NO20053780L - Alfa-aminamidderivater nyttig som antimigrenemidler - Google Patents

Alfa-aminamidderivater nyttig som antimigrenemidler

Info

Publication number
NO20053780L
NO20053780L NO20053780A NO20053780A NO20053780L NO 20053780 L NO20053780 L NO 20053780L NO 20053780 A NO20053780 A NO 20053780A NO 20053780 A NO20053780 A NO 20053780A NO 20053780 L NO20053780 L NO 20053780L
Authority
NO
Norway
Prior art keywords
alpha
derivatives useful
aminamide
migraine agents
migraine
Prior art date
Application number
NO20053780A
Other languages
English (en)
Other versions
NO20053780D0 (no
NO333610B1 (no
Inventor
Patricia Salvati
Piero Melloni
Marcello Calabresi
Luciano Dho
Orietta Veneroni
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of NO20053780D0 publication Critical patent/NO20053780D0/no
Publication of NO20053780L publication Critical patent/NO20053780L/no
Publication of NO333610B1 publication Critical patent/NO333610B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

a-aminamidderivater er nyttige som antimigrenemidler, spesielt for behandling av hodepinetilstander slik som migrene, klosterhodepine eller annen alvorlig hodepine angitt. Antimigrenemidlene ifølge oppfinnelsen er i stand til å redusere eller enda stoppe smerten som kommer fra slike tilstander uten praktisk talt noen bivirkninger.
NO20053780A 2003-01-16 2005-08-09 Anvendelse av alfa-aminamidderivater ved fremstilling av et medikament for behandling av hodepinetilstander NO333610B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03000921A EP1438956A1 (en) 2003-01-16 2003-01-16 Alpha-aminoamide derivatives useful as antimigraine agents
PCT/EP2003/012889 WO2004062655A1 (en) 2003-01-16 2003-11-18 Alpha-aminoamide derivatives useful as antimigraine agents

Publications (3)

Publication Number Publication Date
NO20053780D0 NO20053780D0 (no) 2005-08-09
NO20053780L true NO20053780L (no) 2005-10-13
NO333610B1 NO333610B1 (no) 2013-07-22

Family

ID=32524140

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053780A NO333610B1 (no) 2003-01-16 2005-08-09 Anvendelse av alfa-aminamidderivater ved fremstilling av et medikament for behandling av hodepinetilstander

Country Status (20)

