防／改善・治療薬
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors
WO2010059836A1 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
CN107233337A (zh) 2009-04-29 2017-10-10 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
CA2807317C (en) * 2010-04-23 2021-01-19 Steam Tech, Llc Surface wiper system
US20130071415A1 (en) * 2010-05-28 2013-03-21 Biocryst Pharmaceuticals, Inc. Heterocyclic Compounds as Janus Kinase Inhibitors
ES2583528T3 (es) 2010-09-07 2016-09-21 Astellas Pharma Inc. Compuesto de pirazoloquinolina
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
BR112013021638A2 (pt) 2011-02-25 2016-08-02 Irm Llc "compostos inibidores de trk, seu uso e composições que os compreendem"
JP5988941B2 (ja) * 2012-09-20 2016-09-07 富士フイルム株式会社 有機銅錯体、有機銅錯体溶液、銅酸化物薄膜、銅酸化物薄膜の製造方法、および、化合物
US10434132B2 (en) * 2013-06-04 2019-10-08 Academia Sinica Galactolipids-enriched plant extracts and the uses thereof
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
TWI695839B (zh) * 2017-11-17 2020-06-11 中央研究院 雙（羥甲基）吡咯并酞嗪混成物、其之製備方法與用途
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
MX2021004471A (es) * 2018-10-17 2021-08-24 Suven Life Sciences Ltd Derivados de pirrolo-pididazina como moduladores alostéricos positivos del receptor muscarínico m1.
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
BR112022024156A2 (pt) 2020-05-29 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Compostos heterocílicos antelmínticos
CN116507336B (zh) 2020-09-10 2026-01-02 Vanda制药公司 治疗pde iv介导的疾病或病症的方法
WO2023073641A1 (en) 2021-11-01 2023-05-04 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic pyrrolopyridazine compounds
WO2025214612A1 (en) 2023-04-14 2025-10-16 Syngenta Crop Protection Ag Pesticidally-active 2,2-dihalocyclopropyl compounds
WO2025261608A1 (en) 2023-06-29 2025-12-26 Syngenta Crop Protection Ag Pesticidally-active 2,2-dihalocyclopropyl compounds
WO2026019979A1 (en) * 2024-07-19 2026-01-22 Merck Sharp & Dohme Llc Pyrrolopyridazine vegfr tyrosine kinase inhibitors
EP4745125A1 (en) 2024-11-18 2026-05-20 Syngenta Crop Protection AG 2,2-DIHALOCYCLOPROPYL COMPOUNDS ACTIVE AS PESTICIDES

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7891891A (en) 1990-05-25 1991-12-31 Fujisawa Pharmaceutical Co., Ltd. Pyrrolopyridazine compounds
DE4224165A1 (de) * 1992-07-22 1994-01-27 Bayer Ag Imidazolinyl-pyrrolo-pyridazine
HU225920B1 (en) * 1994-01-19 2008-01-28 Sankyo Co Pyrrolo[2,3-d]pyridazine derivatives, process for their preparation and pharmaceutical compositions containing them
KR20010034881A (ko) * 1998-05-21 2001-04-25 시오노 요시히코 ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
CA2397661C (en) * 2000-03-01 2012-01-03 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
AU2001267823A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Compounds exhibiting x-type spla2 inhibiting effect
AU3276002A (en) * 2000-11-17 2002-05-27 Bristol Myers Squibb Co Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
TWI312347B (en) * 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
EP1426050A4 (en) * 2001-08-23 2005-05-25 Takeda Pharmaceutical JNK INHIBITORS
US6900208B2 (en) * 2002-03-28 2005-05-31 Bristol Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
PL378245A1 (pl) 2003-01-09 2006-03-20 Astellas Pharma Inc. Pochodne pirolopirydazyny

Also Published As

Publication number Publication date
ATE376549T1 (de) 2007-11-15
DE60317102T2 (de) 2009-01-29
DK1581535T5 (da) 2009-12-21
CA2513081C (en) 2011-04-19
US20060270678A1 (en) 2006-11-30
EP1581535B1 (en) 2007-10-24
KR20050092738A (ko) 2005-09-22
ES2291729T3 (es) 2008-03-01
EP1581535B9 (en) 2008-03-19
ES2291729T7 (es) 2010-03-31
US7317009B2 (en) 2008-01-08
NZ541232A (en) 2008-02-29
JP4671104B2 (ja) 2011-04-13
EP1581535B3 (en) 2009-09-02
RU2328499C2 (ru) 2008-07-10
AR042833A1 (es) 2005-07-06
PL378245A1 (pl) 2006-03-20
WO2004063197A1 (en) 2004-07-29
KR101026819B1 (ko) 2011-04-04
MXPA05007462A (es) 2006-01-27
BR0317358A (pt) 2005-12-13
DE60317102T3 (de) 2010-02-18
DK1581535T3 (da) 2008-02-11
RU2005125209A (ru) 2006-01-27
CY1107084T1 (el) 2012-10-24
TWI332004B (en) 2010-10-21
US20050075342A1 (en) 2005-04-07
NO20053748D0 (no) 2005-08-04
DE60317102D1 (de) 2007-12-06
JP2006515597A (ja) 2006-06-01
HK1088900A1 (zh) 2006-11-17
IL169500A0 (en) 2007-07-04
PT1581535E (pt) 2007-12-12
US7153854B2 (en) 2006-12-26
CA2513081A1 (en) 2004-07-29
TW200418861A (en) 2004-10-01
EP1581535A1 (en) 2005-10-05

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