NO20060469L - Syntese av -L-2-deoksynukleosider - Google Patents
Syntese av -L-2-deoksynukleosiderInfo
- Publication number
- NO20060469L NO20060469L NO20060469A NO20060469A NO20060469L NO 20060469 L NO20060469 L NO 20060469L NO 20060469 A NO20060469 A NO 20060469A NO 20060469 A NO20060469 A NO 20060469A NO 20060469 L NO20060469 L NO 20060469L
- Authority
- NO
- Norway
- Prior art keywords
- anhydro
- deoxynucleosides
- furanosyl
- preparation
- good yields
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000003352 sequestering agent Substances 0.000 abstract 2
- IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 abstract 2
- -1 Red-Al Substances 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000005650 intramolecular substitution reaction Methods 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 229940127073 nucleoside analogue Drugs 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48371103P | 2003-06-30 | 2003-06-30 | |
| US55861604P | 2004-04-01 | 2004-04-01 | |
| PCT/US2004/021281 WO2005003374A2 (en) | 2003-06-30 | 2004-06-30 | SYNTHESIS OF β-L-2-DEOXY NUCLEOSIDES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20060469L true NO20060469L (no) | 2006-03-30 |
Family
ID=33567697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20060469A NO20060469L (no) | 2003-06-30 | 2006-01-30 | Syntese av -L-2-deoksynukleosider |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050059632A1 (pt) |
| EP (2) | EP1639121A4 (pt) |
| JP (1) | JP2007527396A (pt) |
| KR (1) | KR20060035652A (pt) |
| AU (1) | AU2004254620A1 (pt) |
| BR (1) | BRPI0412031A (pt) |
| CA (1) | CA2531412A1 (pt) |
| MX (1) | MXPA06000162A (pt) |
| NO (1) | NO20060469L (pt) |
| NZ (1) | NZ544634A (pt) |
| RU (2) | RU2361875C2 (pt) |
| WO (1) | WO2005003374A2 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005289964A (ja) * | 2004-03-12 | 2005-10-20 | Ajinomoto Co Inc | ２−デオキシ−ｌ−リボース化合物の製造方法 |
| JP5260279B2 (ja) * | 2005-05-25 | 2013-08-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 対応する４−ハロゲン誘導体の還元的脱離による２，５−２置換テトラヒドロピラン誘導体類の調製方法 |
| EA016838B1 (ru) * | 2005-06-07 | 2012-07-30 | Йельский Университет | Способы лечения рака и других заболеваний или патологических состояний с применением клевудина (lfmau) и телбивудина (ldt) |
| US7951788B2 (en) * | 2005-12-02 | 2011-05-31 | Yale University | Method of treating cancer and other conditions or disease states using L-cytosine nucleoside analogs |
| ES2422290T3 (es) * | 2005-12-23 | 2013-09-10 | Idenix Pharmaceuticals Inc | Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados |
| MX2008011719A (es) * | 2006-03-15 | 2008-09-24 | Novartis Ag | Proceso para preparar derivados de acido b-nucleico e intermediarios de los mismos. |
| GB2443410B (en) * | 2006-10-31 | 2012-05-16 | Cb Fleet Co Inc | A process for the preparation of 6-bromo-6-deoxy-2,3-anhydro-D-manno-1,4-lactone |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| CN101302239B (zh) * | 2007-05-11 | 2011-05-11 | 上海医药工业研究院 | 汰比夫定及其中间体的合成方法 |
| CN101531639B (zh) * | 2009-04-16 | 2011-10-26 | 药源药物化学（上海）有限公司 | 三价铁的无机盐催化2-嘧啶酮及其衍生物的5位碘代方法 |
| PT3038601T (pt) | 2013-08-27 | 2020-06-30 | Gilead Pharmasset Llc | Formulação combinada de dois compostos antivirais |
| CN104744538A (zh) * | 2013-12-26 | 2015-07-01 | 康普药业股份有限公司 | 一种替比夫定的制备方法 |
| MX391226B (es) | 2015-09-23 | 2025-03-21 | Merck Sharp & Dohme Llc | Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos. |
| CN105732732B (zh) * | 2016-04-14 | 2018-04-06 | 四川理工学院 | 一种制备2‑脱氧‑d‑核糖的方法 |
| BR112021024039A2 (pt) * | 2019-07-19 | 2022-02-08 | Bp Corp North America Inc | Sínteses de furanos substituídos |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1191307B (de) | 1958-02-25 | 1965-04-15 | David Berreklouw Jun | Klemme zum Festhalten von Gegenstaenden geringer Breite, z. B. Naegeln, Schrauben oder Draehten |
