NO20062677L - Benzyleteraminforbindelser anvendbare som CCR-5-antagonister - Google Patents

Benzyleteraminforbindelser anvendbare som CCR-5-antagonister

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Publication number
NO20062677L
NO20062677L NO20062677A NO20062677A NO20062677L NO 20062677 L NO20062677 L NO 20062677L NO 20062677 A NO20062677 A NO 20062677A NO 20062677 A NO20062677 A NO 20062677A NO 20062677 L NO20062677 L NO 20062677L
Authority
NO
Norway
Prior art keywords
ccr
antagonists
benzyl
compounds useful
compounds
Prior art date
Application number
NO20062677A
Other languages
English (en)
Inventor
David D Davey
Gary B Phillips
Bin Ye
Wheeseong Lee
Shou-Fu Lu
Guo Ping Wei
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20062677L publication Critical patent/NO20062677L/no

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C07D211/40—Oxygen atoms
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Abstract

Den foreliggende oppfinnelse vedrører forbindelser som er CCR-5-reseptorantagonister med den generelle formel (I) hvor R1, R2, R3, R4 , Ra, Rb, Rc, Rd, X, m og n er som definert her. Oppfinnelsen omfatter videre farmasøytiske preparater som omfatter slike forbindelser, samt anvendelsen av slike forbindelser til behandling av CCR-5-medierte forstyrrelser.
NO20062677A 2003-11-10 2006-06-09 Benzyleteraminforbindelser anvendbare som CCR-5-antagonister NO20062677L (no)

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US51900203P 2003-11-10 2003-11-10
PCT/US2004/037258 WO2005047249A1 (en) 2003-11-10 2004-11-08 Benzylether amine compounds useful as ccr-5 antagonists

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DE102005061657A1 (de) * 2005-06-16 2006-12-28 Merck Patent Gmbh Verwendung von substituierten Piperazin- und Morpholinderivaten
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RU2006120084A (ru) 2008-01-10
KR20060123292A (ko) 2006-12-01
CN1902171A (zh) 2007-01-24
US20050101644A1 (en) 2005-05-12
CA2543913A1 (en) 2005-05-26
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