Country Link
US (2) US7709523B2 (no)
EP (2) EP1438956A1 (no)
JP (1) JP4885455B2 (no)
KR (1) KR101049694B1 (no)
CN (1) CN100418517C (no)
AT (1) ATE380026T1 (no)
AU (1) AU2003279399B8 (no)
BR (1) BRPI0317795B8 (no)
CA (1) CA2510514C (no)
CY (1) CY1107274T1 (no)
DE (1) DE60317935T2 (no)
DK (1) DK1585510T3 (no)
ES (1) ES2295658T3 (no)
MX (1) MXPA05007339A (no)
NO (1) NO333610B1 (no)
NZ (1) NZ541117A (no)
PT (1) PT1585510E (no)
RU (1) RU2336077C2 (no)
SI (1) SI1585510T1 (no)
WO (1) WO2004062655A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
DK1423168T3 (da) * 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
DK1658062T3 (da) * 2003-08-25 2010-05-31 Newron Pharm Spa Alfa-aminoamid-derivater anvendelige som anti-inflammatoriske midler
DK1809271T5 (da) * 2004-09-10 2010-12-06 Newron Pharm Spa Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer
EP1963280B1 (en) 2005-12-22 2015-10-28 Newron Pharmaceuticals S.p.A. 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
HUE030233T2 (en) * 2006-06-19 2017-04-28 Newron Pharm Spa High purity 2- [4- (3- and 2-fluorobenzyloxy) benzylamino] propanamides for use as medicaments and pharmaceutical compositions containing them
FR2903985B1 (fr) 2006-07-24 2008-09-05 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
CA2689561C (en) 2007-06-15 2015-11-17 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
US8530701B2 (en) 2007-12-11 2013-09-10 Newron Pharmaceuticals, S.P.A. High purity 2-[4-(3- OR 2-fluorobenzyloxy)benzylamino]propanamides and methods of use thereof
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
SI2563355T1 (sl) 2010-04-27 2016-10-28 Newron Pharmaceuticals S.P.A. Postopek za izdelavo metansulfonatnih soli ralfinamida ali njihovih R-enantiomerov
WO2015102390A1 (ko) * 2013-12-30 2015-07-09 이화여자대학교 산학협력단 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
CN107522654B (zh) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 新的α-氨基酰胺衍生物及其医药用途
CN112041296B (zh) * 2018-04-28 2023-12-29 上海璃道医药科技有限公司 包含苯并含氧脂肪环结构的氨基乙酰胺类化合物及其用途
CN112716927B (zh) * 2020-10-12 2022-10-14 复旦大学 α-氨基酰胺类化合物及其制备方法与应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658967A (en) 1966-06-23 1972-04-25 Ici Ltd Carboxylic acid derivatives for lowering the concentration of triglycerides in the blood
GB1140748A (en) 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
CH480308A (de) 1966-08-11 1969-10-31 Ciba Geigy Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen
US4049663A (en) 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
US4311853A (en) 1979-02-06 1982-01-19 The Radiochemical Centre Limited Selenium derivatives of thyroxine and tri-iodothyronine
DE3010599A1 (de) 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung
US4267354A (en) 1979-04-25 1981-05-12 E. R. Squibb & Sons, Inc. Substituted amides having antiinflammatory activity and intermediates
ZA805476B (en) 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
DE3483308D1 (de) 1983-11-21 1990-10-31 Fujisawa Pharmaceutical Co Semicarbazid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4839369A (en) 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
GB8714901D0 (en) 1986-07-23 1987-07-29 Ici Plc Amide derivatives
GB2216515A (en) 1988-03-04 1989-10-11 Nippon Shinyaku Co Ltd Acylphenol derivatives
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
DE3928488A1 (de) 1989-08-29 1991-03-07 Standard Elektrik Lorenz Ag Interferometrisches messsystem
DE69224861T2 (de) 1991-07-30 1998-08-06 Korea Res Inst Chem Tech Neue Phenylacetamidderivate und Verfahren zu ihrer Herstellung
US5498610A (en) 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
GB9306886D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
GB9306899D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
US5475007A (en) 1993-05-28 1995-12-12 The Regents Of The University Of California 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof
US5482964A (en) 1994-10-11 1996-01-09 Warner-Lambert Company Substituted phenoxyhydroxypropyl amines as central nervous system agents
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
KR0147963B1 (ko) 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
US5849737A (en) 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
GB9515412D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
GB9515411D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa N-(4-substituted-benzyl)-2-aminolactam derivatives
US5688830A (en) 1996-01-25 1997-11-18 Syntex (U.S.A.) Inc. Treatment of neuropathic pain
JP4160136B2 (ja) * 1996-08-29 2008-10-01 武田薬品工業株式会社 縮合環状エーテル類、その製造法および剤
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
GB9625795D0 (en) 1996-12-12 1997-01-29 Smithkline Beecham Plc Novel treatment
GB9706730D0 (en) 1997-04-03 1997-05-21 Pharmacia & Upjohn Spa 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives
NZ500590A (en) 1997-04-22 2001-11-30 Cocensys Inc Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
EP1032377B1 (en) * 1997-11-21 2010-11-17 Purdue Neuroscience Company Substituted 2-aminoacetamides and the use thereof
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
GB9727521D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
EP1058550A4 (en) * 1998-02-04 2002-12-18 Euro Celtique Sa SUBSTITUTED SEMICARBAZIDES AND THEIR USE
JP2000191533A (ja) * 1998-10-19 2000-07-11 Eisai Co Ltd 鎮痛剤
CA2345406A1 (en) * 1998-10-19 2000-04-27 Eisai Co., Ltd. Analgesic
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
TW502019B (en) * 1999-03-26 2002-09-11 Cocensys Inc Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
DK1169060T3 (da) * 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
DK1423168T3 (da) * 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
DK1809271T5 (da) 2004-09-10 2010-12-06 Newron Pharm Spa Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer

