NO20062895L - Mykkapsel av butylftalid og fremgangsmate for fremstilling - Google Patents

Mykkapsel av butylftalid og fremgangsmate for fremstilling

Info

Publication number
NO20062895L
NO20062895L NO20062895A NO20062895A NO20062895L NO 20062895 L NO20062895 L NO 20062895L NO 20062895 A NO20062895 A NO 20062895A NO 20062895 A NO20062895 A NO 20062895A NO 20062895 L NO20062895 L NO 20062895L
Authority
NO
Norway
Prior art keywords
butylphthalide
soft capsule
capsule
preparation
drug
Prior art date
Application number
NO20062895A
Other languages
English (en)
Other versions
NO338520B1 (no
Inventor
Min Bai
Jianqing Li
Wenmin Guo
Surui Chen
Liyun Liu
Guirong Zhou
Original Assignee
Shijiazhuang Pharma Group Nbp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Pharma Group Nbp filed Critical Shijiazhuang Pharma Group Nbp
Publication of NO20062895L publication Critical patent/NO20062895L/no
Publication of NO338520B1 publication Critical patent/NO338520B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Formation And Processing Of Food Products (AREA)

Abstract

Foreliggende oppfinnelse beskriver en ny mykkapsel av butylftalid og en fremgangsmåte for fremstilling av denne. Mykkapselen av butylftalid består av kapselveggmateriale og en legemiddelinneholdende olje, hvor den legemiddelinneholdende oljen hovedsakelig består av butylftalid og en vegetabilsk olje som løsningsmiddel i et vektforhold på omtrent 1:0~10. Kapselveggmatriks består av kapselveggmateriale, et plastiseringsmiddel og vann i et vektforhold på 1:0,2~0,4:0,8~1,3. Mykkapselen av butylftalid beskrevet i foreliggende oppfinnelse kan maskere den sterke og spesielle lukten av butylftalid, og overkomme problemene assosiert med formulering av oljelignende aktive ingredienser i oral formulering. Nedbrytningstiden av mykkapslene tilfredstiller reglementet til Pharmacopoeia of P.R. China.
NO20062895A 2003-12-05 2006-06-20 Mykkapsel av butylftalid NO338520B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2003101193361A CN1257711C (zh) 2003-12-05 2003-12-05 丁苯酞软胶囊及其制备工艺
PCT/CN2004/001411 WO2005053658A1 (en) 2003-12-05 2004-12-03 Butylphthalide soft gel capsule and its preparatin procedure

Publications (2)

Publication Number Publication Date
NO20062895L true NO20062895L (no) 2006-09-04
NO338520B1 NO338520B1 (no) 2016-08-29

Family

ID=34638049

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062895A NO338520B1 (no) 2003-12-05 2006-06-20 Mykkapsel av butylftalid

Country Status (14)

