NO20054263L - Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav - Google Patents

Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav

Info

Publication number: NO20054263L
Authority: NO; Norway
Prior art keywords: optionally substituted; hydrogen; lower alkyl; beta amyloid; trifluoroalkyl
Prior art date: 2003-03-31

Application number

NO20054263A

Other languages

English (en)

Norwegian (no)

Other versions

NO20054263D0 (no

Inventor

Boyd Lynn Harrison

Derek Cecil Cole

Minsheng Zhang

Anthony Frank Kreft

Scott Christian Mayer

Lynn Resnick

George Diamantidis

Tingzhong Wang

Rocco Galante

Molly Hoke

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-31

Filing date

2005-09-15

Publication date

2005-12-14

2005-09-15 Application filed by Wyeth Corp filed Critical Wyeth Corp

2005-09-15 Publication of NO20054263D0 publication Critical patent/NO20054263D0/no

2005-12-14 Publication of NO20054263L publication Critical patent/NO20054263L/no

Links

102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 2
108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 title 1
229910052731 fluorine Inorganic materials 0.000 title 1
239000011737 fluorine Substances 0.000 title 1
-1 heterocyclic sulfonamide Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
125000004950 trifluoroalkyl group Chemical group 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
150000001993 dienes Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
201000010374 Down Syndrome Diseases 0.000 abstract 1
101100134927 Gallus gallus COR8 gene Chemical group 0.000 abstract 1
125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20054263A 2003-03-31 2005-09-15 Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav NO20054263L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45922803P	2003-03-31	2003-03-31
PCT/US2004/009268 WO2004092155A1 (en)	2003-03-31	2004-03-26	Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Publications (2)

Publication Number	Publication Date
NO20054263D0 NO20054263D0 (no)	2005-09-15
NO20054263L true NO20054263L (no)	2005-12-14

Family

ID=33299665

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20054263A NO20054263L (no)	2003-03-31	2005-09-15	Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav

Country Status (22)

Country	Link
US (3)	US7300951B2 (es)
EP (1)	EP1608638A1 (es)
JP (1)	JP2006522126A (es)
KR (1)	KR20060002908A (es)
CN (2)	CN1780829B (es)
AR (1)	AR043940A1 (es)
AU (1)	AU2004230844B2 (es)
BR (1)	BRPI0408962A (es)
CA (1)	CA2517155A1 (es)
CL (1)	CL2004000647A1 (es)
CO (1)	CO5640049A2 (es)
CR (1)	CR7951A (es)
EC (1)	ECSP056128A (es)
MX (1)	MXPA05010368A (es)
NO (1)	NO20054263L (es)
NZ (1)	NZ542468A (es)
RU (1)	RU2342374C2 (es)
SG (1)	SG167669A1 (es)
TW (1)	TWI336698B (es)
UA (1)	UA82093C2 (es)
WO (1)	WO2004092155A1 (es)
ZA (1)	ZA200507896B (es)

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UA82093C2 (uk)	2003-03-31	2008-03-11	Уайт	Фтор- та трифторалкіловмісні гетероциклічні сульфонамідні інгібітори утворення бета-амілоїду та їх похідні
CA2552558A1 (en)	2004-01-16	2005-08-11	Wyeth	Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
AR059518A1 (es)	2006-02-17	2008-04-09	Wyeth Corp	Metodos para preparar alcoholes sustituidos con sulfonamidas y sus compuestos intermedios
EP1984347A1 (en)	2006-02-17	2008-10-29	Wyeth a Corporation of the State of Delaware	Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
US7550629B2 (en)	2006-04-21	2009-06-23	Wyeth	Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
CA2649396A1 (en)	2006-04-21	2007-11-08	Wyeth	Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof
US7476762B2 (en)	2006-04-21	2009-01-13	Wyeth	Methods for preparing sulfonamide compounds
WO2009012205A1 (en)	2007-07-16	2009-01-22	Wyeth	Inhibitors of beta amyloid production
PA8789801A1 (es)	2007-07-16	2009-02-09	Wyeth Corp	Procesos e intermadiarios para la preparacion de compuestos de silfonamida heterocíclica
PA8789601A1 (es)	2007-07-16	2009-02-09	Wyeth Corp	Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicas

