NO20062533L - 5-fluor, 5-klor- og cyanopyridin-2-yl-tetrazoler som ligander for den metabotrofe glutamatreseptor-5 - Google Patents

5-fluor, 5-klor- og cyanopyridin-2-yl-tetrazoler som ligander for den metabotrofe glutamatreseptor-5

Info

Publication number
NO20062533L
NO20062533L NO20062533A NO20062533A NO20062533L NO 20062533 L NO20062533 L NO 20062533L NO 20062533 A NO20062533 A NO 20062533A NO 20062533 A NO20062533 A NO 20062533A NO 20062533 L NO20062533 L NO 20062533L
Authority
NO
Norway
Prior art keywords
cyanopyridin
tetrazoles
ligands
fluoro
chloro
Prior art date
Application number
NO20062533A
Other languages
English (en)
Inventor
Donald A Mcleod
Methvin Benjamin Isaac
Thomas M Stormann
David Wensbo
Tao Xin
Louise Edwards
Abdelmalik Slassi
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34748746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20062533(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20062533L publication Critical patent/NO20062533L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår nye forbindelser med formel I hvor Z, Q, X1, X2, R1 og R2 er som definert som i formel I, eller salter, solvater eller sovalterte salter av disse, fremgangsmåter ofr deres fremstilling, farmasøytiske preparater som inneholder nevnte forbindelser og bruken av nevnte forbindelser i terapi.
NO20062533A 2003-12-19 2006-06-01 5-fluor, 5-klor- og cyanopyridin-2-yl-tetrazoler som ligander for den metabotrofe glutamatreseptor-5 NO20062533L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53063303P 2003-12-19 2003-12-19
PCT/US2004/041401 WO2005066155A1 (en) 2003-12-19 2004-12-13 5-fluoro-, chloro- and cyano-pyridin-2-yl-tetrazoles as ligands of the metabotropic glutamate receptor-5

Publications (1)

Publication Number Publication Date
NO20062533L true NO20062533L (no) 2006-09-19

Family

ID=34748746

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062533A NO20062533L (no) 2003-12-19 2006-06-01 5-fluor, 5-klor- og cyanopyridin-2-yl-tetrazoler som ligander for den metabotrofe glutamatreseptor-5

Country Status (20)

Country Link
US (1) US20070255061A1 (no)
EP (1) EP1713791B1 (no)
JP (1) JP2007514790A (no)
KR (1) KR20060126993A (no)
CN (1) CN1906187A (no)
AR (1) AR046768A1 (no)
AT (1) ATE393767T1 (no)
AU (1) AU2004312342A1 (no)
BR (1) BRPI0417308A (no)
CA (1) CA2548039A1 (no)
DE (1) DE602004013469T9 (no)
ES (1) ES2303969T3 (no)
IL (1) IL175909A0 (no)
MX (1) MXPA06006674A (no)
NO (1) NO20062533L (no)
RU (1) RU2006118021A (no)
TW (1) TW200524602A (no)
UY (1) UY28685A1 (no)
WO (1) WO2005066155A1 (no)
ZA (1) ZA200604681B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1706392A2 (en) * 2004-01-08 2006-10-04 Syngenta Participations AG Pesticidal heterocyclic dihaloallyl compounds
UY29796A1 (es) 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US20120095056A1 (en) * 2009-03-19 2012-04-19 Neurosearch A/S 2,5-disubstituted tetrazole derivatives and their use as nicotinic acetylcholine receptor modulators
WO2011073297A1 (en) * 2009-12-18 2011-06-23 Neurosearch A/S Tetrazole derivatives as nicotinic acetylcholine receptor moudlators
WO2011073298A1 (en) * 2009-12-18 2011-06-23 Neurosearch A/S Tetrazole derivatives as nicotinic acetylcholine receptor modulators
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
GB201312800D0 (en) 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
WO2016001452A1 (en) 2014-07-04 2016-01-07 Universität Zürich Compounds, in particular for use in the treatment of a disease or condition for which a bromodomain inhibitor is indicated

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA2462289C (en) * 2001-10-04 2010-02-23 Nicholas D. Cosford Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5

Also Published As

Publication number Publication date
UY28685A1 (es) 2005-06-30
RU2006118021A (ru) 2007-12-10
HK1095598A1 (en) 2007-05-11
IL175909A0 (en) 2008-02-09
EP1713791A1 (en) 2006-10-25
WO2005066155A1 (en) 2005-07-21
DE602004013469T2 (de) 2009-06-18
AR046768A1 (es) 2005-12-21
ATE393767T1 (de) 2008-05-15
MXPA06006674A (es) 2007-04-16
US20070255061A1 (en) 2007-11-01
AU2004312342A1 (en) 2005-07-21
EP1713791B1 (en) 2008-04-30
ZA200604681B (en) 2007-04-25
CN1906187A (zh) 2007-01-31
TW200524602A (en) 2005-08-01
KR20060126993A (ko) 2006-12-11
JP2007514790A (ja) 2007-06-07
DE602004013469D1 (de) 2008-06-12
BRPI0417308A (pt) 2007-09-11
CA2548039A1 (en) 2005-07-21
ES2303969T3 (es) 2008-09-01
DE602004013469T9 (de) 2009-09-24

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