NO20060123L - Benzo(4,5)tieno(2,3-D)pyrimidin-4-oner og deres anvendelse i terapi - Google Patents

Benzo(4,5)tieno(2,3-D)pyrimidin-4-oner og deres anvendelse i terapi

Info

Publication number: NO20060123L
Authority: NO; Norway
Prior art keywords: cancer; disorder; steroid hormone; uterine; type
Prior art date: 2003-06-10

Application number

NO20060123A

Other languages

English (en)

Norwegian (no)

Inventor

Leena Hirvela

Nina Johansson

Pasi Koskimies

Olli Taneli Pentikainen

Tommi Nyronen

Tiina Annamaria Salminen

Mark Stuart Johnson

Pekka Lehtovuori

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-10

Filing date

2006-01-09

Publication date

2006-03-09

2006-01-09 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2006-03-09 Publication of NO20060123L publication Critical patent/NO20060123L/no

Links

UELJJSQADCDBMU-UHFFFAOYSA-N 3h-[1]benzothiolo[2,3-d]pyrimidin-4-one Chemical class S1C2=CC=CC=C2C2=C1N=CNC2=O UELJJSQADCDBMU-UHFFFAOYSA-N 0.000 title abstract 2
238000002560 therapeutic procedure Methods 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
230000001419 dependent effect Effects 0.000 abstract 3
201000010099 disease Diseases 0.000 abstract 3
208000035475 disorder Diseases 0.000 abstract 3
239000003270 steroid hormone Substances 0.000 abstract 3
208000002874 Acne Vulgaris Diseases 0.000 abstract 2
206010000496 acne Diseases 0.000 abstract 2
108010070743 3(or 17)-beta-hydroxysteroid dehydrogenase Proteins 0.000 abstract 1
208000005641 Adenomyosis Diseases 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
208000002177 Cataract Diseases 0.000 abstract 1
206010009944 Colon cancer Diseases 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
206010058314 Dysplasia Diseases 0.000 abstract 1
206010014733 Endometrial cancer Diseases 0.000 abstract 1
206010014759 Endometrial neoplasm Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
206010033128 Ovarian cancer Diseases 0.000 abstract 1
206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
206010060862 Prostate cancer Diseases 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
206010039792 Seborrhoea Diseases 0.000 abstract 1
208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
201000006828 endometrial hyperplasia Diseases 0.000 abstract 1
201000009274 endometriosis of uterus Diseases 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
201000010260 leiomyoma Diseases 0.000 abstract 1
208000007106 menorrhagia Diseases 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
201000007094 prostatitis Diseases 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
210000001519 tissue Anatomy 0.000 abstract 1
206010046766 uterine cancer Diseases 0.000 abstract 1
230000037303 wrinkles Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Pregnancy & Childbirth (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Joining Of Glass To Other Materials (AREA)

NO20060123A 2003-06-10 2006-01-09 Benzo(4,5)tieno(2,3-D)pyrimidin-4-oner og deres anvendelse i terapi NO20060123L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47704703P	2003-06-10	2003-06-10
PCT/EP2004/006230 WO2005032527A2 (en)	2003-06-10	2004-06-09	Benzo (4, 5) thieno (2, 3-d) pyrimidin-4-ones and their use in therapy

Publications (1)

Publication Number	Publication Date
NO20060123L true NO20060123L (no)	2006-03-09

Family

ID=34421462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20060123A NO20060123L (no)	2003-06-10	2006-01-09	Benzo(4,5)tieno(2,3-D)pyrimidin-4-oner og deres anvendelse i terapi

Country Status (24)

Country	Link
US (1)	US7465739B2 (de)
EP (1)	EP1635839B1 (de)
JP (1)	JP4605800B2 (de)
KR (1)	KR20060054189A (de)
CN (1)	CN1791412A (de)
AR (1)	AR044650A1 (de)
AT (1)	ATE479437T1 (de)
AU (1)	AU2004277311B8 (de)
BR (1)	BRPI0411295A (de)
CA (1)	CA2527617A1 (de)
DE (1)	DE602004028934D1 (de)
DK (1)	DK1635839T3 (de)
ES (2)	ES2352552T3 (de)
IL (1)	IL172316A0 (de)
MX (1)	MXPA05012745A (de)
NO (1)	NO20060123L (de)
PL (1)	PL1635839T3 (de)
PT (1)	PT1635839E (de)
RU (1)	RU2412190C2 (de)
SA (1)	SA04250159B1 (de)
SI (1)	SI1635839T1 (de)
TW (1)	TWI349551B (de)
WO (1)	WO2005032527A2 (de)
ZA (1)	ZA200508296B (de)

