NO20056006L - Aminsalter av (-)-{[2-(4-hydroksyfenyl)etyl]tio}-3-[4-(2-{4-[(metylsulfonyl)oksy]etyl)fenyl]propansyre og deres anvendelse som medikament - Google Patents

Aminsalter av (-)-{[2-(4-hydroksyfenyl)etyl]tio}-3-[4-(2-{4-[(metylsulfonyl)oksy]etyl)fenyl]propansyre og deres anvendelse som medikament

Info

Publication number: NO20056006L
Authority: NO; Norway
Prior art keywords: ethyl; salt; methylsulfonyl; thio; hydroxyphenyl
Prior art date: 2003-06-18

Application number

NO20056006A

Other languages

English (en)

Norwegian (no)

Inventor

Bengt Ohlsson

Nigel Phillip Taylor

Mikael Ulf Johan Dahlstrom

Matti Ahlqvist

Richard Anthony Storey

Rebecca Woods

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-18

Filing date

2005-12-16

Publication date

2006-02-24

2005-12-16 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2006-02-24 Publication of NO20056006L publication Critical patent/NO20056006L/no

Links

-1 Amine salts Chemical class 0.000 title 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
235000019260 propionic acid Nutrition 0.000 title 1
PGZGQQFVPOZCAQ-UHFFFAOYSA-N 2-[2-(4-hydroxyphenyl)ethylsulfanyl]-3-[4-[2-(4-methylsulfonyloxyphenoxy)ethyl]phenyl]propanoic acid Chemical compound C1=CC(OS(=O)(=O)C)=CC=C1OCCC(C=C1)=CC=C1CC(C(O)=O)SCCC1=CC=C(O)C=C1 PGZGQQFVPOZCAQ-UHFFFAOYSA-N 0.000 abstract 1
239000004381 Choline salt Substances 0.000 abstract 1
208000032928 Dyslipidaemia Diseases 0.000 abstract 1
206010022489 Insulin Resistance Diseases 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical class C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 abstract 1
235000019417 choline salt Nutrition 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
150000004885 piperazines Chemical class 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003248 quinolines Chemical class 0.000 abstract 1
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20056006A 2003-06-18 2005-12-16 Aminsalter av (-)-{[2-(4-hydroksyfenyl)etyl]tio}-3-[4-(2-{4-[(metylsulfonyl)oksy]etyl)fenyl]propansyre og deres anvendelse som medikament NO20056006L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0314130.6A GB0314130D0 (en)	2003-06-18	2003-06-18	Therapeutic agents
PCT/GB2004/002576 WO2004113283A1 (en)	2003-06-18	2004-06-16	Amine salts of (-)-2-{`2-(4-hydroxyphenyl) ethyl!-thio}-3-`4-(2-{4-`(methylsulfonyl)oxy! phenoxy}ethyl)phenyl! propanoic acid and there use in medicine

Publications (1)

Publication Number	Publication Date
NO20056006L true NO20056006L (no)	2006-02-24

Family

ID=27636789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20056006A NO20056006L (no)	2003-06-18	2005-12-16	Aminsalter av (-)-{[2-(4-hydroksyfenyl)etyl]tio}-3-[4-(2-{4-[(metylsulfonyl)oksy]etyl)fenyl]propansyre og deres anvendelse som medikament

Country Status (20)

Country	Link
US (1)	US20070099928A1 (pt)
EP (1)	EP1638930A1 (pt)
JP (1)	JP3927594B2 (pt)
KR (1)	KR20060023165A (pt)
CN (1)	CN1835919A (pt)
AR (1)	AR044826A1 (pt)
AU (1)	AU2004249483A1 (pt)
BR (1)	BRPI0411580A (pt)
CA (1)	CA2529544A1 (pt)
CO (1)	CO5630026A2 (pt)
GB (1)	GB0314130D0 (pt)
IL (1)	IL172633A0 (pt)
IS (1)	IS8224A (pt)
MX (1)	MXPA05013718A (pt)
NO (1)	NO20056006L (pt)
RU (1)	RU2005141061A (pt)
TW (1)	TW200503671A (pt)
UY (1)	UY28372A1 (pt)
WO (1)	WO2004113283A1 (pt)
ZA (1)	ZA200510263B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0104333D0 (sv) *	2001-12-19	2001-12-19	Astrazeneca Ab	Therapeutic agents
PL375074A1 (en)	2002-06-20	2005-11-14	Astrazeneca Ab	Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
GB0314131D0 (en) *	2003-06-18	2003-07-23	Astrazeneca Ab	Therapeutic agents
GB0314075D0 (en) *	2003-06-18	2003-07-23	Astrazeneca Ab	Therapeutic agents
GB0427524D0 (en)	2004-12-16	2005-01-19	Astrazeneca Ab	Chemical process
GB0427701D0 (en) *	2004-12-17	2005-01-19	Astrazeneca Ab	Therapeutic agents
ES2609825T3 (es) *	2007-01-18	2017-04-24	Evolva Sa	1,3-Dioxanos sustituidos útiles como moduladores de PPAR