| US3116282A (en) * | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
| DE2122991C2 (de) * | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
| DE2508312A1 (de) | 1975-02-24 | 1976-09-02 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
| DE2757365A1 (de) * | 1977-12-20 | 1979-06-21 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
| DE3401949A1 (de) * | 1984-01-20 | 1985-08-01 | Bayer Ag, 5090 Leverkusen | Norbornan- und norbornencarbonsaeureamide, verfahren zu deren herstellung sowie die verwendung von norbornan- und norbornencarbonsaeureamiden als arzneimittel |
| JPS61124534A (ja) | 1984-11-22 | 1986-06-12 | Nippon Steel Corp | 熱処理炉用ロ−ル |
| JPS61204193A (ja) * | 1985-03-05 | 1986-09-10 | Takeda Chem Ind Ltd | シトシンヌクレオシド類の製造法 |
| US4754026A (en) * | 1985-06-04 | 1988-06-28 | Takeda Chemical Industries, Ltd. | Conversion of uracil derivatives to cytosine derivatives |
| GB8719367D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Therapeutic compounds |
| US4914233A (en) * | 1988-03-01 | 1990-04-03 | Ethyl Corporation | Synthesis of beta-thymidine |
| US5008384A (en) | 1988-07-12 | 1991-04-16 | Pfizer Inc. | Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine |
| SE8802687D0 (sv) | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
| US6060592A (en) | 1990-01-11 | 2000-05-09 | Isis Pharmaceuticals, Inc. | Pyrimidine nucleoside compounds and oligonucleoside compounds containing same |
| US5200514A (en) | 1990-01-19 | 1993-04-06 | University Of Georgia Research Foundation, Inc. | Synthesis of 2'-deoxypyrimidine nucleosides |
| US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| US5212293A (en) * | 1990-08-06 | 1993-05-18 | American Cyanamid Company | Process for the preparation of deoxynucleosides |
| US5414078A (en) * | 1991-04-05 | 1995-05-09 | Emory University | Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors |
| GB9218810D0 (en) * | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
| JP3693357B2 (ja) | 1993-04-09 | 2005-09-07 | 峯郎 実吉 | 逆転写酵素阻害剤 |
| FR2709754B1 (fr) | 1993-09-10 | 1995-12-01 | Centre Nat Rech Scient | Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale. |
| DE69415506T2 (de) * | 1994-05-20 | 1999-08-12 | Council Of Scientific And Industrial Research, New Delhi | Verfahren zur Herstellung von Beta-Thymidine |
| EP0767657A4 (en) | 1994-06-22 | 1999-01-20 | Nexstar Pharmaceuticals Inc | NOVEL PROCESS FOR THE PRODUCTION OF KNOWN AND NEW NUCLEOSIDES, MODIFIED IN THE 2 'POSITION BY INTRAMOLECULAR NUCLEOPHILIC DISPLACEMENT |
| DE4423647A1 (de) | 1994-07-06 | 1996-01-11 | Thomas Mueller | Fahrrad |
| AT400953B (de) | 1994-08-25 | 1996-05-28 | Joern Saischek | Pentofuranosid-derivate, deren herstellung und verwendung |
| RU2108339C1 (ru) * | 1994-09-27 | 1998-04-10 | Закрытое акционерное общество Производственно-коммерческая ассоциация "АЗТ" | Способ получения 2'-дезоксиксилотимидина, производные d-ксилофуранозы, производные ксилотимидина |
| US5559101A (en) | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
| JPH08149398A (ja) | 1994-11-21 | 1996-06-07 | Matsushita Electric Ind Co Ltd | 画像表示装置 |
| DE19513330A1 (de) * | 1995-04-03 | 1996-10-10 | Schering Ag | Neues Verfahren zur Herstellung von Nucleosiden |
| PT831852E (pt) | 1995-06-07 | 2007-02-28 | Uab Research Foundation | Nucleósidos com actividade anti-vírus da hepatite b |
| JPH0959293A (ja) * | 1995-08-23 | 1997-03-04 | Yamasa Shoyu Co Ltd | ２位炭素鎖置換アデノシン誘導体の製造法 |
| JPH0959292A (ja) | 1995-08-25 | 1997-03-04 | Yamasa Shoyu Co Ltd | ４−アミノピリミジンヌクレオシドの製造法 |
| EP0877554A1 (en) * | 1995-10-31 | 1998-11-18 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
