MA45920A - Inhibiteurs de pyridopyrimidinone cdk2/4/6 - Google Patents

Inhibiteurs de pyridopyrimidinone cdk2/4/6

Info

Publication number
MA45920A
MA45920A MA045920A MA45920A MA45920A MA 45920 A MA45920 A MA 45920A MA 045920 A MA045920 A MA 045920A MA 45920 A MA45920 A MA 45920A MA 45920 A MA45920 A MA 45920A
Authority
MA
Morocco
Prior art keywords
pyridopyrimidinone
cdk2
inhibitors
compounds
salts
Prior art date
Application number
MA045920A
Other languages
English (en)
Other versions
MA45920B1 (fr
Inventor
Douglas Carl Behenna
Ping Chen
Kevin Daniel Freeman-Cook
Robert Louis Hoffman
Mehran Jalaie
Asako Nagata
Sajiv Krishnan Nair
Sacha Ninkovic
Martha Alicia Ornelas
Cynthia Louise Palmer
Eugene Yuanjin Rui
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA45920A publication Critical patent/MA45920A/fr
Publication of MA45920B1 publication Critical patent/MA45920B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés de formule générale (i), et des sels pharmaceutiquement acceptables de ceux-ci, dans lesquels r1, r2, r2a, r2b, r3, r4, r5a, r5b, r6, r7, r8, r9, p, q et r sont tels que définis dans la description, ainsi que des compositions pharmaceutiques comprenant de tels composés et sels, et sur des procédés d'utilisation de tels composés, sels et compositions pour le traitement d'une croissance cellulaire anormale, y compris le cancer.
MA45920A 2016-08-15 2017-07-31 Inhibiteurs de pyridopyrimidinone cdk2/4/6 MA45920B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662371602P 2016-08-15 2016-08-15
US201762533347P 2017-07-17 2017-07-17
PCT/IB2017/054655 WO2018033815A1 (fr) 2016-08-15 2017-07-31 Inhibiteurs de pyridopyrimidinone cdk2/4/6

Publications (2)

Publication Number Publication Date
MA45920A true MA45920A (fr) 2019-06-19
MA45920B1 MA45920B1 (fr) 2021-08-31

Family

ID=59631834

Family Applications (1)

Application Number Title Priority Date Filing Date
MA45920A MA45920B1 (fr) 2016-08-15 2017-07-31 Inhibiteurs de pyridopyrimidinone cdk2/4/6

Country Status (43)