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US7524853B2 (en)	2003-06-10	2009-04-28	Solvay Pharmaceuticals B.V.	Compounds and their use in therapy
JP2007536239A (ja) *	2004-05-06	2007-12-13	スミスクライン・ビーチャム・コーポレイション	カルシウム受容体アンタゴニスト化合物
WO2006044826A2 (en) *	2004-10-20	2006-04-27	Compass Pharmaceuticals Llc	Thiophens and their use as anti-tumor agents
PL1828197T3 (pl) *	2004-12-13	2009-11-30	Solvay Pharm Gmbh	Nowe podstawione pochodne tiofenopirymidynonu jako inhibitory dehydrogenazy 17ß-hydroksysteroidowej
FR2904000A1 (fr) *	2006-07-19	2008-01-25	Galderma Res & Dev S N C Snc	Modulateurs de hsd17b7 dans le traitement de l'acne ou de l'hyperseborrhee
FR2904318B1 (fr) *	2006-07-27	2011-02-25	Scras	Derives de pyrimidinone et leur utilisation comme medicament
US8080540B2 (en)	2006-09-19	2011-12-20	Abbott Products Gmbh	Therapeutically active triazoles and their use
US8288367B2 (en)	2006-11-30	2012-10-16	Solvay Pharmaceuticals Gmbh	Substituted estratriene derivatives as 17BETA HSD inhibitors
DE102007015169A1 (de) *	2007-03-27	2008-10-02	Universität des Saarlandes Campus Saarbrücken	17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
WO2009001214A2 (en) *	2007-06-28	2008-12-31	Pfizer Products Inc.	Thieno[2,3-d]pyrimidin-4(3h)-one, isoxazolo[5,4-d]pyrimidin-4(5h)-one and isothiazolo[5,4-d]pyrimidin-4(5h)-one derivatives as calcium receptor antagonists
DE102007040243A1 (de)	2007-08-25	2009-02-26	Universität des Saarlandes	17Beta-Hydroxysteriod-Dehydrogenase Typ1 Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
JP2012513481A (ja) *	2008-12-23	2012-06-14	プレジデントアンドフェロウズオブハーバードカレッジ	ネクロトーシスの小分子阻害剤
EP2609089A1 (de)	2010-08-27	2013-07-03	Universität des Saarlandes	Selektive 17-beta-hydroxysteroid-dehydrogenase-typ-1-hemmer
WO2012119605A1 (en) *	2011-03-10	2012-09-13	Akar Yahya Ahmed Abdellhafeez Salem	New disperse dye with potent anticancer activity
TW201520219A (zh) *	2013-03-12	2015-06-01	Lilly Co Eli	咪唑並吡啶化合物
US20160024098A1 (en)	2013-03-15	2016-01-28	President And Fellows Of Harvard College	Hybrid necroptosis inhibitors
TW201512215A (zh)	2013-06-25	2015-04-01	Forendo Pharma Ltd	治療活性雌三烯噻唑衍生物
JP6556125B2 (ja)	2013-06-25	2019-08-07	フォレンドファーマリミテッド	１７β−ヒドロキシステロイドデヒドロゲナーゼの阻害剤としての治療的に活性な１７−窒素置換エストラトリエンチアゾール誘導体
JP6456373B2 (ja)	2013-06-25	2019-01-23	フォレンドファーマリミテッド	１７β−ヒドロキシステロイドデヒドロゲナーゼタイプ１の阻害剤として治療活性のあるエストラトリエンチアゾール誘導体
EP3089969A2 (de)	2014-01-03	2016-11-09	Elexopharm GmbH	Inhibitoren der 17-beta-hydroxysteroid-dehydrogenase typ 1 und typ 2
WO2015114663A1 (en)	2014-01-30	2015-08-06	Council Of Scientific & Industrial Research	Novel thieno [2,3-d]pyrimidin-4(3h)-one compounds with antimycobacterial properties
GB201419102D0 (en) *	2014-10-27	2014-12-10	Imp Innovations Ltd	Novel compounds
CN107207561B (zh)	2014-12-23	2020-03-31	佛恩多制药有限公司	17β-HSD1–抑制剂的前药
JP6545266B2 (ja)	2014-12-23	2019-07-17	フォレンドファーマリミテッド	１７β‐ＨＳＤ１抑制剤のプロドラッグ
US20180312493A1 (en) *	2015-11-04	2018-11-01	Simon Fraser University	Antibiotic Compounds, Pharmaceutical Formulations Thereof And Methods And Uses Therefor
HRP20240679T1 (hr)	2017-06-08	2024-08-16	Organon R&D Finland Ltd	17-oksimi 15.beta.-[3-propanamido]-supstituiranih etera-1,3,5(10)-trien-17-ona za uporabu u inhibiciji 17.beta.-hidroksisteroid dehidrogenaza
CN109503572B (zh) *	2017-09-15	2021-10-08	上海交通大学	一种合成吲哚喹啉类化合物的方法
JP7417608B2 (ja)	2018-12-05	2024-01-18	フォレンドファーマリミテッド	１７－ｈｓｄ１阻害剤としての１６（１７）位でピラゾール環と縮合しているエストラ－１，３，５（１０）－トリエン化合物
EP4514805A4 (de) *	2022-04-28	2026-01-21	Enanta Pharm Inc	Pyrimidinonhaltige 17-beta-hydroxysteroiddehydrogenase-typ-13-hemmer
US20250154163A1 (en) *	2023-10-26	2025-05-15	Enanta Pharmaceuticals, Inc.	Pyrimidinone-Containing 17-Beta-Hydroxysteroid Dehydrogenase Type 13 Inhibitors