Also Published As

Publication number Publication date
DK1585510T3 (da) 2008-02-25
NZ541117A (en) 2008-02-29
NO20053780D0 (no) 2005-08-09
AU2003279399A1 (en) 2004-08-10
SI1585510T1 (sl) 2008-04-30
US20060079570A1 (en) 2006-04-13
CA2510514A1 (en) 2004-07-29
RU2005125919A (ru) 2006-01-10
DE60317935T2 (de) 2008-11-27
EP1585510A1 (en) 2005-10-19
HK1086487A1 (zh) 2006-09-22
RU2336077C2 (ru) 2008-10-20
CN1738611A (zh) 2006-02-22
KR20050094852A (ko) 2005-09-28
AU2003279399B8 (en) 2009-01-29
NO333610B1 (no) 2013-07-22
BRPI0317795B1 (pt) 2019-04-02
EP1438956A1 (en) 2004-07-21
ATE380026T1 (de) 2007-12-15
KR101049694B1 (ko) 2011-07-19
CN100418517C (zh) 2008-09-17
CY1107274T1 (el) 2012-11-21
US20100267835A1 (en) 2010-10-21
US7709523B2 (en) 2010-05-04
JP2006514060A (ja) 2006-04-27
CA2510514C (en) 2011-07-26
BR0317795A (pt) 2005-11-22
DE60317935D1 (de) 2008-01-17
EP1585510B1 (en) 2007-12-05
JP4885455B2 (ja) 2012-02-29
ES2295658T3 (es) 2008-04-16
PT1585510E (pt) 2008-02-28
WO2004062655A1 (en) 2004-07-29
MXPA05007339A (es) 2005-09-30
BRPI0317795B8 (pt) 2021-05-25
AU2003279399B2 (en) 2008-11-27

Similar Documents

Publication Publication Date Title
CY1107274T1 (el) Παραγωγα αλφα-αμινοαμιδιου χρησιμα σαν παραγοντες κατα της ημικρανιας
SE0203713D0 (sv) Novel compounds
TW200510301A (en) Novel compounds
TW200510303A (en) Novel compounds
SE0303180D0 (sv) Novel compounds
TW200407305A (en) Novel compounds
NO20082136L (no) 1,5-substituerte indol-2-yl-amidderivater
NO20082096L (no) Azaindol-2-karboksamidderivativer
NO20092711L (no) Metoder for anvendelse av cyclopaminanaloger
JO2764B1 (en) Indole derivatives or benzimidazole derivatives to modify the enzyme AKP kinase
DE602004013563D1 (de) Rantagonisten
MX2009011002A (es) Composiciones de proteccion de isquemia/reperfusion y metodos de uso.
EP1606286A4 (en) BENZODIAZEPINE SPIROHYDANTOINES AS CGRP RECEPTOR ANTAGONISTS
IS8505A (is) (S)-2-N-própýlamínó-5-hýdroxýetralín sem D3-gerandefni
MX2008013196A (es) 5-amido-2-carboxiamida-indoles.
IL189298A0 (en) 3.5-disubstituted phenyl-piperidines as modulators of dopamine meurotransmission
MX2024015763A (es) Composiciones y metodos para inhibir la expresion de serina proteasa transmembrana 6 (tmprss6)
TR200401028T2 (tr) Kistik fibrozun tedavisine yönelik metot
EP1441724B8 (en) Methods of increasing endogenous testosterone levels
DE602006010738D1 (de) Pyrroloä2,3-cüpyridinderivate
DK1658062T3 (da) Alfa-aminoamid-derivater anvendelige som anti-inflammatoriske midler
PH12022551033A1 (en) Solid forms of an s1p-receptor modulator
EA200602081A1 (ru) Пиридиновые производные алкилоксиндолов в качестве агентов, активных в отношении рецептора 5-нт7
NO20074562L (no) Fremgangsmater for behandling av Parkinsons sykdom
ATE289510T1 (de) Sulfonylpyridazinone derivate zur behandlung von ischämischem gewebeschaden

Legal Events

Date Code Title Description
MK1K Patent expired