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9801992D0 (sv) *	1998-06-04	1998-06-04	Astra Ab	New 3-aryl-2-hydroxypropionic acid derivative I
MA26634A1 (fr) *	1998-06-04	2004-12-20	Astra Ab	Nouveaux derives de l'acide 3-aryl propionique et analogues
SE0104333D0 (sv) *	2001-12-19	2001-12-19	Astrazeneca Ab	Therapeutic agents

2003
- 2003-06-18 GB GBGB0314130.6A patent/GB0314130D0/en not_active Ceased
2004
- 2004-06-16 CN CNA2004800231462A patent/CN1835919A/zh active Pending
- 2004-06-16 CA CA002529544A patent/CA2529544A1/en not_active Abandoned
- 2004-06-16 KR KR1020057024314A patent/KR20060023165A/ko not_active Withdrawn
- 2004-06-16 BR BRPI0411580-5A patent/BRPI0411580A/pt not_active IP Right Cessation
- 2004-06-16 MX MXPA05013718A patent/MXPA05013718A/es unknown
- 2004-06-16 AU AU2004249483A patent/AU2004249483A1/en not_active Abandoned
- 2004-06-16 EP EP04736922A patent/EP1638930A1/en not_active Withdrawn
- 2004-06-16 RU RU2005141061/04A patent/RU2005141061A/ru not_active Application Discontinuation
- 2004-06-16 US US10/561,222 patent/US20070099928A1/en not_active Abandoned
- 2004-06-16 WO PCT/GB2004/002576 patent/WO2004113283A1/en not_active Ceased
- 2004-06-16 JP JP2006516428A patent/JP3927594B2/ja not_active Expired - Fee Related
- 2004-06-17 UY UY28372A patent/UY28372A1/es not_active Application Discontinuation
- 2004-06-18 TW TW093117824A patent/TW200503671A/zh unknown
- 2004-06-18 AR ARP040102136A patent/AR044826A1/es not_active Application Discontinuation
2005
- 2005-12-15 ZA ZA200510263A patent/ZA200510263B/en unknown
- 2005-12-15 IL IL172633A patent/IL172633A0/en unknown
- 2005-12-16 NO NO20056006A patent/NO20056006L/no not_active Application Discontinuation
2006
- 2006-01-05 CO CO06001009A patent/CO5630026A2/es not_active Application Discontinuation
- 2006-01-10 IS IS8224A patent/IS8224A/is unknown

Also Published As

Publication number	Publication date
BRPI0411580A (pt)	2006-08-08
JP2006527749A (ja)	2006-12-07
US20070099928A1 (en)	2007-05-03
KR20060023165A (ko)	2006-03-13
TW200503671A (en)	2005-02-01
WO2004113283A1 (en)	2004-12-29
CO5630026A2 (es)	2006-04-28
MXPA05013718A (es)	2006-06-27
EP1638930A1 (en)	2006-03-29
JP3927594B2 (ja)	2007-06-13
CN1835919A (zh)	2006-09-20
RU2005141061A (ru)	2006-08-27
ZA200510263B (en)	2007-02-28
IL172633A0 (en)	2006-04-10
CA2529544A1 (en)	2004-12-29
IS8224A (is)	2006-01-10
GB0314130D0 (en)	2003-07-23
UY28372A1 (es)	2005-01-31
AR044826A1 (es)	2005-10-05
AU2004249483A1 (en)	2004-12-29

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Legal Events

Date	Code	Title	Description
2009-02-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application