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JPS62132884A (ja)	1985-12-05	1987-06-16	Mitsubishi Chem Ind Ltd	２−ベンジルチエノ〔２，３−ｄ〕ピリミジン−４（３Ｈ）−オン誘導体
WO1989008113A1 (en)	1988-03-02	1989-09-08	Yoshitomi Pharmaceutical Industries, Ltd.	3,4-DIHYDROTHIENO[2,3-d]PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL APPLICATION THEREOF
US5597823A (en) *	1995-01-27	1997-01-28	Abbott Laboratories	Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists
JP3783810B2 (ja)	1997-01-14	2006-06-07	第一製薬株式会社	新規ベンゾフラノン誘導体及びその製造方法
JPH10273467A (ja)	1997-01-29	1998-10-13	Snow Brand Milk Prod Co Ltd	新規テトラロン又はベンゾピラノン誘導体及びその製造方法
WO1999012540A1 (en)	1997-09-11	1999-03-18	Snow Brand Milk Products Co., Ltd.	Remedies for hormone-dependent diseases
HUP0101809A3 (en)	1998-03-11	2002-07-29	Endorech Inc Sainte Foy	Inhibitors of type 5 and type 3 17betha-hydroxysteroid dehydrogenase and methods for their use
WO2000007996A2 (en)	1998-08-07	2000-02-17	Chiron Corporation	Pyrazoles as estrogen receptor modulators
GB9929302D0 (en)	1999-12-11	2000-02-02	Univ Cardiff	Benzyl tetralins compositions and uses thereof
US6784167B2 (en)	2000-09-29	2004-08-31	Bayer Pharmaceuticals Corporation	17-beta-hydroxysteroid dehydrogenase-II inhibitors
WO2003017973A1 (en)	2001-08-31	2003-03-06	Pantarhei Bioscience B.V.	A method of treating benign gynaecological disorders and a drug delivery vehicle for use in such a method
PE20030703A1 (es)	2001-09-06	2003-08-21	Schering Corp	Inhibidores de la 17b-hidroxiesteroide deshidrogenasa tipo 3
US6750248B2 (en)	2001-11-09	2004-06-15	National University Of Singapore	Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof

2004
- 2004-06-07 US US10/861,907 patent/US7465739B2/en not_active Expired - Fee Related
- 2004-06-08 AR ARP040101983A patent/AR044650A1/es not_active Application Discontinuation
- 2004-06-08 TW TW093116411A patent/TWI349551B/zh not_active IP Right Cessation
- 2004-06-09 BR BRPI0411295-4A patent/BRPI0411295A/pt not_active IP Right Cessation
- 2004-06-09 WO PCT/EP2004/006230 patent/WO2005032527A2/en not_active Ceased
- 2004-06-09 KR KR1020057022958A patent/KR20060054189A/ko not_active Abandoned
- 2004-06-09 AT AT04803089T patent/ATE479437T1/de active
- 2004-06-09 RU RU2006100033/04A patent/RU2412190C2/ru not_active IP Right Cessation
- 2004-06-09 CN CNA200480013515XA patent/CN1791412A/zh active Pending
- 2004-06-09 ES ES04803089T patent/ES2352552T3/es not_active Expired - Lifetime
- 2004-06-09 JP JP2006515869A patent/JP4605800B2/ja not_active Expired - Fee Related
- 2004-06-09 CA CA002527617A patent/CA2527617A1/en not_active Abandoned
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US20050038053A1 (en)	2005-02-17
CN1791412A (zh)	2006-06-21
SA04250159B1 (ar)	2008-06-21
US7465739B2 (en)	2008-12-16
KR20060054189A (ko)	2006-05-22
IL172316A0 (en)	2011-08-01
MXPA05012745A (es)	2006-05-17
BRPI0411295A (pt)	2006-08-01
JP2006527226A (ja)	2006-11-30
RU2006100033A (ru)	2007-07-20
AU2004277311B2 (en)	2010-04-29
TWI349551B (en)	2011-10-01
RU2412190C2 (ru)	2011-02-20
PL1635839T3 (pl)	2011-02-28
ES2352554T3 (es)	2011-02-21
WO2005032527A2 (en)	2005-04-14
WO2005032527A3 (en)	2005-08-04
DE602004028934D1 (de)	2010-10-14
AU2004277311A1 (en)	2005-04-14
PT1635839E (pt)	2010-10-12
ATE479437T1 (de)	2010-09-15
SI1635839T1 (sl)	2010-12-31
AU2004277311B8 (en)	2010-05-27
TW200509937A (en)	2005-03-16
ES2352552T3 (es)	2011-02-21
AR044650A1 (es)	2005-09-21
ZA200508296B (en)	2007-01-31
EP1635839B1 (de)	2010-09-01
DK1635839T3 (da)	2011-01-03
JP4605800B2 (ja)	2011-01-05
CA2527617A1 (en)	2005-04-14
WO2005032527B1 (en)	2005-09-22
EP1635839A2 (de)	2006-03-22

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