Country Link
US (4) US20080020034A1 (no)
EP (1) EP1702612B1 (no)
JP (1) JP4634394B2 (no)
KR (1) KR100761437B1 (no)
CN (1) CN1257711C (no)
AT (1) ATE427104T1 (no)
AU (1) AU2004294254B2 (no)
BR (1) BRPI0417339C8 (no)
CA (1) CA2549498C (no)
DE (1) DE602004020381D1 (no)
MX (1) MXPA06006401A (no)
NO (1) NO338520B1 (no)
RU (1) RU2322976C1 (no)
WO (1) WO2005053658A1 (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100471494C (zh) * 2005-12-24 2009-03-25 石药集团中奇制药技术（石家庄）有限公司 丁苯酞滴丸及制备方法
RU2420291C3 (ru) * 2006-01-24 2020-07-21 Р-Тек Уено, Лтд. Состав в мягкой желатиновой капсуле
CN101342152B (zh) * 2007-07-10 2010-10-13 石药集团中奇制药技术（石家庄）有限公司 丁苯酞片及其制备方法
US8726005B2 (en) 2009-12-10 2014-05-13 George Mason Intellectual Properties, Inc. Website matching based on network traffic
CN102058560B (zh) * 2010-12-30 2013-07-24 张家界茅岩莓有限公司 一种二氢杨梅素软胶囊及制备方法
CN102178643B (zh) * 2011-04-29 2014-05-14 石药集团恩必普药业有限公司 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法
CN103169685B (zh) * 2011-12-23 2018-03-06 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞控释制剂及其制备方法
CN107648222A (zh) * 2012-06-06 2018-02-02 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞药物活性组合物及其制备方法
CN102716103B (zh) * 2012-07-02 2013-12-18 西安力邦制药有限公司 2,2′,6,6′-四异丙基-4,4′-二联苯酚软胶囊制剂及其制备方法
CN104224772A (zh) * 2013-06-13 2014-12-24 石药集团中奇制药技术（石家庄）有限公司 一种包含丁苯酞和冰片的药物组合物及其应用
CN106606498A (zh) * 2016-07-25 2017-05-03 山东诚创医药技术开发有限公司 一种丁苯酞软胶囊
CN106580959B (zh) * 2017-01-10 2019-04-23 山东省立医院 一种缓解急性缺血性脑卒中的丁苯酞尼群地平软胶囊
CN109432042B (zh) * 2018-12-24 2022-04-22 石药集团恩必普药业有限公司 一种软胶囊囊壳及其制备方法
CN112336700B (zh) * 2019-08-08 2023-12-01 河北菲尼斯生物技术有限公司 一种稳定的含丁苯酞药物及其制备方法
CN114073694B (zh) * 2020-08-14 2024-03-12 北京科莱博医药开发有限责任公司 丁苯酞制剂及其制备方法
KR102294072B1 (ko) 2020-11-19 2021-08-26 (주)알피바이오 식물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 식물성 츄어블 연질캡슐
KR102523186B1 (ko) 2020-11-19 2023-04-18 (주)알피바이오 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐
CN113975242A (zh) * 2021-10-14 2022-01-28 山东诚创蓝海医药科技有限公司 一种提高口服生物利用度的丁苯酞软胶囊
KR102909778B1 (ko) * 2022-08-17 2026-01-07 김미숙 초임계 유체 잣 추출물을 함유한 잣오일 캡슐 제조방법 및 그 방법에 의해 제조되는 잣오일 캡슐
CN115469039B (zh) * 2022-10-28 2024-04-26 成都施贝康生物医药科技有限公司 一种丁苯酞及其有关物质检测方法
CN115453014B (zh) * 2022-10-28 2024-04-19 成都施贝康生物医药科技有限公司 一种丁苯酞及其有关物质的检测方法
KR102945311B1 (ko) * 2023-12-15 2026-04-01 한국 한의학 연구원 부틸프탈라이드 또는 이의 허용 가능한 염을 유효성분으로 포함하는 노화에 의한 난소 저반응군의 예방, 개선 또는 치료용 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3927195A (en) * 1974-01-31 1975-12-16 Lilly Industries Ltd Production of capsules
NL7510104A (nl) * 1975-08-27 1977-03-01 Akzo Nv Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat.
US4366145A (en) * 1981-06-24 1982-12-28 Sandoz, Inc. Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation
AU552068B2 (en) * 1981-09-21 1986-05-22 Asama Chemical Co. Ltd. Preservation of edible oils
FR2608456B1 (fr) * 1986-12-18 1993-06-18 Mero Rousselot Satia Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention
JPH01199958A (ja) * 1987-07-23 1989-08-11 Tsumura & Co 新規なフタリド誘導体およびその製造方法
PL176595B1 (pl) * 1993-06-25 1999-06-30 Main Camp Marketing Pty Ltd Środek leczniczy w postaci koncentratu z nasion selera i sposób otrzymywania środka leczniczego w postaci koncentratu z nasion selera
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
AUPO990397A0 (en) 1997-10-22 1997-11-13 R.P. Scherer Holdings Pty Ltd Clear solutions of herbal extracts
CN1086942C (zh) * 1998-12-18 2002-07-03 中国医学科学院药物研究所 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用
US6800329B2 (en) * 1999-02-12 2004-10-05 Lts Lohmann Therapie-Systeme Ag Method for producing film-type dosage
US6193999B1 (en) * 1999-03-01 2001-02-27 Banner Pharmacaps, Inc. Gum acacia substituted soft gelatin capsules
CN1102397C (zh) * 2000-03-01 2003-03-05 山东绿叶制药股份有限公司 当归油软胶囊及其制备工艺
CN1375288A (zh) * 2002-05-13 2002-10-23 周桂荣 一种治疗脑血管疾病的药物组合物
ATE489972T1 (de) 2002-08-21 2010-12-15 Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd Einschlusskomplexe aus butylphthalid und cyclodextrin derivaten und verfahren zu deren herstellung