Country Link
US (4) US10233188B2 (fr)
EP (1) EP3497103B1 (fr)
JP (1) JP6563623B1 (fr)
KR (1) KR102236605B1 (fr)
CN (2) CN109803968A (fr)
AU (1) AU2017311645B2 (fr)
BR (1) BR112019002610A2 (fr)
CA (1) CA2975033C (fr)
CL (1) CL2019000368A1 (fr)
CO (1) CO2019001240A2 (fr)
CR (1) CR20190062A (fr)
CU (1) CU24522B1 (fr)
CY (1) CY1124206T1 (fr)
DK (1) DK3497103T3 (fr)
DO (1) DOP2019000030A (fr)
EC (1) ECSP19011216A (fr)
ES (1) ES2876411T3 (fr)
GE (1) GEP20217234B (fr)
HR (1) HRP20210871T1 (fr)
HU (1) HUE055978T2 (fr)
IL (1) IL264687B (fr)
LT (1) LT3497103T (fr)
MA (1) MA45920B1 (fr)
MD (1) MD3497103T2 (fr)
MX (1) MX389597B (fr)
MY (1) MY198534A (fr)
NI (1) NI201900013A (fr)
NZ (1) NZ750410A (fr)
PE (1) PE20190475A1 (fr)
PH (1) PH12019500329A1 (fr)
PL (1) PL3497103T3 (fr)
PT (1) PT3497103T (fr)
RS (1) RS61934B1 (fr)
RU (1) RU2726115C1 (fr)
SG (1) SG11201900799XA (fr)
SI (1) SI3497103T1 (fr)
SV (1) SV2019005836A (fr)
TN (1) TN2019000039A1 (fr)
TW (1) TWI663169B (fr)
UA (1) UA124804C2 (fr)
UY (1) UY37352A (fr)
WO (1) WO2018033815A1 (fr)
ZA (1) ZA201900716B (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6563623B1 (ja) * 2016-08-15 2019-08-21 ファイザー・インク ピリドピリミジノンｃｄｋ２／４／６阻害剤
JP6952747B2 (ja) 2018-09-18 2021-10-20 ファイザー・インク がん処置のためのＴＧＦβ阻害剤およびＣＤＫ阻害剤の組合せ
JP2020097562A (ja) * 2018-09-25 2020-06-25 ファイザー・インク ピリド［２，３−ｄ］ピリミジン−７（８ｈ）−オンの合成
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
US20220127262A1 (en) * 2019-01-17 2022-04-28 Pfizer Inc. Crystalline form of a cdk inhibitor
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
MA54947A (fr) * 2019-02-15 2021-12-22 Incyte Corp Biomarqueurs de kinase 2 dépendant de la cycline et leurs utilisations
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020205560A1 (fr) 2019-03-29 2020-10-08 Incyte Corporation Composés sulfonylamides utilisés comme inhibiteurs de la cdk2
MX2021012491A (es) * 2019-04-19 2022-01-24 Pfizer Agentes antiproliferativos para el tratamiento de la hipertensión arterial pulmonar.
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
EP3976043A1 (fr) * 2019-05-24 2022-04-06 Pfizer Inc. Polythérapies à l'aide d'inhibiteurs cdk
CN113874036A (zh) * 2019-05-24 2021-12-31 辉瑞公司 使用cdk抑制剂的联合治疗
WO2021014360A1 (fr) 2019-07-23 2021-01-28 Pfizer Inc. Formes posologiques à libération modifiée par voie orale
MX2022001940A (es) 2019-08-14 2022-05-10 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2.
CN119930610A (zh) * 2019-10-11 2025-05-06 因赛特公司 作为cdk2抑制剂的双环胺
EP4046999A4 (fr) * 2019-10-17 2023-11-22 Cisen Pharmaceutical Co., Ltd. Composé aminopyrimidine utilisé comme inhibiteur triple de cdk2/4/6
JP7369297B2 (ja) 2019-12-17 2023-10-25 ファイザー・インク Ｃｄ４７、ｐｄ－ｌ１に特異的な抗体、およびその使用
US20230135215A1 (en) * 2020-02-28 2023-05-04 Fochon Biosciences, Ltd. Compounds as cdk2/4/6 inhibitors
WO2021176349A1 (fr) 2020-03-05 2021-09-10 Pfizer Inc. Combinaison d'un inhibiteur de kinase du lymphome anaplasique et d'un inhibiteur de kinase dépendant de la cycline
JP2021167301A (ja) 2020-04-08 2021-10-21 ファイザー・インク Ｃｄｋ２阻害剤に対する腫瘍適応を抑制するためのｃｄｋ４／６およびｃｄｋ２阻害剤による同時処置
CN113773315A (zh) * 2020-06-10 2021-12-10 无锡佰翱得生物科学有限公司 细胞周期蛋白依赖性激酶2（cdk2）高选择性氘代抑制剂
WO2021254384A1 (fr) * 2020-06-17 2021-12-23 微境生物医药科技(上海)有限公司 Nouveau dérivé de pyrido[2,3-d]pyrimidine-7(8h)-one
WO2022015670A1 (fr) * 2020-07-14 2022-01-20 Nikang Therapeutics, Inc. Dérivés de pyrido[2,3-d]pyrimidin-7(8h)-one utilisés en tant qu'inhibiteurs de kinase 2 dépendant de la cycline
WO2022018667A1 (fr) 2020-07-24 2022-01-27 Pfizer Inc. Polythérapies utilisant des inhibiteurs de cdk2 et de cdc25a
ES3022913T3 (en) 2020-09-15 2025-05-29 Pfizer Solid forms of a cdk4 inhibitor
AR124154A1 (es) 2020-11-27 2023-02-22 Rhizen Pharmaceuticals Ag Inhibidores de cdk
WO2022140472A1 (fr) * 2020-12-22 2022-06-30 Nikang Therapeutics, Inc. Composés pour la dégradation de la kinase 2 dépendante des cyclines par l'intermédiaire d'une voie de l'ubiquitine-protéosome
WO2022149057A1 (fr) 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Inhibiteurs de cdk
WO2022152259A1 (fr) * 2021-01-15 2022-07-21 江苏先声药业有限公司 Inhibiteur de cdk2/4/6, son procédé de préparation et son application
KR20240020735A (ko) 2021-05-07 2024-02-15 카이메라 쎄라퓨틱스 인코포레이티드 Cdk2 분해제 및 그 용도
WO2022258023A1 (fr) * 2021-06-09 2022-12-15 郑州同源康医药有限公司 Composé utile en tant qu'inhibiteur de kinase dépendante des cyclines et son utilisation
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
WO2023281413A1 (fr) 2021-07-09 2023-01-12 Pfizer Inc. Méthodes et schémas posologiques comprenant pf-06873600 pour le traitement du cancer
CN116390921A (zh) * 2021-09-29 2023-07-04 中国医药研究开发中心有限公司 具有细胞周期蛋白依赖性激酶抑制活性的杂环化合物及其制备方法和医药用途
IL312844A (en) * 2021-11-18 2024-07-01 Onconova Therapeutics Inc Methods and compositions for treating cancer
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
US20250049802A1 (en) 2021-12-14 2025-02-13 Pfizer Inc. Combination therapies and uses for treating cancer
WO2023141522A2 (fr) * 2022-01-21 2023-07-27 Slap Pharmaceuticals Llc Composés multicycliques
MX2024009105A (es) * 2022-01-25 2024-09-18 Kinnate Biopharma Inc Inhibidores de las cinasas cdk4/6.
CN119451967A (zh) * 2022-06-22 2025-02-14 霖康疗法公司 用于经由泛素蛋白酶体途径降解细胞周期蛋白依赖性激酶2的含有吡啶并[2,3-d]嘧啶-7(8H)-酮衍生物的双功能化合物
EP4573094A2 (fr) * 2022-08-19 2025-06-25 Kymera Therapeutics, Inc. Inhibiteurs de cdk2 et utilisations associées
EP4604961A1 (fr) 2022-10-18 2025-08-27 Pfizer Inc. Composés pour le traitement du cancer
WO2024173766A1 (fr) * 2023-02-17 2024-08-22 Differentiated Therapeutics, Inc. Agents de dégradation de kinase dépendant de la cycline et leurs méthodes d'utilisation
WO2024246285A1 (fr) 2023-06-01 2024-12-05 H. Lundbeck A/S Agonistes du récepteur de l'orexine 2 spiromacrocycliques
WO2025175258A1 (fr) * 2024-02-17 2025-08-21 Padarn Therapeutics, Inc. Inhibiteurs de cdk2
WO2025207957A1 (fr) * 2024-03-28 2025-10-02 Yale University Inhibiteurs de pi5p4k alpha/bêta à petites molécules et procédés les utilisant
CN120842218A (zh) * 2024-04-26 2025-10-28 郑州同源康医药有限公司 一种嘧啶并氮杂环类化合物的晶型及其制备方法及应用
WO2026024674A1 (fr) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Méthodes de traitement de cancers associés à skp2

