NO20054841L - Makrocyklisk isokinolin peptid inhibitorer av hepatitt C virus - Google Patents

Makrocyklisk isokinolin peptid inhibitorer av hepatitt C virus

Info

Publication number
NO20054841L
NO20054841L NO20054841A NO20054841A NO20054841L NO 20054841 L NO20054841 L NO 20054841L NO 20054841 A NO20054841 A NO 20054841A NO 20054841 A NO20054841 A NO 20054841A NO 20054841 L NO20054841 L NO 20054841L
Authority
NO
Norway
Prior art keywords
hepatitis
virus
peptide inhibitors
macrocyclic
isoquinoline
Prior art date
Application number
NO20054841A
Other languages
English (en)
Other versions
NO333049B1 (no
NO20054841D0 (no
Inventor
Andrea Stanley V D
Paul M Scola
Zhizhen Barbara Zheng
Andrew Charles Good
Fiona Mcphee
Wenying Li
Jeffrey A Campbell
David J Carini
Barry L Johnson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20054841D0 publication Critical patent/NO20054841D0/no
Publication of NO20054841L publication Critical patent/NO20054841L/no
Publication of NO333049B1 publication Critical patent/NO333049B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Makrosykliske isokinolin-peptider er beskrevet som har den generelle formel: En forbindelse med formel I: hvor Ri til R, Q og W er beskrevet i beskrivelsen. Preparater omfattende forbindelsene og metodene for anvendelse av forbindelsene til å hemme HCV er også beskrevet.
NO20054841A 2003-04-16 2005-10-19 Makrocykliske isokinolin-peptid-forbindelser, preparat omfattende slike forbindelser samt slike forbindelser og preparater for anvendelse ved behandling av sykdom NO333049B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46342303P 2003-04-16 2003-04-16
PCT/US2004/011824 WO2004094452A2 (en) 2003-04-16 2004-04-16 Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus

Publications (3)

Publication Number Publication Date
NO20054841D0 NO20054841D0 (no) 2005-10-19
NO20054841L true NO20054841L (no) 2006-01-11
NO333049B1 NO333049B1 (no) 2013-02-18

Family

ID=33310775

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20054841A NO333049B1 (no) 2003-04-16 2005-10-19 Makrocykliske isokinolin-peptid-forbindelser, preparat omfattende slike forbindelser samt slike forbindelser og preparater for anvendelse ved behandling av sykdom
NO20110945A NO337510B1 (no) 2003-04-16 2011-06-30 Fremgangsmåte for spaltning av en blanding av alkylesterenantiomerer

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20110945A NO337510B1 (no) 2003-04-16 2011-06-30 Fremgangsmåte for spaltning av en blanding av alkylesterenantiomerer

Country Status (9)

Country Link
US (2) US7173004B2 (no)
EP (2) EP2033654B1 (no)
JP (2) JP4733023B2 (no)
AT (1) ATE422895T1 (no)
DE (1) DE602004019518D1 (no)
ES (2) ES2320771T3 (no)
IS (1) IS8073A (no)
NO (2) NO333049B1 (no)
WO (1) WO2004094452A2 (no)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
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