BRPI0606942A2 - derivados de n-[(4,5-difenil-2-tienil)metil]amina, o respectivo processo e a respectiva aplicação em terapêutica - Google Patents

derivados de n-[(4,5-difenil-2-tienil)metil]amina, o respectivo processo e a respectiva aplicação em terapêutica

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Publication number
BRPI0606942A2
BRPI0606942A2 BRPI0606942-8A BRPI0606942A BRPI0606942A2 BR PI0606942 A2 BRPI0606942 A2 BR PI0606942A2 BR PI0606942 A BRPI0606942 A BR PI0606942A BR PI0606942 A2 BRPI0606942 A2 BR PI0606942A2
Authority
BR
Brazil
Prior art keywords
diphenyl
methyl
amine derivatives
thienyl
therapeutic application
Prior art date
Application number
BRPI0606942-8A
Other languages
English (en)
Inventor
Francis Barth
Murielle Rinaldi-Carmona
Christian Congy
Jean-Philippe Ducoux
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0606942A2 publication Critical patent/BRPI0606942A2/pt

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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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Abstract

DERIVADOS DE N-[(4,5-DIFENIL -2-TIENIL) METIL] AMINA, O RESPECTIVO PROCESSO E A RESPECTIVA APLICAçãO EM TERAPêUTICA. A presente invenção tem por objeto os compostos correspondentes à fórmula (I), na qual: -X representa um grupo fórmula (II); -R~ 3~ representa uma fenila não substituida ou mono-, di- ou trissubstituído; - R~ 4~ representa uma fenila não substituida ou mono-, di- ou trissubstituída. Processo de preparação e aplicação como antagonistas dos receptores CB~ 1~ dos canabinóides.
BRPI0606942-8A 2005-02-09 2006-02-01 derivados de n-[(4,5-difenil-2-tienil)metil]amina, o respectivo processo e a respectiva aplicação em terapêutica BRPI0606942A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0501366A FR2881744B1 (fr) 2005-02-09 2005-02-09 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
PCT/FR2006/000219 WO2006084975A1 (fr) 2005-02-09 2006-02-01 Derives de n-[(4, 5-diphenyl-3 -alkyl-2-thienyl) methyl] amine (amide , thiouree et uree) comme antagonistes des recepteurs cb1 des cannabinoides

Publications (1)

Publication Number Publication Date
BRPI0606942A2 true BRPI0606942A2 (pt) 2009-07-28

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BRPI0606942-8A BRPI0606942A2 (pt) 2005-02-09 2006-02-01 derivados de n-[(4,5-difenil-2-tienil)metil]amina, o respectivo processo e a respectiva aplicação em terapêutica

Country Status (16)

Country Link
US (2) US7687537B2 (pt)
EP (1) EP1858872A1 (pt)
JP (1) JP4823236B2 (pt)
KR (1) KR20070115941A (pt)
CN (1) CN101128451A (pt)
AR (1) AR052898A1 (pt)
AU (1) AU2006212162A1 (pt)
BR (1) BRPI0606942A2 (pt)
CA (1) CA2596613A1 (pt)
FR (1) FR2881744B1 (pt)
IL (1) IL185035A0 (pt)
MX (1) MX2007009439A (pt)
RU (1) RU2007133602A (pt)
TW (1) TW200639160A (pt)
UY (1) UY29366A1 (pt)
WO (1) WO2006084975A1 (pt)

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FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
CN104922117A (zh) 2005-03-22 2015-09-23 阿泽范药品公司 用于治疗月经前病症的β-内酰氨基链烷酸
FR2894579B1 (fr) * 2005-12-12 2008-01-18 Sanofi Aventis Sa Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique.
WO2008034032A2 (en) * 2006-09-14 2008-03-20 Azevan Pharmaceuticals, Inc. Beta-lactam cannabinoid receptor modulators
FR2908766B1 (fr) * 2006-11-20 2009-01-09 Sanofi Aventis Sa Derives de pyrrole,leur preparation et leur utilisation en therapeutique.
EP1939181A1 (en) * 2006-12-27 2008-07-02 sanofi-aventis Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase
JP5379690B2 (ja) * 2007-09-28 2013-12-25 武田薬品工業株式会社 ５員複素環化合物
JP5345140B2 (ja) * 2007-09-28 2013-11-20 武田薬品工業株式会社 プロトンポンプ阻害剤としての５員複素環化合物
FR2934594B1 (fr) * 2008-08-01 2010-09-10 Sanofi Aventis Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique.
FR2943672B1 (fr) * 2009-03-27 2011-03-25 Sanofi Aventis Derives de 3-alcoxy-4,5-diarylthiophene-2-carboxamide,leur preparation et leur application en therapeutique.
US8609663B2 (en) * 2009-11-18 2013-12-17 University Of Massachusetts Compounds for modulating TLR2
AU2011272738B2 (en) 2010-07-01 2015-08-20 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
BR112016022575A2 (pt) 2014-03-28 2017-08-15 Azevan Pharmaceuticals Inc Composições e métodos para o tratamento de doenças neurodegenerativas
KR102790657B1 (ko) 2017-09-15 2025-04-02 아제반 파마슈티칼스, 인코퍼레이티드 뇌 손상을 치료하기 위한 조성물 및 방법
CN114269719A (zh) * 2019-06-28 2022-04-01 Rti国际 作为cb1变构调节剂的脲衍生物

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JP4823236B2 (ja) 2011-11-24
US20100137402A1 (en) 2010-06-03
CA2596613A1 (fr) 2006-08-17
KR20070115941A (ko) 2007-12-06
FR2881744B1 (fr) 2007-04-27
WO2006084975A1 (fr) 2006-08-17
TW200639160A (en) 2006-11-16
JP2008530060A (ja) 2008-08-07
CN101128451A (zh) 2008-02-20
AU2006212162A1 (en) 2006-08-17
IL185035A0 (en) 2007-12-03
US7687537B2 (en) 2010-03-30
US20080009543A1 (en) 2008-01-10
RU2007133602A (ru) 2009-03-20
FR2881744A1 (fr) 2006-08-11
AR052898A1 (es) 2007-04-11
MX2007009439A (es) 2008-03-06
EP1858872A1 (fr) 2007-11-28

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