NO20055893L - New linkomycin derivatives with antimicrobial activity - Google Patents

New linkomycin derivatives with antimicrobial activity

Info

Publication number
NO20055893L
NO20055893L NO20055893A NO20055893A NO20055893L NO 20055893 L NO20055893 L NO 20055893L NO 20055893 A NO20055893 A NO 20055893A NO 20055893 A NO20055893 A NO 20055893A NO 20055893 L NO20055893 L NO 20055893L
Authority
NO
Norway
Prior art keywords
linkomycin
derivatives
new
antimicrobial activity
compounds
Prior art date
Application number
NO20055893A
Other languages
Norwegian (no)
Inventor
Mikhail F Gordeev
Sampath K Anandan
Jason Gustaf Lewis
Hardwin O'dowd
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/642,807 external-priority patent/US7164011B2/en
Priority claimed from US10/777,455 external-priority patent/US7199105B2/en
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of NO20055893L publication Critical patent/NO20055893L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Nye linkomycin-derivater er beskrevet. Disse linkomycin-derivater viser antibakteriell aktivitet. Forbindelsene ifølge foreliggende oppfinnelse kan vise kraftig aktivitet mot bakterier, omfattende gram-positive organismer og kan være nyttige, antimikrobielle midler. Metoder for syntese og anvendelige forbindelser er også beskrevet.New linkomycin derivatives are described. These linkomycin derivatives show antibacterial activity. The compounds of the present invention can show potent activity against bacteria, comprising gram-positive organisms and can be useful antimicrobial agents. Methods of synthesis and useful compounds are also described.

NO20055893A 2003-06-17 2005-12-12 New linkomycin derivatives with antimicrobial activity NO20055893L (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47950203P 2003-06-17 2003-06-17
US47929603P 2003-06-17 2003-06-17
US10/642,807 US7164011B2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/777,455 US7199105B2 (en) 2002-08-15 2004-02-11 Lincomycin derivatives possessing antibacterial activity
PCT/US2004/019689 WO2005012320A2 (en) 2003-06-17 2004-06-17 Novel lincomycin derivatives possessing antimicrobial activity

Publications (1)

Publication Number Publication Date
NO20055893L true NO20055893L (en) 2006-03-14

Family

ID=40203032

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055893A NO20055893L (en) 2003-06-17 2005-12-12 New linkomycin derivatives with antimicrobial activity

Country Status (16)

Country Link
EP (1) EP1644393A2 (en)
JP (1) JP2007516172A (en)
KR (1) KR20060091050A (en)
AU (1) AU2004261550A1 (en)
BR (1) BRPI0411534A (en)
CA (1) CA2528592A1 (en)
EC (1) ECSP056233A (en)
GE (1) GEP20084437B (en)
IL (1) IL172183A0 (en)
IS (1) IS8147A (en)
MA (1) MA27860A1 (en)
MX (1) MXPA05013915A (en)
NO (1) NO20055893L (en)
OA (1) OA13179A (en)
RS (1) RS20050931A (en)
WO (1) WO2005012320A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05001689A (en) 2002-08-15 2005-05-27 Vicuron Pharm Inc Lincomycin derivatives possessing antibacterial activity.
US7199105B2 (en) 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
WO2005007665A2 (en) * 2003-06-17 2005-01-27 Vicuron Pharmaceuticals Inc. Lincomycin derivatives possessing antibacterial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7361743B2 (en) 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
RU2008108215A (en) * 2005-08-31 2009-10-10 Вайет (Us) 9-AMINOCARBONYL SUBSTITUTED DERIVATIVES OF GLYCYCLICLINS
EP1970377A4 (en) 2005-12-09 2013-02-27 Meiji Seika Kaisha Lincomycin derivative and antibacterial agent containing the same as active ingredient
EP2166015A4 (en) 2007-05-31 2012-09-05 Meiji Seika Kaisha Lincosamide derivative, and antibacterial agent comprising the same as active ingredient
WO2008146917A1 (en) * 2007-05-31 2008-12-04 Meiji Seika Kaisha, Ltd. Lincomycin derivatives and antibacterial agents containing the same as the active ingredient
US8822679B2 (en) * 2011-06-24 2014-09-02 California Institute Of Technology Quaternary heteroatom containing compounds
US20130267699A1 (en) 2011-06-24 2013-10-10 California Institute Of Technology Quaternary heteroatom containing compounds
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
CA2981041C (en) 2015-03-27 2023-09-05 California Institute Of Technology Asymmetric catalytic decarboxylative alkyl alkylation using low catalyst concentrations and a robust precatalyst
US10040784B2 (en) 2016-03-11 2018-08-07 California Institute Of Technology Compositions and methods for acylating lactams
US10358422B2 (en) 2017-11-01 2019-07-23 California Institute Of Technology Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
EP3699173A1 (en) 2018-10-18 2020-08-26 California Institute of Technology Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
CN110357839A (en) * 2019-08-29 2019-10-22 重庆经致制药技术开发有限公司 The preparation method of Bu Waxitan chiral intermediate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128232C (en) * 1964-04-13
US3268556A (en) * 1964-04-13 1966-08-23 Upjohn Co Novel lincomycin derivatives
NL146501C (en) * 1964-07-01
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
NL140527B (en) * 1965-02-08 1973-12-17 Upjohn Co PROCESS FOR PREPARING LINCOMYCIN RELATED COMPOUNDS.
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
US3549615A (en) * 1968-10-17 1970-12-22 Upjohn Co Lincomycin derivatives and process for producing the same
DE2118636A1 (en) * 1970-04-20 1971-11-04 The Upjohn Co., Kalamazoo, Mich. (V.StA.) 3-nucleotides of lincomycin and their analogues, processes for their preparation and their use in therapeutic preparations
US3787390A (en) * 1971-06-23 1974-01-22 Upjohn Co Analogs of lincomycin and process
US3849396A (en) * 1973-01-08 1974-11-19 Upjohn Co Lincomycin and clindamycin 1-o-ethers
US3923602A (en) * 1973-10-25 1975-12-02 Upjohn Co Composition of matter and process
JPS5641239A (en) * 1979-09-13 1981-04-17 Hitachi Cable Ltd Flame-retardant composition
US4278789A (en) * 1979-11-23 1981-07-14 The Upjohn Company Lincomycin compounds
MXPA05001689A (en) * 2002-08-15 2005-05-27 Vicuron Pharm Inc Lincomycin derivatives possessing antibacterial activity.
JP2007528360A (en) * 2003-06-17 2007-10-11 ビキュロン・ファーマシューティカルズ・インコーポレイテッド Lincomycin derivatives with antibacterial activity

Also Published As

Publication number Publication date
GEP20084437B (en) 2008-07-25
RS20050931A (en) 2008-04-04
AU2004261550A1 (en) 2005-02-10
EP1644393A2 (en) 2006-04-12
JP2007516172A (en) 2007-06-21
CA2528592A1 (en) 2005-02-10
ECSP056233A (en) 2006-04-19
MA27860A1 (en) 2006-04-03
BRPI0411534A (en) 2006-08-22
WO2005012320A2 (en) 2005-02-10
OA13179A (en) 2006-12-13
KR20060091050A (en) 2006-08-17
HK1090061A1 (en) 2006-12-15
IS8147A (en) 2005-11-24
IL172183A0 (en) 2011-08-01
WO2005012320A3 (en) 2005-10-20
MXPA05013915A (en) 2006-07-03

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application