Also Published As

Publication number Publication date
EP1702612B1 (en) 2009-04-01
EP1702612A4 (en) 2006-12-20
MXPA06006401A (es) 2007-11-13
JP4634394B2 (ja) 2011-02-16
ATE427104T1 (de) 2009-04-15
US20070134316A1 (en) 2007-06-14
EP1702612A1 (en) 2006-09-20
BRPI0417339B8 (pt) 2020-06-02
BRPI0417339A (pt) 2007-02-21
CA2549498A1 (en) 2005-06-16
DE602004020381D1 (de) 2009-05-14
RU2322976C1 (ru) 2008-04-27
RU2006122207A (ru) 2008-01-10
CN1257711C (zh) 2006-05-31
WO2005053658A8 (en) 2005-10-13
NO338520B1 (no) 2016-08-29
US20120052117A1 (en) 2012-03-01
BRPI0417339B1 (pt) 2017-12-19
US20080020034A1 (en) 2008-01-24
KR100761437B1 (ko) 2007-10-04
AU2004294254A1 (en) 2005-06-16
BRPI0417339C8 (pt) 2022-02-01
US8609137B2 (en) 2013-12-17
JP2007513097A (ja) 2007-05-24
CN1623542A (zh) 2005-06-08
CA2549498C (en) 2011-07-12
HK1090302A1 (en) 2006-12-22
US20080305163A1 (en) 2008-12-11
AU2004294254B2 (en) 2008-02-07
KR20060105013A (ko) 2006-10-09
BRPI0417339C1 (pt) 2021-05-25
WO2005053658A1 (en) 2005-06-16

Similar Documents

Publication Publication Date Title
BRPI0417339C1 (pt) cápsula macia de butilftalida
EP2108362A3 (en) Method of producing a cationic liposomal preparation comprising a lipophilic compound
CA2385890A1 (en) Controlled release compositions comprising nimesulide
WO1997012583A3 (en) Stable compositions containing n-propargyl-1-aminoindan
EA200500891A1 (ru) Фармацевтические композиции, содержащие щелочные или соответственно кислые лекарственные соединения, поверхностно-активное вещество и физиологически приемлемую водорастворимую кислоту или соответственно основание
NO20080827L (no) Faste doseringsformuleringer av narkotiske legemidler som har forbedret bukal adsorpsjon
WO2002045686A3 (en) Pharmaceutical paste comprising an acid-labile active ingredient
HUP0102676A2 (hu) Szilárd, gyorsan széteső cetirizint tartalmazó gyógyszerkészítmények
FR2850576B1 (fr) Composition comprenant un melange de principes actifs, et procede de preparation
MY144992A (en) Substituted 1,2,3,4-tetrahydroisoquinoline derivatives.
ES2185452A1 (es) Composicion farmaceutica de fluoxetina en comprimido dispersable recubierto y su proceso de fabricacion.
DE50112438D1 (de) Zahnpflegemittel in portionskapseln
GR20010100377A (el) Φαρμακευτικη συνθεση περιεχουσα σιταλοπραμη
WO2005112881A8 (fr) Comprime de montmorillonite dispersible et sa technique de preparation
AR046226A1 (es) Formulaciones farmaceuticas que contienen saborizante con caracteristicas farmaceuticas mejoradas
WO2004071156A3 (en) Use of edible acid in fast-dispersing pharmaceutical solid dosage forms
MY137570A (en) Method for the preparation of a pharmaceutical composition comprising 5-aminosalicyclic acid for use in treatment of ulcerative colitis crohn's disease
WO2004087102A3 (en) A process for preparing a pharmaceutical active ingredient with high specific surface area
RU2000117517A (ru) Способ приготовления лечебно-профилактического препарата на основе живых штаммов микроорганизмов "lb комплекс"
WO2002011668A3 (en) 5'-deoxy-n-(substituted oxycarbonyl)-5-fluorocytosine and derivatives thereof, method of preparing same, and anticancer composition comprising same as active ingredients
WO2002018611A3 (de) Verfahren zur verbesserten herstellung und isolierung von trans-dihydroxy-cyclohexadien-carbonsäuren und/oder deren folgeprodukte sowie ein dazu geeigneter genetisch veränderter organismus
HK1054508A1 (zh) 新型製劑
MY127289A (en) Caloporoside derivatives, process for the preparation thereof, and the use thereof
JP2003119141A5 (no)
CA2538019A1 (en) Oral itraconazole composition which is not affected by ingested food and process for preparing same

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY, CN