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
TW477787B (en) 1996-08-27 2002-03-01 Pfizer Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
CN1237177A (zh) 1996-11-27 1999-12-01 辉瑞大药厂 稠合的二环嘧啶衍生物
WO2000035298A1 (fr) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing-gum contenant des agents medicamenteux actifs
US6498163B1 (en) * 1997-02-05 2002-12-24 Warner-Lambert Company Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
DE69839338T2 (de) 1997-02-05 2008-07-10 Warner-Lambert Company Llc Pyrido (2,3-d) pyrimidine und 4-amino-pyrimidine als inhibitoren der zellulären proliferation
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
CN1433417A (zh) * 2000-01-27 2003-07-30 沃尼尔·朗伯公司 用于治疗神经变性疾病的吡啶并嘧啶酮衍生物
YU66502A (sh) 2000-03-06 2005-09-19 Warner-Lambert Company 5-alkilpirido(2,3-d)pirimidini, inhibitori tirozinkinaza
CZ20032416A3 (cs) 2001-02-12 2004-07-14 F. Hoffmann-La Roche Ag 6-Substituované pyridopyrimidiny
DE60303009T2 (de) 2002-01-22 2006-07-13 Warner-Lambert Co. Llc 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-one
PA8577501A1 (es) * 2002-07-25 2004-02-07 Warner Lambert Co Inhibidores de quinasas
US6951769B2 (en) 2003-06-04 2005-10-04 Texas Instruments Incorporated Method for stripping sacrificial layer in MEMS assembly
JP4053073B2 (ja) 2003-07-11 2008-02-27 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 選択的ｃｄｋ４阻害剤のイセチオン酸塩
JP2007523151A (ja) 2004-02-18 2007-08-16 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ２−（ピリジン−３−イルアミノ）−ピリド［２，３−ｄ］ピリミジン−７−オン
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
US8247408B2 (en) * 2005-10-07 2012-08-21 Exelixis, Inc. Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer
US8044062B2 (en) * 2005-10-07 2011-10-25 Exelixis, Inc. Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha
RU2009108006A (ru) 2006-09-08 2010-10-20 Пфайзер Продактс Инк. (Us) Синтез 2-(пиридин-2-иламино)-пиридо[2, 3-d]пиримидин-7-онов
GEP20115306B (fr) * 2006-09-15 2011-10-10 Pfizer Prod Inc
EP1914234A1 (fr) * 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines et leur utilisation comme inhibiteurs de kinases
UA100979C2 (ru) * 2007-04-10 2013-02-25 Экселиксис, Инк. Применение пиридопиримидиноновых ингибиторов pi3k альфа для лечения рака
CN102015704A (zh) * 2008-04-29 2011-04-13 霍夫曼-拉罗奇有限公司 Jnk的嘧啶基吡啶酮抑制剂
US8557809B2 (en) 2008-08-19 2013-10-15 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
JP2012505927A (ja) 2008-10-22 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドン阻害剤
EP2694504A4 (fr) * 2011-04-08 2014-08-27 Afraxis Holdings Inc 8-éthyl-6(aryl)pyrido [2,3-d]pyrimidin-7(8h)-ones utilisables en vue du traitement d'affections touchant le système nerveux, ainsi qu'en vue du traitement du cancer
EP2701690A1 (fr) * 2011-04-29 2014-03-05 Exelixis, Inc. Méthode de traitement d'un lymphome à l'aide d'inhibiteurs de pyridopyrimidinone de pi3k/mtor
TW201306842A (zh) * 2011-06-15 2013-02-16 Exelixis Inc 使用ｐｉ３ｋ／ｍｔｏｒ吡啶並嘧啶酮抑制劑及苯達莫司汀及／或利妥昔單抗治療惡性血液疾病之組合療法
AR088082A1 (es) 2011-10-13 2014-05-07 Lilly Co Eli Moduladores selectivos del receptor androgeno
EP2817308B1 (fr) * 2012-02-23 2016-09-07 AbbVie Inc. Dérivés de pyridopyrimidinone et leur utilisation comme inhibiteurs de kinases
PL2958916T3 (pl) 2013-02-21 2019-01-31 Pfizer Inc. Stałe postacie selektywnego inhibitora CDK4/6
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP3076789A4 (fr) * 2013-12-04 2017-11-22 The Scripps Research Institute Nouveaux composés utilisables en tant qu'inhibiteurs des janus kinases
US9753991B2 (en) 2014-07-31 2017-09-05 Linkedin Corporation Personalized search based on similarity
CZ201589A3 (cs) * 2015-02-11 2016-08-24 Zentiva, K.S. Pevné formy soli Palbociclibu
JP6563623B1 (ja) * 2016-08-15 2019-08-21 ファイザー・インク ピリドピリミジノンｃｄｋ２／４／６阻害剤