2004
- 2004-03-26 UA UAA200510177A patent/UA82093C2/uk unknown
- 2004-03-26 NZ NZ542468A patent/NZ542468A/en not_active IP Right Cessation
- 2004-03-26 WO PCT/US2004/009268 patent/WO2004092155A1/en not_active Ceased
- 2004-03-26 CN CN2004800087813A patent/CN1780829B/zh not_active Expired - Fee Related
- 2004-03-26 TW TW093108219A patent/TWI336698B/zh not_active IP Right Cessation
- 2004-03-26 AR ARP040101022A patent/AR043940A1/es unknown
- 2004-03-26 CL CL200400647A patent/CL2004000647A1/es unknown
- 2004-03-26 JP JP2006509331A patent/JP2006522126A/ja active Pending
- 2004-03-26 CN CNA2008100013400A patent/CN101274926A/zh active Pending
- 2004-03-26 BR BRPI0408962-6A patent/BRPI0408962A/pt not_active IP Right Cessation
- 2004-03-26 AU AU2004230844A patent/AU2004230844B2/en not_active Expired - Fee Related
- 2004-03-26 KR KR1020057018637A patent/KR20060002908A/ko not_active Ceased
- 2004-03-26 MX MXPA05010368A patent/MXPA05010368A/es active IP Right Grant
- 2004-03-26 RU RU2005133434/04A patent/RU2342374C2/ru not_active IP Right Cessation
- 2004-03-26 CA CA002517155A patent/CA2517155A1/en not_active Abandoned
- 2004-03-26 SG SG200708961-8A patent/SG167669A1/en unknown
- 2004-03-26 US US10/810,517 patent/US7300951B2/en not_active Expired - Fee Related
- 2004-03-26 EP EP04758978A patent/EP1608638A1/en not_active Withdrawn
2005
- 2005-08-19 CR CR7951A patent/CR7951A/es unknown
- 2005-09-15 NO NO20054263A patent/NO20054263L/no not_active Application Discontinuation
- 2005-09-29 ZA ZA200507896A patent/ZA200507896B/en unknown
- 2005-10-26 CO CO05109226A patent/CO5640049A2/es not_active Application Discontinuation
- 2005-10-28 EC EC2005006128A patent/ECSP056128A/es unknown
2007
- 2007-06-15 US US11/818,630 patent/US7547725B2/en not_active Expired - Fee Related
2009
- 2009-05-05 US US12/435,442 patent/US7858658B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MXPA05010368A (es)	2005-11-17
NZ542468A (en)	2009-01-31
ECSP056128A (es)	2006-03-01
KR20060002908A (ko)	2006-01-09
RU2342374C2 (ru)	2008-12-27
US20090227667A1 (en)	2009-09-10
CO5640049A2 (es)	2006-05-31
AR043940A1 (es)	2005-08-17
CN101274926A (zh)	2008-10-01
BRPI0408962A (pt)	2006-04-04
TWI336698B (en)	2011-02-01
NO20054263D0 (no)	2005-09-15
US7547725B2 (en)	2009-06-16
ZA200507896B (en)	2007-03-28
AU2004230844A1 (en)	2004-10-28
CA2517155A1 (en)	2004-10-28
UA82093C2 (uk)	2008-03-11
US20070254929A1 (en)	2007-11-01
US20040198778A1 (en)	2004-10-07
SG167669A1 (en)	2011-01-28
EP1608638A1 (en)	2005-12-28
US7300951B2 (en)	2007-11-27
CR7951A (es)	2008-10-29
CL2004000647A1 (es)	2005-02-04
AU2004230844B2 (en)	2010-12-09
WO2004092155A1 (en)	2004-10-28
US7858658B2 (en)	2010-12-28
RU2005133434A (ru)	2006-07-10
JP2006522126A (ja)	2006-09-28
CN1780829B (zh)	2010-12-29
CN1780829A (zh)	2006-05-31
TW200504047A (en)	2005-02-01

Legal Events

Date	Code	Title	Description
2012-10-22	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
MXPA05010368A (es)	2005-11-17	Sulfonamidas heterociclicas que contienen fluor- y trifluoroalquilo como inhibidores de la produccion beta amiloide y derivados de las mismas.
EP2297120B1 (en)	2015-08-19	Aminodihydrothiazine derivatives as bace inhibitors for the treatment of alzheimer's disease
NO20032801L (no)	2003-08-04	Tiazolderivater for behandling av PPAR-relaterte forstyrrelser
DE602004014347D1 (de)	2008-07-24	Chinazolin-derivate als tgf-beta-inhibitoren
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NO20050828L (no)	2005-04-05	lndol-3-svovelderivater
NO20064366L (no)	2006-11-08	Tiazolderivat
BRPI0608732A2 (pt)	2016-11-08	composto ou um sal, hidrato, solvato, complexo ou pró-droga farmaceuticamente aceitável do mesmo, sal de um composto, processo para a preparação de um composto, uso de um composto, composição farmacêutica, e, produto
BR0310106A (pt)	2005-02-22	Composto, processo para a produção de um composto, composição farmacêutica, uso do composto e método para o tratamento de um sujeito em sofrimento de uma condição ou doença patalógica
MY209048A (en)	2025-06-18	Pyrrolotriazine derivatives for treating kit- and pdgfra-mediated diseases
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DE602005005167D1 (de)	2008-04-17	1-isopropyl-2-oxo-1,2-dihydropyridin-3-carbonsäureamidderivate mit agonistischer wirkung am 5-ht4-rezeptor
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BR112012032813A2 (pt)	2016-11-08	composto, composição farmacêutica, e, método para prevenir, tratar ou melhorar uma doença ou condição.
PE20050077A1 (es)	2005-03-01	Derivados de 4-pirrolidino-fenil-bencil-eter
ATE393146T1 (de)	2008-05-15	3,6-substituierte 5-arylamino-1h-pyidin-2-on derivative und verwandte verbindungen als poly(adp-ribose)polymerase (parp) inhibitoren zur behandlung von durch nekose oder apoptose verursachten gewebeschäden oder erkankungen
NO20070564L (no)	2007-03-15	Kinoliner uten tiazolinonsubstituenter.
EA200600829A1 (ru)	2006-08-25	Новые кристаллические формы {2-[1-(3,5-бистрифторметилбензил)-5-пиридин-4-ил-1н-[1,2,3]триазол-4-ил]-пиридин-3-ил}-(2-хлорфенил)метанона
ATE446948T1 (de)	2009-11-15	Alpha-ketoamidderivativ, herstellungsverfahren und verwendung davon
EA200700103A1 (ru)	2007-08-31	НОВЫЕ 2-ЗАМЕЩЁННЫЕ D-ГОМО-ЭСТРА-1,3,5(10)-ТРИЕНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ 17β-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЫ ТИПА 1
DK0982305T3 (da)	2002-06-24	Indan-1-ol-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende derivaterne
NO20064012L (no)	2006-11-06	Kjemisk prosess
DE60227421D1 (de)	2008-08-14	Rmazeutische zusammensetzung und verwendung davon
DE602004029383D1 (de)	2010-11-11	Isten und antagonisten