| US5760208A (en) * | 1996-08-14 | 1998-06-02 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Process to prepare pyrimidine nucleosides |
| WO1999043691A1 (en) * | 1998-02-25 | 1999-09-02 | Emory University | 2'-fluoronucleosides |
| US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
| PT2415776T (pt) | 1998-08-10 | 2016-07-07 | Novartis Ag | Beta-l-2'-desoxi-nucleosidos para o tratamento da hepatite b |
| US6399765B1 (en) * | 1999-03-17 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Methods for removing dimethoxytrityl groups from oligonucleotides |
| KR100367986B1 (ko) | 2000-03-27 | 2003-01-14 | 국제약품공업주식회사 | 광학활성을 갖는 시아노부탄트리올 유도체 및 그의 제조방법 |
| DE10020275A1 (de) * | 2000-04-25 | 2001-10-31 | Manfred Schneider | Enantiomere Bausteine der 2-Deoxy-L-Ribose und 2-Deoxy-D-Ribose, Verfahren zu ihrer Herstellung sowie Verwendung zur Synthese von natürlichen und nicht natürliche L- und D-Nucleinsäuren, L- und D- konfigurierten Oligonucleotiden, L- und D-konfigurierter DNA und davon abgeleiteten pharmazeutischen Wirkstoffen |
| US6875751B2 (en) * | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| MY141594A (en) | 2000-06-15 | 2010-05-14 | Novirio Pharmaceuticals Ltd | 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES |
| JP2002322192A (ja) * | 2000-08-10 | 2002-11-08 | Sankyo Co Ltd | ２’−ｏ，４’−ｃ−架橋ヌクレオシドトリリン酸体 |
| DE60144573D1 (de) | 2000-11-29 | 2011-06-16 | Mitsui Chemicals Inc | Verfahren und Zwischenprodukte bei der Synthese von L-Thymidin |
| SK286630B6 (sk) * | 2001-01-22 | 2009-02-05 | Merck & Co., Inc. | Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| US6539837B2 (en) | 2001-05-17 | 2003-04-01 | Delphi Technologies, Inc. | Apparatus and method of attaching a connecting member and a tube member to a housing of a vacuum brake booster |
| DE10216426A1 (de) | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin |
| WO2004084453A2 (en) * | 2003-03-20 | 2004-09-30 | Microbiologica Quimica E Farmaceutica Ltd. | METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES |
-
2004
- 2004-06-30 WO PCT/US2004/021281 patent/WO2005003374A2/en not_active Ceased
- 2004-06-30 US US10/882,893 patent/US20050059632A1/en not_active Abandoned
- 2004-06-30 RU RU2006102518/04A patent/RU2361875C2/ru not_active IP Right Cessation
- 2004-06-30 EP EP04777433A patent/EP1639121A4/en not_active Withdrawn
- 2004-06-30 JP JP2006518785A patent/JP2007527396A/ja active Pending
- 2004-06-30 CA CA002531412A patent/CA2531412A1/en not_active Abandoned
- 2004-06-30 AU AU2004254620A patent/AU2004254620A1/en not_active Abandoned
- 2004-06-30 MX MXPA06000162A patent/MXPA06000162A/es unknown
- 2004-06-30 NZ NZ544634A patent/NZ544634A/en unknown
- 2004-06-30 BR BRPI0412031-0A patent/BRPI0412031A/pt not_active IP Right Cessation
- 2004-06-30 EP EP09075403A patent/EP2157095A3/en not_active Withdrawn
- 2004-06-30 KR KR1020057025429A patent/KR20060035652A/ko not_active Ceased
-
2006
- 2006-01-30 NO NO20060469A patent/NO20060469L/no not_active Application Discontinuation
-
2009
- 2009-04-24 RU RU2009115775/04A patent/RU2009115775A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06000162A (es) | 2006-03-21 |
| EP2157095A2 (en) | 2010-02-24 |
| EP1639121A4 (en) | 2008-04-16 |
| CA2531412A1 (en) | 2005-01-13 |
| WO2005003374A3 (en) | 2005-09-01 |
| EP2157095A3 (en) | 2010-09-08 |
| RU2006102518A (ru) | 2006-07-27 |
| NZ544634A (en) | 2009-10-30 |
| AU2004254620A1 (en) | 2005-01-13 |
| EP1639121A2 (en) | 2006-03-29 |
| RU2361875C2 (ru) | 2009-07-20 |
| JP2007527396A (ja) | 2007-09-27 |
| US20050059632A1 (en) | 2005-03-17 |
| WO2005003374A2 (en) | 2005-01-13 |
| BRPI0412031A (pt) | 2006-09-19 |
| KR20060035652A (ko) | 2006-04-26 |
| RU2009115775A (ru) | 2010-10-27 |
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