NO20055230L - HIV-integraseinhibitorer - Google Patents

HIV-integraseinhibitorer

Info

Publication number
NO20055230L
NO20055230L NO20055230A NO20055230A NO20055230L NO 20055230 L NO20055230 L NO 20055230L NO 20055230 A NO20055230 A NO 20055230A NO 20055230 A NO20055230 A NO 20055230A NO 20055230 L NO20055230 L NO 20055230L
Authority
NO
Norway
Prior art keywords
optionally
substituted
multisubstituted
het2
nr8r9
Prior art date
Application number
NO20055230A
Other languages
English (en)
Inventor
Wim Gaston Verschueren
Dominique Louis Nest Surleraux
Frederik Frans Desire Daeyaert
Inge Dierynck
Original Assignee
Tibtec Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibtec Pharmaceuticals Ltd filed Critical Tibtec Pharmaceuticals Ltd
Publication of NO20055230L publication Critical patent/NO20055230L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A, sammen med de to karbonatomer av fenylringen som den er bundet til, danner monocyklisk aryl eller monocyklisk Het2; R1 er hydrogen, halo, nitro, cyano, sultam, sultim, C3.7-cykloalkyl, C(=O)-R5, S(=O)y-R6, OR7, NR8R9, C(=NR8)-R5, valgfritt flersubstituert C^-alkyl, valgfritt flersubsti-tuert C2.6-alkenyl eller valgfritt flersubstituert C2.6-alkynyl; R2 er hydrogen, C3.7-cykloalkyl, aryl, Het1, Het2, C(=O)-R5, S(=O)y-R6, OR7, NR8R9, C (=NR8) -R5 eller valgfritt flersubstituert C^g-alkyl, valgfritt flersubstituert C2.6-alkenyl eller valgfritt flersubstituert C2.6-alkynyl. Anvendelse derav som HIV-integraseinhibitorer, fremgangs-mater for deres fremstilling samt farmasoytiske sammenset-ninger og diagnostiske sett som inneholder dem. Dessuten kombinasjoner derav med andre anti-retrovirale midler og deres anvendelse i assayer som referanseforbindelser eller som reagensmidler.
NO20055230A 2003-04-28 2005-11-07 HIV-integraseinhibitorer NO20055230L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46598703P 2003-04-28 2003-04-28
EP03101164 2003-04-28
PCT/EP2004/050621 WO2004096807A2 (en) 2003-04-28 2004-04-27 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
NO20055230L true NO20055230L (no) 2005-11-07

Family

ID=33420586

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055230A NO20055230L (no) 2003-04-28 2005-11-07 HIV-integraseinhibitorer

Country Status (13)

Country Link
US (1) US20060211724A1 (no)
EP (1) EP1625130A2 (no)
KR (1) KR20060006047A (no)
CN (1) CN1812992A (no)
AP (1) AP2005003451A0 (no)
AR (1) AR044518A1 (no)
AU (1) AU2004234087A1 (no)
BR (1) BRPI0409873A (no)
CA (1) CA2522990A1 (no)
MX (1) MXPA05011726A (no)
NO (1) NO20055230L (no)
TW (1) TW200507848A (no)
WO (1) WO2004096807A2 (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1888581A2 (en) * 2005-05-16 2008-02-20 Gilead Sciences, Inc. Hiv-integrase inhibitor compounds
US8013159B2 (en) 2005-05-19 2011-09-06 Merck Canada Inc. Quinoline derivatives as EP4 antagonists
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
US20080076740A1 (en) * 2005-07-27 2008-03-27 Gilead Sciences, Inc. Antiviral compounds
EP1973908A2 (en) * 2005-12-21 2008-10-01 Gilead Sciences, Inc. Processes and intermediates useful for preparing integrase inhibitor compounds
WO2007136714A2 (en) * 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
EP1916249A1 (en) * 2006-10-10 2008-04-30 LEK Pharmaceuticals D.D. 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(thio)oxo-2-(thio)oxo-azolidin-5-ylidene derivatives as antibacterial agents
CN101686680B (zh) 2007-03-09 2015-12-09 伊沃泰克美国股份有限公司 作为p2x7调节剂的双环杂芳基化合物及其用途
US20090291921A1 (en) * 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
CN101977610B (zh) 2008-01-25 2012-05-16 奇默里克斯公司 治疗病毒感染的方法
DK2262807T3 (en) 2008-03-19 2015-11-30 Chembridge Corp NOVEL tyrosine kinase inhibitors
US9249147B2 (en) 2008-03-19 2016-02-02 Chembridge Corporation Tyrosine kinase inhibitors
MX2011010582A (es) * 2009-04-09 2011-10-19 Boehringer Ingelheim Int Inhibidores de la replicacion del vih.
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
PT2534150T (pt) 2010-02-12 2017-05-02 Chimerix Inc Métodos para tratar uma infecção viral
WO2012037155A2 (en) 2010-09-13 2012-03-22 Gtx, Inc. Tyrosine kinase inhibitors
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
CA3106239A1 (en) 2018-07-27 2020-01-30 Biotheryx, Inc. Bifunctional compounds as cdk modulators
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
DE60124577T2 (de) * 2000-10-12 2007-09-27 Merck & Co., Inc. Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
WO2004035577A2 (en) * 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US7442773B2 (en) * 2004-01-23 2008-10-28 The Board Of Trustees Of The University Of Illinois Universal peptide-binding scaffolds and protein chips

Also Published As

Publication number Publication date
TW200507848A (en) 2005-03-01
US20060211724A1 (en) 2006-09-21
AP2005003451A0 (en) 2005-12-31
BRPI0409873A (pt) 2006-05-16
CN1812992A (zh) 2006-08-02
KR20060006047A (ko) 2006-01-18
AR044518A1 (es) 2005-09-14
AU2004234087A1 (en) 2004-11-11
CA2522990A1 (en) 2004-11-11
WO2004096807A3 (en) 2005-01-06
MXPA05011726A (es) 2006-01-23
EP1625130A2 (en) 2006-02-15
WO2004096807A8 (en) 2005-09-22
WO2004096807A2 (en) 2004-11-11

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Legal Events

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