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Publication number Publication date
KR20190038915A (ko) 2019-04-09
PT3497103T (pt) 2021-06-17
CA2975033A1 (fr) 2018-02-15
CU24522B1 (es) 2021-06-08
EP3497103B1 (fr) 2021-05-05
IL264687B (en) 2021-04-29
TW201819383A (zh) 2018-06-01
MX389597B (es) 2025-03-20
HUE055978T2 (hu) 2022-01-28
ES2876411T3 (es) 2021-11-12
PH12019500329A1 (en) 2019-10-28
DOP2019000030A (es) 2019-06-30
CL2019000368A1 (es) 2019-05-10
LT3497103T (lt) 2021-07-26
US20190135817A1 (en) 2019-05-09
UY37352A (es) 2018-03-23
RU2726115C1 (ru) 2020-07-09
SG11201900799XA (en) 2019-02-27
CN114394966B (zh) 2024-10-11
WO2018033815A1 (fr) 2018-02-22
JP2019527722A (ja) 2019-10-03
PE20190475A1 (es) 2019-04-04
CY1124206T1 (el) 2022-05-27
US20220324872A1 (en) 2022-10-13
ZA201900716B (en) 2022-03-30
CN109803968A (zh) 2019-05-24
TWI663169B (zh) 2019-06-21
US10800783B2 (en) 2020-10-13
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KR102236605B1 (ko) 2021-04-05
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US20180044344A1 (en) 2018-02-15
ECSP19011216A (es) 2019-03-29
US20200392142A1 (en) 2020-12-17
US11396512B2 (en) 2022-07-26
CA2975033C (fr) 2023-01-24
PL3497103T3 (pl) 2021-10-25
SV2019005836A (es) 2019-03-19
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HRP20210871T1 (hr) 2021-07-09
CO2019001240A2 (es) 2019-02-19
MD3497103T2 (ro) 2021-08-31
MA45920B1 (fr) 2021-08-31
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SI3497103T1 (sl) 2021-07-30
US10233188B2 (en) 2019-03-19
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TN2019000039A1 (en) 2020-07-15
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